Phosphoacetylglucosamine mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoacetylglucosamine mutase-like gene

Species:

Leishmania braziliensis

UniProt:

A4H3S0_LEIBR

TriTrypDb:

LbrM.04.0010 , LBRM2903_070016400

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3S0

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006040	amino sugar metabolic process	4	11
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	11
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046349	amino sugar biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006041	glucosamine metabolic process	6	1
GO:1901071	glucosamine-containing compound metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	12
GO:0004610	phosphoacetylglucosamine mutase activity	5	11
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	540	544	PF00656	0.383
CLV_MEL_PAP_1	59	65	PF00089	0.415
CLV_NRD_NRD_1	470	472	PF00675	0.468
CLV_NRD_NRD_1	530	532	PF00675	0.431
CLV_PCSK_KEX2_1	355	357	PF00082	0.543
CLV_PCSK_KEX2_1	470	472	PF00082	0.468
CLV_PCSK_KEX2_1	530	532	PF00082	0.420
CLV_PCSK_KEX2_1	77	79	PF00082	0.487
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.543
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.487
CLV_PCSK_SKI1_1	359	363	PF00082	0.505
CLV_PCSK_SKI1_1	450	454	PF00082	0.493
CLV_PCSK_SKI1_1	462	466	PF00082	0.389
CLV_PCSK_SKI1_1	530	534	PF00082	0.372
CLV_Separin_Metazoa	22	26	PF03568	0.370
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DEG_SPOP_SBC_1	6	10	PF00917	0.400
DOC_CKS1_1	195	200	PF01111	0.352
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.364
DOC_MAPK_gen_1	355	363	PF00069	0.461
DOC_MAPK_gen_1	429	437	PF00069	0.424
DOC_MAPK_MEF2A_6	429	437	PF00069	0.424
DOC_PP1_RVXF_1	344	351	PF00149	0.300
DOC_PP2B_LxvP_1	55	58	PF13499	0.364
DOC_PP4_FxxP_1	559	562	PF00568	0.298
DOC_USP7_MATH_1	130	134	PF00917	0.454
DOC_USP7_MATH_1	213	217	PF00917	0.517
DOC_USP7_MATH_1	317	321	PF00917	0.528
DOC_USP7_MATH_1	544	548	PF00917	0.398
DOC_USP7_MATH_1	6	10	PF00917	0.570
DOC_USP7_MATH_1	61	65	PF00917	0.392
DOC_USP7_UBL2_3	355	359	PF12436	0.500
DOC_WW_Pin1_4	185	190	PF00397	0.418
DOC_WW_Pin1_4	194	199	PF00397	0.315
DOC_WW_Pin1_4	311	316	PF00397	0.467
DOC_WW_Pin1_4	323	328	PF00397	0.503
DOC_WW_Pin1_4	531	536	PF00397	0.407
LIG_14-3-3_CanoR_1	522	528	PF00244	0.319
LIG_14-3-3_CanoR_1	62	66	PF00244	0.380
LIG_APCC_ABBA_1	433	438	PF00400	0.320
LIG_APCC_ABBA_1	569	574	PF00400	0.298
LIG_BRCT_BRCA1_1	16	20	PF00533	0.477
LIG_BRCT_BRCA1_1	401	405	PF00533	0.423
LIG_FHA_1	178	184	PF00498	0.489
LIG_FHA_1	401	407	PF00498	0.339
LIG_FHA_1	442	448	PF00498	0.377
LIG_FHA_1	522	528	PF00498	0.303
LIG_FHA_1	563	569	PF00498	0.298
LIG_FHA_1	86	92	PF00498	0.418
LIG_FHA_2	281	287	PF00498	0.471
LIG_FHA_2	456	462	PF00498	0.505
LIG_FHA_2	495	501	PF00498	0.487
LIG_FHA_2	523	529	PF00498	0.409
LIG_IBAR_NPY_1	98	100	PF08397	0.419
