Coiled-coil domain-containing protein 177

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3S6_LEIBR

TriTrypDb:

LbrM.04.0100 , LBRM2903_040005800

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.673
CLV_NRD_NRD_1	244	246	PF00675	0.520
CLV_NRD_NRD_1	257	259	PF00675	0.443
CLV_NRD_NRD_1	336	338	PF00675	0.579
CLV_NRD_NRD_1	446	448	PF00675	0.517
CLV_NRD_NRD_1	453	455	PF00675	0.477
CLV_NRD_NRD_1	460	462	PF00675	0.471
CLV_NRD_NRD_1	474	476	PF00675	0.526
CLV_NRD_NRD_1	517	519	PF00675	0.646
CLV_PCSK_FUR_1	174	178	PF00082	0.511
CLV_PCSK_KEX2_1	121	123	PF00082	0.558
CLV_PCSK_KEX2_1	176	178	PF00082	0.511
CLV_PCSK_KEX2_1	243	245	PF00082	0.528
CLV_PCSK_KEX2_1	257	259	PF00082	0.432
CLV_PCSK_KEX2_1	273	275	PF00082	0.618
CLV_PCSK_KEX2_1	336	338	PF00082	0.645
CLV_PCSK_KEX2_1	448	450	PF00082	0.562
CLV_PCSK_KEX2_1	453	455	PF00082	0.568
CLV_PCSK_KEX2_1	462	464	PF00082	0.566
CLV_PCSK_KEX2_1	474	476	PF00082	0.437
CLV_PCSK_KEX2_1	517	519	PF00082	0.646
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.558
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.511
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.528
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.659
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.448
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.535
CLV_PCSK_PC7_1	449	455	PF00082	0.404
CLV_PCSK_SKI1_1	121	125	PF00082	0.560
CLV_PCSK_SKI1_1	162	166	PF00082	0.632
CLV_PCSK_SKI1_1	258	262	PF00082	0.446
CLV_PCSK_SKI1_1	324	328	PF00082	0.545
CLV_PCSK_SKI1_1	393	397	PF00082	0.607
CLV_PCSK_SKI1_1	542	546	PF00082	0.549
CLV_Separin_Metazoa	435	439	PF03568	0.402
DEG_APCC_KENBOX_2	486	490	PF00400	0.398
DEG_COP1_1	264	272	PF00400	0.545
DOC_CKS1_1	197	202	PF01111	0.547
DOC_MAPK_gen_1	174	184	PF00069	0.610
DOC_MAPK_gen_1	438	446	PF00069	0.584
DOC_USP7_MATH_1	109	113	PF00917	0.624
DOC_USP7_MATH_1	343	347	PF00917	0.559
DOC_USP7_MATH_1	439	443	PF00917	0.399
DOC_USP7_MATH_1	505	509	PF00917	0.615
DOC_USP7_MATH_1	528	532	PF00917	0.746
DOC_WW_Pin1_4	196	201	PF00397	0.557
DOC_WW_Pin1_4	258	263	PF00397	0.458
DOC_WW_Pin1_4	31	36	PF00397	0.656
DOC_WW_Pin1_4	356	361	PF00397	0.677
DOC_WW_Pin1_4	520	525	PF00397	0.593
LIG_14-3-3_CanoR_1	10	15	PF00244	0.638
LIG_14-3-3_CanoR_1	237	242	PF00244	0.519
LIG_14-3-3_CanoR_1	274	282	PF00244	0.573
LIG_14-3-3_CanoR_1	322	327	PF00244	0.629
LIG_14-3-3_CanoR_1	336	341	PF00244	0.546
