C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3S4_LEIBR

TriTrypDb:

LbrM.04.0080 , LBRM2903_040005600

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	542	544	PF00082	0.571
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.571
CLV_PCSK_SKI1_1	105	109	PF00082	0.553
CLV_PCSK_SKI1_1	408	412	PF00082	0.497
CLV_PCSK_SKI1_1	480	484	PF00082	0.473
DEG_SPOP_SBC_1	208	212	PF00917	0.798
DEG_SPOP_SBC_1	260	264	PF00917	0.564
DEG_SPOP_SBC_1	532	536	PF00917	0.555
DOC_CDC14_PxL_1	28	36	PF14671	0.490
DOC_CDC14_PxL_1	80	88	PF14671	0.521
DOC_CKS1_1	516	521	PF01111	0.591
DOC_MAPK_gen_1	214	223	PF00069	0.735
DOC_MAPK_gen_1	266	274	PF00069	0.533
DOC_MAPK_gen_1	383	391	PF00069	0.427
DOC_MAPK_gen_1	396	406	PF00069	0.587
DOC_MAPK_MEF2A_6	247	255	PF00069	0.390
DOC_MAPK_MEF2A_6	351	359	PF00069	0.511
DOC_PP2B_LxvP_1	74	77	PF13499	0.519
DOC_PP4_MxPP_1	79	82	PF00568	0.525
DOC_USP7_MATH_1	15	19	PF00917	0.494
DOC_USP7_MATH_1	156	160	PF00917	0.670
DOC_USP7_MATH_1	208	212	PF00917	0.798
DOC_USP7_MATH_1	267	271	PF00917	0.492
DOC_USP7_MATH_1	328	332	PF00917	0.648
DOC_USP7_MATH_1	485	489	PF00917	0.620
DOC_USP7_UBL2_3	429	433	PF12436	0.529
DOC_USP7_UBL2_3	489	493	PF12436	0.411
DOC_WW_Pin1_4	109	114	PF00397	0.541
DOC_WW_Pin1_4	172	177	PF00397	0.705
DOC_WW_Pin1_4	197	202	PF00397	0.790
DOC_WW_Pin1_4	39	44	PF00397	0.503
DOC_WW_Pin1_4	507	512	PF00397	0.630
DOC_WW_Pin1_4	515	520	PF00397	0.542
DOC_WW_Pin1_4	68	73	PF00397	0.529
LIG_14-3-3_CanoR_1	105	110	PF00244	0.552
LIG_14-3-3_CanoR_1	266	275	PF00244	0.480
LIG_14-3-3_CanoR_1	302	308	PF00244	0.562
LIG_14-3-3_CanoR_1	36	42	PF00244	0.498
LIG_Actin_RPEL_3	280	299	PF02755	0.352
LIG_BIR_III_4	276	280	PF00653	0.359
LIG_BRCT_BRCA1_1	18	22	PF00533	0.496
LIG_Clathr_ClatBox_1	25	29	PF01394	0.489
LIG_CtBP_PxDLS_1	8	12	PF00389	0.499
LIG_EVH1_1	80	84	PF00568	0.522
LIG_EVH1_2	148	152	PF00568	0.529
LIG_FHA_1	198	204	PF00498	0.693
LIG_FHA_1	21	27	PF00498	0.490
LIG_FHA_1	248	254	PF00498	0.531
LIG_FHA_1	363	369	PF00498	0.523
LIG_FHA_1	409	415	PF00498	0.560
LIG_FHA_1	417	423	PF00498	0.531
LIG_FHA_1	460	466	PF00498	0.453
LIG_FHA_1	50	56	PF00498	0.536
LIG_FHA_1	69	75	PF00498	0.472
LIG_LIR_Gen_1	19	28	PF02991	0.492
LIG_LIR_Nem_3	19	25	PF02991	0.494
LIG_LIR_Nem_3	40	44	PF02991	0.503
LIG_LIR_Nem_3	437	442	PF02991	0.556
LIG_LYPXL_yS_3	83	86	PF13949	0.525
LIG_MYND_1	73	77	PF01753	0.528
LIG_MYND_1	84	88	PF01753	0.487
LIG_NRBOX	512	518	PF00104	0.562
LIG_PTB_Apo_2	311	318	PF02174	0.551
LIG_PTB_Phospho_1	311	317	PF10480	0.555
LIG_Rb_LxCxE_1	276	295	PF01857	0.348
LIG_SH2_GRB2like	256	259	PF00017	0.585
LIG_SH2_SRC	378	381	PF00017	0.355
LIG_SH2_STAP1	219	223	PF00017	0.458
LIG_SH2_STAP1	256	260	PF00017	0.583
LIG_SH2_STAP1	317	321	PF00017	0.536
LIG_SH2_STAP1	335	339	PF00017	0.449
LIG_SH2_STAP1	524	528	PF00017	0.546
LIG_SH2_STAT3	297	300	PF00017	0.523
LIG_SH2_STAT3	316	319	PF00017	0.534
LIG_SH2_STAT5	142	145	PF00017	0.639
LIG_SH2_STAT5	151	154	PF00017	0.721
LIG_SH2_STAT5	297	300	PF00017	0.523
LIG_SH2_STAT5	353	356	PF00017	0.494
LIG_SH2_STAT5	378	381	PF00017	0.475
LIG_SH2_STAT5	451	454	PF00017	0.461
LIG_SH3_3	150	156	PF00018	0.561
LIG_SH3_3	2	8	PF00018	0.500
LIG_SH3_3	243	249	PF00018	0.408
LIG_SH3_3	29	35	PF00018	0.489
LIG_SH3_3	67	73	PF00018	0.531
LIG_SH3_3	78	84	PF00018	0.530
LIG_SH3_3	93	99	PF00018	0.733
LIG_SUMO_SIM_anti_2	356	361	PF11976	0.511
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.609
LIG_SUMO_SIM_par_1	23	29	PF11976	0.442
LIG_SUMO_SIM_par_1	353	358	PF11976	0.595
LIG_SUMO_SIM_par_1	512	518	PF11976	0.540
LIG_SUMO_SIM_par_1	7	12	PF11976	0.499
LIG_TRAF2_1	425	428	PF00917	0.649
LIG_UBA3_1	513	520	PF00899	0.682
LIG_WW_1	148	151	PF00397	0.524
MOD_CDK_SPK_2	172	177	PF00069	0.794
MOD_CDK_SPK_2	507	512	PF00069	0.630
MOD_CDK_SPK_2	515	520	PF00069	0.542
MOD_CDK_SPxxK_3	172	179	PF00069	0.798
MOD_CK1_1	159	165	PF00069	0.587
MOD_CK1_1	171	177	PF00069	0.695
MOD_CK1_1	18	24	PF00069	0.493
MOD_CK1_1	185	191	PF00069	0.618
MOD_CK1_1	193	199	PF00069	0.636
MOD_CK1_1	202	208	PF00069	0.676
MOD_CK1_1	262	268	PF00069	0.673
MOD_CK1_1	432	438	PF00069	0.538
MOD_CK1_1	445	451	PF00069	0.451
MOD_CK1_1	459	465	PF00069	0.352
MOD_CK1_1	501	507	PF00069	0.700
MOD_CK1_1	65	71	PF00069	0.703
MOD_CK2_1	193	199	PF00069	0.688
MOD_GlcNHglycan	145	148	PF01048	0.687
MOD_GlcNHglycan	170	173	PF01048	0.732
MOD_GlcNHglycan	182	185	PF01048	0.578
MOD_GlcNHglycan	195	198	PF01048	0.626
MOD_GlcNHglycan	206	209	PF01048	0.616
MOD_GlcNHglycan	322	325	PF01048	0.616
MOD_GlcNHglycan	330	333	PF01048	0.582
MOD_GlcNHglycan	434	437	PF01048	0.589
MOD_GlcNHglycan	453	456	PF01048	0.638
MOD_GSK3_1	105	112	PF00069	0.667
MOD_GSK3_1	159	166	PF00069	0.610
MOD_GSK3_1	16	23	PF00069	0.495
MOD_GSK3_1	168	175	PF00069	0.755
MOD_GSK3_1	193	200	PF00069	0.800
MOD_GSK3_1	204	211	PF00069	0.757
MOD_GSK3_1	247	254	PF00069	0.520
MOD_GSK3_1	428	435	PF00069	0.568
MOD_GSK3_1	49	56	PF00069	0.535
MOD_GSK3_1	503	510	PF00069	0.621
MOD_GSK3_1	524	531	PF00069	0.622
MOD_GSK3_1	532	539	PF00069	0.541
MOD_GSK3_1	64	71	PF00069	0.502
MOD_N-GLC_1	15	20	PF02516	0.494
MOD_N-GLC_1	360	365	PF02516	0.478
MOD_N-GLC_1	498	503	PF02516	0.475
MOD_NEK2_1	143	148	PF00069	0.746
MOD_NEK2_1	180	185	PF00069	0.733
MOD_NEK2_1	20	25	PF00069	0.493
MOD_NEK2_1	204	209	PF00069	0.808
MOD_NEK2_1	251	256	PF00069	0.544
MOD_NEK2_1	261	266	PF00069	0.577
MOD_NEK2_1	291	296	PF00069	0.589
MOD_NEK2_1	360	365	PF00069	0.507
MOD_NEK2_2	209	214	PF00069	0.750
MOD_PIKK_1	188	194	PF00454	0.693
MOD_PIKK_1	315	321	PF00454	0.534
MOD_PIKK_1	483	489	PF00454	0.523
MOD_PIKK_1	62	68	PF00454	0.557
MOD_PIKK_1	9	15	PF00454	0.500
MOD_PKA_2	301	307	PF00069	0.558
MOD_Plk_1	15	21	PF00069	0.494
MOD_Plk_1	355	361	PF00069	0.543
MOD_Plk_1	445	451	PF00069	0.545
MOD_Plk_1	524	530	PF00069	0.548
MOD_Plk_4	199	205	PF00069	0.793
MOD_Plk_4	21	27	PF00069	0.490
MOD_Plk_4	293	299	PF00069	0.357
MOD_Plk_4	355	361	PF00069	0.573
MOD_Plk_4	418	424	PF00069	0.550
MOD_Plk_4	456	462	PF00069	0.535
MOD_Plk_4	92	98	PF00069	0.674
MOD_ProDKin_1	109	115	PF00069	0.539
MOD_ProDKin_1	172	178	PF00069	0.707
MOD_ProDKin_1	197	203	PF00069	0.790
MOD_ProDKin_1	39	45	PF00069	0.504
MOD_ProDKin_1	507	513	PF00069	0.624
MOD_ProDKin_1	515	521	PF00069	0.548
MOD_ProDKin_1	68	74	PF00069	0.529
TRG_DiLeu_BaEn_1	350	355	PF01217	0.633
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.489
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.526
TRG_ENDOCYTIC_2	151	154	PF00928	0.685
TRG_ENDOCYTIC_2	439	442	PF00928	0.555
TRG_ENDOCYTIC_2	83	86	PF00928	0.525
TRG_NES_CRM1_1	356	369	PF08389	0.518
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.538
TRG_PTS1	543	546	PF00515	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3X9	Leptomonas seymouri	60%	100%
A0A451EJV0	Leishmania donovani	83%	100%
A4HRZ9	Leishmania infantum	83%	100%
E9AJY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q95Z91	Leishmania major	84%	100%