Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3T2_LEIBR

TriTrypDb:

LbrM.04.0160 , LBRM2903_040006400

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.620
CLV_NRD_NRD_1	125	127	PF00675	0.643
CLV_NRD_NRD_1	215	217	PF00675	0.627
CLV_NRD_NRD_1	258	260	PF00675	0.508
CLV_NRD_NRD_1	335	337	PF00675	0.624
CLV_NRD_NRD_1	79	81	PF00675	0.460
CLV_PCSK_KEX2_1	125	127	PF00082	0.643
CLV_PCSK_KEX2_1	215	217	PF00082	0.657
CLV_PCSK_KEX2_1	258	260	PF00082	0.508
CLV_PCSK_KEX2_1	335	337	PF00082	0.580
CLV_PCSK_KEX2_1	79	81	PF00082	0.516
CLV_PCSK_KEX2_1	87	89	PF00082	0.571
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.637
CLV_PCSK_SKI1_1	117	121	PF00082	0.511
CLV_PCSK_SKI1_1	138	142	PF00082	0.501
CLV_PCSK_SKI1_1	215	219	PF00082	0.656
CLV_PCSK_SKI1_1	40	44	PF00082	0.384
DEG_APCC_DBOX_1	39	47	PF00400	0.383
DEG_Nend_Nbox_1	1	3	PF02207	0.648
DOC_CKS1_1	219	224	PF01111	0.714
DOC_PP1_RVXF_1	143	150	PF00149	0.366
DOC_PP4_FxxP_1	315	318	PF00568	0.504
DOC_USP7_MATH_1	17	21	PF00917	0.451
DOC_USP7_MATH_1	210	214	PF00917	0.499
DOC_USP7_MATH_1	291	295	PF00917	0.770
DOC_USP7_MATH_1	340	344	PF00917	0.532
DOC_WW_Pin1_4	218	223	PF00397	0.670
DOC_WW_Pin1_4	266	271	PF00397	0.680
DOC_WW_Pin1_4	287	292	PF00397	0.746
DOC_WW_Pin1_4	295	300	PF00397	0.801
DOC_WW_Pin1_4	314	319	PF00397	0.664
LIG_14-3-3_CanoR_1	11	19	PF00244	0.738
LIG_14-3-3_CanoR_1	293	298	PF00244	0.619
LIG_CSL_BTD_1	267	270	PF09270	0.515
LIG_FHA_1	1	7	PF00498	0.726
LIG_FHA_1	122	128	PF00498	0.378
LIG_FHA_1	225	231	PF00498	0.546
LIG_FHA_1	320	326	PF00498	0.445
LIG_FHA_1	39	45	PF00498	0.412
LIG_FHA_2	132	138	PF00498	0.543
LIG_FHA_2	166	172	PF00498	0.459
LIG_FHA_2	190	196	PF00498	0.465
LIG_FHA_2	306	312	PF00498	0.780
LIG_Integrin_RGD_1	88	90	PF01839	0.380
LIG_LIR_Apic_2	294	300	PF02991	0.584
LIG_LIR_Apic_2	314	318	PF02991	0.514
LIG_LIR_Gen_1	146	157	PF02991	0.501
LIG_LIR_Gen_1	25	35	PF02991	0.468
LIG_LIR_Nem_3	146	152	PF02991	0.502
LIG_LIR_Nem_3	212	217	PF02991	0.504
LIG_LIR_Nem_3	25	30	PF02991	0.464
LIG_SH2_CRK	214	218	PF00017	0.660
LIG_SH2_CRK	297	301	PF00017	0.614
LIG_SH2_SRC	59	62	PF00017	0.620
LIG_SH2_STAP1	59	63	PF00017	0.517
LIG_SH2_STAT5	297	300	PF00017	0.612
LIG_SH3_1	216	222	PF00018	0.650
LIG_SH3_3	216	222	PF00018	0.647
LIG_SH3_3	43	49	PF00018	0.540
LIG_Sin3_3	53	60	PF02671	0.626
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.368
LIG_SUMO_SIM_par_1	32	37	PF11976	0.368
LIG_SUMO_SIM_par_1	41	48	PF11976	0.537
LIG_TRAF2_1	119	122	PF00917	0.465
LIG_TRAF2_1	133	136	PF00917	0.479
LIG_TRAF2_1	151	154	PF00917	0.518
LIG_TRAF2_1	168	171	PF00917	0.600
LIG_TRAF2_1	20	23	PF00917	0.663
LIG_TRAF2_1	83	86	PF00917	0.520
LIG_TYR_ITSM	210	217	PF00017	0.502
LIG_WRC_WIRS_1	312	317	PF05994	0.535
LIG_WW_3	298	302	PF00397	0.581
MOD_CDC14_SPxK_1	290	293	PF00782	0.583
MOD_CDK_SPK_2	266	271	PF00069	0.732
MOD_CDK_SPxK_1	287	293	PF00069	0.767
MOD_CDK_SPxK_1	295	301	PF00069	0.723
MOD_CDK_SPxxK_3	266	273	PF00069	0.676
MOD_CDK_SPxxK_3	314	321	PF00069	0.746
MOD_CK1_1	112	118	PF00069	0.625
MOD_CK1_1	189	195	PF00069	0.481
MOD_CK1_1	269	275	PF00069	0.759
MOD_CK2_1	130	136	PF00069	0.539
MOD_CK2_1	165	171	PF00069	0.541
MOD_CK2_1	17	23	PF00069	0.626
MOD_CK2_1	189	195	PF00069	0.452
MOD_CK2_1	26	32	PF00069	0.470
MOD_CK2_1	305	311	PF00069	0.783
MOD_CK2_1	80	86	PF00069	0.598
MOD_GlcNHglycan	188	191	PF01048	0.534
MOD_GlcNHglycan	19	22	PF01048	0.559
MOD_GlcNHglycan	195	199	PF01048	0.603
MOD_GlcNHglycan	23	27	PF01048	0.535
MOD_GlcNHglycan	242	246	PF01048	0.444
MOD_GlcNHglycan	305	308	PF01048	0.779
MOD_GlcNHglycan	48	52	PF01048	0.473
MOD_GlcNHglycan	82	85	PF01048	0.376
MOD_GSK3_1	109	116	PF00069	0.579
MOD_GSK3_1	121	128	PF00069	0.324
MOD_GSK3_1	185	192	PF00069	0.447
MOD_GSK3_1	22	29	PF00069	0.636
MOD_GSK3_1	287	294	PF00069	0.617
MOD_GSK3_1	295	302	PF00069	0.743
MOD_LATS_1	239	245	PF00433	0.444
MOD_N-GLC_1	303	308	PF02516	0.823
MOD_NEK2_1	194	199	PF00069	0.702
MOD_NEK2_1	209	214	PF00069	0.556
MOD_NEK2_1	338	343	PF00069	0.521
MOD_NEK2_1	66	71	PF00069	0.613
MOD_PIKK_1	131	137	PF00454	0.653
MOD_PIKK_1	291	297	PF00454	0.675
MOD_PIKK_1	305	311	PF00454	0.740
MOD_PKA_1	125	131	PF00069	0.392
MOD_PKA_2	125	131	PF00069	0.633
MOD_PKA_2	240	246	PF00069	0.446
MOD_PKA_2	300	306	PF00069	0.730
MOD_Plk_1	143	149	PF00069	0.620
MOD_Plk_4	189	195	PF00069	0.660
MOD_Plk_4	226	232	PF00069	0.586
MOD_Plk_4	275	281	PF00069	0.607
MOD_ProDKin_1	218	224	PF00069	0.663
MOD_ProDKin_1	266	272	PF00069	0.675
MOD_ProDKin_1	287	293	PF00069	0.749
MOD_ProDKin_1	295	301	PF00069	0.803
MOD_ProDKin_1	314	320	PF00069	0.653
MOD_SUMO_rev_2	329	334	PF00179	0.600
TRG_DiLeu_BaEn_4	122	128	PF01217	0.569
TRG_DiLeu_BaEn_4	136	142	PF01217	0.518
TRG_DiLeu_BaEn_4	329	335	PF01217	0.605
TRG_ENDOCYTIC_2	214	217	PF00928	0.661
TRG_ER_diArg_1	125	127	PF00400	0.643
TRG_ER_diArg_1	214	216	PF00400	0.666
TRG_ER_diArg_1	270	273	PF00400	0.564
TRG_ER_diArg_1	334	336	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB32	Leptomonas seymouri	45%	96%
A0A3S5H577	Leishmania donovani	74%	99%
A4HS07	Leishmania infantum	74%	99%
E9AJZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q9GRM8	Leishmania major	73%	100%