Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3R6_LEIBR

TriTrypDb:

LbrM.03.0950 , LBRM2903_030009300

Length:

1046

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1027	1029	PF00675	0.476
CLV_NRD_NRD_1	119	121	PF00675	0.618
CLV_NRD_NRD_1	166	168	PF00675	0.763
CLV_NRD_NRD_1	174	176	PF00675	0.839
CLV_NRD_NRD_1	587	589	PF00675	0.597
CLV_NRD_NRD_1	616	618	PF00675	0.589
CLV_NRD_NRD_1	907	909	PF00675	0.787
CLV_NRD_NRD_1	94	96	PF00675	0.863
CLV_PCSK_FUR_1	614	618	PF00082	0.589
CLV_PCSK_FUR_1	905	909	PF00082	0.778
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.482
CLV_PCSK_KEX2_1	119	121	PF00082	0.618
CLV_PCSK_KEX2_1	166	168	PF00082	0.768
CLV_PCSK_KEX2_1	174	176	PF00082	0.844
CLV_PCSK_KEX2_1	587	589	PF00082	0.597
CLV_PCSK_KEX2_1	616	618	PF00082	0.589
CLV_PCSK_KEX2_1	907	909	PF00082	0.787
CLV_PCSK_KEX2_1	94	96	PF00082	0.863
CLV_PCSK_PC7_1	1022	1028	PF00082	0.461
CLV_PCSK_PC7_1	170	176	PF00082	0.869
CLV_PCSK_SKI1_1	107	111	PF00082	0.853
CLV_PCSK_SKI1_1	537	541	PF00082	0.672
CLV_PCSK_SKI1_1	742	746	PF00082	0.563
CLV_PCSK_SKI1_1	763	767	PF00082	0.568
CLV_PCSK_SKI1_1	807	811	PF00082	0.498
CLV_PCSK_SKI1_1	907	911	PF00082	0.788
CLV_PCSK_SKI1_1	987	991	PF00082	0.755
DEG_APCC_DBOX_1	806	814	PF00400	0.501
DEG_COP1_1	912	922	PF00400	0.577
DEG_Nend_UBRbox_3	1	3	PF02207	0.595
DEG_SCF_FBW7_1	746	751	PF00400	0.560
DEG_SPOP_SBC_1	370	374	PF00917	0.595
DEG_SPOP_SBC_1	415	419	PF00917	0.571
DEG_SPOP_SBC_1	670	674	PF00917	0.674
DOC_CKS1_1	1	6	PF01111	0.591
DOC_CKS1_1	203	208	PF01111	0.842
DOC_CKS1_1	366	371	PF01111	0.690
DOC_CKS1_1	442	447	PF01111	0.803
DOC_CKS1_1	449	454	PF01111	0.768
DOC_CKS1_1	521	526	PF01111	0.809
DOC_CKS1_1	765	770	PF01111	0.817
DOC_CYCLIN_RxL_1	104	114	PF00134	0.846
DOC_CYCLIN_RxL_1	447	458	PF00134	0.582
DOC_MAPK_gen_1	447	457	PF00069	0.585
DOC_MAPK_gen_1	574	584	PF00069	0.560
DOC_MAPK_MEF2A_6	450	459	PF00069	0.579
DOC_PP2B_LxvP_1	100	103	PF13499	0.825
DOC_PP2B_LxvP_1	471	474	PF13499	0.670
DOC_PP2B_LxvP_1	990	993	PF13499	0.798
DOC_PP2B_PxIxI_1	523	529	PF00149	0.775
DOC_PP4_MxPP_1	20	23	PF00568	0.597
DOC_USP7_MATH_1	15	19	PF00917	0.698
DOC_USP7_MATH_1	185	189	PF00917	0.612
DOC_USP7_MATH_1	311	315	PF00917	0.527
DOC_USP7_MATH_1	377	381	PF00917	0.588
DOC_USP7_MATH_1	383	387	PF00917	0.555
DOC_USP7_MATH_1	423	427	PF00917	0.792
DOC_USP7_MATH_1	46	50	PF00917	0.602
DOC_USP7_MATH_1	508	512	PF00917	0.834
DOC_USP7_MATH_1	513	517	PF00917	0.739
