START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3R2_LEIBR

TriTrypDb:

LbrM.03.0910 , LBRM2903_290037100

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.318
CLV_C14_Caspase3-7	86	90	PF00656	0.404
CLV_MEL_PAP_1	192	198	PF00089	0.540
CLV_NRD_NRD_1	122	124	PF00675	0.413
CLV_NRD_NRD_1	150	152	PF00675	0.509
CLV_NRD_NRD_1	194	196	PF00675	0.511
CLV_NRD_NRD_1	363	365	PF00675	0.346
CLV_PCSK_KEX2_1	122	124	PF00082	0.393
CLV_PCSK_KEX2_1	150	152	PF00082	0.374
CLV_PCSK_KEX2_1	194	196	PF00082	0.511
CLV_PCSK_KEX2_1	240	242	PF00082	0.502
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.418
CLV_Separin_Metazoa	147	151	PF03568	0.302
DEG_APCC_DBOX_1	149	157	PF00400	0.327
DEG_SPOP_SBC_1	107	111	PF00917	0.241
DEG_SPOP_SBC_1	225	229	PF00917	0.421
DEG_SPOP_SBC_1	31	35	PF00917	0.722
DOC_PP1_RVXF_1	97	104	PF00149	0.381
DOC_PP2B_LxvP_1	27	30	PF13499	0.423
DOC_PP4_FxxP_1	37	40	PF00568	0.494
DOC_USP7_MATH_1	219	223	PF00917	0.629
DOC_USP7_MATH_1	249	253	PF00917	0.424
DOC_USP7_MATH_1	31	35	PF00917	0.510
DOC_USP7_MATH_1	47	51	PF00917	0.508
DOC_USP7_MATH_2	59	65	PF00917	0.285
DOC_WW_Pin1_4	18	23	PF00397	0.618
DOC_WW_Pin1_4	92	97	PF00397	0.498
LIG_14-3-3_CanoR_1	127	135	PF00244	0.460
LIG_14-3-3_CanoR_1	151	157	PF00244	0.431
LIG_14-3-3_CanoR_1	207	211	PF00244	0.390
LIG_14-3-3_CanoR_1	296	302	PF00244	0.463
LIG_14-3-3_CanoR_1	9	16	PF00244	0.558
LIG_Actin_WH2_2	109	124	PF00022	0.421
LIG_BIR_III_4	46	50	PF00653	0.275
LIG_BRCT_BRCA1_1	33	37	PF00533	0.510
LIG_BRCT_BRCA1_1	63	67	PF00533	0.282
LIG_deltaCOP1_diTrp_1	57	67	PF00928	0.339
LIG_FHA_1	107	113	PF00498	0.381
LIG_FHA_1	308	314	PF00498	0.348
LIG_FHA_1	326	332	PF00498	0.438
LIG_FHA_1	73	79	PF00498	0.493
LIG_FHA_2	109	115	PF00498	0.400
LIG_FHA_2	128	134	PF00498	0.334
LIG_FHA_2	140	146	PF00498	0.476
LIG_LIR_Apic_2	34	40	PF02991	0.502
LIG_LIR_Gen_1	110	121	PF02991	0.410
LIG_LIR_Gen_1	126	136	PF02991	0.292
LIG_LIR_Gen_1	229	236	PF02991	0.485
LIG_LIR_Gen_1	270	281	PF02991	0.357
LIG_LIR_Nem_3	110	116	PF02991	0.419
LIG_LIR_Nem_3	126	132	PF02991	0.278
LIG_LIR_Nem_3	229	235	PF02991	0.450
LIG_LIR_Nem_3	270	276	PF02991	0.361
LIG_MYND_1	347	351	PF01753	0.504
LIG_Pex14_1	125	129	PF04695	0.357
LIG_SH2_CRK	232	236	PF00017	0.370
LIG_SH2_CRK	367	371	PF00017	0.423
LIG_SH2_NCK_1	232	236	PF00017	0.353
LIG_SH2_SRC	210	213	PF00017	0.226
LIG_SH2_SRC	232	235	PF00017	0.349
LIG_SH2_SRC	87	90	PF00017	0.561
LIG_SH2_STAP1	210	214	PF00017	0.363
LIG_SH2_STAP1	232	236	PF00017	0.339
LIG_SH2_STAP1	25	29	PF00017	0.582
LIG_SH2_STAP1	367	371	PF00017	0.358
LIG_SH2_STAT5	115	118	PF00017	0.343
LIG_SH2_STAT5	129	132	PF00017	0.438
LIG_SH2_STAT5	87	90	PF00017	0.322
LIG_SH3_3	102	108	PF00018	0.304
LIG_SH3_3	274	280	PF00018	0.334
LIG_SH3_3	341	347	PF00018	0.378
LIG_Sin3_3	12	19	PF02671	0.449
LIG_SUMO_SIM_anti_2	334	340	PF11976	0.315
LIG_SUMO_SIM_par_1	303	310	PF11976	0.404
LIG_SUMO_SIM_par_1	333	340	PF11976	0.335
LIG_TRAF2_1	242	245	PF00917	0.278
LIG_TRAF2_1	265	268	PF00917	0.521
LIG_UBA3_1	358	365	PF00899	0.433
MOD_CDK_SPxxK_3	92	99	PF00069	0.548
MOD_CK1_1	322	328	PF00069	0.423
MOD_CK2_1	108	114	PF00069	0.543
MOD_CK2_1	127	133	PF00069	0.266
MOD_CK2_1	210	216	PF00069	0.377
MOD_GlcNHglycan	216	219	PF01048	0.510
MOD_GlcNHglycan	220	224	PF01048	0.545
MOD_GlcNHglycan	236	239	PF01048	0.352
MOD_GlcNHglycan	244	249	PF01048	0.454
MOD_GlcNHglycan	339	342	PF01048	0.374
MOD_GlcNHglycan	376	381	PF01048	0.580
MOD_GSK3_1	206	213	PF00069	0.269
MOD_GSK3_1	317	324	PF00069	0.553
MOD_GSK3_1	354	361	PF00069	0.494
MOD_GSK3_1	376	383	PF00069	0.540
MOD_GSK3_1	88	95	PF00069	0.482
MOD_N-GLC_1	117	122	PF02516	0.494
MOD_N-GLC_1	127	132	PF02516	0.410
MOD_N-GLC_1	73	78	PF02516	0.514
MOD_NEK2_1	214	219	PF00069	0.545
MOD_NEK2_1	236	241	PF00069	0.487
MOD_NEK2_1	32	37	PF00069	0.653
MOD_NEK2_1	336	341	PF00069	0.327
MOD_NEK2_1	8	13	PF00069	0.586
MOD_NEK2_2	108	113	PF00069	0.372
MOD_NEK2_2	210	215	PF00069	0.242
MOD_NEK2_2	47	52	PF00069	0.436
MOD_PIKK_1	20	26	PF00454	0.507
MOD_PIKK_1	317	323	PF00454	0.463
MOD_PIKK_1	73	79	PF00454	0.285
MOD_PKA_1	158	164	PF00069	0.300
MOD_PKA_2	206	212	PF00069	0.311
MOD_PKA_2	214	220	PF00069	0.437
MOD_PKA_2	307	313	PF00069	0.367
MOD_PKA_2	322	328	PF00069	0.460
MOD_PKA_2	8	14	PF00069	0.621
MOD_Plk_1	117	123	PF00069	0.469
MOD_Plk_1	127	133	PF00069	0.439
MOD_Plk_1	166	172	PF00069	0.295
MOD_Plk_1	73	79	PF00069	0.513
MOD_Plk_2-3	41	47	PF00069	0.428
MOD_Plk_2-3	61	67	PF00069	0.436
MOD_Plk_4	108	114	PF00069	0.539
MOD_Plk_4	166	172	PF00069	0.524
MOD_Plk_4	188	194	PF00069	0.299
MOD_Plk_4	2	8	PF00069	0.671
MOD_Plk_4	300	306	PF00069	0.353
MOD_Plk_4	32	38	PF00069	0.638
MOD_Plk_4	331	337	PF00069	0.340
MOD_Plk_4	354	360	PF00069	0.411
MOD_ProDKin_1	18	24	PF00069	0.618
MOD_ProDKin_1	92	98	PF00069	0.495
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.343
TRG_ENDOCYTIC_2	113	116	PF00928	0.429
TRG_ENDOCYTIC_2	129	132	PF00928	0.265
TRG_ENDOCYTIC_2	205	208	PF00928	0.348
TRG_ENDOCYTIC_2	232	235	PF00928	0.367
TRG_ENDOCYTIC_2	367	370	PF00928	0.365
TRG_ER_diArg_1	121	123	PF00400	0.419
TRG_ER_diArg_1	149	151	PF00400	0.465
TRG_ER_diArg_1	193	195	PF00400	0.545
TRG_ER_diArg_1	81	84	PF00400	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG75	Leptomonas seymouri	52%	100%
A0A0S4J6P5	Bodo saltans	25%	90%
A0A1X0PAK7	Trypanosomatidae	37%	99%
A0A3S5H7M1	Leishmania donovani	69%	100%
A0A422NJ09	Trypanosoma rangeli	37%	100%
A4I4Y1	Leishmania infantum	69%	100%
C9ZLM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AEE9	Leishmania major	70%	100%
E9ALD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
V5B889	Trypanosoma cruzi	39%	93%