Putative exosome complex exonuclease RRP40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome complex exonuclease RRP40, putative

Species:

Leishmania braziliensis

UniProt:

A4H3T3_LEIBR

TriTrypDb:

LbrM.04.0170 , LBRM2903_040006500

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1905354	exoribonuclease complex	3	12
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H3T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T3

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071034	CUT catabolic process	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071043	CUT metabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	8
GO:0004527	exonuclease activity	5	8
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.505
CLV_C14_Caspase3-7	260	264	PF00656	0.388
CLV_NRD_NRD_1	195	197	PF00675	0.330
CLV_NRD_NRD_1	239	241	PF00675	0.334
CLV_NRD_NRD_1	269	271	PF00675	0.370
CLV_NRD_NRD_1	67	69	PF00675	0.475
CLV_NRD_NRD_1	82	84	PF00675	0.392
CLV_PCSK_KEX2_1	195	197	PF00082	0.357
CLV_PCSK_KEX2_1	239	241	PF00082	0.334
CLV_PCSK_KEX2_1	269	271	PF00082	0.370
CLV_PCSK_KEX2_1	67	69	PF00082	0.475
CLV_PCSK_SKI1_1	195	199	PF00082	0.295
DEG_APCC_DBOX_1	194	202	PF00400	0.518
DOC_CDC14_PxL_1	14	22	PF14671	0.427
DOC_CKS1_1	61	66	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.534
DOC_MAPK_gen_1	195	203	PF00069	0.379
DOC_MAPK_gen_1	239	247	PF00069	0.534
DOC_MAPK_HePTP_8	237	249	PF00069	0.462
DOC_MAPK_MEF2A_6	240	249	PF00069	0.462
DOC_MAPK_MEF2A_6	72	80	PF00069	0.373
DOC_PP2B_LxvP_1	187	190	PF13499	0.534
DOC_PP2B_LxvP_1	197	200	PF13499	0.534
DOC_PP4_FxxP_1	41	44	PF00568	0.418
DOC_USP7_MATH_1	132	136	PF00917	0.502
DOC_USP7_MATH_1	2	6	PF00917	0.517
DOC_USP7_MATH_1	273	277	PF00917	0.455
DOC_WW_Pin1_4	137	142	PF00397	0.458
DOC_WW_Pin1_4	201	206	PF00397	0.507
DOC_WW_Pin1_4	60	65	PF00397	0.589
DOC_WW_Pin1_4	67	72	PF00397	0.493
LIG_14-3-3_CanoR_1	131	137	PF00244	0.583
LIG_14-3-3_CanoR_1	256	265	PF00244	0.536
LIG_14-3-3_CanoR_1	269	273	PF00244	0.410
LIG_14-3-3_CanoR_1	83	91	PF00244	0.439
LIG_BIR_II_1	1	5	PF00653	0.417
LIG_BIR_III_1	1	5	PF00653	0.417
LIG_BIR_III_3	1	5	PF00653	0.417
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.393
LIG_eIF4E_1	193	199	PF01652	0.435
LIG_FHA_1	269	275	PF00498	0.388
LIG_FHA_2	149	155	PF00498	0.597
LIG_FHA_2	158	164	PF00498	0.389
LIG_FHA_2	170	176	PF00498	0.347
LIG_FHA_2	216	222	PF00498	0.491
LIG_FHA_2	22	28	PF00498	0.697
LIG_FHA_2	284	290	PF00498	0.378
LIG_LIR_Apic_2	39	44	PF02991	0.515
LIG_LIR_Gen_1	122	133	PF02991	0.398
LIG_LIR_Nem_3	122	128	PF02991	0.353
LIG_LIR_Nem_3	175	181	PF02991	0.356
LIG_MYND_1	18	22	PF01753	0.439
LIG_NRBOX	232	238	PF00104	0.448
LIG_Pex14_2	37	41	PF04695	0.396
