40S ribosomal protein S19 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S19 protein

Species:

Leishmania braziliensis

UniProt:

A4H3R3_LEIBR

TriTrypDb:

LbrM.03.0920 , LBRM2903_290037000

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	16
GO:0015935	small ribosomal subunit	4	2
GO:0022627	cytosolic small ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A4H3R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R3

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	16
GO:0006518	peptide metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009058	biosynthetic process	2	16
GO:0009059	macromolecule biosynthetic process	4	16
GO:0009987	cellular process	1	16
GO:0019538	protein metabolic process	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	16
GO:0043043	peptide biosynthetic process	5	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043603	amide metabolic process	3	16
GO:0043604	amide biosynthetic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0044271	cellular nitrogen compound biosynthetic process	4	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16
GO:1901566	organonitrogen compound biosynthetic process	4	16
GO:1901576	organic substance biosynthetic process	3	16
GO:0000028	ribosomal small subunit assembly	7	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	16
GO:0005198	structural molecule activity	1	16
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	156	162	PF00089	0.402
CLV_NRD_NRD_1	205	207	PF00675	0.414
CLV_NRD_NRD_1	221	223	PF00675	0.456
CLV_NRD_NRD_1	38	40	PF00675	0.522
CLV_NRD_NRD_1	77	79	PF00675	0.565
CLV_NRD_NRD_1	81	83	PF00675	0.576
CLV_PCSK_KEX2_1	158	160	PF00082	0.402
CLV_PCSK_KEX2_1	38	40	PF00082	0.522
CLV_PCSK_KEX2_1	58	60	PF00082	0.573
CLV_PCSK_KEX2_1	77	79	PF00082	0.561
CLV_PCSK_KEX2_1	81	83	PF00082	0.581
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.402
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.481
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.649
CLV_PCSK_PC7_1	34	40	PF00082	0.515
CLV_PCSK_PC7_1	77	83	PF00082	0.623
CLV_PCSK_SKI1_1	101	105	PF00082	0.402
CLV_PCSK_SKI1_1	186	190	PF00082	0.453
CLV_PCSK_SKI1_1	83	87	PF00082	0.500
CLV_PCSK_SKI1_1	94	98	PF00082	0.465
DEG_APCC_DBOX_1	45	53	PF00400	0.576
DEG_SPOP_SBC_1	174	178	PF00917	0.546
DOC_CKS1_1	27	32	PF01111	0.506
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.469
DOC_MAPK_gen_1	101	111	PF00069	0.449
DOC_MAPK_gen_1	206	217	PF00069	0.395
DOC_USP7_MATH_1	184	188	PF00917	0.435
DOC_USP7_UBL2_3	104	108	PF12436	0.454
DOC_USP7_UBL2_3	186	190	PF12436	0.397
DOC_WW_Pin1_4	26	31	PF00397	0.506
DOC_WW_Pin1_4	44	49	PF00397	0.491
DOC_WW_Pin1_4	51	56	PF00397	0.464
LIG_14-3-3_CanoR_1	3	9	PF00244	0.554
LIG_14-3-3_CanoR_1	59	67	PF00244	0.739
LIG_14-3-3_CanoR_1	82	88	PF00244	0.586
LIG_14-3-3_CanoR_1	94	103	PF00244	0.216
LIG_Actin_WH2_2	72	90	PF00022	0.618
LIG_BRCT_BRCA1_1	156	160	PF00533	0.402
LIG_BRCT_BRCA1_1	213	217	PF00533	0.474
LIG_BRCT_BRCA1_1	24	28	PF00533	0.509
LIG_FHA_1	113	119	PF00498	0.361
LIG_FHA_1	176	182	PF00498	0.546
LIG_FHA_1	27	33	PF00498	0.506
LIG_FHA_2	84	90	PF00498	0.396
LIG_LIR_Nem_3	132	136	PF02991	0.402
LIG_LIR_Nem_3	91	96	PF02991	0.499
LIG_LRP6_Inhibitor_1	71	77	PF00058	0.525
LIG_LYPXL_yS_3	66	69	PF13949	0.455
LIG_PDZ_Class_1	224	229	PF00595	0.562
LIG_SH2_CRK	153	157	PF00017	0.422
LIG_SH2_STAT3	13	16	PF00017	0.472
LIG_SH2_STAT5	13	16	PF00017	0.472
LIG_SH2_STAT5	135	138	PF00017	0.402
LIG_SH2_STAT5	146	149	PF00017	0.402
LIG_SH3_3	125	131	PF00018	0.420
LIG_TRFH_1	13	17	PF08558	0.467
LIG_TYR_ITIM	151	156	PF00017	0.445
MOD_CDK_SPxxK_3	51	58	PF00069	0.477
MOD_CK1_1	23	29	PF00069	0.647
MOD_CK1_1	4	10	PF00069	0.463
MOD_CK1_1	44	50	PF00069	0.489
MOD_CK1_1	54	60	PF00069	0.454
MOD_CK1_1	65	71	PF00069	0.555
MOD_CK2_1	165	171	PF00069	0.402
MOD_Cter_Amidation	79	82	PF01082	0.565
MOD_GlcNHglycan	199	202	PF01048	0.413
MOD_GlcNHglycan	3	6	PF01048	0.631
MOD_GlcNHglycan	43	46	PF01048	0.619
MOD_GlcNHglycan	89	93	PF01048	0.513
MOD_GSK3_1	170	177	PF00069	0.513
MOD_GSK3_1	22	29	PF00069	0.505
MOD_GSK3_1	44	51	PF00069	0.591
MOD_N-GLC_1	112	117	PF02516	0.474
MOD_N-GLC_1	174	179	PF02516	0.298
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	117	122	PF00069	0.533
MOD_NEK2_1	211	216	PF00069	0.546
MOD_NEK2_1	224	229	PF00069	0.523
MOD_PKA_2	202	208	PF00069	0.421
MOD_Plk_1	170	176	PF00069	0.563
MOD_Plk_1	20	26	PF00069	0.494
MOD_Plk_1	88	94	PF00069	0.487
MOD_Plk_4	23	29	PF00069	0.748
MOD_Plk_4	4	10	PF00069	0.632
MOD_Plk_4	48	54	PF00069	0.660
MOD_ProDKin_1	26	32	PF00069	0.506
MOD_ProDKin_1	44	50	PF00069	0.489
MOD_ProDKin_1	51	57	PF00069	0.465
MOD_SUMO_for_1	103	106	PF00179	0.421
TRG_DiLeu_BaEn_2	105	111	PF01217	0.474
TRG_ENDOCYTIC_2	153	156	PF00928	0.402
TRG_ENDOCYTIC_2	66	69	PF00928	0.455
TRG_ER_diArg_1	37	39	PF00400	0.516
TRG_ER_diArg_1	76	78	PF00400	0.502
TRG_NLS_MonoExtN_4	78	85	PF00514	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IY51	Bodo saltans	66%	100%
A0A1X0P9W6	Trypanosomatidae	69%	100%
A0A1X0P9X9	Trypanosomatidae	71%	100%
A0A3Q8IFE1	Leishmania donovani	94%	100%
A0A3Q8INI0	Leishmania donovani	95%	100%
A0A3R7KIF6	Trypanosoma rangeli	69%	100%
A0A422NEU2	Trypanosoma rangeli	73%	100%
A4HAZ5	Leishmania braziliensis	99%	100%
A4I4Y2	Leishmania infantum	94%	100%
A4IA55	Leishmania infantum	96%	100%
E9AEE8	Leishmania major	94%	100%
E9ALD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B569	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q2R6	Leishmania major	96%	100%