CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3P5_LEIBR

TriTrypDb:

LbrM.03.0740 , LBRM2903_030013300

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.399
CLV_NRD_NRD_1	243	245	PF00675	0.460
CLV_NRD_NRD_1	72	74	PF00675	0.413
CLV_NRD_NRD_1	86	88	PF00675	0.467
CLV_PCSK_KEX2_1	107	109	PF00082	0.472
CLV_PCSK_KEX2_1	235	237	PF00082	0.509
CLV_PCSK_KEX2_1	86	88	PF00082	0.574
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.453
CLV_PCSK_SKI1_1	107	111	PF00082	0.396
CLV_PCSK_SKI1_1	14	18	PF00082	0.351
CLV_PCSK_SKI1_1	186	190	PF00082	0.375
CLV_PCSK_SKI1_1	193	197	PF00082	0.328
CLV_PCSK_SKI1_1	25	29	PF00082	0.414
CLV_PCSK_SKI1_1	332	336	PF00082	0.540
CLV_PCSK_SKI1_1	41	45	PF00082	0.365
CLV_PCSK_SKI1_1	62	66	PF00082	0.363
CLV_PCSK_SKI1_1	74	78	PF00082	0.386
DEG_APCC_DBOX_1	24	32	PF00400	0.430
DEG_APCC_DBOX_1	72	80	PF00400	0.532
DEG_Kelch_Keap1_1	166	171	PF01344	0.472
DEG_Nend_UBRbox_1	1	4	PF02207	0.286
DOC_CYCLIN_RxL_1	103	113	PF00134	0.401
DOC_CYCLIN_RxL_1	183	194	PF00134	0.474
DOC_CYCLIN_RxL_1	38	46	PF00134	0.365
DOC_MAPK_gen_1	73	81	PF00069	0.546
DOC_MAPK_MEF2A_6	148	156	PF00069	0.348
DOC_MAPK_MEF2A_6	172	181	PF00069	0.409
DOC_USP7_MATH_1	116	120	PF00917	0.445
DOC_USP7_MATH_1	126	130	PF00917	0.453
DOC_USP7_MATH_1	131	135	PF00917	0.405
DOC_USP7_MATH_1	272	276	PF00917	0.302
DOC_USP7_MATH_1	35	39	PF00917	0.479
DOC_USP7_UBL2_3	155	159	PF12436	0.294
DOC_USP7_UBL2_3	245	249	PF12436	0.340
DOC_WW_Pin1_4	219	224	PF00397	0.443
LIG_14-3-3_CanoR_1	115	121	PF00244	0.415
LIG_14-3-3_CanoR_1	2	11	PF00244	0.433
LIG_14-3-3_CanoR_1	73	77	PF00244	0.335
LIG_Actin_WH2_2	102	117	PF00022	0.288
LIG_APCC_ABBA_1	289	294	PF00400	0.474
LIG_BIR_III_4	194	198	PF00653	0.350
LIG_Clathr_ClatBox_1	188	192	PF01394	0.451
LIG_FAT_LD_1	181	189	PF03623	0.401
LIG_FHA_1	147	153	PF00498	0.338
LIG_FHA_2	326	332	PF00498	0.491
LIG_GBD_Chelix_1	180	188	PF00786	0.407
LIG_IBAR_NPY_1	130	132	PF08397	0.267
LIG_Integrin_RGD_1	204	206	PF01839	0.495
LIG_LIR_Gen_1	119	127	PF02991	0.456
LIG_LIR_Gen_1	225	234	PF02991	0.422
LIG_LIR_Gen_1	46	56	PF02991	0.384
LIG_LIR_Gen_1	96	106	PF02991	0.515
LIG_LIR_Nem_3	119	124	PF02991	0.523
LIG_LIR_Nem_3	194	199	PF02991	0.374
LIG_LIR_Nem_3	96	101	PF02991	0.494
LIG_PCNA_PIPBox_1	58	67	PF02747	0.389
LIG_Pex14_1	330	334	PF04695	0.470
LIG_SH2_CRK	121	125	PF00017	0.375
LIG_SH2_GRB2like	237	240	PF00017	0.272
LIG_SH2_SRC	293	296	PF00017	0.490
LIG_SH2_STAP1	112	116	PF00017	0.280
LIG_SH2_STAP1	121	125	PF00017	0.353
LIG_SH2_STAP1	226	230	PF00017	0.262
LIG_SH2_STAT5	12	15	PF00017	0.430
LIG_SH2_STAT5	132	135	PF00017	0.483
LIG_SH2_STAT5	240	243	PF00017	0.384
LIG_SH3_3	266	272	PF00018	0.550
LIG_SH3_3	31	37	PF00018	0.358
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.456
LIG_SUMO_SIM_par_1	177	183	PF11976	0.457
LIG_SUMO_SIM_par_1	187	192	PF11976	0.392
LIG_TRAF2_1	305	308	PF00917	0.477
LIG_UBA3_1	152	159	PF00899	0.281
LIG_UBA3_1	229	235	PF00899	0.383
MOD_CK2_1	301	307	PF00069	0.501
MOD_CK2_1	325	331	PF00069	0.466
MOD_Cter_Amidation	84	87	PF01082	0.417
MOD_GlcNHglycan	133	136	PF01048	0.477
MOD_GlcNHglycan	5	8	PF01048	0.523
MOD_GSK3_1	138	145	PF00069	0.458
MOD_GSK3_1	3	10	PF00069	0.571
MOD_N-GLC_1	325	330	PF02516	0.584
MOD_N-GLC_2	239	241	PF02516	0.469
MOD_NEK2_1	125	130	PF00069	0.431
MOD_NEK2_1	210	215	PF00069	0.502
MOD_PKA_2	72	78	PF00069	0.297
MOD_Plk_1	325	331	PF00069	0.526
MOD_Plk_4	116	122	PF00069	0.318
MOD_Plk_4	224	230	PF00069	0.283
MOD_Plk_4	272	278	PF00069	0.459
MOD_Plk_4	7	13	PF00069	0.421
MOD_Plk_4	72	78	PF00069	0.297
MOD_ProDKin_1	219	225	PF00069	0.442
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.344
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.491
TRG_ENDOCYTIC_2	121	124	PF00928	0.330
TRG_ENDOCYTIC_2	226	229	PF00928	0.329
TRG_ER_diArg_1	106	108	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P542	Leptomonas seymouri	64%	87%
A0A0S4IVU1	Bodo saltans	38%	99%
A0A1X0P922	Trypanosomatidae	50%	87%
A0A451EJT2	Leishmania donovani	86%	85%
C9ZKH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E8NHC8	Leishmania infantum	86%	85%
E9ACM8	Leishmania major	84%	100%
E9AJW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
V5DTZ7	Trypanosoma cruzi	50%	84%