Protein brambleberry-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3T1_LEIBR

TriTrypDb:

LbrM.04.0150 , LBRM2903_040006300

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H3T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.524
CLV_C14_Caspase3-7	516	520	PF00656	0.856
CLV_NRD_NRD_1	50	52	PF00675	0.729
CLV_NRD_NRD_1	546	548	PF00675	0.597
CLV_NRD_NRD_1	593	595	PF00675	0.537
CLV_PCSK_FUR_1	579	583	PF00082	0.470
CLV_PCSK_KEX2_1	102	104	PF00082	0.563
CLV_PCSK_KEX2_1	311	313	PF00082	0.745
CLV_PCSK_KEX2_1	50	52	PF00082	0.727
CLV_PCSK_KEX2_1	545	547	PF00082	0.598
CLV_PCSK_KEX2_1	581	583	PF00082	0.468
CLV_PCSK_KEX2_1	593	595	PF00082	0.535
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.603
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.745
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.505
CLV_PCSK_SKI1_1	20	24	PF00082	0.405
CLV_PCSK_SKI1_1	395	399	PF00082	0.721
CLV_PCSK_SKI1_1	549	553	PF00082	0.635
CLV_PCSK_SKI1_1	560	564	PF00082	0.503
DEG_APCC_DBOX_1	19	27	PF00400	0.424
DEG_APCC_DBOX_1	248	256	PF00400	0.340
DEG_SPOP_SBC_1	585	589	PF00917	0.674
DOC_CYCLIN_RxL_1	392	402	PF00134	0.509
DOC_MAPK_gen_1	17	26	PF00069	0.538
DOC_MAPK_gen_1	341	350	PF00069	0.330
DOC_MAPK_MEF2A_6	122	129	PF00069	0.394
DOC_MAPK_MEF2A_6	17	26	PF00069	0.472
DOC_MAPK_NFAT4_5	122	130	PF00069	0.394
DOC_PP1_RVXF_1	344	350	PF00149	0.266
DOC_USP7_MATH_1	244	248	PF00917	0.521
DOC_USP7_MATH_1	298	302	PF00917	0.424
DOC_USP7_MATH_1	403	407	PF00917	0.513
DOC_USP7_MATH_1	486	490	PF00917	0.833
DOC_USP7_MATH_1	517	521	PF00917	0.866
DOC_USP7_MATH_2	533	539	PF00917	0.859
DOC_WW_Pin1_4	421	426	PF00397	0.662
DOC_WW_Pin1_4	501	506	PF00397	0.768
DOC_WW_Pin1_4	510	515	PF00397	0.682
DOC_WW_Pin1_4	539	544	PF00397	0.797
DOC_WW_Pin1_4	95	100	PF00397	0.486
LIG_14-3-3_CanoR_1	212	220	PF00244	0.518
LIG_14-3-3_CanoR_1	275	284	PF00244	0.523
LIG_14-3-3_CanoR_1	370	376	PF00244	0.513
LIG_14-3-3_CanoR_1	430	435	PF00244	0.651
LIG_14-3-3_CanoR_1	586	592	PF00244	0.696
LIG_Actin_WH2_2	259	277	PF00022	0.463
LIG_EVH1_2	70	74	PF00568	0.515
LIG_FHA_1	147	153	PF00498	0.387
LIG_FHA_1	156	162	PF00498	0.312
LIG_FHA_1	29	35	PF00498	0.494
LIG_FHA_1	318	324	PF00498	0.435
LIG_FHA_2	400	406	PF00498	0.385
LIG_FHA_2	514	520	PF00498	0.701
LIG_FHA_2	550	556	PF00498	0.785
LIG_GBD_Chelix_1	347	355	PF00786	0.261
LIG_IRF3_LxIS_1	486	493	PF10401	0.650
LIG_LIR_Gen_1	170	181	PF02991	0.401
LIG_LIR_Gen_1	374	384	PF02991	0.468
LIG_LIR_Gen_1	394	403	PF02991	0.417
LIG_LIR_Nem_3	170	176	PF02991	0.405
LIG_LIR_Nem_3	374	379	PF02991	0.468
LIG_LIR_Nem_3	39	45	PF02991	0.604
LIG_LIR_Nem_3	394	399	PF02991	0.433
LIG_LIR_Nem_3	401	407	PF02991	0.365
LIG_MYND_1	71	75	PF01753	0.622
LIG_NRBOX	332	338	PF00104	0.536
LIG_SH2_CRK	423	427	PF00017	0.584
LIG_SH2_NCK_1	423	427	PF00017	0.549
LIG_SH2_STAP1	173	177	PF00017	0.398
LIG_SH2_STAT3	465	468	PF00017	0.800
LIG_SH2_STAT5	189	192	PF00017	0.400
LIG_SH2_STAT5	423	426	PF00017	0.657
LIG_SH2_STAT5	465	468	PF00017	0.659
LIG_SH3_3	379	385	PF00018	0.299
LIG_SH3_3	464	470	PF00018	0.741
LIG_SH3_3	49	55	PF00018	0.555
LIG_SH3_3	527	533	PF00018	0.807
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.525
LIG_SUMO_SIM_par_1	356	361	PF11976	0.405
LIG_SUMO_SIM_par_1	497	502	PF11976	0.652
LIG_TRAF2_1	435	438	PF00917	0.627
LIG_WW_3	69	73	PF00397	0.523
MOD_CDK_SPK_2	501	506	PF00069	0.841
MOD_CDK_SPxK_1	539	545	PF00069	0.865
MOD_CDK_SPxxK_3	539	546	PF00069	0.865
MOD_CDK_SPxxK_3	95	102	PF00069	0.482
MOD_CK1_1	117	123	PF00069	0.304
MOD_CK1_1	148	154	PF00069	0.516
MOD_CK1_1	277	283	PF00069	0.467
MOD_CK1_1	306	312	PF00069	0.537
MOD_CK1_1	520	526	PF00069	0.801
MOD_CK1_1	564	570	PF00069	0.693
MOD_CK1_1	7	13	PF00069	0.757
MOD_CK2_1	220	226	PF00069	0.418
MOD_CK2_1	399	405	PF00069	0.469
MOD_CMANNOS	18	21	PF00535	0.358
MOD_GlcNHglycan	170	173	PF01048	0.648
MOD_GlcNHglycan	222	225	PF01048	0.614
MOD_GlcNHglycan	537	540	PF01048	0.608
MOD_GlcNHglycan	588	591	PF01048	0.477
MOD_GSK3_1	133	140	PF00069	0.454
MOD_GSK3_1	151	158	PF00069	0.315
MOD_GSK3_1	211	218	PF00069	0.462
MOD_GSK3_1	273	280	PF00069	0.468
MOD_GSK3_1	399	406	PF00069	0.501
MOD_GSK3_1	486	493	PF00069	0.650
MOD_GSK3_1	497	504	PF00069	0.778
MOD_GSK3_1	513	520	PF00069	0.864
MOD_GSK3_1	535	542	PF00069	0.789
MOD_GSK3_1	577	584	PF00069	0.771
MOD_N-GLC_1	36	41	PF02516	0.241
MOD_N-GLC_1	490	495	PF02516	0.450
MOD_N-GLC_1	517	522	PF02516	0.485
MOD_NEK2_1	168	173	PF00069	0.409
MOD_NEK2_1	210	215	PF00069	0.515
MOD_NEK2_1	220	225	PF00069	0.440
MOD_NEK2_1	231	236	PF00069	0.456
MOD_NEK2_1	274	279	PF00069	0.499
MOD_NEK2_1	358	363	PF00069	0.411
MOD_NEK2_1	399	404	PF00069	0.510
MOD_NEK2_1	407	412	PF00069	0.418
MOD_NEK2_1	457	462	PF00069	0.731
MOD_NEK2_1	490	495	PF00069	0.806
MOD_NEK2_1	499	504	PF00069	0.659
MOD_NEK2_2	244	249	PF00069	0.342
MOD_PIKK_1	231	237	PF00454	0.529
MOD_PIKK_1	303	309	PF00454	0.474
MOD_PIKK_1	561	567	PF00454	0.673
MOD_PKA_1	581	587	PF00069	0.706
MOD_PKA_2	211	217	PF00069	0.516
MOD_PKA_2	274	280	PF00069	0.503
MOD_PKA_2	581	587	PF00069	0.694
MOD_PKB_1	547	555	PF00069	0.782
MOD_Plk_1	117	123	PF00069	0.485
MOD_Plk_1	36	42	PF00069	0.452
MOD_Plk_2-3	114	120	PF00069	0.314
MOD_Plk_4	371	377	PF00069	0.524
MOD_Plk_4	457	463	PF00069	0.626
MOD_ProDKin_1	421	427	PF00069	0.664
MOD_ProDKin_1	501	507	PF00069	0.770
MOD_ProDKin_1	510	516	PF00069	0.683
MOD_ProDKin_1	539	545	PF00069	0.798
MOD_ProDKin_1	95	101	PF00069	0.480
TRG_DiLeu_BaEn_1	226	231	PF01217	0.450
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.411
TRG_ENDOCYTIC_2	173	176	PF00928	0.398
TRG_ER_diArg_1	121	124	PF00400	0.391
TRG_ER_diArg_1	339	342	PF00400	0.555
TRG_ER_diArg_1	343	346	PF00400	0.464
TRG_ER_diArg_1	429	432	PF00400	0.675
TRG_ER_diArg_1	50	52	PF00400	0.525
TRG_ER_diArg_1	545	547	PF00400	0.799
TRG_ER_diArg_1	592	594	PF00400	0.702
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	479	484	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X8	Leptomonas seymouri	50%	96%
A0A451EJV6	Leishmania donovani	77%	100%
A4HS06	Leishmania infantum	77%	100%
E9AJZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q9N858	Leishmania major	78%	97%