Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3S9_LEIBR

TriTrypDb:

LbrM.04.0130 , LBRM2903_040006100

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.644
CLV_NRD_NRD_1	2	4	PF00675	0.647
CLV_NRD_NRD_1	71	73	PF00675	0.613
CLV_NRD_NRD_1	83	85	PF00675	0.459
CLV_PCSK_KEX2_1	15	17	PF00082	0.644
CLV_PCSK_KEX2_1	2	4	PF00082	0.647
CLV_PCSK_KEX2_1	71	73	PF00082	0.621
CLV_PCSK_KEX2_1	83	85	PF00082	0.430
CLV_PCSK_PC7_1	11	17	PF00082	0.504
CLV_PCSK_SKI1_1	61	65	PF00082	0.511
DEG_APCC_DBOX_1	106	114	PF00400	0.496
DEG_APCC_DBOX_1	121	129	PF00400	0.546
DEG_APCC_DBOX_1	60	68	PF00400	0.520
DEG_APCC_DBOX_1	71	79	PF00400	0.529
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DEG_SPOP_SBC_1	46	50	PF00917	0.588
DOC_CYCLIN_RxL_1	98	109	PF00134	0.512
DOC_MAPK_MEF2A_6	61	69	PF00069	0.523
DOC_PP1_RVXF_1	99	106	PF00149	0.370
DOC_USP7_MATH_1	137	141	PF00917	0.632
LIG_14-3-3_CanoR_1	111	118	PF00244	0.445
LIG_14-3-3_CanoR_1	15	25	PF00244	0.662
LIG_14-3-3_CanoR_1	30	35	PF00244	0.519
LIG_FHA_1	48	54	PF00498	0.487
LIG_FHA_2	54	60	PF00498	0.475
LIG_LIR_Nem_3	57	63	PF02991	0.483
LIG_NRBOX	63	69	PF00104	0.525
LIG_PDZ_Class_2	149	154	PF00595	0.556
LIG_SH2_CRK	60	64	PF00017	0.541
LIG_SH3_3	18	24	PF00018	0.503
LIG_SH3_3	49	55	PF00018	0.602
MOD_CK1_1	14	20	PF00069	0.604
MOD_CK1_1	33	39	PF00069	0.494
MOD_CK1_1	45	51	PF00069	0.601
MOD_CK2_1	133	139	PF00069	0.509
MOD_GlcNHglycan	135	138	PF01048	0.547
MOD_GlcNHglycan	44	47	PF01048	0.657
MOD_GSK3_1	10	17	PF00069	0.531
MOD_GSK3_1	133	140	PF00069	0.499
MOD_GSK3_1	40	47	PF00069	0.627
MOD_LATS_1	99	105	PF00433	0.485
MOD_N-GLC_1	40	45	PF02516	0.571
MOD_PKA_1	15	21	PF00069	0.643
MOD_PKA_1	71	77	PF00069	0.545
MOD_PKA_2	10	16	PF00069	0.631
MOD_PKA_2	132	138	PF00069	0.474
MOD_PKA_2	71	77	PF00069	0.545
MOD_Plk_1	101	107	PF00069	0.591
MOD_Plk_1	120	126	PF00069	0.373
MOD_Plk_4	101	107	PF00069	0.359
MOD_Plk_4	30	36	PF00069	0.485
MOD_SUMO_rev_2	85	93	PF00179	0.519
TRG_ENDOCYTIC_2	60	63	PF00928	0.480
TRG_ER_diArg_1	1	3	PF00400	0.665
TRG_ER_diArg_1	122	125	PF00400	0.542
TRG_ER_diArg_1	70	72	PF00400	0.562
TRG_ER_diArg_1	82	84	PF00400	0.423
TRG_NES_CRM1_1	108	121	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC29	Leptomonas seymouri	44%	75%
A0A3S5H575	Leishmania donovani	72%	97%
A4HE83	Leishmania braziliensis	82%	100%
A4HS04	Leishmania infantum	71%	97%
C9ZY02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	68%
E9AJZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	97%
Q9BLQ6	Leishmania major	76%	100%