LIG_14-3-3_CanoR_1	342	348	PF00244	0.499
LIG_14-3-3_CanoR_1	362	366	PF00244	0.756
LIG_14-3-3_CanoR_1	393	402	PF00244	0.535
LIG_14-3-3_CanoR_1	413	422	PF00244	0.398
LIG_14-3-3_CanoR_1	438	446	PF00244	0.457
LIG_14-3-3_CanoR_1	461	466	PF00244	0.454
LIG_14-3-3_CanoR_1	509	515	PF00244	0.571
LIG_14-3-3_CanoR_1	517	525	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BRCT_BRCA1_1	397	401	PF00533	0.384
LIG_Clathr_ClatBox_1	429	433	PF01394	0.534
LIG_FHA_1	372	378	PF00498	0.500
LIG_FHA_1	543	549	PF00498	0.550
LIG_FHA_2	285	291	PF00498	0.557
LIG_FHA_2	394	400	PF00498	0.535
LIG_FHA_2	49	55	PF00498	0.573
LIG_FHA_2	538	544	PF00498	0.557
LIG_IBAR_NPY_1	501	503	PF08397	0.618
LIG_LIR_Gen_1	500	511	PF02991	0.589
LIG_LIR_Nem_3	235	241	PF02991	0.530
LIG_LIR_Nem_3	500	506	PF02991	0.584
LIG_SH2_STAP1	385	389	PF00017	0.530
LIG_SH2_STAP1	97	101	PF00017	0.558
LIG_SH2_STAT5	415	418	PF00017	0.409
LIG_SH2_STAT5	47	50	PF00017	0.564
LIG_SH2_STAT5	503	506	PF00017	0.464
LIG_SH3_2	170	175	PF14604	0.657
LIG_SH3_3	145	151	PF00018	0.546
LIG_SH3_3	167	173	PF00018	0.664
LIG_SH3_3	188	194	PF00018	0.612
LIG_SH3_3	264	270	PF00018	0.616
LIG_SH3_3	32	38	PF00018	0.629
LIG_SH3_3	372	378	PF00018	0.657
LIG_SH3_CIN85_PxpxPR_1	169	174	PF14604	0.531
LIG_TRAF2_1	113	116	PF00917	0.603
LIG_TRAF2_1	278	281	PF00917	0.724
LIG_TRAF2_1	51	54	PF00917	0.627
LIG_TRAF2_1	66	69	PF00917	0.564
LIG_TRAF2_1	72	75	PF00917	0.569
LIG_TRAF2_1	78	81	PF00917	0.556
LIG_WRC_WIRS_1	511	516	PF05994	0.502
MOD_CDC14_SPxK_1	359	362	PF00782	0.521
MOD_CDK_SPK_2	196	201	PF00069	0.557
MOD_CDK_SPxK_1	356	362	PF00069	0.680
MOD_CK1_1	222	228	PF00069	0.414
MOD_CK1_1	283	289	PF00069	0.559
MOD_CK1_1	350	356	PF00069	0.692
MOD_CK1_1	442	448	PF00069	0.431
MOD_CK1_1	512	518	PF00069	0.655
MOD_CK1_1	520	526	PF00069	0.635
MOD_CK1_1	537	543	PF00069	0.558
MOD_CK2_1	10	16	PF00069	0.645
MOD_CK2_1	109	115	PF00069	0.616
MOD_CK2_1	127	133	PF00069	0.524
MOD_CK2_1	275	281	PF00069	0.570
MOD_CK2_1	284	290	PF00069	0.537
MOD_CK2_1	385	391	PF00069	0.542
MOD_CK2_1	393	399	PF00069	0.503
MOD_CK2_1	47	53	PF00069	0.698
MOD_CK2_1	537	543	PF00069	0.685
MOD_CK2_1	63	69	PF00069	0.583
MOD_CK2_1	70	76	PF00069	0.568
MOD_GlcNHglycan	111	114	PF01048	0.550
MOD_GlcNHglycan	156	159	PF01048	0.567
MOD_GlcNHglycan	226	229	PF01048	0.422
MOD_GlcNHglycan	277	280	PF01048	0.628
MOD_GlcNHglycan	3	6	PF01048	0.536
MOD_GlcNHglycan	327	330	PF01048	0.632
MOD_GlcNHglycan	352	355	PF01048	0.609
