Calcium-translocating P-type ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

organelle-type calcium ATPase

Species:

Leishmania braziliensis

UniProt:

A4H3S3_LEIBR

TriTrypDb:

LbrM.04.0050 , LBRM2903_040005000

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H3S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017076	purine nucleotide binding	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.255
CLV_NRD_NRD_1	37	39	PF00675	0.174
CLV_PCSK_KEX2_1	37	39	PF00082	0.174
CLV_PCSK_SKI1_1	165	169	PF00082	0.212
CLV_PCSK_SKI1_1	190	194	PF00082	0.203
CLV_PCSK_SKI1_1	277	281	PF00082	0.299
CLV_PCSK_SKI1_1	3	7	PF00082	0.266
CLV_PCSK_SKI1_1	44	48	PF00082	0.264
CLV_PCSK_SKI1_1	69	73	PF00082	0.292
DOC_CKS1_1	51	56	PF01111	0.524
DOC_PP1_RVXF_1	86	92	PF00149	0.271
DOC_PP2B_LxvP_1	4	7	PF13499	0.629
DOC_PP4_FxxP_1	91	94	PF00568	0.174
DOC_USP7_MATH_1	118	122	PF00917	0.578
DOC_USP7_MATH_1	75	79	PF00917	0.191
DOC_WW_Pin1_4	243	248	PF00397	0.425
DOC_WW_Pin1_4	264	269	PF00397	0.518
DOC_WW_Pin1_4	50	55	PF00397	0.487
LIG_14-3-3_CanoR_1	165	170	PF00244	0.374
LIG_14-3-3_CanoR_1	201	207	PF00244	0.417
LIG_14-3-3_CanoR_1	224	234	PF00244	0.489
LIG_14-3-3_CanoR_1	277	287	PF00244	0.518
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_Clathr_ClatBox_1	166	170	PF01394	0.374
LIG_EH1_1	94	102	PF00400	0.191
LIG_FHA_1	127	133	PF00498	0.398
LIG_FHA_1	136	142	PF00498	0.468
LIG_FHA_1	209	215	PF00498	0.478
LIG_FHA_1	270	276	PF00498	0.500
LIG_FHA_2	225	231	PF00498	0.374
LIG_LIR_Apic_2	90	94	PF02991	0.174
LIG_LIR_Gen_1	197	207	PF02991	0.374
LIG_LIR_Gen_1	267	276	PF02991	0.635
LIG_LIR_Gen_1	93	103	PF02991	0.309
LIG_LIR_Nem_3	197	202	PF02991	0.374
LIG_LIR_Nem_3	267	273	PF02991	0.640
LIG_LIR_Nem_3	53	59	PF02991	0.398
LIG_LIR_Nem_3	93	98	PF02991	0.402
LIG_NRP_CendR_1	290	293	PF00754	0.356
LIG_Pex14_2	91	95	PF04695	0.174
LIG_SH3_3	4	10	PF00018	0.567
LIG_SH3_3	45	51	PF00018	0.417
LIG_SUMO_SIM_par_1	165	172	PF11976	0.421
LIG_SUMO_SIM_par_1	20	26	PF11976	0.374
LIG_SUMO_SIM_par_1	96	102	PF11976	0.231
LIG_UBA3_1	17	25	PF00899	0.374
LIG_WRC_WIRS_1	76	81	PF05994	0.191
MOD_CDK_SPxxK_3	50	57	PF00069	0.374
MOD_CK1_1	194	200	PF00069	0.530
MOD_CK2_1	118	124	PF00069	0.610
MOD_CK2_1	17	23	PF00069	0.525
MOD_CK2_1	224	230	PF00069	0.374
MOD_CK2_1	234	240	PF00069	0.400
MOD_CK2_1	279	285	PF00069	0.505
MOD_GSK3_1	165	172	PF00069	0.374
MOD_GSK3_1	222	229	PF00069	0.385
MOD_NEK2_1	169	174	PF00069	0.374
MOD_NEK2_1	17	22	PF00069	0.374
MOD_NEK2_1	279	284	PF00069	0.543
MOD_NEK2_1	63	68	PF00069	0.476
MOD_NEK2_1	99	104	PF00069	0.231
MOD_NEK2_2	118	123	PF00069	0.534
MOD_PIKK_1	135	141	PF00454	0.468
MOD_PKA_2	208	214	PF00069	0.374
MOD_Plk_1	169	175	PF00069	0.455
MOD_Plk_1	176	182	PF00069	0.360
MOD_Plk_1	234	240	PF00069	0.505
MOD_Plk_1	63	69	PF00069	0.374
MOD_Plk_4	137	143	PF00069	0.422
MOD_Plk_4	17	23	PF00069	0.459
MOD_Plk_4	176	182	PF00069	0.374
MOD_Plk_4	202	208	PF00069	0.469
MOD_Plk_4	63	69	PF00069	0.455
MOD_ProDKin_1	243	249	PF00069	0.425
MOD_ProDKin_1	264	270	PF00069	0.518
MOD_ProDKin_1	50	56	PF00069	0.487
MOD_SUMO_for_1	260	263	PF00179	0.584
MOD_SUMO_rev_2	20	27	PF00179	0.374
MOD_SUMO_rev_2	237	247	PF00179	0.374
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.374
TRG_ER_diArg_1	287	290	PF00400	0.540
TRG_ER_diArg_1	37	39	PF00400	0.374
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.203

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J4M8	Bodo saltans	30%	97%
A0A0S4KPA7	Bodo saltans	30%	66%