Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3R1_LEIBR

TriTrypDb:

LbrM.03.0900 , LBRM2903_340005300 , LBRM2903_340005400

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 32
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	35
GO:0016020	membrane	2	3
GO:0042995	cell projection	2	35
GO:0043226	organelle	2	35
GO:0043227	membrane-bounded organelle	3	35
GO:0110165	cellular anatomical entity	1	35
GO:0120025	plasma membrane bounded cell projection	3	35
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0005737	cytoplasm	2	1
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H3R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3R1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006457	protein folding	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	4
GO:0004672	protein kinase activity	3	1
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	1
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1
GO:0016787	hydrolase activity	2	2
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.429
CLV_C14_Caspase3-7	169	173	PF00656	0.300
CLV_C14_Caspase3-7	288	292	PF00656	0.523
CLV_C14_Caspase3-7	423	427	PF00656	0.490
CLV_C14_Caspase3-7	555	559	PF00656	0.242
CLV_C14_Caspase3-7	90	94	PF00656	0.374
CLV_NRD_NRD_1	111	113	PF00675	0.394
CLV_NRD_NRD_1	443	445	PF00675	0.306
CLV_NRD_NRD_1	637	639	PF00675	0.633
CLV_NRD_NRD_1	671	673	PF00675	0.507
CLV_PCSK_KEX2_1	429	431	PF00082	0.260
CLV_PCSK_KEX2_1	443	445	PF00082	0.561
CLV_PCSK_KEX2_1	677	679	PF00082	0.515
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.260
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.501
CLV_PCSK_SKI1_1	113	117	PF00082	0.458
CLV_PCSK_SKI1_1	176	180	PF00082	0.410
CLV_PCSK_SKI1_1	443	447	PF00082	0.507
CLV_PCSK_SKI1_1	485	489	PF00082	0.367
CLV_PCSK_SKI1_1	548	552	PF00082	0.322
CLV_PCSK_SKI1_1	674	678	PF00082	0.521
DEG_Nend_UBRbox_3	1	3	PF02207	0.352
DEG_ODPH_VHL_1	268	279	PF01847	0.235
DEG_ODPH_VHL_1	403	414	PF01847	0.226
DEG_ODPH_VHL_1	538	549	PF01847	0.260
DOC_ANK_TNKS_1	677	684	PF00023	0.508
DOC_CDC14_PxL_1	202	210	PF14671	0.431
DOC_CDC14_PxL_1	316	324	PF14671	0.323
DOC_CDC14_PxL_1	451	459	PF14671	0.452
DOC_CDC14_PxL_1	496	504	PF14671	0.253
DOC_CDC14_PxL_1	586	594	PF14671	0.356
DOC_CDC14_PxL_1	631	639	PF14671	0.467
DOC_CYCLIN_RxL_1	214	225	PF00134	0.439
DOC_CYCLIN_RxL_1	427	436	PF00134	0.299
DOC_CYCLIN_RxL_1	517	528	PF00134	0.321
DOC_CYCLIN_yClb5_NLxxxL_5	380	389	PF00134	0.239
DOC_MAPK_gen_1	112	118	PF00069	0.411
DOC_MAPK_gen_1	485	493	PF00069	0.394
DOC_MAPK_MEF2A_6	252	259	PF00069	0.258
DOC_MAPK_MEF2A_6	36	44	PF00069	0.413
DOC_MAPK_MEF2A_6	95	104	PF00069	0.333
DOC_PP1_RVXF_1	389	395	PF00149	0.205
DOC_PP1_RVXF_1	76	83	PF00149	0.386
DOC_USP7_MATH_1	552	556	PF00917	0.407
DOC_USP7_MATH_1	642	646	PF00917	0.535
DOC_USP7_UBL2_3	673	677	PF12436	0.474
DOC_WW_Pin1_4	178	183	PF00397	0.326
DOC_WW_Pin1_4	361	366	PF00397	0.417
DOC_WW_Pin1_4	56	61	PF00397	0.540
LIG_14-3-3_CanoR_1	112	118	PF00244	0.349
LIG_14-3-3_CanoR_1	14	23	PF00244	0.446
LIG_14-3-3_CanoR_1	166	175	PF00244	0.463
LIG_14-3-3_CanoR_1	278	283	PF00244	0.380
LIG_14-3-3_CanoR_1	303	310	PF00244	0.419
LIG_14-3-3_CanoR_1	321	326	PF00244	0.268
LIG_14-3-3_CanoR_1	443	449	PF00244	0.492
LIG_14-3-3_CanoR_1	456	461	PF00244	0.383
LIG_14-3-3_CanoR_1	579	584	PF00244	0.415
LIG_14-3-3_CanoR_1	623	629	PF00244	0.381
LIG_14-3-3_CanoR_1	86	92	PF00244	0.466
LIG_Actin_WH2_2	160	178	PF00022	0.326
LIG_Actin_WH2_2	354	370	PF00022	0.522
LIG_Actin_WH2_2	487	505	PF00022	0.438
LIG_Actin_WH2_2	96	114	PF00022	0.353
LIG_APCC_ABBA_1	62	67	PF00400	0.311
LIG_APCC_ABBAyCdc20_2	429	435	PF00400	0.246
LIG_BIR_III_4	71	75	PF00653	0.313
LIG_BRCT_BRCA1_1	123	127	PF00533	0.307
LIG_BRCT_BRCA1_1	233	237	PF00533	0.527
LIG_BRCT_BRCA1_1	345	349	PF00533	0.259
LIG_BRCT_BRCA1_1	49	53	PF00533	0.406
LIG_Clathr_ClatBox_1	602	606	PF01394	0.410
LIG_Clathr_ClatBox_1	614	618	PF01394	0.428
LIG_DLG_GKlike_1	219	226	PF00625	0.422
LIG_FHA_1	166	172	PF00498	0.572
LIG_FHA_1	194	200	PF00498	0.457
LIG_FHA_1	420	426	PF00498	0.380
LIG_FHA_1	457	463	PF00498	0.315
LIG_FHA_2	303	309	PF00498	0.479
LIG_FHA_2	32	38	PF00498	0.413
LIG_FHA_2	418	424	PF00498	0.282
LIG_FHA_2	473	479	PF00498	0.412
LIG_FHA_2	684	690	PF00498	0.511
LIG_FHA_2	88	94	PF00498	0.395
LIG_IBAR_NPY_1	154	156	PF08397	0.425
LIG_LIR_Gen_1	124	132	PF02991	0.473
LIG_LIR_Gen_1	570	578	PF02991	0.218
LIG_LIR_Nem_3	124	130	PF02991	0.379
LIG_LIR_Nem_3	149	153	PF02991	0.597
LIG_LIR_Nem_3	506	512	PF02991	0.248
LIG_LIR_Nem_3	570	574	PF02991	0.206
LIG_LIR_Nem_3	76	80	PF02991	0.589
LIG_MLH1_MIPbox_1	49	53	PF16413	0.406
LIG_Pex14_2	106	110	PF04695	0.466
LIG_PTB_Apo_2	478	485	PF02174	0.406
LIG_RPA_C_Fungi	667	679	PF08784	0.465
LIG_SH2_PTP2	663	666	PF00017	0.429
LIG_SH2_STAT5	151	154	PF00017	0.411
LIG_SH2_STAT5	663	666	PF00017	0.732
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.310
LIG_SUMO_SIM_anti_2	37	44	PF11976	0.270
LIG_SUMO_SIM_par_1	138	144	PF11976	0.333
LIG_SUMO_SIM_par_1	253	258	PF11976	0.443
LIG_SUMO_SIM_par_1	354	360	PF11976	0.404
LIG_SUMO_SIM_par_1	600	606	PF11976	0.477
LIG_TRFH_1	151	155	PF08558	0.420
LIG_TRFH_1	156	160	PF08558	0.424
LIG_TYR_ITIM	614	619	PF00017	0.224
LIG_TYR_ITIM	661	666	PF00017	0.405
LIG_UBA3_1	31	36	PF00899	0.334
MOD_CDK_SPxxK_3	361	368	PF00069	0.240
MOD_CDK_SPxxK_3	56	63	PF00069	0.543
MOD_CK1_1	195	201	PF00069	0.492
MOD_CK1_1	222	228	PF00069	0.421
MOD_CK1_1	281	287	PF00069	0.414
MOD_CK1_1	357	363	PF00069	0.435
MOD_CK1_1	542	548	PF00069	0.492
MOD_CK1_1	76	82	PF00069	0.614
MOD_CK2_1	135	141	PF00069	0.430
MOD_CK2_1	282	288	PF00069	0.254
MOD_CK2_1	302	308	PF00069	0.400
MOD_CK2_1	417	423	PF00069	0.478
MOD_CK2_1	472	478	PF00069	0.490
MOD_CK2_1	683	689	PF00069	0.519
MOD_GlcNHglycan	113	116	PF01048	0.578
MOD_GlcNHglycan	123	126	PF01048	0.312
MOD_GlcNHglycan	361	364	PF01048	0.436
MOD_GlcNHglycan	374	377	PF01048	0.401
MOD_GlcNHglycan	415	418	PF01048	0.366
MOD_GlcNHglycan	47	50	PF01048	0.493
MOD_GlcNHglycan	541	544	PF01048	0.359
MOD_GlcNHglycan	554	557	PF01048	0.319
MOD_GlcNHglycan	599	602	PF01048	0.345
MOD_GlcNHglycan	631	634	PF01048	0.467
MOD_GlcNHglycan	644	647	PF01048	0.367
MOD_GlcNHglycan	655	658	PF01048	0.526
MOD_GlcNHglycan	674	677	PF01048	0.671
MOD_GlcNHglycan	81	85	PF01048	0.405
MOD_GSK3_1	131	138	PF00069	0.484
MOD_GSK3_1	178	185	PF00069	0.456
MOD_GSK3_1	278	285	PF00069	0.392
MOD_GSK3_1	321	328	PF00069	0.361
MOD_GSK3_1	343	350	PF00069	0.408
MOD_GSK3_1	357	364	PF00069	0.400
MOD_GSK3_1	413	420	PF00069	0.450
MOD_GSK3_1	433	440	PF00069	0.528
MOD_GSK3_1	47	54	PF00069	0.389
MOD_GSK3_1	507	514	PF00069	0.427
MOD_GSK3_1	552	559	PF00069	0.327
MOD_GSK3_1	597	604	PF00069	0.326
MOD_GSK3_1	683	690	PF00069	0.575
MOD_GSK3_1	76	83	PF00069	0.496
MOD_LATS_1	12	18	PF00433	0.268
MOD_N-GLC_1	1	6	PF02516	0.427
MOD_N-GLC_1	392	397	PF02516	0.410
MOD_N-GLC_1	437	442	PF02516	0.240
MOD_N-GLC_1	480	485	PF02516	0.373
MOD_N-GLC_1	642	647	PF02516	0.545
MOD_N-GLC_2	384	386	PF02516	0.249
MOD_N-GLC_2	564	566	PF02516	0.257
MOD_N-GLC_2	609	611	PF02516	0.480
MOD_NEK2_1	1	6	PF00069	0.534
MOD_NEK2_1	104	109	PF00069	0.484
MOD_NEK2_1	111	116	PF00069	0.507
MOD_NEK2_1	201	206	PF00069	0.470
MOD_NEK2_1	325	330	PF00069	0.419
MOD_NEK2_1	356	361	PF00069	0.434
MOD_NEK2_1	439	444	PF00069	0.481
MOD_NEK2_1	572	577	PF00069	0.290
MOD_NEK2_1	617	622	PF00069	0.367
MOD_NEK2_2	182	187	PF00069	0.306
MOD_NEK2_2	209	214	PF00069	0.247
MOD_OFUCOSY	469	476	PF10250	0.221
MOD_PK_1	278	284	PF00069	0.403
MOD_PK_1	591	597	PF00069	0.254
MOD_PKA_1	443	449	PF00069	0.290
MOD_PKA_1	672	678	PF00069	0.486
MOD_PKA_2	111	117	PF00069	0.439
MOD_PKA_2	165	171	PF00069	0.381
MOD_PKA_2	209	215	PF00069	0.468
MOD_PKA_2	21	27	PF00069	0.526
MOD_PKA_2	302	308	PF00069	0.435
MOD_PKA_2	443	449	PF00069	0.512
MOD_PKA_2	578	584	PF00069	0.259
MOD_PKB_1	670	678	PF00069	0.469
MOD_Plk_1	1	7	PF00069	0.408
MOD_Plk_1	219	225	PF00069	0.442
MOD_Plk_1	255	261	PF00069	0.375
MOD_Plk_1	347	353	PF00069	0.281
MOD_Plk_1	480	486	PF00069	0.405
MOD_Plk_1	505	511	PF00069	0.257
MOD_Plk_1	642	648	PF00069	0.513
MOD_Plk_2-3	135	141	PF00069	0.246
MOD_Plk_2-3	286	292	PF00069	0.512
MOD_Plk_4	105	111	PF00069	0.489
MOD_Plk_4	135	141	PF00069	0.365
MOD_Plk_4	233	239	PF00069	0.389
MOD_Plk_4	255	261	PF00069	0.419
MOD_Plk_4	489	495	PF00069	0.453
MOD_Plk_4	591	597	PF00069	0.273
MOD_ProDKin_1	178	184	PF00069	0.332
MOD_ProDKin_1	361	367	PF00069	0.412
MOD_ProDKin_1	56	62	PF00069	0.533
MOD_SUMO_rev_2	390	400	PF00179	0.249
TRG_DiLeu_BaEn_1	489	494	PF01217	0.295
TRG_DiLeu_BaEn_2	232	238	PF01217	0.228
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.526
TRG_ENDOCYTIC_2	150	153	PF00928	0.537
TRG_ENDOCYTIC_2	29	32	PF00928	0.438
TRG_ENDOCYTIC_2	616	619	PF00928	0.220
TRG_ENDOCYTIC_2	65	68	PF00928	0.361
TRG_ENDOCYTIC_2	663	666	PF00928	0.429
TRG_ER_diArg_1	443	445	PF00400	0.323
TRG_ER_diArg_1	455	458	PF00400	0.328
TRG_ER_diArg_1	635	638	PF00400	0.399
TRG_NES_CRM1_1	423	435	PF08389	0.542
TRG_NLS_MonoExtN_4	670	676	PF00514	0.461
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.271
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	520	525	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	33%	100%
A0A0N0P8N9	Leptomonas seymouri	30%	100%
A0A0N1I0W0	Leptomonas seymouri	29%	100%
A0A0N1P921	Leptomonas seymouri	27%	85%
A0A0S4JC97	Bodo saltans	24%	82%
A0A0S4KN43	Bodo saltans	26%	100%
A0A1X0P4M6	Trypanosomatidae	23%	100%
A0A3Q8I8N4	Leishmania donovani	30%	96%
A0A3Q8IGD6	Leishmania donovani	23%	85%
A0A3S5H7C2	Leishmania donovani	26%	100%
A0A3S7X2V4	Leishmania donovani	69%	90%
A4H3H4	Leishmania braziliensis	27%	71%
A4H7G0	Leishmania braziliensis	29%	94%
A4I0G3	Leishmania infantum	26%	100%
A4I6T8	Leishmania infantum	23%	85%
C9ZK22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	85%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	82%
E9ACE9	Leishmania major	26%	69%
E9AEF0	Leishmania major	69%	100%
E9AG21	Leishmania infantum	26%	69%
E9AGK6	Leishmania infantum	29%	96%
E9AGT5	Leishmania infantum	27%	100%
E9AHJ6	Leishmania infantum	69%	90%
E9AJN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	71%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	85%
Q4Q6A2	Leishmania major	23%	100%
Q4QFY4	Leishmania major	30%	96%
Q4QJ77	Leishmania major	23%	100%
Q4QJ80	Leishmania major	27%	100%
V5BKI3	Trypanosoma cruzi	23%	83%
V5BXQ3	Trypanosoma cruzi	25%	74%