LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H3Q8_LEIBR
TriTrypDb:
LbrM.03.0870 , LBRM2903_030014700
Length:
104

Annotations

LeishMANIAdb annotations

A very short protein with a possible mitochondrial transit signal. Ancient and conserved without known function.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Q8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Q8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 49 51 PF00675 0.575
CLV_NRD_NRD_1 67 69 PF00675 0.538
CLV_PCSK_KEX2_1 67 69 PF00082 0.550
CLV_PCSK_SKI1_1 17 21 PF00082 0.391
DEG_APCC_DBOX_1 93 101 PF00400 0.393
DOC_MAPK_DCC_7 7 16 PF00069 0.664
DOC_MAPK_gen_1 5 13 PF00069 0.594
DOC_MAPK_MEF2A_6 7 16 PF00069 0.664
LIG_BRCT_BRCA1_1 32 36 PF00533 0.385
LIG_LIR_Gen_1 20 31 PF02991 0.562
LIG_LIR_Nem_3 70 76 PF02991 0.379
LIG_LRP6_Inhibitor_1 66 72 PF00058 0.633
LIG_OCRL_FandH_1 35 47 PF00620 0.469
LIG_Pex14_1 54 58 PF04695 0.385
LIG_SH2_CRK 73 77 PF00017 0.381
LIG_SH2_STAT5 3 6 PF00017 0.596
LIG_SH2_STAT5 43 46 PF00017 0.443
LIG_TYR_ITIM 71 76 PF00017 0.445
LIG_UBA3_1 31 39 PF00899 0.344
MOD_CK1_1 42 48 PF00069 0.371
MOD_NEK2_1 1 6 PF00069 0.599
MOD_PIKK_1 17 23 PF00454 0.591
MOD_Plk_4 30 36 PF00069 0.351
MOD_SUMO_rev_2 81 90 PF00179 0.389
TRG_ENDOCYTIC_2 23 26 PF00928 0.449
TRG_ENDOCYTIC_2 73 76 PF00928 0.360

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJT6 Leptomonas seymouri 92% 100%
A0A0S4ISH0 Bodo saltans 61% 100%
A0A1X0P8Z5 Trypanosomatidae 81% 100%
A0A3S5H570 Leishmania donovani 95% 100%
A0A422MTR4 Trypanosoma rangeli 76% 100%
A4HRY2 Leishmania infantum 96% 100%
C9ZKJ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
E9AJY0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q1X7K5 Leishmania major 96% 100%
V5C2D3 Trypanosoma cruzi 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS