MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Q9_LEIBR

TriTrypDb:

LbrM.03.0880 , LBRM2903_030014800

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Q9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.383
CLV_PCSK_KEX2_1	201	203	PF00082	0.288
CLV_PCSK_KEX2_1	292	294	PF00082	0.469
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.288
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.440
CLV_PCSK_PC7_1	288	294	PF00082	0.299
DEG_Nend_UBRbox_3	1	3	PF02207	0.357
DOC_ANK_TNKS_1	154	161	PF00023	0.479
DOC_MAPK_gen_1	16	22	PF00069	0.458
DOC_USP7_UBL2_3	221	225	PF12436	0.332
DOC_USP7_UBL2_3	264	268	PF12436	0.472
LIG_14-3-3_CanoR_1	109	115	PF00244	0.287
LIG_deltaCOP1_diTrp_1	242	248	PF00928	0.335
LIG_deltaCOP1_diTrp_1	42	48	PF00928	0.374
LIG_EH1_1	155	163	PF00400	0.488
LIG_FHA_1	297	303	PF00498	0.505
LIG_FHA_1	67	73	PF00498	0.383
LIG_FHA_2	33	39	PF00498	0.577
LIG_FHA_2	41	47	PF00498	0.400
LIG_LIR_Nem_3	226	231	PF02991	0.329
LIG_LIR_Nem_3	277	283	PF02991	0.464
LIG_LYPXL_yS_3	280	283	PF13949	0.494
LIG_Pex14_1	44	48	PF04695	0.380
LIG_Pex14_2	59	63	PF04695	0.493
LIG_REV1ctd_RIR_1	99	110	PF16727	0.307
LIG_SH2_CRK	112	116	PF00017	0.302
LIG_SH2_CRK	26	30	PF00017	0.278
LIG_SH2_CRK	73	77	PF00017	0.380
LIG_SH2_GRB2like	210	213	PF00017	0.288
LIG_SH2_NCK_1	26	30	PF00017	0.502
LIG_SH2_SRC	210	213	PF00017	0.288
LIG_SH2_STAP1	26	30	PF00017	0.450
LIG_SH2_STAT5	112	115	PF00017	0.273
LIG_SH2_STAT5	174	177	PF00017	0.310
LIG_SH2_STAT5	21	24	PF00017	0.442
LIG_SH2_STAT5	210	213	PF00017	0.304
LIG_SH3_3	292	298	PF00018	0.461
LIG_SUMO_SIM_par_1	299	307	PF11976	0.304
LIG_UBA3_1	143	150	PF00899	0.578
LIG_WRC_WIRS_1	111	116	PF05994	0.327
MOD_CK1_1	66	72	PF00069	0.357
MOD_CK1_1	93	99	PF00069	0.443
MOD_CK2_1	256	262	PF00069	0.381
MOD_CK2_1	297	303	PF00069	0.423
MOD_CK2_1	32	38	PF00069	0.666
MOD_CK2_1	48	54	PF00069	0.429
MOD_Cter_Amidation	103	106	PF01082	0.288
MOD_GlcNHglycan	216	219	PF01048	0.277
MOD_GlcNHglycan	51	54	PF01048	0.504
MOD_GlcNHglycan	83	86	PF01048	0.285
MOD_GlcNHglycan	92	95	PF01048	0.269
MOD_GSK3_1	32	39	PF00069	0.618
MOD_NEK2_1	48	53	PF00069	0.422
MOD_NEK2_1	63	68	PF00069	0.300
MOD_PKA_2	287	293	PF00069	0.432
MOD_Plk_2-3	36	42	PF00069	0.581
MOD_Plk_4	110	116	PF00069	0.327
MOD_Plk_4	188	194	PF00069	0.292
MOD_Plk_4	256	262	PF00069	0.423
MOD_Plk_4	297	303	PF00069	0.410
MOD_Plk_4	40	46	PF00069	0.403
MOD_SUMO_rev_2	259	265	PF00179	0.421
TRG_ENDOCYTIC_2	112	115	PF00928	0.296
TRG_ENDOCYTIC_2	231	234	PF00928	0.210
TRG_ENDOCYTIC_2	26	29	PF00928	0.277
TRG_ENDOCYTIC_2	280	283	PF00928	0.490
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVW7	Leptomonas seymouri	77%	98%
A0A0N1IIK8	Leptomonas seymouri	30%	89%
A0A0S4IT41	Bodo saltans	52%	99%
A0A0S4KIY0	Bodo saltans	32%	89%
A0A1X0NTG8	Trypanosomatidae	28%	72%
A0A1X0P8X9	Trypanosomatidae	58%	98%
A0A3S7X3U7	Leishmania donovani	29%	89%
A0A451EJU5	Leishmania donovani	86%	98%
A4HIR9	Leishmania braziliensis	29%	89%
A4HRY3	Leishmania infantum	86%	98%
A4I615	Leishmania infantum	29%	89%
C9ZKJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	98%
E9ACP2	Leishmania major	86%	100%
E9AJY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	89%
Q4Q6V8	Leishmania major	29%	89%
V5B1N1	Trypanosoma cruzi	30%	91%
V5DTY1	Trypanosoma cruzi	62%	98%