Multicopper oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Multicopper oxidase

Gene product:

multicopper oxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Q7_LEIBR

TriTrypDb:

LbrM.03.0860 , LBRM2903_030014600

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 3
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H3Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Q7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005507	copper ion binding	6	11
GO:0016491	oxidoreductase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.380
CLV_NRD_NRD_1	167	169	PF00675	0.628
CLV_NRD_NRD_1	232	234	PF00675	0.654
CLV_NRD_NRD_1	249	251	PF00675	0.544
CLV_NRD_NRD_1	358	360	PF00675	0.664
CLV_NRD_NRD_1	481	483	PF00675	0.607
CLV_NRD_NRD_1	77	79	PF00675	0.499
CLV_PCSK_KEX2_1	193	195	PF00082	0.616
CLV_PCSK_KEX2_1	232	234	PF00082	0.654
CLV_PCSK_KEX2_1	249	251	PF00082	0.530
CLV_PCSK_KEX2_1	358	360	PF00082	0.690
CLV_PCSK_KEX2_1	481	483	PF00082	0.607
CLV_PCSK_KEX2_1	77	79	PF00082	0.499
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.616
CLV_PCSK_SKI1_1	14	18	PF00082	0.485
CLV_PCSK_SKI1_1	201	205	PF00082	0.414
CLV_PCSK_SKI1_1	441	445	PF00082	0.513
DEG_APCC_DBOX_1	13	21	PF00400	0.386
DEG_APCC_DBOX_1	248	256	PF00400	0.380
DOC_CKS1_1	115	120	PF01111	0.323
DOC_MAPK_DCC_7	288	296	PF00069	0.296
DOC_MAPK_gen_1	193	200	PF00069	0.400
DOC_MAPK_HePTP_8	190	202	PF00069	0.397
DOC_MAPK_MEF2A_6	193	202	PF00069	0.374
DOC_MAPK_MEF2A_6	386	394	PF00069	0.205
DOC_MAPK_MEF2A_6	498	507	PF00069	0.214
DOC_PP1_RVXF_1	199	205	PF00149	0.322
DOC_PP1_RVXF_1	312	319	PF00149	0.336
DOC_PP4_FxxP_1	366	369	PF00568	0.282
DOC_PP4_FxxP_1	38	41	PF00568	0.292
DOC_USP7_MATH_1	147	151	PF00917	0.453
DOC_USP7_MATH_1	205	209	PF00917	0.300
DOC_USP7_MATH_1	91	95	PF00917	0.226
DOC_WW_Pin1_4	114	119	PF00397	0.511
DOC_WW_Pin1_4	143	148	PF00397	0.360
DOC_WW_Pin1_4	297	302	PF00397	0.470
DOC_WW_Pin1_4	468	473	PF00397	0.375
DOC_WW_Pin1_4	541	546	PF00397	0.734
LIG_14-3-3_CanoR_1	187	193	PF00244	0.444
LIG_14-3-3_CanoR_1	232	236	PF00244	0.382
LIG_14-3-3_CanoR_1	249	253	PF00244	0.271
LIG_14-3-3_CanoR_1	309	313	PF00244	0.399
LIG_14-3-3_CanoR_1	481	491	PF00244	0.329
LIG_Actin_WH2_2	125	140	PF00022	0.335
LIG_Actin_WH2_2	219	234	PF00022	0.352
LIG_Actin_WH2_2	413	428	PF00022	0.205
LIG_deltaCOP1_diTrp_1	239	244	PF00928	0.362
LIG_EH_1	58	62	PF12763	0.358
LIG_FHA_1	114	120	PF00498	0.389
LIG_FHA_1	187	193	PF00498	0.361
LIG_FHA_1	232	238	PF00498	0.378
LIG_FHA_1	365	371	PF00498	0.360
LIG_FHA_1	373	379	PF00498	0.290
LIG_FHA_1	4	10	PF00498	0.338
LIG_FHA_1	420	426	PF00498	0.288
LIG_FHA_1	71	77	PF00498	0.379
LIG_FHA_2	222	228	PF00498	0.417
LIG_FHA_2	542	548	PF00498	0.718
LIG_LIR_Apic_2	172	176	PF02991	0.449
LIG_LIR_Gen_1	208	216	PF02991	0.356
LIG_LIR_Gen_1	239	247	PF02991	0.332
LIG_LIR_Gen_1	300	307	PF02991	0.379
LIG_LIR_Gen_1	499	510	PF02991	0.335
LIG_LIR_Gen_1	94	104	PF02991	0.213
LIG_LIR_Nem_3	239	244	PF02991	0.343
LIG_LIR_Nem_3	300	306	PF02991	0.385
LIG_LIR_Nem_3	311	316	PF02991	0.331
LIG_LIR_Nem_3	326	332	PF02991	0.417
LIG_LIR_Nem_3	346	352	PF02991	0.316
LIG_LIR_Nem_3	361	366	PF02991	0.298
LIG_LIR_Nem_3	466	470	PF02991	0.285
LIG_LIR_Nem_3	499	505	PF02991	0.335
LIG_LIR_Nem_3	94	99	PF02991	0.213
LIG_LYPXL_yS_3	196	199	PF13949	0.240
LIG_PCNA_PIPBox_1	128	137	PF02747	0.390
LIG_PCNA_PIPBox_1	97	106	PF02747	0.205
LIG_PCNA_yPIPBox_3	128	142	PF02747	0.417
LIG_PDZ_Class_1	551	556	PF00595	0.602
LIG_Pex14_2	491	495	PF04695	0.559
LIG_PTB_Apo_2	42	49	PF02174	0.362
LIG_SH2_CRK	470	474	PF00017	0.451
LIG_SH2_CRK	96	100	PF00017	0.205
LIG_SH2_GRB2like	210	213	PF00017	0.385
LIG_SH2_NCK_1	173	177	PF00017	0.442
LIG_SH2_PTP2	502	505	PF00017	0.227
LIG_SH2_STAP1	72	76	PF00017	0.306
LIG_SH2_STAT5	210	213	PF00017	0.385
LIG_SH2_STAT5	243	246	PF00017	0.303
LIG_SH2_STAT5	276	279	PF00017	0.354
LIG_SH2_STAT5	303	306	PF00017	0.330
LIG_SH2_STAT5	330	333	PF00017	0.350
LIG_SH2_STAT5	467	470	PF00017	0.282
LIG_SH2_STAT5	502	505	PF00017	0.390
LIG_SH2_STAT5	520	523	PF00017	0.708
LIG_SH2_STAT5	72	75	PF00017	0.288
LIG_SH3_3	115	121	PF00018	0.498
LIG_SH3_3	157	163	PF00018	0.493
LIG_SH3_3	291	297	PF00018	0.411
LIG_SH3_3	466	472	PF00018	0.356
LIG_SH3_3	60	66	PF00018	0.361
LIG_SH3_5	472	476	PF00018	0.292
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.326
LIG_SUMO_SIM_anti_2	178	183	PF11976	0.253
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.350
LIG_SUMO_SIM_par_1	233	239	PF11976	0.444
LIG_TYR_ITAM	310	332	PF00017	0.476
LIG_TYR_ITIM	468	473	PF00017	0.254
LIG_TYR_ITSM	309	316	PF00017	0.459
LIG_UBA3_1	130	138	PF00899	0.324
LIG_UBA3_1	15	22	PF00899	0.306
LIG_UBA3_1	273	278	PF00899	0.398
LIG_WRC_WIRS_1	399	404	PF05994	0.313
MOD_CDK_SPxxK_3	541	548	PF00069	0.700
MOD_CK1_1	308	314	PF00069	0.370
MOD_CK1_1	485	491	PF00069	0.467
MOD_CK2_1	541	547	PF00069	0.717
MOD_Cter_Amidation	356	359	PF01082	0.656
MOD_GlcNHglycan	511	514	PF01048	0.494
MOD_GSK3_1	143	150	PF00069	0.312
MOD_GSK3_1	154	161	PF00069	0.320
MOD_GSK3_1	217	224	PF00069	0.249
MOD_GSK3_1	337	344	PF00069	0.403
MOD_GSK3_1	66	73	PF00069	0.337
MOD_N-GLC_1	211	216	PF02516	0.499
MOD_N-GLC_1	29	34	PF02516	0.521
MOD_N-GLC_1	342	347	PF02516	0.613
MOD_N-GLC_1	41	46	PF02516	0.435
MOD_N-GLC_1	411	416	PF02516	0.482
MOD_NEK2_1	137	142	PF00069	0.299
MOD_NEK2_1	221	226	PF00069	0.354
MOD_NEK2_1	242	247	PF00069	0.316
MOD_NEK2_1	28	33	PF00069	0.354
MOD_NEK2_1	341	346	PF00069	0.424
MOD_NEK2_1	425	430	PF00069	0.334
MOD_NEK2_1	463	468	PF00069	0.282
MOD_NEK2_1	491	496	PF00069	0.555
MOD_NEK2_1	509	514	PF00069	0.362
MOD_NEK2_1	551	556	PF00069	0.779
MOD_NEK2_1	70	75	PF00069	0.288
MOD_NEK2_2	188	193	PF00069	0.339
MOD_NEK2_2	205	210	PF00069	0.301
MOD_NEK2_2	434	439	PF00069	0.386
MOD_NEK2_2	91	96	PF00069	0.205
MOD_PIKK_1	124	130	PF00454	0.413
MOD_PIKK_1	137	143	PF00454	0.436
MOD_PIKK_1	226	232	PF00454	0.248
MOD_PIKK_1	316	322	PF00454	0.356
MOD_PIKK_1	529	535	PF00454	0.738
MOD_PKA_2	186	192	PF00069	0.415
MOD_PKA_2	231	237	PF00069	0.374
MOD_PKA_2	248	254	PF00069	0.271
MOD_PKA_2	308	314	PF00069	0.389
MOD_PKA_2	425	431	PF00069	0.282
MOD_Plk_1	211	217	PF00069	0.320
MOD_Plk_1	314	320	PF00069	0.359
MOD_Plk_1	411	417	PF00069	0.283
MOD_Plk_4	154	160	PF00069	0.494
MOD_Plk_4	217	223	PF00069	0.251
MOD_Plk_4	308	314	PF00069	0.411
MOD_Plk_4	369	375	PF00069	0.292
MOD_Plk_4	463	469	PF00069	0.282
MOD_Plk_4	491	497	PF00069	0.486
MOD_Plk_4	66	72	PF00069	0.386
MOD_Plk_4	91	97	PF00069	0.214
MOD_ProDKin_1	114	120	PF00069	0.501
MOD_ProDKin_1	143	149	PF00069	0.366
MOD_ProDKin_1	297	303	PF00069	0.463
MOD_ProDKin_1	468	474	PF00069	0.376
MOD_ProDKin_1	541	547	PF00069	0.733
MOD_SUMO_for_1	277	280	PF00179	0.358
MOD_SUMO_rev_2	251	261	PF00179	0.322
TRG_DiLeu_LyEn_5	547	552	PF01217	0.755
TRG_ENDOCYTIC_2	196	199	PF00928	0.409
TRG_ENDOCYTIC_2	210	213	PF00928	0.379
TRG_ENDOCYTIC_2	303	306	PF00928	0.388
TRG_ENDOCYTIC_2	313	316	PF00928	0.375
TRG_ENDOCYTIC_2	329	332	PF00928	0.269
TRG_ENDOCYTIC_2	349	352	PF00928	0.214
TRG_ENDOCYTIC_2	363	366	PF00928	0.282
TRG_ENDOCYTIC_2	470	473	PF00928	0.315
TRG_ENDOCYTIC_2	502	505	PF00928	0.476
TRG_ENDOCYTIC_2	96	99	PF00928	0.296
TRG_ER_diArg_1	231	233	PF00400	0.371
TRG_ER_diArg_1	358	360	PF00400	0.492
TRG_ER_diArg_1	480	482	PF00400	0.308
TRG_ER_diArg_1	76	78	PF00400	0.205
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX0	Leptomonas seymouri	62%	87%
A0A1X0P996	Trypanosomatidae	49%	86%
A0A3R7JTK5	Trypanosoma rangeli	52%	87%
A0A3S5H569	Leishmania donovani	80%	88%
A4HRY1	Leishmania infantum	80%	88%
C9ZKJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	86%
E9ACP0	Leishmania major	78%	100%
E9AJX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BXB2	Trypanosoma cruzi	51%	88%