TPR_MLP1_2 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3R9_LEIBR

TriTrypDb:

LbrM.03.0980 , LBRM2903_030007700 , LBRM2903_030007800

Length:

1172

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Show entries

Cellular components
Term	Name	Level	Count
GO:0000795	synaptonemal complex	3	1
GO:0005576	extracellular region	2	5
GO:0016020	membrane	2	1
GO:0099086	synaptonemal structure	2	1
GO:0110165	cellular anatomical entity	1	6

Previous1Next

Expansion

Sequence features

A4H3R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R9

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	5
GO:0006810	transport	3	5
GO:0006869	lipid transport	5	5
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0007130	synaptonemal complex assembly	4	1
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	1
GO:0003777	microtubule motor activity	2	1
GO:0005488	binding	1	5
GO:0008289	lipid binding	2	5
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0140657	ATP-dependent activity	1	1

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	904	906	PF00675	0.645
CLV_NRD_NRD_1	960	962	PF00675	0.510
CLV_PCSK_KEX2_1	904	906	PF00082	0.645
CLV_PCSK_KEX2_1	960	962	PF00082	0.510
CLV_PCSK_SKI1_1	1090	1094	PF00082	0.488
CLV_PCSK_SKI1_1	49	53	PF00082	0.660
CLV_PCSK_SKI1_1	963	967	PF00082	0.498
DEG_APCC_DBOX_1	92	100	PF00400	0.334
DEG_APCC_DBOX_1	923	931	PF00400	0.298
DEG_APCC_DBOX_1	962	970	PF00400	0.303

Previous1 2 3 4 5…22Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H530	Leishmania donovani	61%	74%
A0A3S7X6W4	Leishmania donovani	33%	100%
A4H3J9	Leishmania braziliensis	94%	81%
C9ZSW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AJR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	85%
E9AKC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q54G05	Dictyostelium discoideum	21%	79%

Previous1Next