Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3S8_LEIBR

TriTrypDb:

LbrM.04.0120 , LBRM2903_040006000

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.454
CLV_PCSK_KEX2_1	17	19	PF00082	0.426
DOC_CYCLIN_RxL_1	58	67	PF00134	0.371
DOC_MAPK_gen_1	186	194	PF00069	0.352
DOC_MAPK_MEF2A_6	186	194	PF00069	0.352
DOC_USP7_MATH_1	160	164	PF00917	0.422
DOC_WW_Pin1_4	236	241	PF00397	0.484
LIG_14-3-3_CanoR_1	202	210	PF00244	0.350
LIG_APCC_ABBA_1	120	125	PF00400	0.262
LIG_APCC_ABBA_1	139	144	PF00400	0.417
LIG_FHA_1	193	199	PF00498	0.350
LIG_FHA_1	57	63	PF00498	0.441
LIG_LIR_Apic_2	195	199	PF02991	0.338
LIG_LIR_Gen_1	197	205	PF02991	0.507
LIG_LIR_Gen_1	22	33	PF02991	0.371
LIG_LIR_Gen_1	39	47	PF02991	0.320
LIG_LIR_Gen_1	99	109	PF02991	0.471
LIG_LIR_Nem_3	137	142	PF02991	0.421
LIG_LIR_Nem_3	185	191	PF02991	0.429
LIG_LIR_Nem_3	197	203	PF02991	0.301
LIG_LIR_Nem_3	22	28	PF02991	0.369
LIG_LIR_Nem_3	221	225	PF02991	0.396
LIG_LIR_Nem_3	228	234	PF02991	0.306
LIG_LIR_Nem_3	39	43	PF02991	0.318
LIG_LIR_Nem_3	89	95	PF02991	0.503
LIG_LIR_Nem_3	99	104	PF02991	0.366
LIG_Pex14_1	15	19	PF04695	0.365
LIG_Pex14_1	196	200	PF04695	0.373
LIG_Pex14_2	139	143	PF04695	0.494
LIG_SH2_CRK	101	105	PF00017	0.335
LIG_SH2_CRK	222	226	PF00017	0.410
LIG_SH2_CRK	92	96	PF00017	0.450
LIG_SH2_STAP1	101	105	PF00017	0.427
LIG_SH2_STAP1	80	84	PF00017	0.505
LIG_SH2_STAT3	47	50	PF00017	0.507
LIG_SH2_STAT3	9	12	PF00017	0.413
LIG_SH2_STAT5	200	203	PF00017	0.414
LIG_SH2_STAT5	205	208	PF00017	0.385
LIG_SH3_3	235	241	PF00018	0.490
LIG_TRAF2_1	10	13	PF00917	0.449
LIG_TYR_ITIM	198	203	PF00017	0.374
LIG_TYR_ITSM	97	104	PF00017	0.475
MOD_CK2_1	7	13	PF00069	0.417
MOD_GlcNHglycan	100	104	PF01048	0.460
MOD_GlcNHglycan	114	117	PF01048	0.540
MOD_GSK3_1	204	211	PF00069	0.537
MOD_GSK3_1	236	243	PF00069	0.519
MOD_GSK3_1	64	71	PF00069	0.335
MOD_N-GLC_1	160	165	PF02516	0.313
MOD_N-GLC_1	218	223	PF02516	0.386
MOD_N-GLC_1	68	73	PF02516	0.267
MOD_N-GLC_2	176	178	PF02516	0.240
MOD_NEK2_1	203	208	PF00069	0.407
MOD_NEK2_1	56	61	PF00069	0.502
MOD_Plk_1	130	136	PF00069	0.438
MOD_Plk_1	160	166	PF00069	0.528
MOD_Plk_1	218	224	PF00069	0.482
MOD_Plk_1	68	74	PF00069	0.314
MOD_Plk_1	99	105	PF00069	0.417
MOD_Plk_2-3	148	154	PF00069	0.335
MOD_Plk_4	27	33	PF00069	0.435
MOD_ProDKin_1	236	242	PF00069	0.496
MOD_SUMO_rev_2	75	85	PF00179	0.522
TRG_ENDOCYTIC_2	101	104	PF00928	0.340
TRG_ENDOCYTIC_2	188	191	PF00928	0.332
TRG_ENDOCYTIC_2	200	203	PF00928	0.300
TRG_ENDOCYTIC_2	222	225	PF00928	0.376
TRG_ENDOCYTIC_2	25	28	PF00928	0.381
TRG_ENDOCYTIC_2	92	95	PF00928	0.456
TRG_ER_diArg_1	17	19	PF00400	0.445
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY0	Leptomonas seymouri	70%	99%
A0A0S4IH71	Bodo saltans	41%	92%
A0A0S4J8X8	Bodo saltans	41%	100%
A0A1X0NMV1	Trypanosomatidae	47%	100%
A0A3S5H574	Leishmania donovani	87%	100%
A0A422NN81	Trypanosoma rangeli	44%	100%
A4HS03	Leishmania infantum	86%	100%
C9ZY01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AJZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P0DPD7	Homo sapiens	32%	96%
P0DPE0	Mus musculus	31%	96%
P0DPE1	Bos taurus	28%	96%
Q95Z88	Leishmania major	87%	100%
V5BI94	Trypanosoma cruzi	45%	100%