Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H3P3_LEIBR

TriTrypDb:

LbrM.03.0720 , LBRM2903_030013000

Length:

1153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H3P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1012	1014	PF00675	0.481
CLV_NRD_NRD_1	1145	1147	PF00675	0.372
CLV_NRD_NRD_1	134	136	PF00675	0.466
CLV_NRD_NRD_1	190	192	PF00675	0.424
CLV_NRD_NRD_1	215	217	PF00675	0.433
CLV_NRD_NRD_1	311	313	PF00675	0.428
CLV_NRD_NRD_1	388	390	PF00675	0.419
CLV_NRD_NRD_1	433	435	PF00675	0.413
CLV_NRD_NRD_1	436	438	PF00675	0.420
CLV_NRD_NRD_1	456	458	PF00675	0.410
CLV_NRD_NRD_1	480	482	PF00675	0.401
CLV_NRD_NRD_1	486	488	PF00675	0.379
CLV_NRD_NRD_1	672	674	PF00675	0.496
CLV_NRD_NRD_1	908	910	PF00675	0.510
CLV_NRD_NRD_1	945	947	PF00675	0.399
CLV_NRD_NRD_1	98	100	PF00675	0.473
CLV_PCSK_FUR_1	434	438	PF00082	0.392
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.481
CLV_PCSK_KEX2_1	1144	1146	PF00082	0.368
CLV_PCSK_KEX2_1	134	136	PF00082	0.463
CLV_PCSK_KEX2_1	211	213	PF00082	0.426
CLV_PCSK_KEX2_1	388	390	PF00082	0.419
CLV_PCSK_KEX2_1	433	435	PF00082	0.413
CLV_PCSK_KEX2_1	436	438	PF00082	0.420
CLV_PCSK_KEX2_1	455	457	PF00082	0.554
CLV_PCSK_KEX2_1	480	482	PF00082	0.442
CLV_PCSK_KEX2_1	486	488	PF00082	0.374
CLV_PCSK_KEX2_1	672	674	PF00082	0.496
CLV_PCSK_KEX2_1	908	910	PF00082	0.510
CLV_PCSK_KEX2_1	945	947	PF00082	0.399
CLV_PCSK_KEX2_1	97	99	PF00082	0.466
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.426
CLV_PCSK_PC7_1	429	435	PF00082	0.440
CLV_PCSK_PC7_1	452	458	PF00082	0.460
CLV_PCSK_SKI1_1	111	115	PF00082	0.519
CLV_PCSK_SKI1_1	162	166	PF00082	0.436
CLV_PCSK_SKI1_1	202	206	PF00082	0.477
CLV_PCSK_SKI1_1	493	497	PF00082	0.277
CLV_PCSK_SKI1_1	686	690	PF00082	0.394
CLV_PCSK_SKI1_1	704	708	PF00082	0.513
CLV_PCSK_SKI1_1	755	759	PF00082	0.540
CLV_PCSK_SKI1_1	77	81	PF00082	0.540
CLV_PCSK_SKI1_1	935	939	PF00082	0.413
DEG_APCC_DBOX_1	485	493	PF00400	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SPOP_SBC_1	25	29	PF00917	0.618
DOC_ANK_TNKS_1	444	451	PF00023	0.581
DOC_CDC14_PxL_1	841	849	PF14671	0.614
DOC_CKS1_1	40	45	PF01111	0.637
DOC_CKS1_1	576	581	PF01111	0.327
DOC_CKS1_1	961	966	PF01111	0.582
DOC_CYCLIN_yCln2_LP_2	961	967	PF00134	0.580
DOC_MAPK_gen_1	486	494	PF00069	0.504
DOC_MAPK_MEF2A_6	487	496	PF00069	0.606
DOC_MAPK_MEF2A_6	976	984	PF00069	0.674
DOC_PP2B_LxvP_1	563	566	PF13499	0.382
DOC_PP2B_LxvP_1	809	812	PF13499	0.623
DOC_PP4_FxxP_1	1030	1033	PF00568	0.629
DOC_PP4_FxxP_1	234	237	PF00568	0.621
DOC_PP4_FxxP_1	515	518	PF00568	0.469
DOC_PP4_FxxP_1	576	579	PF00568	0.328
DOC_PP4_FxxP_1	659	662	PF00568	0.617
DOC_USP7_MATH_1	1007	1011	PF00917	0.713