DOC_USP7_MATH_1	542	546	PF00917	0.632
DOC_USP7_MATH_1	607	611	PF00917	0.817
DOC_USP7_MATH_1	624	628	PF00917	0.512
DOC_USP7_MATH_1	65	69	PF00917	0.534
DOC_USP7_MATH_1	714	718	PF00917	0.593
DOC_USP7_MATH_1	748	752	PF00917	0.561
DOC_USP7_MATH_1	942	946	PF00917	0.736
DOC_WW_Pin1_4	13	18	PF00397	0.784
DOC_WW_Pin1_4	202	207	PF00397	0.842
DOC_WW_Pin1_4	351	356	PF00397	0.807
DOC_WW_Pin1_4	360	365	PF00397	0.708
DOC_WW_Pin1_4	391	396	PF00397	0.619
DOC_WW_Pin1_4	437	442	PF00397	0.826
DOC_WW_Pin1_4	448	453	PF00397	0.658
DOC_WW_Pin1_4	487	492	PF00397	0.709
DOC_WW_Pin1_4	497	502	PF00397	0.668
DOC_WW_Pin1_4	520	525	PF00397	0.801
DOC_WW_Pin1_4	529	534	PF00397	0.655
DOC_WW_Pin1_4	659	664	PF00397	0.749
DOC_WW_Pin1_4	67	72	PF00397	0.816
DOC_WW_Pin1_4	681	686	PF00397	0.714
DOC_WW_Pin1_4	699	704	PF00397	0.565
DOC_WW_Pin1_4	744	749	PF00397	0.812
DOC_WW_Pin1_4	764	769	PF00397	0.485
DOC_WW_Pin1_4	77	82	PF00397	0.681
DOC_WW_Pin1_4	781	786	PF00397	0.546
DOC_WW_Pin1_4	829	834	PF00397	0.790
DOC_WW_Pin1_4	851	856	PF00397	0.579
DOC_WW_Pin1_4	976	981	PF00397	0.728
LIG_14-3-3_CanoR_1	1028	1034	PF00244	0.710
LIG_14-3-3_CanoR_1	1039	1046	PF00244	0.604
LIG_14-3-3_CanoR_1	107	112	PF00244	0.639
LIG_14-3-3_CanoR_1	247	252	PF00244	0.566
LIG_14-3-3_CanoR_1	416	424	PF00244	0.711
LIG_14-3-3_CanoR_1	425	430	PF00244	0.791
LIG_14-3-3_CanoR_1	47	51	PF00244	0.600
LIG_14-3-3_CanoR_1	606	615	PF00244	0.560
LIG_14-3-3_CanoR_1	742	747	PF00244	0.573
LIG_14-3-3_CanoR_1	94	104	PF00244	0.692
LIG_Actin_WH2_2	104	121	PF00022	0.599
LIG_APCC_ABBA_1	340	345	PF00400	0.580
LIG_BRCT_BRCA1_1	560	564	PF00533	0.557
LIG_deltaCOP1_diTrp_1	780	788	PF00928	0.826
LIG_EVH1_1	100	104	PF00568	0.823
LIG_FHA_1	250	256	PF00498	0.597
LIG_FHA_1	521	527	PF00498	0.811
LIG_FHA_1	631	637	PF00498	0.714
LIG_FHA_1	874	880	PF00498	0.810
LIG_FHA_1	941	947	PF00498	0.782
LIG_FHA_2	373	379	PF00498	0.594
LIG_FHA_2	488	494	PF00498	0.821
LIG_HCF-1_HBM_1	303	306	PF13415	0.586
LIG_LIR_Apic_2	363	369	PF02991	0.803
LIG_LIR_Apic_2	391	395	PF02991	0.809
LIG_LIR_Apic_2	516	520	PF02991	0.552
LIG_LIR_Apic_2	679	685	PF02991	0.833
LIG_LIR_Apic_2	780	785	PF02991	0.827
LIG_LIR_Gen_1	826	836	PF02991	0.688
LIG_LIR_Gen_1	839	850	PF02991	0.677
LIG_LIR_Gen_1	888	896	PF02991	0.738
LIG_LIR_Nem_3	275	281	PF02991	0.622
LIG_LIR_Nem_3	479	485	PF02991	0.570
LIG_LIR_Nem_3	57	62	PF02991	0.592
LIG_LIR_Nem_3	826	831	PF02991	0.713