LIG_KLC1_Yacidic_2	503	507	PF13176	0.358
LIG_LIR_Gen_1	17	27	PF02991	0.454
LIG_LIR_Gen_1	196	207	PF02991	0.230
LIG_LIR_Gen_1	276	285	PF02991	0.399
LIG_LIR_Gen_1	357	368	PF02991	0.389
LIG_LIR_Gen_1	369	380	PF02991	0.362
LIG_LIR_Gen_1	500	509	PF02991	0.410
LIG_LIR_Nem_3	102	108	PF02991	0.377
LIG_LIR_Nem_3	17	23	PF02991	0.465
LIG_LIR_Nem_3	191	195	PF02991	0.430
LIG_LIR_Nem_3	196	202	PF02991	0.382
LIG_LIR_Nem_3	215	221	PF02991	0.384
LIG_LIR_Nem_3	276	281	PF02991	0.406
LIG_LIR_Nem_3	283	287	PF02991	0.324
LIG_LIR_Nem_3	335	340	PF02991	0.331
LIG_LIR_Nem_3	357	363	PF02991	0.388
LIG_LIR_Nem_3	369	375	PF02991	0.325
LIG_LIR_Nem_3	500	504	PF02991	0.401
LIG_LYPXL_yS_3	192	195	PF13949	0.496
LIG_MAD2	346	354	PF02301	0.444
LIG_MLH1_MIPbox_1	16	20	PF16413	0.477
LIG_Pex14_1	501	505	PF04695	0.346
LIG_Pex14_2	15	19	PF04695	0.485
LIG_Rb_pABgroove_1	346	354	PF01858	0.449
LIG_SH2_CRK	372	376	PF00017	0.358
LIG_SH2_GRB2like	397	400	PF00017	0.322
LIG_SH2_NCK_1	415	419	PF00017	0.363
LIG_SH2_NCK_1	572	576	PF00017	0.373
LIG_SH2_SRC	397	400	PF00017	0.322
LIG_SH2_SRC	505	508	PF00017	0.265
LIG_SH2_SRC	572	575	PF00017	0.342
LIG_SH2_STAP1	372	376	PF00017	0.314
LIG_SH2_STAT3	308	311	PF00017	0.487
LIG_SH2_STAT5	233	236	PF00017	0.246
LIG_SH2_STAT5	415	418	PF00017	0.335
LIG_SH2_STAT5	436	439	PF00017	0.317
LIG_SH2_STAT5	505	508	PF00017	0.334
LIG_SH3_3	503	509	PF00018	0.379
LIG_SH3_5	354	358	PF00018	0.305
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.267
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.461
LIG_SUMO_SIM_par_1	443	449	PF11976	0.462
LIG_TRAF2_1	118	121	PF00917	0.279
LIG_TRAF2_1	169	172	PF00917	0.430
LIG_TYR_ITIM	370	375	PF00017	0.355
LIG_UBA3_1	264	273	PF00899	0.253
LIG_UBA3_1	370	378	PF00899	0.440
LIG_WRC_WIRS_1	281	286	PF05994	0.439
MOD_CDK_SPK_2	185	190	PF00069	0.312
MOD_CK1_1	163	169	PF00069	0.437
MOD_CK1_1	237	243	PF00069	0.578
MOD_CK1_1	276	282	PF00069	0.408
MOD_CK1_1	457	463	PF00069	0.360
MOD_CK1_1	8	14	PF00069	0.375
MOD_CK2_1	115	121	PF00069	0.381
MOD_CK2_1	166	172	PF00069	0.467
MOD_CK2_1	280	286	PF00069	0.475
MOD_CK2_1	455	461	PF00069	0.566
MOD_CK2_1	523	529	PF00069	0.408
MOD_CK2_1	548	554	PF00069	0.503
MOD_CK2_1	560	566	PF00069	0.298
MOD_CK2_1	576	582	PF00069	0.298
MOD_CMANNOS	119	122	PF00535	0.415
MOD_Cter_Amidation	75	78	PF01082	0.400
MOD_DYRK1A_RPxSP_1	531	535	PF00069	0.376
MOD_GlcNHglycan	130	133	PF01048	0.522
MOD_GlcNHglycan	168	171	PF01048	0.403
MOD_GlcNHglycan	236	239	PF01048	0.488
MOD_GlcNHglycan	315	318	PF01048	0.518
MOD_GlcNHglycan	319	322	PF01048	0.493
MOD_GlcNHglycan	323	326	PF01048	0.464
MOD_GlcNHglycan	562	565	PF01048	0.298
MOD_GlcNHglycan	584	587	PF01048	0.419
MOD_GSK3_1	213	220	PF00069	0.569
MOD_GSK3_1	269	276	PF00069	0.443
MOD_GSK3_1	295	302	PF00069	0.523
MOD_GSK3_1	313	320	PF00069	0.388
MOD_GSK3_1	332	339	PF00069	0.431
MOD_GSK3_1	388	395	PF00069	0.269
MOD_GSK3_1	441	448	PF00069	0.422
