DNA topoisomerase type IB small subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA topoisomerase type IB small subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H3S7_LEIBR

TriTrypDb:

LbrM.04.0110 , LBRM2903_040005900

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H3S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006265	DNA topological change	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006996	organelle organization	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0051276	chromosome organization	5	7
GO:0071103	DNA conformation change	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0006260	DNA replication	5	1
GO:0007059	chromosome segregation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0003916	DNA topoisomerase activity	3	7
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	7
GO:0005488	binding	1	7
GO:0016853	isomerase activity	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.609
CLV_NRD_NRD_1	92	94	PF00675	0.628
CLV_PCSK_KEX2_1	92	94	PF00082	0.628
CLV_PCSK_SKI1_1	165	169	PF00082	0.558
CLV_PCSK_SKI1_1	66	70	PF00082	0.668
DEG_Nend_UBRbox_3	1	3	PF02207	0.619
DOC_CYCLIN_yCln2_LP_2	178	181	PF00134	0.592
DOC_MAPK_DCC_7	69	77	PF00069	0.511
DOC_MAPK_gen_1	203	213	PF00069	0.388
DOC_PP2B_LxvP_1	178	181	PF13499	0.592
DOC_PP4_MxPP_1	85	88	PF00568	0.531
DOC_USP7_UBL2_3	214	218	PF12436	0.312
DOC_WW_Pin1_4	19	24	PF00397	0.471
DOC_WW_Pin1_4	3	8	PF00397	0.723
DOC_WW_Pin1_4	31	36	PF00397	0.520
DOC_WW_Pin1_4	70	75	PF00397	0.506
LIG_14-3-3_CanoR_1	137	146	PF00244	0.600
LIG_14-3-3_CanoR_1	233	239	PF00244	0.388
LIG_14-3-3_CanoR_1	38	42	PF00244	0.577
LIG_BRCT_BRCA1_1	246	250	PF00533	0.231
LIG_CtBP_PxDLS_1	23	27	PF00389	0.465
LIG_FHA_1	222	228	PF00498	0.312
LIG_FHA_2	20	26	PF00498	0.632
LIG_FHA_2	55	61	PF00498	0.501
LIG_LIR_Nem_3	129	135	PF02991	0.507
LIG_MYND_1	176	180	PF01753	0.602
LIG_PDZ_Class_2	264	269	PF00595	0.312
LIG_SH2_PTP2	229	232	PF00017	0.312
LIG_SH2_SRC	229	232	PF00017	0.312
LIG_SH2_STAT5	229	232	PF00017	0.312
LIG_SH3_3	177	183	PF00018	0.516
LIG_SH3_3	5	11	PF00018	0.628
LIG_UBA3_1	62	69	PF00899	0.590
LIG_WW_3	179	183	PF00397	0.506
MOD_CDC14_SPxK_1	73	76	PF00782	0.508
MOD_CDK_SPxK_1	70	76	PF00069	0.509
MOD_CDK_SPxxK_3	31	38	PF00069	0.559
MOD_CK1_1	104	110	PF00069	0.685
MOD_CK1_1	111	117	PF00069	0.688
MOD_CK1_1	121	127	PF00069	0.644
MOD_CK1_1	130	136	PF00069	0.588
MOD_CK1_1	138	144	PF00069	0.619
MOD_CK1_1	188	194	PF00069	0.377
MOD_CK1_1	221	227	PF00069	0.312
MOD_CK1_1	97	103	PF00069	0.697
MOD_CK2_1	116	122	PF00069	0.559
MOD_CK2_1	144	150	PF00069	0.596
MOD_GlcNHglycan	107	110	PF01048	0.638
MOD_GlcNHglycan	143	146	PF01048	0.682
MOD_GlcNHglycan	250	253	PF01048	0.412
MOD_GlcNHglycan	262	265	PF01048	0.361
MOD_GSK3_1	103	110	PF00069	0.708
MOD_GSK3_1	112	119	PF00069	0.605
MOD_GSK3_1	122	129	PF00069	0.640
MOD_GSK3_1	131	138	PF00069	0.769
MOD_GSK3_1	218	225	PF00069	0.312
MOD_GSK3_1	244	251	PF00069	0.238
MOD_GSK3_1	33	40	PF00069	0.497
MOD_GSK3_1	94	101	PF00069	0.640
MOD_N-GLC_1	127	132	PF02516	0.548
MOD_NEK2_1	222	227	PF00069	0.312
MOD_NEK2_1	250	255	PF00069	0.315
MOD_PIKK_1	1	7	PF00454	0.521
MOD_PIKK_1	156	162	PF00454	0.496
MOD_PKA_2	136	142	PF00069	0.618
MOD_PKA_2	37	43	PF00069	0.694
MOD_PKA_2	95	101	PF00069	0.556
MOD_Plk_1	127	133	PF00069	0.698
MOD_Plk_1	135	141	PF00069	0.668
MOD_Plk_1	149	155	PF00069	0.487
MOD_Plk_1	24	30	PF00069	0.551
MOD_Plk_2-3	118	124	PF00069	0.673
MOD_Plk_4	149	155	PF00069	0.496
MOD_Plk_4	174	180	PF00069	0.606
MOD_Plk_4	250	256	PF00069	0.276
MOD_Plk_4	67	73	PF00069	0.607
MOD_ProDKin_1	19	25	PF00069	0.467
MOD_ProDKin_1	3	9	PF00069	0.723
MOD_ProDKin_1	31	37	PF00069	0.514
MOD_ProDKin_1	70	76	PF00069	0.509
MOD_SUMO_rev_2	215	220	PF00179	0.312
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.519
TRG_ER_diArg_1	50	53	PF00400	0.525
TRG_ER_diArg_1	91	93	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IID6	Leptomonas seymouri	62%	100%
A0A451EJV3	Leishmania donovani	79%	100%
A4HS02	Leishmania infantum	78%	100%
E9AJZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q95Z89	Leishmania major	80%	97%