LeishMANIAdb
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TPR_MLP1_2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_MLP1_2 domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
A4H3R9_LEIBR
TriTrypDb:
LbrM.03.0980 , LBRM2903_030007700 , LBRM2903_030007800
Length:
1172

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 5
GO:0110165 cellular anatomical entity 1 6
GO:0000795 synaptonemal complex 3 1
GO:0099086 synaptonemal structure 2 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A4H3R9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R9

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 5
GO:0006810 transport 3 5
GO:0006869 lipid transport 5 5
GO:0008152 metabolic process 1 5
GO:0019538 protein metabolic process 3 5
GO:0042157 lipoprotein metabolic process 4 5
GO:0043170 macromolecule metabolic process 3 5
GO:0044238 primary metabolic process 2 5
GO:0051179 localization 1 5
GO:0051234 establishment of localization 2 5
GO:0071702 organic substance transport 4 5
GO:0071704 organic substance metabolic process 2 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:0006996 organelle organization 4 1
GO:0007130 synaptonemal complex assembly 4 1
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0022414 reproductive process 1 1
GO:0022607 cellular component assembly 4 1
GO:0051276 chromosome organization 5 1
GO:0070192 chromosome organization involved in meiotic cell cycle 3 1
GO:0070193 synaptonemal complex organization 6 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1903046 meiotic cell cycle process 2 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 5
GO:0008289 lipid binding 2 5
GO:0043167 ion binding 2 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3
GO:0003774 cytoskeletal motor activity 1 1
GO:0003777 microtubule motor activity 2 1
GO:0140657 ATP-dependent activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 904 906 PF00675 0.645
CLV_NRD_NRD_1 960 962 PF00675 0.510
CLV_PCSK_KEX2_1 904 906 PF00082 0.645
CLV_PCSK_KEX2_1 960 962 PF00082 0.510
CLV_PCSK_SKI1_1 1090 1094 PF00082 0.488
CLV_PCSK_SKI1_1 49 53 PF00082 0.660
CLV_PCSK_SKI1_1 963 967 PF00082 0.498
DEG_APCC_DBOX_1 92 100 PF00400 0.334
DEG_APCC_DBOX_1 923 931 PF00400 0.298
DEG_APCC_DBOX_1 962 970 PF00400 0.303
DEG_Nend_Nbox_1 1 2 PF02207 0.576
DEG_SPOP_SBC_1 1121 1125 PF00917 0.639
DEG_SPOP_SBC_1 6 10 PF00917 0.681
DOC_CKS1_1 21 26 PF01111 0.687
DOC_CKS1_1 40 45 PF01111 0.541
DOC_MAPK_gen_1 1090 1099 PF00069 0.492
DOC_USP7_MATH_1 1121 1125 PF00917 0.687
DOC_USP7_MATH_1 1126 1130 PF00917 0.639
DOC_USP7_MATH_1 19 23 PF00917 0.865
DOC_USP7_MATH_1 6 10 PF00917 0.711
DOC_WW_Pin1_4 1122 1127 PF00397 0.643
DOC_WW_Pin1_4 1155 1160 PF00397 0.581
DOC_WW_Pin1_4 1162 1167 PF00397 0.566
DOC_WW_Pin1_4 20 25 PF00397 0.666
DOC_WW_Pin1_4 39 44 PF00397 0.563
DOC_WW_Pin1_4 7 12 PF00397 0.678
LIG_14-3-3_CanoR_1 1109 1115 PF00244 0.661
LIG_14-3-3_CanoR_1 1120 1126 PF00244 0.613
LIG_14-3-3_CanoR_1 174 183 PF00244 0.298
LIG_14-3-3_CanoR_1 213 222 PF00244 0.298
LIG_14-3-3_CanoR_1 252 261 PF00244 0.298
LIG_14-3-3_CanoR_1 291 300 PF00244 0.298
LIG_14-3-3_CanoR_1 330 339 PF00244 0.298
LIG_14-3-3_CanoR_1 369 378 PF00244 0.256
LIG_14-3-3_CanoR_1 408 417 PF00244 0.256
LIG_14-3-3_CanoR_1 447 456 PF00244 0.256
