LeishMANIAdb
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C6H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C6H2-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H3P6_LEIBR
TriTrypDb:
LbrM.03.0750 , LBRM2903_030013400
Length:
978

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3P6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3P6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 238 242 PF00656 0.540
CLV_C14_Caspase3-7 302 306 PF00656 0.614
CLV_C14_Caspase3-7 477 481 PF00656 0.504
CLV_C14_Caspase3-7 622 626 PF00656 0.559
CLV_C14_Caspase3-7 644 648 PF00656 0.563
CLV_C14_Caspase3-7 884 888 PF00656 0.603
CLV_NRD_NRD_1 113 115 PF00675 0.608
CLV_NRD_NRD_1 256 258 PF00675 0.386
CLV_NRD_NRD_1 472 474 PF00675 0.621
CLV_NRD_NRD_1 528 530 PF00675 0.736
CLV_NRD_NRD_1 640 642 PF00675 0.464
CLV_NRD_NRD_1 677 679 PF00675 0.476
CLV_NRD_NRD_1 718 720 PF00675 0.791
CLV_NRD_NRD_1 80 82 PF00675 0.678
CLV_NRD_NRD_1 864 866 PF00675 0.475
CLV_NRD_NRD_1 895 897 PF00675 0.608
CLV_NRD_NRD_1 908 910 PF00675 0.561
CLV_NRD_NRD_1 924 926 PF00675 0.527
CLV_NRD_NRD_1 960 962 PF00675 0.658
CLV_PCSK_FUR_1 637 641 PF00082 0.343
CLV_PCSK_FUR_1 925 929 PF00082 0.641
CLV_PCSK_KEX2_1 113 115 PF00082 0.593
CLV_PCSK_KEX2_1 256 258 PF00082 0.386
CLV_PCSK_KEX2_1 527 529 PF00082 0.702
CLV_PCSK_KEX2_1 639 641 PF00082 0.463
CLV_PCSK_KEX2_1 66 68 PF00082 0.788
CLV_PCSK_KEX2_1 677 679 PF00082 0.454
CLV_PCSK_KEX2_1 864 866 PF00082 0.475
CLV_PCSK_KEX2_1 87 89 PF00082 0.694
CLV_PCSK_KEX2_1 908 910 PF00082 0.593
CLV_PCSK_KEX2_1 927 929 PF00082 0.640
CLV_PCSK_KEX2_1 960 962 PF00082 0.686
CLV_PCSK_KEX2_1 971 973 PF00082 0.586
CLV_PCSK_KEX2_1 975 977 PF00082 0.537
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.740
CLV_PCSK_PC1ET2_1 66 68 PF00082 0.734
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.694
CLV_PCSK_PC1ET2_1 927 929 PF00082 0.640
CLV_PCSK_PC1ET2_1 971 973 PF00082 0.616
CLV_PCSK_PC1ET2_1 975 977 PF00082 0.593
CLV_PCSK_PC7_1 923 929 PF00082 0.647
CLV_PCSK_SKI1_1 315 319 PF00082 0.402
CLV_PCSK_SKI1_1 36 40 PF00082 0.255
CLV_PCSK_SKI1_1 474 478 PF00082 0.560
CLV_PCSK_SKI1_1 640 644 PF00082 0.347
CLV_PCSK_SKI1_1 719 723 PF00082 0.775
CLV_PCSK_SKI1_1 901 905 PF00082 0.611
CLV_PCSK_SKI1_1 928 932 PF00082 0.553
CLV_PCSK_SKI1_1 960 964 PF00082 0.649
CLV_PCSK_SKI1_1 971 975 PF00082 0.659
CLV_Separin_Metazoa 871 875 PF03568 0.556
DEG_Nend_UBRbox_1 1 4 PF02207 0.530
DEG_SIAH_1 143 151 PF03145 0.577
DEG_SPOP_SBC_1 274 278 PF00917 0.606
DEG_SPOP_SBC_1 367 371 PF00917 0.717
DOC_CDC14_PxL_1 581 589 PF14671 0.470
DOC_CKS1_1 134 139 PF01111 0.591
DOC_CYCLIN_RxL_1 825 834 PF00134 0.329
DOC_CYCLIN_yClb5_NLxxxL_5 431 440 PF00134 0.291
DOC_MAPK_DCC_7 532 542 PF00069 0.512
DOC_MAPK_gen_1 629 638 PF00069 0.381
DOC_MAPK_gen_1 677 685 PF00069 0.459
DOC_MAPK_gen_1 911 920 PF00069 0.661
DOC_MAPK_MEF2A_6 835 844 PF00069 0.460
DOC_PP1_RVXF_1 313 320 PF00149 0.427
DOC_PP1_RVXF_1 675 682 PF00149 0.545
DOC_PP1_RVXF_1 826 833 PF00149 0.325
DOC_PP1_RVXF_1 872 878 PF00149 0.729
DOC_PP2B_LxvP_1 141 144 PF13499 0.599
DOC_PP2B_LxvP_1 364 367 PF13499 0.560
DOC_PP2B_LxvP_1 708 711 PF13499 0.704
DOC_USP7_MATH_1 101 105 PF00917 0.789
DOC_USP7_MATH_1 188 192 PF00917 0.684
DOC_USP7_MATH_1 229 233 PF00917 0.746
DOC_USP7_MATH_1 236 240 PF00917 0.782
DOC_USP7_MATH_1 272 276 PF00917 0.618
DOC_USP7_MATH_1 292 296 PF00917 0.415
DOC_USP7_MATH_1 367 371 PF00917 0.663
DOC_USP7_MATH_1 372 376 PF00917 0.686
DOC_USP7_MATH_1 383 387 PF00917 0.598
DOC_USP7_MATH_1 508 512 PF00917 0.611
DOC_USP7_MATH_1 561 565 PF00917 0.693
DOC_USP7_MATH_1 619 623 PF00917 0.507
DOC_USP7_MATH_1 627 631 PF00917 0.520
DOC_USP7_MATH_1 711 715 PF00917 0.764
DOC_USP7_MATH_1 756 760 PF00917 0.688
DOC_USP7_MATH_1 769 773 PF00917 0.520
DOC_USP7_MATH_1 892 896 PF00917 0.605
DOC_USP7_UBL2_3 927 931 PF12436 0.425
DOC_USP7_UBL2_3 963 967 PF12436 0.712
DOC_USP7_UBL2_3 971 975 PF12436 0.634
DOC_WW_Pin1_4 133 138 PF00397 0.517
DOC_WW_Pin1_4 244 249 PF00397 0.654
DOC_WW_Pin1_4 342 347 PF00397 0.421
DOC_WW_Pin1_4 357 362 PF00397 0.480
DOC_WW_Pin1_4 368 373 PF00397 0.695
DOC_WW_Pin1_4 386 391 PF00397 0.640
DOC_WW_Pin1_4 512 517 PF00397 0.668
DOC_WW_Pin1_4 543 548 PF00397 0.599
DOC_WW_Pin1_4 565 570 PF00397 0.651
DOC_WW_Pin1_4 598 603 PF00397 0.500
DOC_WW_Pin1_4 727 732 PF00397 0.698
LIG_14-3-3_CanoR_1 273 280 PF00244 0.625
LIG_14-3-3_CanoR_1 473 479 PF00244 0.486
LIG_14-3-3_CanoR_1 529 539 PF00244 0.736
LIG_14-3-3_CanoR_1 53 57 PF00244 0.510
LIG_14-3-3_CanoR_1 629 638 PF00244 0.349
LIG_14-3-3_CanoR_1 864 872 PF00244 0.477
LIG_APCC_ABBA_1 844 849 PF00400 0.438
LIG_BIR_III_4 509 513 PF00653 0.495
LIG_BIR_III_4 663 667 PF00653 0.577
LIG_BRCT_BRCA1_1 248 252 PF00533 0.605
LIG_BRCT_BRCA1_1 466 470 PF00533 0.445
LIG_CaM_NSCaTE_8 170 177 PF13499 0.456
LIG_CSL_BTD_1 117 120 PF09270 0.523
LIG_EVH1_1 118 122 PF00568 0.604
LIG_FHA_1 134 140 PF00498 0.524
LIG_FHA_1 216 222 PF00498 0.516
LIG_FHA_1 260 266 PF00498 0.396
LIG_FHA_1 312 318 PF00498 0.486
LIG_FHA_1 405 411 PF00498 0.450
LIG_FHA_1 554 560 PF00498 0.762
LIG_FHA_1 641 647 PF00498 0.535
LIG_FHA_1 747 753 PF00498 0.626
LIG_FHA_1 837 843 PF00498 0.506
LIG_FHA_1 868 874 PF00498 0.606
LIG_FHA_2 101 107 PF00498 0.777
LIG_FHA_2 297 303 PF00498 0.534
LIG_FHA_2 324 330 PF00498 0.684
LIG_FHA_2 343 349 PF00498 0.514
LIG_FHA_2 475 481 PF00498 0.415
LIG_FHA_2 642 648 PF00498 0.501
LIG_FHA_2 89 95 PF00498 0.725
LIG_LIR_Apic_2 592 598 PF02991 0.343
LIG_LIR_Gen_1 129 140 PF02991 0.533
LIG_LIR_Nem_3 129 135 PF02991 0.514
LIG_LIR_Nem_3 341 347 PF02991 0.578
LIG_LIR_Nem_3 434 440 PF02991 0.441
LIG_LIR_Nem_3 575 580 PF02991 0.510
LIG_LIR_Nem_3 772 778 PF02991 0.574
LIG_LIR_Nem_3 853 858 PF02991 0.418
LIG_MLH1_MIPbox_1 248 252 PF16413 0.605
LIG_PCNA_PIPBox_1 163 172 PF02747 0.364
LIG_PCNA_yPIPBox_3 157 170 PF02747 0.435
LIG_PCNA_yPIPBox_3 793 807 PF02747 0.601
LIG_Pex14_2 45 49 PF04695 0.479
LIG_Pex14_2 608 612 PF04695 0.449
LIG_Pex14_2 832 836 PF04695 0.418
LIG_RPA_C_Fungi 626 638 PF08784 0.528
LIG_SH2_CRK 615 619 PF00017 0.549
LIG_SH2_CRK 662 666 PF00017 0.418
LIG_SH2_CRK 668 672 PF00017 0.464
LIG_SH2_CRK 775 779 PF00017 0.402
LIG_SH2_GRB2like 577 580 PF00017 0.578
LIG_SH2_NCK_1 344 348 PF00017 0.486
LIG_SH2_NCK_1 662 666 PF00017 0.418
LIG_SH2_SRC 548 551 PF00017 0.767
LIG_SH2_SRC 595 598 PF00017 0.308
LIG_SH2_SRC 617 620 PF00017 0.502
LIG_SH2_STAP1 203 207 PF00017 0.401
LIG_SH2_STAP1 577 581 PF00017 0.587
LIG_SH2_STAT5 179 182 PF00017 0.494
LIG_SH2_STAT5 251 254 PF00017 0.537
LIG_SH2_STAT5 342 345 PF00017 0.561
LIG_SH2_STAT5 424 427 PF00017 0.575
LIG_SH2_STAT5 438 441 PF00017 0.498
LIG_SH2_STAT5 458 461 PF00017 0.197
LIG_SH2_STAT5 581 584 PF00017 0.519
LIG_SH2_STAT5 595 598 PF00017 0.334
LIG_SH2_STAT5 617 620 PF00017 0.497
LIG_SH2_STAT5 695 698 PF00017 0.512
LIG_SH2_STAT5 818 821 PF00017 0.459
LIG_SH3_1 114 120 PF00018 0.402
LIG_SH3_3 114 120 PF00018 0.518
LIG_SH3_3 134 140 PF00018 0.362
LIG_SH3_3 144 150 PF00018 0.445
LIG_SH3_3 222 228 PF00018 0.433
LIG_SH3_3 295 301 PF00018 0.436
LIG_SH3_3 387 393 PF00018 0.497
LIG_SH3_3 544 550 PF00018 0.757
LIG_SH3_3 563 569 PF00018 0.451
LIG_SH3_3 808 814 PF00018 0.475
LIG_SUMO_SIM_anti_2 345 353 PF11976 0.643
LIG_SUMO_SIM_par_1 295 302 PF11976 0.528
LIG_SUMO_SIM_par_1 360 365 PF11976 0.431
LIG_TRAF2_1 570 573 PF00917 0.660
LIG_TRAF2_1 802 805 PF00917 0.459
LIG_TYR_ITIM 660 665 PF00017 0.491
LIG_WRC_WIRS_1 605 610 PF05994 0.514
LIG_WW_2 119 122 PF00397 0.640
MOD_CK1_1 16 22 PF00069 0.421
MOD_CK1_1 232 238 PF00069 0.739
MOD_CK1_1 275 281 PF00069 0.644
MOD_CK1_1 386 392 PF00069 0.584