LIG_LIR_Nem_3	839	845	PF02991	0.705
LIG_LIR_Nem_3	888	892	PF02991	0.742
LIG_LYPXL_yS_3	409	412	PF13949	0.546
LIG_NRBOX	889	895	PF00104	0.734
LIG_PTAP_UEV_1	22	27	PF05743	0.602
LIG_RPA_C_Fungi	1034	1046	PF08784	0.521
LIG_SH2_CRK	366	370	PF00017	0.805
LIG_SH2_CRK	42	46	PF00017	0.615
LIG_SH2_CRK	517	521	PF00017	0.552
LIG_SH2_NCK_1	837	841	PF00017	0.785
LIG_SH2_SRC	135	138	PF00017	0.610
LIG_SH2_SRC	733	736	PF00017	0.572
LIG_SH2_STAT3	306	309	PF00017	0.571
LIG_SH2_STAT3	683	686	PF00017	0.836
LIG_SH2_STAT3	712	715	PF00017	0.596
LIG_SH2_STAT5	135	138	PF00017	0.707
LIG_SH2_STAT5	482	485	PF00017	0.596
LIG_SH2_STAT5	733	736	PF00017	0.572
LIG_SH3_1	11	17	PF00018	0.598
LIG_SH3_2	352	357	PF14604	0.579
LIG_SH3_3	11	17	PF00018	0.687
LIG_SH3_3	20	26	PF00018	0.856
LIG_SH3_3	200	206	PF00018	0.727
LIG_SH3_3	278	284	PF00018	0.792
LIG_SH3_3	349	355	PF00018	0.574
LIG_SH3_3	446	452	PF00018	0.792
LIG_SH3_3	47	53	PF00018	0.722
LIG_SH3_3	914	920	PF00018	0.580
LIG_SH3_3	974	980	PF00018	0.851
LIG_SH3_3	98	104	PF00018	0.828
LIG_SUMO_SIM_anti_2	580	586	PF11976	0.567
LIG_SUMO_SIM_anti_2	888	894	PF11976	0.739
LIG_SUMO_SIM_par_1	107	114	PF11976	0.583
LIG_SUMO_SIM_par_1	661	667	PF11976	0.685
LIG_SUMO_SIM_par_1	849	854	PF11976	0.665
LIG_SUMO_SIM_par_1	875	880	PF11976	0.805
LIG_TRAF2_1	154	157	PF00917	0.838
LIG_TRAF2_2	790	795	PF00917	0.777
LIG_UBA3_1	267	272	PF00899	0.796
LIG_WW_1	53	56	PF00397	0.833
MOD_CDC14_SPxK_1	354	357	PF00782	0.794
MOD_CDC14_SPxK_1	80	83	PF00782	0.603
MOD_CDK_SPK_2	448	453	PF00069	0.840
MOD_CDK_SPK_2	487	492	PF00069	0.573
MOD_CDK_SPxK_1	351	357	PF00069	0.789
MOD_CDK_SPxK_1	441	447	PF00069	0.838
MOD_CDK_SPxK_1	699	705	PF00069	0.612
MOD_CDK_SPxK_1	744	750	PF00069	0.813
MOD_CDK_SPxK_1	77	83	PF00069	0.599
MOD_CDK_SPxxK_3	360	367	PF00069	0.842
MOD_CK1_1	113	119	PF00069	0.598
MOD_CK1_1	18	24	PF00069	0.713
MOD_CK1_1	249	255	PF00069	0.821
MOD_CK1_1	314	320	PF00069	0.625
MOD_CK1_1	440	446	PF00069	0.835
MOD_CK1_1	472	478	PF00069	0.808
MOD_CK1_1	57	63	PF00069	0.841
MOD_CK1_1	662	668	PF00069	0.827
MOD_CK1_1	671	677	PF00069	0.678
MOD_CK1_1	829	835	PF00069	0.813
MOD_CK1_1	873	879	PF00069	0.813
MOD_CK1_1	928	934	PF00069	0.769
MOD_CK1_1	975	981	PF00069	0.701
MOD_CK2_1	372	378	PF00069	0.595
MOD_CK2_1	487	493	PF00069	0.825
MOD_CK2_1	624	630	PF00069	0.547
MOD_CK2_1	774	780	PF00069	0.693
MOD_CK2_1	859	865	PF00069	0.834
MOD_GlcNHglycan	1029	1032	PF01048	0.730