LIG_14-3-3_CanoR_1 486 495 PF00244 0.256
LIG_14-3-3_CanoR_1 525 534 PF00244 0.298
LIG_14-3-3_CanoR_1 56 64 PF00244 0.640
LIG_14-3-3_CanoR_1 564 573 PF00244 0.298
LIG_14-3-3_CanoR_1 603 612 PF00244 0.298
LIG_14-3-3_CanoR_1 642 651 PF00244 0.298
LIG_14-3-3_CanoR_1 681 690 PF00244 0.298
LIG_14-3-3_CanoR_1 720 729 PF00244 0.298
LIG_14-3-3_CanoR_1 759 768 PF00244 0.298
LIG_14-3-3_CanoR_1 798 807 PF00244 0.298
LIG_14-3-3_CanoR_1 837 846 PF00244 0.298
LIG_14-3-3_CanoR_1 876 885 PF00244 0.298
LIG_14-3-3_CanoR_1 904 910 PF00244 0.378
LIG_Actin_WH2_2 1075 1092 PF00022 0.547
LIG_Actin_WH2_2 92 109 PF00022 0.331
LIG_Actin_WH2_2 948 965 PF00022 0.298
LIG_FHA_1 1006 1012 PF00498 0.318
LIG_FHA_1 107 113 PF00498 0.362
LIG_FHA_1 40 46 PF00498 0.627
LIG_FHA_2 1028 1034 PF00498 0.564
LIG_FHA_2 159 165 PF00498 0.314
LIG_FHA_2 198 204 PF00498 0.314
LIG_FHA_2 237 243 PF00498 0.314
LIG_FHA_2 276 282 PF00498 0.314
LIG_FHA_2 315 321 PF00498 0.314
LIG_FHA_2 354 360 PF00498 0.277
LIG_FHA_2 393 399 PF00498 0.277
LIG_FHA_2 432 438 PF00498 0.277
LIG_FHA_2 471 477 PF00498 0.314
LIG_FHA_2 510 516 PF00498 0.277
LIG_FHA_2 549 555 PF00498 0.314
LIG_FHA_2 58 64 PF00498 0.616
LIG_FHA_2 588 594 PF00498 0.314
LIG_FHA_2 627 633 PF00498 0.314
LIG_FHA_2 666 672 PF00498 0.314
LIG_FHA_2 705 711 PF00498 0.314
LIG_FHA_2 744 750 PF00498 0.314
LIG_FHA_2 783 789 PF00498 0.314
LIG_FHA_2 822 828 PF00498 0.314
LIG_FHA_2 861 867 PF00498 0.364
LIG_LIR_Gen_1 1104 1114 PF02991 0.543
LIG_LIR_Nem_3 1104 1110 PF02991 0.528
LIG_PCNA_yPIPBox_3 892 903 PF02747 0.298
LIG_SH2_STAP1 35 39 PF00017 0.655
LIG_SH3_3 1115 1121 PF00018 0.666
LIG_SH3_3 1138 1144 PF00018 0.600
LIG_SH3_3 23 29 PF00018 0.704
LIG_SH3_3 37 43 PF00018 0.581
LIG_SH3_3 920 926 PF00018 0.256
LIG_SUMO_SIM_par_1 1095 1101 PF11976 0.494
LIG_TRAF2_1 1007 1010 PF00917 0.338
LIG_TRAF2_1 1018 1021 PF00917 0.557
LIG_TRAF2_1 1064 1067 PF00917 0.582
MOD_CDK_SPxK_1 7 13 PF00069 0.725
MOD_CK1_1 1105 1111 PF00069 0.630
MOD_CK1_1 1124 1130 PF00069 0.589
MOD_CK1_1 1132 1138 PF00069 0.590
MOD_CK1_1 41 47 PF00069 0.640
MOD_CK2_1 1004 1010 PF00069 0.253
MOD_CK2_1 1027 1033 PF00069 0.582
MOD_CK2_1 135 141 PF00069 0.298
MOD_CK2_1 158 164 PF00069 0.304
MOD_CK2_1 174 180 PF00069 0.250
MOD_CK2_1 197 203 PF00069 0.301
MOD_CK2_1 213 219 PF00069 0.237
MOD_CK2_1 236 242 PF00069 0.298
MOD_CK2_1 252 258 PF00069 0.231
MOD_CK2_1 275 281 PF00069 0.304
MOD_CK2_1 291 297 PF00069 0.250
MOD_CK2_1 314 320 PF00069 0.301
MOD_CK2_1 330 336 PF00069 0.237
MOD_CK2_1 353 359 PF00069 0.259
MOD_CK2_1 369 375 PF00069 0.235
MOD_CK2_1 392 398 PF00069 0.259
MOD_CK2_1 408 414 PF00069 0.235
MOD_CK2_1 431 437 PF00069 0.259
MOD_CK2_1 447 453 PF00069 0.235
MOD_CK2_1 470 476 PF00069 0.298
MOD_CK2_1 486 492 PF00069 0.218
MOD_CK2_1 509 515 PF00069 0.271
MOD_CK2_1 525 531 PF00069 0.283
MOD_CK2_1 548 554 PF00069 0.301
MOD_CK2_1 564 570 PF00069 0.237
MOD_CK2_1 587 593 PF00069 0.298
MOD_CK2_1 603 609 PF00069 0.231
MOD_CK2_1 626 632 PF00069 0.302
MOD_CK2_1 642 648 PF00069 0.218
MOD_CK2_1 665 671 PF00069 0.304
MOD_CK2_1 681 687 PF00069 0.250
MOD_CK2_1 704 710 PF00069 0.301
MOD_CK2_1 720 726 PF00069 0.237
MOD_CK2_1 743 749 PF00069 0.301
MOD_CK2_1 759 765 PF00069 0.237
MOD_CK2_1 782 788 PF00069 0.301
MOD_CK2_1 798 804 PF00069 0.237
MOD_CK2_1 821 827 PF00069 0.298
MOD_CK2_1 837 843 PF00069 0.314
MOD_CK2_1 860 866 PF00069 0.301
MOD_CK2_1 876 882 PF00069 0.336
MOD_CK2_1 985 991 PF00069 0.307
MOD_GlcNHglycan 1069 1072 PF01048 0.488
MOD_GlcNHglycan 1110 1113 PF01048 0.698
MOD_GlcNHglycan 1128 1131 PF01048 0.563
MOD_GlcNHglycan 3 6 PF01048 0.737
MOD_GlcNHglycan 326 329 PF01048 0.472
MOD_GlcNHglycan 84 87 PF01048 0.634
MOD_GSK3_1 1 8 PF00069 0.737
MOD_GSK3_1 1097 1104 PF00069 0.579
MOD_GSK3_1 1120 1127 PF00069 0.673
MOD_GSK3_1 1129 1136 PF00069 0.658
MOD_GSK3_1 1162 1169 PF00069 0.583
MOD_GSK3_1 170 177 PF00069 0.298
MOD_GSK3_1 209 216 PF00069 0.298
MOD_GSK3_1 248 255 PF00069 0.298
MOD_GSK3_1 25 32 PF00069 0.732
MOD_GSK3_1 287 294 PF00069 0.298
MOD_GSK3_1 326 333 PF00069 0.298
MOD_GSK3_1 34 41 PF00069 0.653
MOD_GSK3_1 365 372 PF00069 0.256
MOD_GSK3_1 404 411 PF00069 0.256
MOD_GSK3_1 443 450 PF00069 0.256
MOD_GSK3_1 482 489 PF00069 0.256
MOD_GSK3_1 521 528 PF00069 0.298
MOD_GSK3_1 560 567 PF00069 0.298
MOD_GSK3_1 599 606 PF00069 0.298
MOD_GSK3_1 638 645 PF00069 0.298
MOD_GSK3_1 677 684 PF00069 0.298
MOD_GSK3_1 716 723 PF00069 0.298
MOD_GSK3_1 755 762 PF00069 0.298
MOD_GSK3_1 794 801 PF00069 0.298
MOD_GSK3_1 833 840 PF00069 0.298
MOD_GSK3_1 872 879 PF00069 0.300
MOD_GSK3_1 97 104 PF00069 0.333
MOD_N-GLC_1 91 96 PF02516 0.591
MOD_N-GLC_1 97 102 PF02516 0.504
MOD_NEK2_1 1 6 PF00069 0.688
MOD_NEK2_1 1013 1018 PF00069 0.554
MOD_NEK2_1 106 111 PF00069 0.350
MOD_NEK2_1 1110 1115 PF00069 0.739
MOD_NEK2_1 52 57 PF00069 0.629
MOD_PIKK_1 122 128 PF00454 0.374
MOD_PIKK_1 17 23 PF00454 0.730
MOD_PIKK_1 29 35 PF00454 0.632
MOD_PKA_2 1067 1073 PF00069 0.496
MOD_PKA_2 1108 1114 PF00069 0.648
MOD_Plk_1 101 107 PF00069 0.350
MOD_Plk_1 1132 1138 PF00069 0.633
MOD_Plk_1 128 134 PF00069 0.298
MOD_Plk_2-3 914 920 PF00069 0.298
MOD_Plk_4 1102 1108 PF00069 0.597
MOD_Plk_4 1133 1139 PF00069 0.634
MOD_Plk_4 985 991 PF00069 0.298
MOD_ProDKin_1 1122 1128 PF00069 0.645
MOD_ProDKin_1 1155 1161 PF00069 0.585
MOD_ProDKin_1 1162 1168 PF00069 0.564
MOD_ProDKin_1 20 26 PF00069 0.658
MOD_ProDKin_1 39 45 PF00069 0.564
MOD_ProDKin_1 7 13 PF00069 0.682
MOD_SUMO_for_1 1092 1095 PF00179 0.493
MOD_SUMO_rev_2 80 85 PF00179 0.566
MOD_SUMO_rev_2 942 950 PF00179 0.339
TRG_DiLeu_BaEn_1 1035 1040 PF01217 0.500
TRG_DiLeu_BaEn_4 101 107 PF01217 0.360
TRG_DiLeu_BaEn_4 957 963 PF01217 0.318
TRG_ER_diArg_1 1000 1003 PF00400 0.360
TRG_ER_diArg_1 1014 1017 PF00400 0.466
TRG_ER_diArg_1 903 905 PF00400 0.432
TRG_ER_diArg_1 960 963 PF00400 0.317
TRG_Pf-PMV_PEXEL_1 1017 1021 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 1052 1056 PF00026 0.554
TRG_Pf-PMV_PEXEL_1 1059 1063 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 56 61 PF00026 0.605
TRG_Pf-PMV_PEXEL_1 953 957 PF00026 0.498
TRG_Pf-PMV_PEXEL_1 960 964 PF00026 0.464
TRG_Pf-PMV_PEXEL_1 992 996 PF00026 0.498

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H530 Leishmania donovani 61% 74%
A0A3S7X6W4 Leishmania donovani 33% 100%
A4H3J9 Leishmania braziliensis 94% 81%
C9ZSW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AJR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 85%
E9AKC9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
Q54G05 Dictyostelium discoideum 21% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS