Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3R5_LEIBR

TriTrypDb:

LbrM.03.0940 , LBRM2903_290036800

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.363
CLV_NRD_NRD_1	130	132	PF00675	0.560
CLV_NRD_NRD_1	164	166	PF00675	0.367
CLV_NRD_NRD_1	86	88	PF00675	0.559
CLV_PCSK_FUR_1	128	132	PF00082	0.436
CLV_PCSK_KEX2_1	130	132	PF00082	0.549
CLV_PCSK_KEX2_1	166	168	PF00082	0.330
CLV_PCSK_KEX2_1	86	88	PF00082	0.600
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.330
CLV_PCSK_SKI1_1	29	33	PF00082	0.554
CLV_PCSK_SKI1_1	56	60	PF00082	0.678
DEG_APCC_DBOX_1	28	36	PF00400	0.441
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.387
DOC_MAPK_MEF2A_6	95	104	PF00069	0.501
DOC_USP7_MATH_1	300	304	PF00917	0.534
DOC_USP7_MATH_1	58	62	PF00917	0.517
DOC_WW_Pin1_4	133	138	PF00397	0.476
DOC_WW_Pin1_4	14	19	PF00397	0.408
DOC_WW_Pin1_4	215	220	PF00397	0.508
LIG_14-3-3_CanoR_1	130	135	PF00244	0.552
LIG_14-3-3_CanoR_1	56	64	PF00244	0.632
LIG_14-3-3_CanoR_1	89	94	PF00244	0.424
LIG_APCC_ABBA_1	98	103	PF00400	0.631
LIG_BIR_III_4	274	278	PF00653	0.484
LIG_BIR_III_4	66	70	PF00653	0.464
LIG_BRCT_BRCA1_1	257	261	PF00533	0.497
LIG_FHA_1	287	293	PF00498	0.460
LIG_Integrin_RGD_1	95	97	PF01839	0.343
LIG_LIR_Apic_2	133	137	PF02991	0.542
LIG_LIR_Apic_2	170	175	PF02991	0.550
LIG_LIR_Gen_1	188	197	PF02991	0.514
LIG_LIR_Gen_1	206	216	PF02991	0.506
LIG_LIR_Gen_1	243	253	PF02991	0.400
LIG_LIR_Gen_1	258	268	PF02991	0.358
LIG_LIR_Gen_1	271	281	PF02991	0.409
LIG_LIR_Nem_3	188	194	PF02991	0.548
LIG_LIR_Nem_3	206	211	PF02991	0.493
LIG_LIR_Nem_3	212	216	PF02991	0.469
LIG_LIR_Nem_3	243	249	PF02991	0.350
LIG_LIR_Nem_3	258	264	PF02991	0.324
LIG_LIR_Nem_3	271	276	PF02991	0.362
LIG_Pex14_2	213	217	PF04695	0.488
LIG_PTB_Apo_2	275	282	PF02174	0.436
LIG_SH2_CRK	134	138	PF00017	0.501
LIG_SH2_GRB2like	172	175	PF00017	0.575
LIG_SH2_GRB2like	191	194	PF00017	0.215
LIG_SH2_NCK_1	134	138	PF00017	0.469
LIG_SH2_NCK_1	172	176	PF00017	0.579
LIG_SH2_SRC	172	175	PF00017	0.575
LIG_SH2_STAP1	295	299	PF00017	0.461
LIG_SUMO_SIM_anti_2	33	41	PF11976	0.434
LIG_SUMO_SIM_par_1	218	224	PF11976	0.310
LIG_UBA3_1	216	223	PF00899	0.272
MOD_CK1_1	111	117	PF00069	0.374
MOD_CK1_1	133	139	PF00069	0.584
MOD_CK1_1	206	212	PF00069	0.557
MOD_CK1_1	218	224	PF00069	0.392
MOD_CK1_1	22	28	PF00069	0.465
MOD_CK2_1	121	127	PF00069	0.485
MOD_CK2_1	30	36	PF00069	0.557
MOD_CK2_1	54	60	PF00069	0.598
MOD_Cter_Amidation	84	87	PF01082	0.695
MOD_GlcNHglycan	110	113	PF01048	0.526
MOD_GlcNHglycan	24	27	PF01048	0.522
MOD_GlcNHglycan	242	245	PF01048	0.400
MOD_GlcNHglycan	251	254	PF01048	0.400
MOD_GlcNHglycan	32	35	PF01048	0.491
MOD_GlcNHglycan	56	59	PF01048	0.478
MOD_GSK3_1	102	109	PF00069	0.525
MOD_GSK3_1	126	133	PF00069	0.585
MOD_GSK3_1	151	158	PF00069	0.440
MOD_GSK3_1	245	252	PF00069	0.344
MOD_GSK3_1	255	262	PF00069	0.344
MOD_GSK3_1	294	301	PF00069	0.475
MOD_GSK3_1	54	61	PF00069	0.601
MOD_N-GLC_2	151	153	PF02516	0.361
MOD_NEK2_1	108	113	PF00069	0.532
MOD_NEK2_1	149	154	PF00069	0.440
MOD_NEK2_1	286	291	PF00069	0.412
MOD_NEK2_1	37	42	PF00069	0.589
MOD_NEK2_2	203	208	PF00069	0.353
MOD_PIKK_1	113	119	PF00454	0.394
MOD_PIKK_1	151	157	PF00454	0.366
MOD_PIKK_1	196	202	PF00454	0.324
MOD_PIKK_1	221	227	PF00454	0.287
MOD_PKA_1	130	136	PF00069	0.524
MOD_PKA_2	130	136	PF00069	0.548
MOD_PKA_2	22	28	PF00069	0.634
MOD_PKB_1	128	136	PF00069	0.333
MOD_PKB_1	87	95	PF00069	0.627
MOD_Plk_1	203	209	PF00069	0.539
MOD_Plk_2-3	121	127	PF00069	0.452
MOD_Plk_4	203	209	PF00069	0.549
MOD_Plk_4	245	251	PF00069	0.366
MOD_Plk_4	300	306	PF00069	0.573
MOD_Plk_4	4	10	PF00069	0.456
MOD_ProDKin_1	133	139	PF00069	0.468
MOD_ProDKin_1	14	20	PF00069	0.405
MOD_ProDKin_1	215	221	PF00069	0.501
TRG_DiLeu_BaEn_4	120	126	PF01217	0.571
TRG_ENDOCYTIC_2	191	194	PF00928	0.545
TRG_ER_diArg_1	128	131	PF00400	0.439
TRG_ER_diArg_1	165	168	PF00400	0.346
TRG_ER_diArg_1	234	237	PF00400	0.383
TRG_ER_diArg_1	86	89	PF00400	0.585
TRG_NLS_MonoExtC_3	164	170	PF00514	0.334
TRG_NLS_MonoExtN_4	162	169	PF00514	0.357
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z2	Leptomonas seymouri	46%	100%
A0A1X0P8Z8	Trypanosomatidae	28%	91%
A0A3Q8IBQ4	Leishmania donovani	64%	99%
A4I4Y4	Leishmania infantum	64%	99%
C9ZKJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	93%
E9AEE6	Leishmania major	63%	100%
E9ALE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
V5BSV9	Trypanosoma cruzi	33%	100%