MOD_GlcNHglycan	137	141	PF01048	0.781
MOD_GlcNHglycan	187	190	PF01048	0.715
MOD_GlcNHglycan	226	229	PF01048	0.571
MOD_GlcNHglycan	23	26	PF01048	0.618
MOD_GlcNHglycan	231	234	PF01048	0.546
MOD_GlcNHglycan	292	295	PF01048	0.834
MOD_GlcNHglycan	345	348	PF01048	0.815
MOD_GlcNHglycan	385	388	PF01048	0.835
MOD_GlcNHglycan	418	421	PF01048	0.568
MOD_GlcNHglycan	567	570	PF01048	0.764
MOD_GlcNHglycan	579	582	PF01048	0.582
MOD_GlcNHglycan	58	62	PF01048	0.782
MOD_GlcNHglycan	609	612	PF01048	0.812
MOD_GlcNHglycan	626	629	PF01048	0.519
MOD_GlcNHglycan	675	678	PF01048	0.719
MOD_GlcNHglycan	716	719	PF01048	0.601
MOD_GlcNHglycan	735	738	PF01048	0.652
MOD_GlcNHglycan	902	905	PF01048	0.740
MOD_GlcNHglycan	930	933	PF01048	0.636
MOD_GlcNHglycan	974	977	PF01048	0.602
MOD_GSK3_1	1035	1042	PF00069	0.547
MOD_GSK3_1	109	116	PF00069	0.800
MOD_GSK3_1	174	181	PF00069	0.690
MOD_GSK3_1	198	205	PF00069	0.654
MOD_GSK3_1	242	249	PF00069	0.784
MOD_GSK3_1	365	372	PF00069	0.678
MOD_GSK3_1	377	384	PF00069	0.665
MOD_GSK3_1	414	421	PF00069	0.823
MOD_GSK3_1	425	432	PF00069	0.639
MOD_GSK3_1	437	444	PF00069	0.632
MOD_GSK3_1	497	504	PF00069	0.577
MOD_GSK3_1	554	561	PF00069	0.559
MOD_GSK3_1	636	643	PF00069	0.573
MOD_GSK3_1	664	671	PF00069	0.808
MOD_GSK3_1	672	679	PF00069	0.682
MOD_GSK3_1	699	706	PF00069	0.789
MOD_GSK3_1	73	80	PF00069	0.637
MOD_GSK3_1	744	751	PF00069	0.679
MOD_GSK3_1	823	830	PF00069	0.764
MOD_GSK3_1	864	871	PF00069	0.700
MOD_GSK3_1	921	928	PF00069	0.782
MOD_GSK3_1	936	943	PF00069	0.696
MOD_GSK3_1	972	979	PF00069	0.795
MOD_LATS_1	172	178	PF00433	0.871
MOD_LATS_1	414	420	PF00433	0.571
MOD_LATS_1	857	863	PF00433	0.757
MOD_LATS_1	93	99	PF00433	0.855
MOD_LATS_1	970	976	PF00433	0.811
MOD_N-GLC_1	224	229	PF02516	0.568
MOD_N-GLC_1	769	774	PF02516	0.557
MOD_N-GLC_1	900	905	PF02516	0.738
MOD_NEK2_1	118	123	PF00069	0.641
MOD_NEK2_1	224	229	PF00069	0.568
MOD_NEK2_1	371	376	PF00069	0.659
MOD_NEK2_1	424	429	PF00069	0.830
MOD_NEK2_1	540	545	PF00069	0.809
MOD_NEK2_1	605	610	PF00069	0.823
MOD_NEK2_1	669	674	PF00069	0.644
MOD_NEK2_2	748	753	PF00069	0.562
MOD_PIKK_1	1039	1045	PF00454	0.526
MOD_PIKK_1	250	256	PF00454	0.829
MOD_PIKK_1	726	732	PF00454	0.833
MOD_PIKK_1	870	876	PF00454	0.824
MOD_PIKK_1	992	998	PF00454	0.533
MOD_PK_1	425	431	PF00069	0.825
MOD_PK_1	868	874	PF00069	0.790
MOD_PKA_1	1027	1033	PF00069	0.466
MOD_PKA_1	166	172	PF00069	0.764
MOD_PKA_1	174	180	PF00069	0.842