MOD_CK1_1 551 557 PF00069 0.753
MOD_CK1_1 564 570 PF00069 0.533
MOD_CK1_1 741 747 PF00069 0.757
MOD_CK1_1 895 901 PF00069 0.637
MOD_CK2_1 323 329 PF00069 0.615
MOD_CK2_1 342 348 PF00069 0.592
MOD_CK2_1 508 514 PF00069 0.662
MOD_CK2_1 567 573 PF00069 0.523
MOD_CK2_1 744 750 PF00069 0.621
MOD_CK2_1 88 94 PF00069 0.705
MOD_Cter_Amidation 79 82 PF01082 0.718
MOD_Cter_Amidation 85 88 PF01082 0.740
MOD_Cter_Amidation 965 968 PF01082 0.661
MOD_GlcNHglycan 108 112 PF01048 0.693
MOD_GlcNHglycan 170 173 PF01048 0.317
MOD_GlcNHglycan 189 193 PF01048 0.574
MOD_GlcNHglycan 203 206 PF01048 0.337
MOD_GlcNHglycan 231 235 PF01048 0.640
MOD_GlcNHglycan 262 265 PF01048 0.488
MOD_GlcNHglycan 268 271 PF01048 0.513
MOD_GlcNHglycan 280 283 PF01048 0.350
MOD_GlcNHglycan 364 367 PF01048 0.623
MOD_GlcNHglycan 374 377 PF01048 0.651
MOD_GlcNHglycan 381 384 PF01048 0.503
MOD_GlcNHglycan 385 388 PF01048 0.587
MOD_GlcNHglycan 393 396 PF01048 0.410
MOD_GlcNHglycan 509 513 PF01048 0.664
MOD_GlcNHglycan 563 566 PF01048 0.692
MOD_GlcNHglycan 569 572 PF01048 0.548
MOD_GlcNHglycan 58 61 PF01048 0.628
MOD_GlcNHglycan 631 634 PF01048 0.544
MOD_GlcNHglycan 647 650 PF01048 0.424
MOD_GlcNHglycan 771 774 PF01048 0.711
MOD_GlcNHglycan 946 950 PF01048 0.608
MOD_GlcNHglycan 96 99 PF01048 0.810
MOD_GSK3_1 14 21 PF00069 0.445
MOD_GSK3_1 180 187 PF00069 0.456
MOD_GSK3_1 232 239 PF00069 0.732
MOD_GSK3_1 246 253 PF00069 0.389
MOD_GSK3_1 274 281 PF00069 0.611
MOD_GSK3_1 282 289 PF00069 0.446
MOD_GSK3_1 292 299 PF00069 0.377
MOD_GSK3_1 338 345 PF00069 0.580
MOD_GSK3_1 362 369 PF00069 0.636
MOD_GSK3_1 379 386 PF00069 0.506
MOD_GSK3_1 508 515 PF00069 0.659
MOD_GSK3_1 52 59 PF00069 0.369
MOD_GSK3_1 548 555 PF00069 0.730
MOD_GSK3_1 561 568 PF00069 0.568
MOD_GSK3_1 641 648 PF00069 0.480
MOD_GSK3_1 722 729 PF00069 0.606
MOD_GSK3_1 738 745 PF00069 0.758
MOD_GSK3_1 756 763 PF00069 0.411
MOD_GSK3_1 836 843 PF00069 0.397
MOD_GSK3_1 863 870 PF00069 0.528
MOD_GSK3_1 941 948 PF00069 0.706
MOD_GSK3_1 96 103 PF00069 0.775
MOD_GSK3_1 971 978 PF00069 0.553
MOD_N-GLC_1 241 246 PF02516 0.603
MOD_N-GLC_1 474 479 PF02516 0.623
MOD_N-GLC_1 914 919 PF02516 0.759
MOD_NEK2_1 286 291 PF00069 0.447
MOD_NEK2_1 296 301 PF00069 0.358
MOD_NEK2_1 431 436 PF00069 0.408
MOD_NEK2_1 552 557 PF00069 0.729
MOD_NEK2_1 56 61 PF00069 0.598
MOD_NEK2_1 589 594 PF00069 0.360
MOD_NEK2_1 760 765 PF00069 0.689
MOD_NEK2_1 836 841 PF00069 0.412
MOD_NEK2_2 464 469 PF00069 0.540
MOD_PIKK_1 251 257 PF00454 0.425
MOD_PIKK_1 38 44 PF00454 0.404
MOD_PIKK_1 742 748 PF00454 0.755
MOD_PK_1 914 920 PF00069 0.498
MOD_PKA_1 640 646 PF00069 0.350
MOD_PKA_1 971 977 PF00069 0.580
MOD_PKA_2 150 156 PF00069 0.666
MOD_PKA_2 266 272 PF00069 0.565
MOD_PKA_2 52 58 PF00069 0.349
MOD_PKA_2 640 646 PF00069 0.570
MOD_PKA_2 741 747 PF00069 0.736
MOD_PKA_2 80 86 PF00069 0.616
MOD_PKA_2 863 869 PF00069 0.493
MOD_PKA_2 895 901 PF00069 0.694
MOD_PKA_2 907 913 PF00069 0.591
MOD_PKA_2 971 977 PF00069 0.560
MOD_PKB_1 639 647 PF00069 0.442
MOD_Plk_1 464 470 PF00069 0.553
MOD_Plk_1 474 480 PF00069 0.501
MOD_Plk_1 681 687 PF00069 0.560
MOD_Plk_2-3 688 694 PF00069 0.527
MOD_Plk_4 282 288 PF00069 0.481
MOD_Plk_4 292 298 PF00069 0.408
MOD_ProDKin_1 133 139 PF00069 0.512
MOD_ProDKin_1 244 250 PF00069 0.649
MOD_ProDKin_1 342 348 PF00069 0.433
MOD_ProDKin_1 357 363 PF00069 0.484
MOD_ProDKin_1 368 374 PF00069 0.700
MOD_ProDKin_1 386 392 PF00069 0.634
MOD_ProDKin_1 512 518 PF00069 0.673
MOD_ProDKin_1 543 549 PF00069 0.599
MOD_ProDKin_1 565 571 PF00069 0.648
MOD_ProDKin_1 598 604 PF00069 0.495
MOD_ProDKin_1 727 733 PF00069 0.699
MOD_SUMO_rev_2 16 22 PF00179 0.227
TRG_DiLeu_BaLyEn_6 488 493 PF01217 0.531
TRG_ENDOCYTIC_2 179 182 PF00928 0.546
TRG_ENDOCYTIC_2 344 347 PF00928 0.566
TRG_ENDOCYTIC_2 437 440 PF00928 0.505
TRG_ENDOCYTIC_2 581 584 PF00928 0.466
TRG_ENDOCYTIC_2 615 618 PF00928 0.559
TRG_ENDOCYTIC_2 662 665 PF00928 0.434
TRG_ENDOCYTIC_2 775 778 PF00928 0.656
TRG_ENDOCYTIC_2 942 945 PF00928 0.599
TRG_ER_diArg_1 113 115 PF00400 0.462
TRG_ER_diArg_1 148 151 PF00400 0.369
TRG_ER_diArg_1 256 258 PF00400 0.387
TRG_ER_diArg_1 528 530 PF00400 0.748
TRG_ER_diArg_1 636 639 PF00400 0.466
TRG_ER_diArg_1 640 642 PF00400 0.467
TRG_ER_diArg_1 677 679 PF00400 0.549
TRG_ER_diArg_1 873 876 PF00400 0.666
TRG_ER_diArg_1 959 961 PF00400 0.766
TRG_NLS_Bipartite_1 908 930 PF00514 0.674
TRG_NLS_MonoCore_2 525 530 PF00514 0.787
TRG_NLS_MonoCore_2 924 929 PF00514 0.640
TRG_NLS_MonoExtN_4 524 531 PF00514 0.787
TRG_NLS_MonoExtN_4 923 930 PF00514 0.533
TRG_Pf-PMV_PEXEL_1 461 465 PF00026 0.405
TRG_Pf-PMV_PEXEL_1 677 682 PF00026 0.551

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBW4 Leptomonas seymouri 59% 100%
A0A1X0P9W0 Trypanosomatidae 40% 100%
A0A422NHM2 Trypanosoma rangeli 43% 100%
A0A451EJT3 Leishmania donovani 79% 100%
C9ZKH8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E8NHC7 Leishmania infantum 80% 100%
E9ACM9 Leishmania major 79% 98%
E9AJW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
V5BC86 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS