Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3S5_LEIBR

TriTrypDb:

LbrM.04.0090 , LBRM2903_040005700

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S5

PDB structure(s): 7aih_BA , 7am2_BA , 7ane_BA

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.401
CLV_PCSK_KEX2_1	131	133	PF00082	0.401
CLV_PCSK_KEX2_1	17	19	PF00082	0.430
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.430
CLV_PCSK_SKI1_1	53	57	PF00082	0.555
CLV_PCSK_SKI1_1	80	84	PF00082	0.587
DEG_SPOP_SBC_1	160	164	PF00917	0.546
DOC_CYCLIN_RxL_1	51	60	PF00134	0.466
DOC_CYCLIN_RxL_1	77	85	PF00134	0.446
DOC_MAPK_gen_1	108	115	PF00069	0.485
DOC_MAPK_gen_1	53	59	PF00069	0.552
DOC_MAPK_gen_1	80	90	PF00069	0.575
DOC_PP1_RVXF_1	78	85	PF00149	0.323
DOC_USP7_MATH_1	153	157	PF00917	0.528
DOC_USP7_MATH_1	160	164	PF00917	0.565
DOC_USP7_MATH_1	39	43	PF00917	0.531
DOC_WW_Pin1_4	60	65	PF00397	0.410
LIG_14-3-3_CanoR_1	122	130	PF00244	0.379
LIG_14-3-3_CanoR_1	132	141	PF00244	0.434
LIG_Actin_WH2_2	40	55	PF00022	0.337
LIG_BIR_II_1	1	5	PF00653	0.412
LIG_eIF4E_1	51	57	PF01652	0.299
LIG_LIR_Gen_1	25	33	PF02991	0.502
LIG_LIR_Gen_1	38	47	PF02991	0.504
LIG_LIR_Nem_3	25	31	PF02991	0.504
LIG_LIR_Nem_3	38	43	PF02991	0.560
LIG_SH2_CRK	40	44	PF00017	0.533
LIG_SH2_STAT3	19	22	PF00017	0.329
LIG_SH2_STAT5	23	26	PF00017	0.535
LIG_SH2_STAT5	40	43	PF00017	0.493
LIG_SH2_STAT5	51	54	PF00017	0.551
LIG_SH3_3	99	105	PF00018	0.376
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.388
LIG_SUMO_SIM_par_1	139	144	PF11976	0.358
LIG_SUMO_SIM_par_1	55	60	PF11976	0.463
LIG_SUMO_SIM_par_1	67	74	PF11976	0.295
MOD_CK1_1	136	142	PF00069	0.554
MOD_CK1_1	156	162	PF00069	0.373
MOD_CK1_1	60	66	PF00069	0.511
MOD_CK2_1	103	109	PF00069	0.469
MOD_CK2_1	160	166	PF00069	0.516
MOD_CK2_1	70	76	PF00069	0.463
MOD_GlcNHglycan	146	149	PF01048	0.362
MOD_GlcNHglycan	155	158	PF01048	0.430
MOD_GlcNHglycan	84	87	PF01048	0.405
MOD_GlcNHglycan	96	99	PF01048	0.380
MOD_GSK3_1	156	163	PF00069	0.641
MOD_GSK3_1	39	46	PF00069	0.586
MOD_GSK3_1	55	62	PF00069	0.422
MOD_N-GLC_2	125	127	PF02516	0.402
MOD_NEK2_1	43	48	PF00069	0.526
MOD_NEK2_1	57	62	PF00069	0.564
MOD_NEK2_1	82	87	PF00069	0.306
MOD_Plk_2-3	70	76	PF00069	0.485
MOD_Plk_4	136	142	PF00069	0.300
MOD_Plk_4	47	53	PF00069	0.574
MOD_ProDKin_1	60	66	PF00069	0.397
TRG_ENDOCYTIC_2	28	31	PF00928	0.567
TRG_ENDOCYTIC_2	40	43	PF00928	0.412
TRG_ER_diArg_1	130	132	PF00400	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ09	Leptomonas seymouri	66%	97%
A0A1X0NLF4	Trypanosomatidae	48%	100%
A0A3R7KUB4	Trypanosoma rangeli	46%	99%
A0A451EJV1	Leishmania donovani	80%	100%
A4HS00	Leishmania infantum	80%	100%
C9ZXZ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ACP5	Leishmania major	78%	100%
E9AJY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%