MOD_PKA_2	1027	1033	PF00069	0.566
MOD_PKA_2	1035	1041	PF00069	0.599
MOD_PKA_2	118	124	PF00069	0.791
MOD_PKA_2	166	172	PF00069	0.766
MOD_PKA_2	173	179	PF00069	0.833
MOD_PKA_2	246	252	PF00069	0.567
MOD_PKA_2	298	304	PF00069	0.722
MOD_PKA_2	415	421	PF00069	0.710
MOD_PKA_2	424	430	PF00069	0.792
MOD_PKA_2	46	52	PF00069	0.596
MOD_PKA_2	605	611	PF00069	0.568
MOD_PKA_2	96	102	PF00069	0.667
MOD_Plk_1	113	119	PF00069	0.598
MOD_Plk_1	198	204	PF00069	0.596
MOD_Plk_1	631	637	PF00069	0.578
MOD_Plk_1	868	874	PF00069	0.829
MOD_Plk_4	15	21	PF00069	0.604
MOD_Plk_4	522	528	PF00069	0.812
MOD_Plk_4	823	829	PF00069	0.592
MOD_Plk_4	846	852	PF00069	0.569
MOD_Plk_4	936	942	PF00069	0.774
MOD_ProDKin_1	13	19	PF00069	0.787
MOD_ProDKin_1	202	208	PF00069	0.842
MOD_ProDKin_1	351	357	PF00069	0.810
MOD_ProDKin_1	360	366	PF00069	0.710
MOD_ProDKin_1	391	397	PF00069	0.619
MOD_ProDKin_1	437	443	PF00069	0.828
MOD_ProDKin_1	448	454	PF00069	0.659
MOD_ProDKin_1	487	493	PF00069	0.708
MOD_ProDKin_1	497	503	PF00069	0.665
MOD_ProDKin_1	520	526	PF00069	0.804
MOD_ProDKin_1	529	535	PF00069	0.656
MOD_ProDKin_1	659	665	PF00069	0.752
MOD_ProDKin_1	67	73	PF00069	0.817
MOD_ProDKin_1	681	687	PF00069	0.713
MOD_ProDKin_1	699	705	PF00069	0.567
MOD_ProDKin_1	744	750	PF00069	0.813
MOD_ProDKin_1	764	770	PF00069	0.486
MOD_ProDKin_1	77	83	PF00069	0.686
MOD_ProDKin_1	781	787	PF00069	0.545
MOD_ProDKin_1	829	835	PF00069	0.787
MOD_ProDKin_1	851	857	PF00069	0.581
MOD_ProDKin_1	976	982	PF00069	0.727
TRG_DiLeu_BaEn_1	760	765	PF01217	0.574
TRG_DiLeu_BaEn_1	888	893	PF01217	0.741
TRG_DiLeu_BaEn_2	644	650	PF01217	0.535
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.555
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.564
TRG_ENDOCYTIC_2	409	412	PF00928	0.546
TRG_ENDOCYTIC_2	42	45	PF00928	0.619
TRG_ENDOCYTIC_2	56	59	PF00928	0.540
TRG_ER_diArg_1	1019	1022	PF00400	0.587
TRG_ER_diArg_1	1026	1028	PF00400	0.541
TRG_ER_diArg_1	118	120	PF00400	0.611
TRG_ER_diArg_1	615	617	PF00400	0.592
TRG_ER_diArg_1	905	908	PF00400	0.777
TRG_ER_diArg_1	94	96	PF00400	0.863
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	750	755	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	908	912	PF00026	0.790

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJP7	Leishmania donovani	62%	99%
E9ACJ1	Leishmania major	64%	100%
E9AG35	Leishmania infantum	62%	99%
E9AJS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%