DOC_USP7_MATH_1	1043	1047	PF00917	0.645
DOC_USP7_MATH_1	167	171	PF00917	0.684
DOC_USP7_MATH_1	185	189	PF00917	0.668
DOC_USP7_MATH_1	200	204	PF00917	0.680
DOC_USP7_MATH_1	25	29	PF00917	0.631
DOC_USP7_MATH_1	325	329	PF00917	0.730
DOC_USP7_MATH_1	464	468	PF00917	0.625
DOC_USP7_MATH_1	501	505	PF00917	0.335
DOC_USP7_MATH_1	518	522	PF00917	0.369
DOC_USP7_MATH_1	544	548	PF00917	0.517
DOC_USP7_MATH_1	566	570	PF00917	0.402
DOC_USP7_MATH_1	62	66	PF00917	0.702
DOC_USP7_MATH_1	651	655	PF00917	0.620
DOC_USP7_MATH_1	660	664	PF00917	0.675
DOC_USP7_MATH_1	737	741	PF00917	0.714
DOC_USP7_MATH_1	834	838	PF00917	0.626
DOC_USP7_MATH_1	907	911	PF00917	0.603
DOC_WW_Pin1_4	120	125	PF00397	0.742
DOC_WW_Pin1_4	333	338	PF00397	0.712
DOC_WW_Pin1_4	39	44	PF00397	0.683
DOC_WW_Pin1_4	546	551	PF00397	0.514
DOC_WW_Pin1_4	55	60	PF00397	0.672
DOC_WW_Pin1_4	575	580	PF00397	0.346
DOC_WW_Pin1_4	658	663	PF00397	0.635
DOC_WW_Pin1_4	800	805	PF00397	0.687
DOC_WW_Pin1_4	830	835	PF00397	0.626
DOC_WW_Pin1_4	930	935	PF00397	0.613
DOC_WW_Pin1_4	950	955	PF00397	0.677
DOC_WW_Pin1_4	960	965	PF00397	0.615
LIG_14-3-3_CanoR_1	1012	1021	PF00244	0.739
LIG_14-3-3_CanoR_1	243	252	PF00244	0.676
LIG_14-3-3_CanoR_1	480	489	PF00244	0.640
LIG_14-3-3_CanoR_1	493	503	PF00244	0.320
LIG_14-3-3_CanoR_1	67	76	PF00244	0.641
LIG_14-3-3_CanoR_1	720	726	PF00244	0.667
LIG_14-3-3_CanoR_1	768	772	PF00244	0.618
LIG_14-3-3_CanoR_1	958	962	PF00244	0.600
LIG_BRCT_BRCA1_1	325	329	PF00533	0.626
LIG_BRCT_BRCA1_1	704	708	PF00533	0.729
LIG_eIF4E_1	570	576	PF01652	0.469
LIG_FHA_1	15	21	PF00498	0.723
LIG_FHA_1	244	250	PF00498	0.728
LIG_FHA_1	277	283	PF00498	0.689
LIG_FHA_1	634	640	PF00498	0.609
LIG_FHA_1	708	714	PF00498	0.720
LIG_FHA_2	1035	1041	PF00498	0.612
LIG_FHA_2	141	147	PF00498	0.644
LIG_FHA_2	220	226	PF00498	0.645
LIG_FHA_2	460	466	PF00498	0.561
LIG_FHA_2	547	553	PF00498	0.487
LIG_FHA_2	78	84	PF00498	0.707
LIG_FHA_2	859	865	PF00498	0.692
LIG_FHA_2	985	991	PF00498	0.575
LIG_LIR_Apic_2	10	16	PF02991	0.607
LIG_LIR_Apic_2	232	237	PF02991	0.623
LIG_LIR_Apic_2	37	43	PF02991	0.632
LIG_LIR_Apic_2	512	518	PF02991	0.564
LIG_LIR_Apic_2	798	804	PF02991	0.661
LIG_LIR_Gen_1	578	588	PF02991	0.313
LIG_LIR_Gen_1	877	888	PF02991	0.646
LIG_LIR_LC3C_4	17	22	PF02991	0.614
LIG_LIR_LC3C_4	884	888	PF02991	0.540
LIG_LIR_Nem_3	467	473	PF02991	0.627
LIG_LIR_Nem_3	567	573	PF02991	0.468
LIG_LIR_Nem_3	578	583	PF02991	0.357
LIG_LIR_Nem_3	790	796	PF02991	0.656
LIG_LIR_Nem_3	877	883	PF02991	0.669
LIG_NRBOX	504	510	PF00104	0.383
LIG_NRBOX	590	596	PF00104	0.310
LIG_NRBOX	968	974	PF00104	0.565
LIG_PCNA_yPIPBox_3	312	323	PF02747	0.617
LIG_Pex14_1	438	442	PF04695	0.542
LIG_Pex14_2	495	499	PF04695	0.245
LIG_Pex14_2	576	580	PF04695	0.424
LIG_Pex14_2	876	880	PF04695	0.632
LIG_PTAP_UEV_1	58	63	PF05743	0.634
LIG_RPA_C_Fungi	475	487	PF08784	0.375
LIG_SH2_CRK	40	44	PF00017	0.625
LIG_SH2_CRK	801	805	PF00017	0.574
LIG_SH2_NCK_1	473	477	PF00017	0.478
LIG_SH2_SRC	116	119	PF00017	0.511
LIG_SH2_STAP1	417	421	PF00017	0.525
LIG_SH2_STAP1	769	773	PF00017	0.594
LIG_SH2_STAT3	396	399	PF00017	0.562
LIG_SH2_STAT3	882	885	PF00017	0.406
LIG_SH2_STAT5	183	186	PF00017	0.588
LIG_SH2_STAT5	252	255	PF00017	0.515
LIG_SH2_STAT5	396	399	PF00017	0.562
LIG_SH2_STAT5	425	428	PF00017	0.381
LIG_SH2_STAT5	488	491	PF00017	0.405
LIG_SH2_STAT5	519	522	PF00017	0.610
LIG_SH2_STAT5	749	752	PF00017	0.515
LIG_SH2_STAT5	882	885	PF00017	0.474
LIG_SH2_STAT5	936	939	PF00017	0.663
LIG_SH3_1	40	46	PF00018	0.536
LIG_SH3_3	1016	1022	PF00018	0.676
LIG_SH3_3	118	124	PF00018	0.624
LIG_SH3_3	19	25	PF00018	0.513
LIG_SH3_3	263	269	PF00018	0.738
LIG_SH3_3	384	390	PF00018	0.668
LIG_SH3_3	394	400	PF00018	0.555
LIG_SH3_3	40	46	PF00018	0.591
LIG_SH3_3	510	516	PF00018	0.469
LIG_SH3_3	56	62	PF00018	0.512
LIG_SH3_3	562	568	PF00018	0.538
LIG_SH3_3	654	660	PF00018	0.514
LIG_SH3_3	839	845	PF00018	0.505
LIG_SH3_3	884	890	PF00018	0.402
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.505
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.525
LIG_SUMO_SIM_anti_2	504	510	PF11976	0.310
LIG_SUMO_SIM_anti_2	998	1004	PF11976	0.550
LIG_SUMO_SIM_par_1	507	512	PF11976	0.346
LIG_SUMO_SIM_par_1	592	598	PF11976	0.310
LIG_TRAF2_1	129	132	PF00917	0.541
LIG_TRAF2_1	207	210	PF00917	0.521
MOD_CDK_SPK_2	930	935	PF00069	0.504
MOD_CK1_1	1034	1040	PF00069	0.580
MOD_CK1_1	270	276	PF00069	0.774
MOD_CK1_1	328	334	PF00069	0.791
MOD_CK1_1	33	39	PF00069	0.684
MOD_CK1_1	344	350	PF00069	0.558
MOD_CK1_1	368	374	PF00069	0.567
MOD_CK1_1	532	538	PF00069	0.573
MOD_CK1_1	65	71	PF00069	0.556
MOD_CK1_1	661	667	PF00069	0.662
MOD_CK1_1	785	791	PF00069	0.492
MOD_CK1_1	837	843	PF00069	0.689
MOD_CK1_1	910	916	PF00069	0.494
MOD_CK1_1	950	956	PF00069	0.595
MOD_CK1_1	960	966	PF00069	0.502
MOD_CK2_1	2	8	PF00069	0.562
MOD_CK2_1	204	210	PF00069	0.521
MOD_CK2_1	219	225	PF00069	0.501
MOD_CK2_1	248	254	PF00069	0.575
MOD_CK2_1	42	48	PF00069	0.540
MOD_CK2_1	459	465	PF00069	0.440
MOD_CK2_1	603	609	PF00069	0.600
MOD_CK2_1	639	645	PF00069	0.574
MOD_CK2_1	984	990	PF00069	0.445
MOD_CMANNOS	1124	1127	PF00535	0.195
MOD_CMANNOS	1129	1132	PF00535	0.418
MOD_CMANNOS	1133	1136	PF00535	0.382
MOD_CMANNOS	1137	1140	PF00535	0.378
MOD_CMANNOS	1147	1150	PF00535	0.450
MOD_Cter_Amidation	453	456	PF01082	0.570
MOD_Cter_Amidation	95	98	PF01082	0.470
MOD_GlcNHglycan	1003	1006	PF01048	0.636
MOD_GlcNHglycan	1015	1018	PF01048	0.557
MOD_GlcNHglycan	1033	1036	PF01048	0.501
MOD_GlcNHglycan	1045	1048	PF01048	0.536
MOD_GlcNHglycan	1056	1059	PF01048	0.490
MOD_GlcNHglycan	140	143	PF01048	0.656
MOD_GlcNHglycan	162	165	PF01048	0.643
MOD_GlcNHglycan	168	172	PF01048	0.555
MOD_GlcNHglycan	187	190	PF01048	0.608
MOD_GlcNHglycan	272	275	PF01048	0.718
MOD_GlcNHglycan	325	328	PF01048	0.624
MOD_GlcNHglycan	330	333	PF01048	0.745
MOD_GlcNHglycan	367	370	PF01048	0.578
MOD_GlcNHglycan	4	7	PF01048	0.651
MOD_GlcNHglycan	474	477	PF01048	0.509
MOD_GlcNHglycan	496	499	PF01048	0.220
MOD_GlcNHglycan	533	537	PF01048	0.591
MOD_GlcNHglycan	546	549	PF01048	0.457
MOD_GlcNHglycan	641	644	PF01048	0.507
MOD_GlcNHglycan	663	666	PF01048	0.627
MOD_GlcNHglycan	695	698	PF01048	0.567
MOD_GlcNHglycan	70	73	PF01048	0.525
MOD_GlcNHglycan	704	707	PF01048	0.767
MOD_GlcNHglycan	721	724	PF01048	0.486
MOD_GlcNHglycan	784	787	PF01048	0.524
MOD_GlcNHglycan	804	807	PF01048	0.526
MOD_GlcNHglycan	814	817	PF01048	0.660
MOD_GlcNHglycan	830	833	PF01048	0.623
MOD_GlcNHglycan	836	839	PF01048	0.723
MOD_GlcNHglycan	848	851	PF01048	0.579
MOD_GlcNHglycan	858	861	PF01048	0.498
MOD_GlcNHglycan	871	874	PF01048	0.602
MOD_GlcNHglycan	902	905	PF01048	0.478
MOD_GlcNHglycan	916	919	PF01048	0.681
MOD_GlcNHglycan	94	97	PF01048	0.466
MOD_GlcNHglycan	941	944	PF01048	0.481
MOD_GSK3_1	1007	1014	PF00069	0.656
MOD_GSK3_1	116	123	PF00069	0.679
MOD_GSK3_1	156	163	PF00069	0.683
MOD_GSK3_1	2	9	PF00069	0.688
MOD_GSK3_1	200	207	PF00069	0.619
MOD_GSK3_1	220	227	PF00069	0.602
MOD_GSK3_1	238	245	PF00069	0.587
MOD_GSK3_1	26	33	PF00069	0.619
MOD_GSK3_1	323	330	PF00069	0.609
MOD_GSK3_1	341	348	PF00069	0.663
MOD_GSK3_1	368	375	PF00069	0.615
MOD_GSK3_1	546	553	PF00069	0.649
MOD_GSK3_1	647	654	PF00069	0.606
MOD_GSK3_1	709	716	PF00069	0.637
MOD_GSK3_1	737	744	PF00069	0.541
MOD_GSK3_1	751	758	PF00069	0.678
MOD_GSK3_1	763	770	PF00069	0.554
MOD_GSK3_1	800	807	PF00069	0.546
MOD_GSK3_1	828	835	PF00069	0.569
MOD_GSK3_1	910	917	PF00069	0.635
MOD_GSK3_1	956	963	PF00069	0.485
MOD_LATS_1	479	485	PF00433	0.375
MOD_N-GLC_1	1028	1033	PF02516	0.745
MOD_N-GLC_1	1052	1057	PF02516	0.478
MOD_N-GLC_1	544	549	PF02516	0.522
MOD_N-GLC_1	828	833	PF02516	0.526
MOD_N-GLC_1	910	915	PF02516	0.492
MOD_N-GLC_1	930	935	PF02516	0.467
MOD_NEK2_1	1	6	PF00069	0.742
MOD_NEK2_1	1001	1006	PF00069	0.559
MOD_NEK2_1	224	229	PF00069	0.518
MOD_NEK2_1	472	477	PF00069	0.482
MOD_NEK2_1	482	487	PF00069	0.423
MOD_NEK2_1	509	514	PF00069	0.383
MOD_NEK2_1	583	588	PF00069	0.354
MOD_NEK2_1	594	599	PF00069	0.207
MOD_NEK2_1	721	726	PF00069	0.542
MOD_NEK2_1	751	756	PF00069	0.624
MOD_NEK2_1	767	772	PF00069	0.619
MOD_NEK2_1	773	778	PF00069	0.640
MOD_NEK2_1	846	851	PF00069	0.553
MOD_NEK2_1	891	896	PF00069	0.412
MOD_NEK2_1	948	953	PF00069	0.650
MOD_NEK2_1	984	989	PF00069	0.441
MOD_NEK2_2	709	714	PF00069	0.634
MOD_PIKK_1	1007	1013	PF00454	0.667
MOD_PIKK_1	294	300	PF00454	0.537
MOD_PIKK_1	423	429	PF00454	0.381
MOD_PKA_1	1012	1018	PF00069	0.598
MOD_PKA_1	191	197	PF00069	0.520
MOD_PKA_1	672	678	PF00069	0.568
MOD_PKA_2	1011	1017	PF00069	0.681
MOD_PKA_2	1031	1037	PF00069	0.485
MOD_PKA_2	156	162	PF00069	0.536
MOD_PKA_2	242	248	PF00069	0.538
MOD_PKA_2	267	273	PF00069	0.637
MOD_PKA_2	423	429	PF00069	0.381
MOD_PKA_2	672	678	PF00069	0.549
MOD_PKA_2	690	696	PF00069	0.742
MOD_PKA_2	719	725	PF00069	0.549
MOD_PKA_2	767	773	PF00069	0.578
MOD_PKA_2	907	913	PF00069	0.476
MOD_PKA_2	957	963	PF00069	0.486
MOD_PKB_1	761	769	PF00069	0.678
MOD_PKB_1	90	98	PF00069	0.479
MOD_Plk_1	464	470	PF00069	0.418
MOD_Plk_1	680	686	PF00069	0.481
MOD_Plk_1	995	1001	PF00069	0.521
MOD_Plk_2-3	995	1001	PF00069	0.521
MOD_Plk_4	116	122	PF00069	0.678
MOD_Plk_4	15	21	PF00069	0.586
MOD_Plk_4	200	206	PF00069	0.524
MOD_Plk_4	248	254	PF00069	0.522
MOD_Plk_4	501	507	PF00069	0.310
MOD_Plk_4	583	589	PF00069	0.310
MOD_Plk_4	804	810	PF00069	0.635
MOD_Plk_4	858	864	PF00069	0.513
MOD_ProDKin_1	120	126	PF00069	0.687
MOD_ProDKin_1	333	339	PF00069	0.638
MOD_ProDKin_1	39	45	PF00069	0.604
MOD_ProDKin_1	546	552	PF00069	0.649
MOD_ProDKin_1	55	61	PF00069	0.585
MOD_ProDKin_1	575	581	PF00069	0.412
MOD_ProDKin_1	658	664	PF00069	0.538
MOD_ProDKin_1	800	806	PF00069	0.612
MOD_ProDKin_1	830	836	PF00069	0.524
MOD_ProDKin_1	930	936	PF00069	0.506
MOD_ProDKin_1	950	956	PF00069	0.595
MOD_ProDKin_1	960	966	PF00069	0.502
MOD_SUMO_rev_2	82	87	PF00179	0.500
TRG_DiLeu_BaLyEn_6	842	847	PF01217	0.503
TRG_ENDOCYTIC_2	469	472	PF00928	0.439
TRG_ENDOCYTIC_2	570	573	PF00928	0.570
TRG_ENDOCYTIC_2	822	825	PF00928	0.703
TRG_ER_diArg_1	1143	1146	PF00400	0.431
TRG_ER_diArg_1	387	389	PF00400	0.518
TRG_ER_diArg_1	433	436	PF00400	0.507
TRG_ER_diArg_1	455	457	PF00400	0.526
TRG_ER_diArg_1	466	469	PF00400	0.482
TRG_ER_diArg_1	480	482	PF00400	0.511
TRG_ER_diArg_1	486	488	PF00400	0.416
TRG_ER_diArg_1	491	494	PF00400	0.256
TRG_ER_diArg_1	671	673	PF00400	0.560
TRG_ER_diArg_1	89	92	PF00400	0.580
TRG_ER_diArg_1	97	99	PF00400	0.584
TRG_ER_FFAT_2	797	807	PF00635	0.515
TRG_Pf-PMV_PEXEL_1	794	798	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	865	869	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B9	Leptomonas seymouri	32%	100%
A0A3S5H561	Leishmania donovani	54%	100%
A4HRW9	Leishmania infantum	54%	100%
E9ACM6	Leishmania major	52%	97%
E9AJW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%