MOD_GlcNHglycan	369	372	PF01048	0.619
MOD_GlcNHglycan	379	382	PF01048	0.607
MOD_GlcNHglycan	385	388	PF01048	0.489
MOD_GlcNHglycan	535	539	PF01048	0.679
MOD_GlcNHglycan	91	95	PF01048	0.545
MOD_GSK3_1	123	130	PF00069	0.564
MOD_GSK3_1	280	287	PF00069	0.567
MOD_GSK3_1	325	332	PF00069	0.652
MOD_GSK3_1	343	350	PF00069	0.519
MOD_GSK3_1	361	368	PF00069	0.688
MOD_GSK3_1	379	386	PF00069	0.397
MOD_GSK3_1	389	396	PF00069	0.607
MOD_GSK3_1	505	512	PF00069	0.664
MOD_GSK3_1	513	520	PF00069	0.742
MOD_GSK3_1	526	533	PF00069	0.604
MOD_GSK3_1	83	90	PF00069	0.695
MOD_N-GLC_1	413	418	PF02516	0.405
MOD_N-GLC_1	518	523	PF02516	0.554
MOD_NEK2_1	1	6	PF00069	0.542
MOD_NEK2_1	123	128	PF00069	0.566
MOD_NEK2_1	224	229	PF00069	0.408
MOD_NEK2_1	367	372	PF00069	0.706
MOD_NEK2_1	83	88	PF00069	0.575
MOD_PIKK_1	281	287	PF00454	0.566
MOD_PIKK_1	309	315	PF00454	0.413
MOD_PIKK_1	413	419	PF00454	0.555
MOD_PIKK_1	424	430	PF00454	0.419
MOD_PIKK_1	530	536	PF00454	0.669
MOD_PIKK_1	55	61	PF00454	0.584
MOD_PKA_1	336	342	PF00069	0.583
MOD_PKA_1	461	467	PF00069	0.411
MOD_PKA_1	517	523	PF00069	0.649
MOD_PKA_2	335	341	PF00069	0.588
MOD_PKA_2	361	367	PF00069	0.809
MOD_PKA_2	371	377	PF00069	0.623
MOD_PKA_2	517	523	PF00069	0.644
MOD_PKA_2	95	101	PF00069	0.573
MOD_Plk_1	219	225	PF00069	0.402
MOD_Plk_1	424	430	PF00069	0.375
MOD_Plk_1	542	548	PF00069	0.548
MOD_Plk_2-3	16	22	PF00069	0.599
MOD_Plk_2-3	76	82	PF00069	0.586
MOD_Plk_4	347	353	PF00069	0.545
MOD_ProDKin_1	196	202	PF00069	0.547
MOD_ProDKin_1	258	264	PF00069	0.460
MOD_ProDKin_1	31	37	PF00069	0.656
MOD_ProDKin_1	356	362	PF00069	0.680
MOD_ProDKin_1	520	526	PF00069	0.597
MOD_SUMO_rev_2	115	123	PF00179	0.543
MOD_SUMO_rev_2	58	66	PF00179	0.588
MOD_SUMO_rev_2	67	72	PF00179	0.565
TRG_DiLeu_BaEn_1	425	430	PF01217	0.530
TRG_DiLeu_BaEn_4	118	124	PF01217	0.549
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.537
TRG_ENDOCYTIC_2	503	506	PF00928	0.609
TRG_ER_diArg_1	256	258	PF00400	0.403
TRG_ER_diArg_1	446	449	PF00400	0.524
TRG_ER_diArg_1	460	463	PF00400	0.418
TRG_NLS_Bipartite_1	162	179	PF00514	0.539
TRG_NLS_Bipartite_1	447	465	PF00514	0.421
TRG_NLS_MonoCore_2	173	178	PF00514	0.671
TRG_NLS_MonoExtN_4	173	179	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H573	Leishmania donovani	58%	100%
A4HS01	Leishmania infantum	58%	100%
E9AJY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q95Z90	Leishmania major	57%	95%