LIG_SH2_CRK	125	129	PF00017	0.329
LIG_SH2_CRK	59	63	PF00017	0.622
LIG_SH2_CRK	91	95	PF00017	0.389
LIG_SH2_PTP2	127	130	PF00017	0.477
LIG_SH2_SRC	136	139	PF00017	0.531
LIG_SH2_STAT3	232	235	PF00017	0.539
LIG_SH2_STAT5	125	128	PF00017	0.399
LIG_SH2_STAT5	136	139	PF00017	0.622
LIG_SH2_STAT5	193	196	PF00017	0.539
LIG_SH2_STAT5	232	235	PF00017	0.539
LIG_SH2_STAT5	297	300	PF00017	0.388
LIG_SH2_STAT5	69	72	PF00017	0.404
LIG_SH2_STAT5	91	94	PF00017	0.329
LIG_SH3_1	15	21	PF00018	0.479
LIG_SH3_3	110	116	PF00018	0.514
LIG_SH3_3	15	21	PF00018	0.479
LIG_SH3_3	161	167	PF00018	0.482
LIG_SH3_3	174	180	PF00018	0.343
LIG_SH3_3	58	64	PF00018	0.566
LIG_SUMO_SIM_par_1	270	276	PF11976	0.477
LIG_TYR_ITIM	123	128	PF00017	0.322
MOD_CDC14_SPxK_1	204	207	PF00782	0.491
MOD_CDK_SPK_2	137	142	PF00069	0.458
MOD_CDK_SPK_2	67	72	PF00069	0.535
MOD_CDK_SPxK_1	201	207	PF00069	0.491
MOD_CDK_SPxxK_3	60	67	PF00069	0.616
MOD_CK1_1	143	149	PF00069	0.649
MOD_CK1_1	215	221	PF00069	0.537
MOD_CK1_1	276	282	PF00069	0.470
MOD_CK2_1	148	154	PF00069	0.635
MOD_CK2_1	157	163	PF00069	0.389
MOD_CK2_1	169	175	PF00069	0.362
MOD_CK2_1	215	221	PF00069	0.519
MOD_CK2_1	283	289	PF00069	0.407
MOD_Cter_Amidation	237	240	PF01082	0.334
MOD_GlcNHglycan	145	148	PF01048	0.579
MOD_GlcNHglycan	172	175	PF01048	0.482
MOD_GlcNHglycan	208	211	PF01048	0.351
MOD_GlcNHglycan	221	225	PF01048	0.383
MOD_GlcNHglycan	4	7	PF01048	0.587
MOD_GlcNHglycan	96	99	PF01048	0.422
MOD_GSK3_1	23	30	PF00069	0.617
MOD_GSK3_1	268	275	PF00069	0.521
MOD_GSK3_1	63	70	PF00069	0.456
MOD_N-GLC_1	215	220	PF02516	0.179
MOD_NEK2_1	45	50	PF00069	0.510
MOD_PIKK_1	27	33	PF00454	0.733
MOD_PIKK_1	83	89	PF00454	0.509
MOD_PKA_1	83	89	PF00069	0.420
MOD_PKA_2	268	274	PF00069	0.366
MOD_Plk_4	132	138	PF00069	0.641
MOD_Plk_4	228	234	PF00069	0.472
MOD_ProDKin_1	137	143	PF00069	0.456
MOD_ProDKin_1	201	207	PF00069	0.507
MOD_ProDKin_1	60	66	PF00069	0.585
MOD_ProDKin_1	67	73	PF00069	0.491
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.630
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.585
TRG_ENDOCYTIC_2	125	128	PF00928	0.306
TRG_ENDOCYTIC_2	91	94	PF00928	0.454
TRG_ER_diArg_1	115	118	PF00400	0.383
TRG_ER_diArg_1	194	196	PF00400	0.556
TRG_ER_diArg_1	239	241	PF00400	0.542
TRG_ER_diArg_1	67	69	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B7	Leptomonas seymouri	70%	91%
A0A0S4IMH2	Bodo saltans	38%	100%
A0A1X0NL22	Trypanosomatidae	50%	99%
A0A3S5H578	Leishmania donovani	86%	100%
A0A422NN72	Trypanosoma rangeli	47%	100%
A4HS08	Leishmania infantum	85%	100%
C9ZY06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9AJZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	90%
Q9N857	Leishmania major	88%	100%
V5BI90	Trypanosoma cruzi	49%	100%