Inorganic diphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inorganic pyrophosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Q3_LEIBR

TriTrypDb:

LbrM.03.0820 , LBRM2903_030014100

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4H3Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004427	inorganic diphosphate phosphatase activity	6	11
GO:0005488	binding	1	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.408
CLV_PCSK_SKI1_1	119	123	PF00082	0.318
CLV_PCSK_SKI1_1	281	285	PF00082	0.266
CLV_PCSK_SKI1_1	316	320	PF00082	0.346
CLV_PCSK_SKI1_1	90	94	PF00082	0.200
CLV_Separin_Metazoa	212	216	PF03568	0.346
DOC_CDC14_PxL_1	14	22	PF14671	0.363
DOC_CYCLIN_RxL_1	54	64	PF00134	0.374
DOC_MAPK_gen_1	129	137	PF00069	0.411
DOC_MAPK_gen_1	160	169	PF00069	0.388
DOC_MAPK_gen_1	281	290	PF00069	0.444
DOC_MAPK_MEF2A_6	284	292	PF00069	0.346
DOC_PP1_RVXF_1	88	94	PF00149	0.294
DOC_PP2B_LxvP_1	202	205	PF13499	0.346
DOC_USP7_MATH_1	100	104	PF00917	0.442
DOC_USP7_MATH_1	13	17	PF00917	0.377
DOC_USP7_MATH_1	318	322	PF00917	0.401
DOC_USP7_MATH_1	32	36	PF00917	0.414
DOC_USP7_MATH_1	66	70	PF00917	0.398
LIG_14-3-3_CanoR_1	119	124	PF00244	0.206
LIG_BIR_II_1	1	5	PF00653	0.400
LIG_BIR_III_3	1	5	PF00653	0.400
LIG_BRCT_BRCA1_1	15	19	PF00533	0.362
LIG_FHA_1	186	192	PF00498	0.486
LIG_FHA_1	50	56	PF00498	0.454
LIG_FHA_1	68	74	PF00498	0.393
LIG_FHA_1	96	102	PF00498	0.467
LIG_FHA_2	112	118	PF00498	0.262
LIG_FHA_2	175	181	PF00498	0.445
LIG_FHA_2	238	244	PF00498	0.540
LIG_FHA_2	256	262	PF00498	0.466
LIG_FHA_2	76	82	PF00498	0.423
LIG_GBD_Chelix_1	47	55	PF00786	0.299
LIG_LIR_Apic_2	177	181	PF02991	0.411
LIG_LIR_Apic_2	26	32	PF02991	0.364
LIG_LIR_Apic_2	264	269	PF02991	0.505
LIG_LIR_Apic_2	7	11	PF02991	0.359
LIG_LIR_Gen_1	103	112	PF02991	0.276
LIG_LIR_Gen_1	23	32	PF02991	0.365
LIG_LIR_Gen_1	298	304	PF02991	0.531
LIG_LIR_Nem_3	103	108	PF02991	0.292
LIG_LIR_Nem_3	16	22	PF02991	0.367
LIG_LIR_Nem_3	210	214	PF02991	0.518
LIG_LIR_Nem_3	227	233	PF02991	0.345
LIG_LIR_Nem_3	23	27	PF02991	0.353
LIG_LIR_Nem_3	243	248	PF02991	0.490
LIG_LIR_Nem_3	261	266	PF02991	0.543
LIG_LIR_Nem_3	298	303	PF02991	0.491
LIG_LIR_Nem_3	86	92	PF02991	0.264
LIG_NRBOX	42	48	PF00104	0.291
LIG_PCNA_yPIPBox_3	250	263	PF02747	0.505
LIG_Pex14_1	262	266	PF04695	0.411
LIG_Pex14_1	89	93	PF04695	0.271
LIG_Pex14_2	169	173	PF04695	0.411
LIG_PTB_Apo_2	163	170	PF02174	0.346
LIG_PTB_Apo_2	307	314	PF02174	0.360
LIG_PTB_Phospho_1	307	313	PF10480	0.362
LIG_REV1ctd_RIR_1	90	98	PF16727	0.301
LIG_SH2_CRK	171	175	PF00017	0.505
LIG_SH2_CRK	245	249	PF00017	0.425
LIG_SH2_CRK	29	33	PF00017	0.365
LIG_SH2_CRK	300	304	PF00017	0.369
LIG_SH2_CRK	8	12	PF00017	0.350
LIG_SH2_NCK_1	8	12	PF00017	0.350
LIG_SH2_SRC	211	214	PF00017	0.346
LIG_SH2_SRC	8	11	PF00017	0.354
LIG_SH2_STAP1	24	28	PF00017	0.366
LIG_SH2_STAP1	300	304	PF00017	0.221
LIG_SH2_STAT5	123	126	PF00017	0.157
LIG_SH2_STAT5	161	164	PF00017	0.471
LIG_SH3_1	139	145	PF00018	0.458
LIG_SH3_2	142	147	PF14604	0.520
LIG_SH3_3	106	112	PF00018	0.316
LIG_SH3_3	139	145	PF00018	0.463
LIG_SH3_3	15	21	PF00018	0.411
LIG_SH3_3	7	13	PF00018	0.459
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.411
LIG_TRAF2_1	138	141	PF00917	0.466
LIG_WRC_WIRS_1	24	29	PF05994	0.368
MOD_CK1_1	83	89	PF00069	0.446
MOD_CK2_1	135	141	PF00069	0.466
MOD_CK2_1	237	243	PF00069	0.540
