Vesicle transport protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Got1/Sft2-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Q4_LEIBR

TriTrypDb:

LbrM.03.0830 , LBRM2903_030014200

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A4H3Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Q4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	22
GO:0008104	protein localization	4	22
GO:0009987	cellular process	1	22
GO:0015031	protein transport	4	22
GO:0016192	vesicle-mediated transport	4	22
GO:0033036	macromolecule localization	2	22
GO:0045184	establishment of protein localization	3	22
GO:0051179	localization	1	22
GO:0051234	establishment of localization	2	22
GO:0051641	cellular localization	2	22
GO:0070727	cellular macromolecule localization	3	22
GO:0071702	organic substance transport	4	22
GO:0071705	nitrogen compound transport	4	22

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.616
CLV_PCSK_SKI1_1	127	131	PF00082	0.279
CLV_PCSK_SKI1_1	188	192	PF00082	0.499
DOC_CYCLIN_RxL_1	30	41	PF00134	0.563
DOC_MAPK_MEF2A_6	184	191	PF00069	0.688
LIG_14-3-3_CanoR_1	184	188	PF00244	0.651
LIG_Actin_WH2_2	173	190	PF00022	0.559
LIG_BRCT_BRCA1_1	114	118	PF00533	0.282
LIG_eIF4E_1	32	38	PF01652	0.560
LIG_FHA_1	184	190	PF00498	0.591
LIG_FHA_1	44	50	PF00498	0.762
LIG_FHA_1	69	75	PF00498	0.627
LIG_FHA_2	126	132	PF00498	0.583
LIG_GBD_Chelix_1	169	177	PF00786	0.260
LIG_LIR_Gen_1	144	153	PF02991	0.311
LIG_LIR_Gen_1	192	201	PF02991	0.500
LIG_LIR_Gen_1	75	86	PF02991	0.337
LIG_LIR_Nem_3	144	149	PF02991	0.320
LIG_LIR_Nem_3	171	177	PF02991	0.319
LIG_LIR_Nem_3	178	182	PF02991	0.349
LIG_LIR_Nem_3	192	196	PF02991	0.604
LIG_NRBOX	85	91	PF00104	0.260
LIG_PCNA_PIPBox_1	147	156	PF02747	0.249
LIG_Pex14_1	97	101	PF04695	0.342
LIG_SH2_CRK	193	197	PF00017	0.634
LIG_SH2_CRK	32	36	PF00017	0.627
LIG_SH2_SRC	141	144	PF00017	0.260
LIG_SH2_STAP1	175	179	PF00017	0.276
LIG_SH2_STAP1	193	197	PF00017	0.574
LIG_SH2_STAP1	70	74	PF00017	0.596
LIG_SH2_STAT3	182	185	PF00017	0.661
LIG_SH2_STAT3	26	29	PF00017	0.641
LIG_SH2_STAT5	141	144	PF00017	0.390
LIG_SH2_STAT5	70	73	PF00017	0.660
LIG_SxIP_EBH_1	173	184	PF03271	0.387
LIG_TYR_ITIM	191	196	PF00017	0.626
LIG_TYR_ITIM	30	35	PF00017	0.498
MOD_CK1_1	192	198	PF00069	0.554
MOD_CK1_1	63	69	PF00069	0.624
MOD_CK2_1	125	131	PF00069	0.433
MOD_GlcNHglycan	150	153	PF01048	0.379
MOD_GlcNHglycan	5	8	PF01048	0.506
MOD_GSK3_1	141	148	PF00069	0.327
MOD_GSK3_1	43	50	PF00069	0.688
MOD_GSK3_1	68	75	PF00069	0.630
MOD_GSK3_1	99	106	PF00069	0.262
MOD_NEK2_1	103	108	PF00069	0.339
MOD_NEK2_1	68	73	PF00069	0.587
MOD_NEK2_2	141	146	PF00069	0.344
MOD_NEK2_2	183	188	PF00069	0.646
MOD_PIKK_1	25	31	PF00454	0.653
MOD_PIKK_1	68	74	PF00454	0.649
MOD_PKA_1	99	105	PF00069	0.329
MOD_PKA_2	183	189	PF00069	0.638
MOD_PKA_2	72	78	PF00069	0.527
MOD_Plk_1	66	72	PF00069	0.607
MOD_Plk_4	112	118	PF00069	0.344
MOD_Plk_4	145	151	PF00069	0.315
MOD_Plk_4	168	174	PF00069	0.370
MOD_Plk_4	175	181	PF00069	0.382
MOD_Plk_4	192	198	PF00069	0.645
MOD_Plk_4	88	94	PF00069	0.373
MOD_SUMO_rev_2	17	23	PF00179	0.559
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.182
TRG_ENDOCYTIC_2	193	196	PF00928	0.625
TRG_ENDOCYTIC_2	32	35	PF00928	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I1	Leptomonas seymouri	71%	99%
A0A0N1I3M5	Leptomonas seymouri	28%	100%
A0A0S4JF33	Bodo saltans	31%	100%
A0A1X0P7F6	Trypanosomatidae	28%	100%
A0A1X0P987	Trypanosomatidae	42%	100%
A0A3Q8IBK0	Leishmania donovani	38%	100%
A0A3S5H567	Leishmania donovani	86%	100%
A0A3S5H5K3	Leishmania donovani	41%	100%
A0A422N175	Trypanosoma rangeli	45%	100%
A4HDV3	Leishmania braziliensis	38%	100%
A4HRX8	Leishmania infantum	86%	100%
A4HSK3	Leishmania infantum	41%	100%
A4I148	Leishmania infantum	38%	100%
C9ZKI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	78%
E9ACN7	Leishmania major	88%	100%
E9AJX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AKI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AX82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QA90	Leishmania major	38%	100%
Q4QJC1	Leishmania major	41%	100%