LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H3R4_LEIBR
TriTrypDb:
LbrM.03.0930 , LBRM2903_290036900
Length:
122

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3R4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 82 86 PF00656 0.523
CLV_NRD_NRD_1 11 13 PF00675 0.703
CLV_NRD_NRD_1 22 24 PF00675 0.547
CLV_NRD_NRD_1 34 36 PF00675 0.569
CLV_PCSK_KEX2_1 11 13 PF00082 0.703
CLV_PCSK_KEX2_1 22 24 PF00082 0.547
CLV_PCSK_KEX2_1 33 35 PF00082 0.540
CLV_PCSK_SKI1_1 22 26 PF00082 0.551
DEG_APCC_DBOX_1 22 30 PF00400 0.538
DEG_Nend_UBRbox_2 1 3 PF02207 0.550
DOC_CYCLIN_RxL_1 16 30 PF00134 0.558
DOC_MAPK_gen_1 22 29 PF00069 0.519
DOC_MAPK_MEF2A_6 22 31 PF00069 0.518
DOC_USP7_MATH_1 4 8 PF00917 0.756
LIG_Clathr_ClatBox_1 24 28 PF01394 0.578
LIG_FHA_1 74 80 PF00498 0.454
LIG_FHA_2 53 59 PF00498 0.727
LIG_FHA_2 67 73 PF00498 0.508
LIG_LIR_Gen_1 88 97 PF02991 0.564
LIG_LIR_Nem_3 88 94 PF02991 0.571
LIG_NRBOX 20 26 PF00104 0.339
LIG_PCNA_yPIPBox_3 11 25 PF02747 0.388
LIG_PDZ_Class_3 117 122 PF00595 0.641
LIG_Pex14_2 97 101 PF04695 0.446
LIG_SH2_CRK 36 40 PF00017 0.577
LIG_SUMO_SIM_anti_2 28 33 PF11976 0.526
LIG_SUMO_SIM_par_1 23 28 PF11976 0.545
MOD_CK2_1 4 10 PF00069 0.760
MOD_CK2_1 66 72 PF00069 0.697
MOD_GlcNHglycan 63 66 PF01048 0.639
MOD_PKA_1 11 17 PF00069 0.438
MOD_PKA_2 11 17 PF00069 0.438
MOD_Plk_1 27 33 PF00069 0.427
MOD_Plk_2-3 68 74 PF00069 0.644
MOD_Plk_4 27 33 PF00069 0.557
MOD_SUMO_rev_2 100 107 PF00179 0.533
TRG_DiLeu_BaLyEn_6 20 25 PF01217 0.513
TRG_ENDOCYTIC_2 36 39 PF00928 0.553
TRG_ER_diArg_1 11 13 PF00400 0.663
TRG_ER_diArg_1 21 23 PF00400 0.507
TRG_ER_diArg_1 32 35 PF00400 0.512
TRG_Pf-PMV_PEXEL_1 11 15 PF00026 0.632
TRG_Pf-PMV_PEXEL_1 23 28 PF00026 0.396

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY97 Leptomonas seymouri 55% 100%
A0A3Q8IFK4 Leishmania donovani 67% 98%
A0A3R7K9Q0 Trypanosoma rangeli 37% 100%
A4I4Y3 Leishmania infantum 67% 98%
C9ZKJ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 90%
E9AEE7 Leishmania major 64% 100%
E9ALD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 98%
V5C2C8 Trypanosoma cruzi 34% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS