FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Q1_LEIBR

TriTrypDb:

LbrM.03.0800 , LBRM2903_030013900

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Q1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.654
CLV_C14_Caspase3-7	488	492	PF00656	0.543
CLV_MEL_PAP_1	285	291	PF00089	0.628
CLV_NRD_NRD_1	160	162	PF00675	0.493
CLV_NRD_NRD_1	424	426	PF00675	0.588
CLV_NRD_NRD_1	482	484	PF00675	0.567
CLV_NRD_NRD_1	621	623	PF00675	0.718
CLV_PCSK_KEX2_1	160	162	PF00082	0.493
CLV_PCSK_KEX2_1	287	289	PF00082	0.594
CLV_PCSK_KEX2_1	482	484	PF00082	0.567
CLV_PCSK_KEX2_1	620	622	PF00082	0.721
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.662
CLV_PCSK_PC7_1	616	622	PF00082	0.703
CLV_PCSK_SKI1_1	160	164	PF00082	0.584
CLV_PCSK_SKI1_1	371	375	PF00082	0.369
CLV_PCSK_SKI1_1	421	425	PF00082	0.434
CLV_PCSK_SKI1_1	572	576	PF00082	0.446
CLV_PCSK_SKI1_1	69	73	PF00082	0.463
CLV_PCSK_SKI1_1	729	733	PF00082	0.519
CLV_PCSK_SKI1_1	87	91	PF00082	0.457
DEG_APCC_DBOX_1	420	428	PF00400	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DEG_SPOP_SBC_1	336	340	PF00917	0.360
DOC_CYCLIN_yClb3_PxF_3	184	190	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	182	185	PF00134	0.566
DOC_MAPK_DCC_7	572	582	PF00069	0.444
DOC_MAPK_gen_1	321	329	PF00069	0.322
DOC_MAPK_gen_1	572	582	PF00069	0.447
DOC_MAPK_MEF2A_6	40	49	PF00069	0.452
DOC_MAPK_MEF2A_6	575	584	PF00069	0.435
DOC_PP1_RVXF_1	158	165	PF00149	0.625
DOC_PP1_RVXF_1	290	297	PF00149	0.556
DOC_PP1_SILK_1	729	734	PF00149	0.579
DOC_PP2B_LxvP_1	181	184	PF13499	0.628
DOC_PP2B_LxvP_1	574	577	PF13499	0.443
DOC_PP2B_LxvP_1	723	726	PF13499	0.497
DOC_PP4_FxxP_1	538	541	PF00568	0.541
DOC_USP7_MATH_1	136	140	PF00917	0.622
DOC_USP7_MATH_1	176	180	PF00917	0.613
DOC_USP7_MATH_1	209	213	PF00917	0.616
DOC_USP7_MATH_1	230	234	PF00917	0.543
DOC_USP7_MATH_1	354	358	PF00917	0.307
DOC_USP7_MATH_1	516	520	PF00917	0.799
DOC_USP7_MATH_1	67	71	PF00917	0.641
DOC_USP7_MATH_1	78	82	PF00917	0.483
DOC_USP7_UBL2_3	565	569	PF12436	0.489
DOC_WW_Pin1_4	258	263	PF00397	0.560
DOC_WW_Pin1_4	533	538	PF00397	0.720
DOC_WW_Pin1_4	539	544	PF00397	0.654
DOC_WW_Pin1_4	599	604	PF00397	0.455
LIG_14-3-3_CanoR_1	279	285	PF00244	0.637
LIG_14-3-3_CanoR_1	288	296	PF00244	0.632
LIG_14-3-3_CanoR_1	371	381	PF00244	0.361
LIG_14-3-3_CanoR_1	482	486	PF00244	0.612
LIG_14-3-3_CanoR_1	94	100	PF00244	0.664
LIG_Actin_WH2_2	718	735	PF00022	0.500
LIG_BIR_III_4	650	654	PF00653	0.681
LIG_Clathr_ClatBox_1	581	585	PF01394	0.452
LIG_deltaCOP1_diTrp_1	220	227	PF00928	0.655
LIG_FHA_1	55	61	PF00498	0.670
LIG_FHA_1	698	704	PF00498	0.563
LIG_FHA_1	88	94	PF00498	0.518
LIG_FHA_2	109	115	PF00498	0.546
LIG_FHA_2	346	352	PF00498	0.300
LIG_FHA_2	486	492	PF00498	0.693
LIG_FHA_2	645	651	PF00498	0.684
LIG_FHA_2	686	692	PF00498	0.654
LIG_GBD_Chelix_1	325	333	PF00786	0.360
LIG_LIR_Apic_2	536	541	PF02991	0.538
LIG_LIR_Gen_1	30	39	PF02991	0.586
LIG_LIR_Gen_1	348	356	PF02991	0.306
LIG_LIR_Gen_1	366	377	PF02991	0.391
LIG_LIR_Gen_1	99	107	PF02991	0.644
LIG_LIR_LC3C_4	596	601	PF02991	0.341
LIG_LIR_LC3C_4	720	725	PF02991	0.485
LIG_LIR_Nem_3	283	289	PF02991	0.597
LIG_LIR_Nem_3	30	36	PF02991	0.596
LIG_LIR_Nem_3	348	352	PF02991	0.314
LIG_LIR_Nem_3	366	372	PF02991	0.440
LIG_LIR_Nem_3	99	103	PF02991	0.739
LIG_MYND_2	302	306	PF01753	0.472
LIG_NRBOX	711	717	PF00104	0.578
LIG_NRBOX	718	724	PF00104	0.479
LIG_PAM2_1	372	384	PF00658	0.360
LIG_Pex14_1	223	227	PF04695	0.651
LIG_Pex14_1	365	369	PF04695	0.360
LIG_SH2_CRK	100	104	PF00017	0.783
LIG_SH2_CRK	286	290	PF00017	0.628
LIG_SH2_CRK	369	373	PF00017	0.360
LIG_SH2_NCK_1	100	104	PF00017	0.529
LIG_SH2_SRC	604	607	PF00017	0.515
LIG_SH2_STAP1	369	373	PF00017	0.360
LIG_SH2_STAP1	393	397	PF00017	0.300
LIG_SH2_STAP1	8	12	PF00017	0.448
LIG_SH2_STAT3	411	414	PF00017	0.360
LIG_SH2_STAT5	20	23	PF00017	0.464
LIG_SH2_STAT5	369	372	PF00017	0.270
LIG_SH2_STAT5	48	51	PF00017	0.448
LIG_SH2_STAT5	604	607	PF00017	0.515
LIG_SH3_3	13	19	PF00018	0.561
LIG_SH3_3	182	188	PF00018	0.651
LIG_SH3_3	199	205	PF00018	0.556
LIG_SH3_3	218	224	PF00018	0.488
LIG_SH3_3	597	603	PF00018	0.431
LIG_SUMO_SIM_anti_2	41	48	PF11976	0.451
LIG_SUMO_SIM_anti_2	579	585	PF11976	0.412
LIG_SUMO_SIM_anti_2	720	727	PF11976	0.490
LIG_SUMO_SIM_par_1	579	585	PF11976	0.436
LIG_SUMO_SIM_par_1	706	717	PF11976	0.649
LIG_SUMO_SIM_par_1	720	727	PF11976	0.464
LIG_TYR_ITIM	284	289	PF00017	0.633
LIG_UBA3_1	1	7	PF00899	0.467
MOD_CDC14_SPxK_1	542	545	PF00782	0.530
MOD_CDK_SPxK_1	539	545	PF00069	0.532
MOD_CK1_1	24	30	PF00069	0.498
MOD_CK1_1	255	261	PF00069	0.731
MOD_CK1_1	337	343	PF00069	0.360
MOD_CK1_1	484	490	PF00069	0.615
MOD_CK1_1	523	529	PF00069	0.751
MOD_CK1_1	54	60	PF00069	0.554
MOD_CK1_1	689	695	PF00069	0.756
MOD_CK1_1	81	87	PF00069	0.520
MOD_CK1_1	88	94	PF00069	0.499
MOD_CK1_1	99	105	PF00069	0.494
MOD_CK2_1	108	114	PF00069	0.688
MOD_CK2_1	345	351	PF00069	0.300
MOD_CK2_1	354	360	PF00069	0.300
MOD_CK2_1	60	66	PF00069	0.546
MOD_CK2_1	714	720	PF00069	0.553
MOD_CK2_1	99	105	PF00069	0.633
MOD_Cter_Amidation	164	167	PF01082	0.619
MOD_GlcNHglycan	138	141	PF01048	0.671
MOD_GlcNHglycan	174	177	PF01048	0.615
MOD_GlcNHglycan	232	235	PF01048	0.592
MOD_GlcNHglycan	298	301	PF01048	0.535
MOD_GlcNHglycan	356	359	PF01048	0.300
MOD_GlcNHglycan	387	390	PF01048	0.334
MOD_GlcNHglycan	445	448	PF01048	0.766
MOD_GlcNHglycan	465	468	PF01048	0.721
MOD_GlcNHglycan	474	477	PF01048	0.670
MOD_GlcNHglycan	496	499	PF01048	0.791
MOD_GlcNHglycan	522	525	PF01048	0.718
MOD_GlcNHglycan	62	65	PF01048	0.553
MOD_GlcNHglycan	69	72	PF01048	0.537
MOD_GlcNHglycan	87	90	PF01048	0.457
MOD_GSK3_1	123	130	PF00069	0.641
MOD_GSK3_1	172	179	PF00069	0.654
MOD_GSK3_1	20	27	PF00069	0.479
MOD_GSK3_1	209	216	PF00069	0.623
MOD_GSK3_1	247	254	PF00069	0.559
MOD_GSK3_1	313	320	PF00069	0.546
MOD_GSK3_1	443	450	PF00069	0.618
MOD_GSK3_1	481	488	PF00069	0.783
MOD_GSK3_1	516	523	PF00069	0.783
MOD_GSK3_1	529	536	PF00069	0.779
MOD_GSK3_1	54	61	PF00069	0.587
MOD_GSK3_1	584	591	PF00069	0.501
MOD_GSK3_1	640	647	PF00069	0.721
MOD_GSK3_1	659	666	PF00069	0.632
MOD_GSK3_1	685	692	PF00069	0.675
MOD_GSK3_1	81	88	PF00069	0.598
MOD_GSK3_1	89	96	PF00069	0.716
MOD_N-GLC_1	108	113	PF02516	0.540
MOD_N-GLC_1	123	128	PF02516	0.500
MOD_N-GLC_1	252	257	PF02516	0.708
MOD_N-GLC_1	463	468	PF02516	0.789
MOD_N-GLC_1	494	499	PF02516	0.777
MOD_NEK2_1	127	132	PF00069	0.560
MOD_NEK2_1	189	194	PF00069	0.593
MOD_NEK2_1	228	233	PF00069	0.642
MOD_NEK2_1	294	299	PF00069	0.562
MOD_NEK2_1	305	310	PF00069	0.530
MOD_NEK2_1	329	334	PF00069	0.300
MOD_NEK2_1	372	377	PF00069	0.302
MOD_NEK2_1	385	390	PF00069	0.294
MOD_NEK2_1	39	44	PF00069	0.471
MOD_NEK2_1	520	525	PF00069	0.697
MOD_NEK2_1	60	65	PF00069	0.550
MOD_NEK2_1	93	98	PF00069	0.509
MOD_NEK2_2	516	521	PF00069	0.544
MOD_NEK2_2	89	94	PF00069	0.500
MOD_PIKK_1	93	99	PF00454	0.569
MOD_PKA_1	287	293	PF00069	0.601
MOD_PKA_1	621	627	PF00069	0.712
MOD_PKA_2	287	293	PF00069	0.586
MOD_PKA_2	450	456	PF00069	0.684
MOD_PKA_2	481	487	PF00069	0.699
MOD_PKA_2	520	526	PF00069	0.661
MOD_PKA_2	615	621	PF00069	0.698
MOD_PKA_2	93	99	PF00069	0.799
MOD_PKB_1	277	285	PF00069	0.670
MOD_Plk_1	123	129	PF00069	0.646
MOD_Plk_1	256	262	PF00069	0.681
MOD_Plk_1	329	335	PF00069	0.300
MOD_Plk_1	529	535	PF00069	0.532
MOD_Plk_1	588	594	PF00069	0.440
MOD_Plk_1	628	634	PF00069	0.541
MOD_Plk_1	689	695	PF00069	0.622
MOD_Plk_2-3	108	114	PF00069	0.686
MOD_Plk_2-3	247	253	PF00069	0.692
MOD_Plk_4	197	203	PF00069	0.535
MOD_Plk_4	280	286	PF00069	0.573
MOD_Plk_4	39	45	PF00069	0.377
MOD_Plk_4	393	399	PF00069	0.300
MOD_Plk_4	588	594	PF00069	0.440
MOD_Plk_4	689	695	PF00069	0.538
MOD_Plk_4	714	720	PF00069	0.578
MOD_ProDKin_1	258	264	PF00069	0.559
MOD_ProDKin_1	533	539	PF00069	0.721
MOD_ProDKin_1	599	605	PF00069	0.459
MOD_SUMO_rev_2	514	519	PF00179	0.690
TRG_DiLeu_BaEn_1	588	593	PF01217	0.501
TRG_DiLeu_BaEn_1	708	713	PF01217	0.599
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.638
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.621
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.500
TRG_ENDOCYTIC_2	100	103	PF00928	0.810
TRG_ENDOCYTIC_2	286	289	PF00928	0.635
TRG_ENDOCYTIC_2	369	372	PF00928	0.360
TRG_ER_diArg_1	160	162	PF00400	0.549
TRG_ER_diArg_1	177	180	PF00400	0.539
TRG_ER_diArg_1	265	268	PF00400	0.666
TRG_ER_diArg_1	276	279	PF00400	0.707
TRG_ER_diArg_1	620	622	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT8	Leptomonas seymouri	54%	100%
A0A3S5H565	Leishmania donovani	78%	100%
A4HRX5	Leishmania infantum	78%	100%
E9ACN4	Leishmania major	76%	98%
E9AJX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BXB7	Trypanosoma cruzi	37%	100%