MOD_GSK3_1	450	457	PF00069	0.399
MOD_GSK3_1	544	551	PF00069	0.405
MOD_GSK3_1	576	583	PF00069	0.345
MOD_N-GLC_1	185	190	PF02516	0.540
MOD_N-GLC_1	494	499	PF02516	0.466
MOD_NEK2_1	234	239	PF00069	0.390
MOD_NEK2_1	299	304	PF00069	0.491
MOD_NEK2_1	388	393	PF00069	0.240
MOD_NEK2_1	494	499	PF00069	0.461
MOD_NEK2_1	548	553	PF00069	0.488
MOD_NEK2_2	177	182	PF00069	0.485
MOD_NEK2_2	280	285	PF00069	0.467
MOD_PIKK_1	237	243	PF00454	0.513
MOD_PIKK_1	471	477	PF00454	0.327
MOD_PKA_2	163	169	PF00069	0.358
MOD_PKA_2	366	372	PF00069	0.304
MOD_PKA_2	521	527	PF00069	0.485
MOD_PKA_2	560	566	PF00069	0.298
MOD_PKA_2	61	67	PF00069	0.388
MOD_PKB_1	520	528	PF00069	0.310
MOD_Plk_1	276	282	PF00069	0.372
MOD_Plk_1	295	301	PF00069	0.444
MOD_Plk_1	388	394	PF00069	0.237
MOD_Plk_1	494	500	PF00069	0.466
MOD_Plk_4	14	20	PF00069	0.454
MOD_Plk_4	217	223	PF00069	0.504
MOD_Plk_4	259	265	PF00069	0.352
MOD_Plk_4	280	286	PF00069	0.451
MOD_Plk_4	295	301	PF00069	0.402
MOD_Plk_4	388	394	PF00069	0.237
MOD_Plk_4	441	447	PF00069	0.302
MOD_Plk_4	61	67	PF00069	0.363
MOD_ProDKin_1	185	191	PF00069	0.417
MOD_ProDKin_1	194	200	PF00069	0.313
MOD_ProDKin_1	311	317	PF00069	0.473
MOD_ProDKin_1	323	329	PF00069	0.508
MOD_ProDKin_1	531	537	PF00069	0.402
MOD_SUMO_rev_2	131	138	PF00179	0.280
MOD_SUMO_rev_2	353	361	PF00179	0.470
TRG_DiLeu_BaEn_1	461	466	PF01217	0.278
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.264
TRG_ENDOCYTIC_2	192	195	PF00928	0.450
TRG_ENDOCYTIC_2	199	202	PF00928	0.411
TRG_ENDOCYTIC_2	222	225	PF00928	0.451
TRG_ENDOCYTIC_2	358	361	PF00928	0.449
TRG_ENDOCYTIC_2	372	375	PF00928	0.343
TRG_ER_diArg_1	469	471	PF00400	0.471
TRG_NES_CRM1_1	21	36	PF08389	0.463
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G0	Leptomonas seymouri	53%	100%
A0A0S4KHH8	Bodo saltans	39%	100%
A0A1X0NPH2	Trypanosomatidae	45%	99%
A0A3R7KD29	Trypanosoma rangeli	46%	98%
A0A3S5H601	Leishmania donovani	85%	100%
A4HTA8	Leishmania infantum	84%	100%
C9ZUL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
E9AL97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
F1RQM2	Sus scrofa	39%	100%
O95394	Homo sapiens	39%	100%
P38628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P57750	Arabidopsis thaliana	35%	100%
Q042H3	Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / BCRC 14619 / CIP 102991 / JCM 1131 / KCTC 3163 / NCIMB 11718 / NCTC 13722 / AM63)	23%	100%
Q09687	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q09770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q4QIK7	Leishmania major	84%	100%
Q5Z1H8	Nocardia farcinica (strain IFM 10152)	24%	100%
Q6ZDQ1	Oryza sativa subsp. japonica	36%	100%
Q74K59	Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)	23%	100%
Q8SSL7	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q9CYR6	Mus musculus	37%	100%
Q9P4V2	Candida albicans	35%	100%
V5B892	Trypanosoma cruzi	44%	98%