MOD_Cter_Amidation	270	273	PF01082	0.242
MOD_GlcNHglycan	102	105	PF01048	0.293
MOD_GlcNHglycan	235	238	PF01048	0.294
MOD_GlcNHglycan	34	37	PF01048	0.348
MOD_GlcNHglycan	80	85	PF01048	0.334
MOD_GSK3_1	233	240	PF00069	0.465
MOD_GSK3_1	49	56	PF00069	0.583
MOD_GSK3_1	76	83	PF00069	0.459
MOD_N-GLC_1	76	81	PF02516	0.332
MOD_NEK2_1	255	260	PF00069	0.455
MOD_NEK2_1	288	293	PF00069	0.346
MOD_NEK2_1	55	60	PF00069	0.376
MOD_NEK2_1	61	66	PF00069	0.430
MOD_PIKK_1	295	301	PF00454	0.501
MOD_PIKK_1	49	55	PF00454	0.304
MOD_Plk_4	23	29	PF00069	0.416
MOD_Plk_4	255	261	PF00069	0.442
MOD_Plk_4	288	294	PF00069	0.429
MOD_SUMO_for_1	133	136	PF00179	0.411
MOD_SUMO_rev_2	224	233	PF00179	0.411
MOD_SUMO_rev_2	276	286	PF00179	0.393
MOD_SUMO_rev_2	80	88	PF00179	0.266
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.385
TRG_ENDOCYTIC_2	164	167	PF00928	0.411
TRG_ENDOCYTIC_2	171	174	PF00928	0.411
TRG_ENDOCYTIC_2	211	214	PF00928	0.505
TRG_ENDOCYTIC_2	24	27	PF00928	0.367
TRG_ENDOCYTIC_2	245	248	PF00928	0.416
TRG_ENDOCYTIC_2	300	303	PF00928	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXJ8	Leptomonas seymouri	60%	100%
A0A0N1PDG0	Leptomonas seymouri	38%	72%
A0A0S4JW75	Bodo saltans	37%	77%
A0A1X0NCY3	Trypanosomatidae	37%	100%
A0A1X0NVA1	Trypanosomatidae	37%	79%
A0A1X0NVH4	Trypanosomatidae	37%	77%
A0A1X0NWW9	Trypanosomatidae	37%	78%
A0A1X0PAB0	Trypanosomatidae	48%	100%
A0A3R7KMZ3	Trypanosoma rangeli	35%	78%
A0A3S7WRH5	Leishmania donovani	38%	73%
A0A422N180	Trypanosoma rangeli	50%	100%
A0A451EJT9	Leishmania donovani	84%	100%
A4H9T7	Leishmania braziliensis	39%	73%
A4HRX7	Leishmania infantum	83%	100%
A4HUT3	Leishmania infantum	38%	73%
C9ZKI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0A7N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	78%
D0A7N2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	78%
E9ACN6	Leishmania major	85%	100%
E9AJX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9ANG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	73%
O13505	Komagataella pastoris	41%	100%
O77460	Drosophila melanogaster	40%	95%
P00817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P13998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	100%
P19117	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
P28239	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P37980	Bos taurus	41%	100%
P83777	Candida albicans (strain SC5314 / ATCC MYA-2876)	38%	100%
Q15181	Homo sapiens	40%	100%
Q18680	Caenorhabditis elegans	36%	75%
Q4QH59	Leishmania major	39%	73%
Q4R543	Macaca fascicularis	39%	100%
Q54PV8	Dictyostelium discoideum	37%	100%
Q5R8T6	Pongo abelii	39%	100%
Q6BWA5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	39%	100%
Q6C1T4	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	100%
Q6FRB7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	39%	100%
Q6MVH7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q757J8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	39%	100%
Q8SR69	Encephalitozoon cuniculi (strain GB-M1)	35%	100%
Q91VM9	Mus musculus	39%	98%
Q93Y52	Chlamydomonas reinhardtii	40%	100%
Q9C0T9	Zygosaccharomyces bailii	40%	100%
Q9D819	Mus musculus	40%	100%
Q9H2U2	Homo sapiens	39%	96%
Q9LXC9	Arabidopsis thaliana	38%	100%
V5BB26	Trypanosoma cruzi	36%	78%
V5BSV4	Trypanosoma cruzi	51%	100%