Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3P0_LEIBR

TriTrypDb:

LbrM.03.0690 , LBRM2903_030012800

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3P0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.491
CLV_C14_Caspase3-7	294	298	PF00656	0.614
CLV_C14_Caspase3-7	328	332	PF00656	0.640
CLV_C14_Caspase3-7	366	370	PF00656	0.562
CLV_C14_Caspase3-7	422	426	PF00656	0.457
CLV_NRD_NRD_1	22	24	PF00675	0.523
CLV_NRD_NRD_1	234	236	PF00675	0.427
CLV_NRD_NRD_1	243	245	PF00675	0.482
CLV_NRD_NRD_1	321	323	PF00675	0.664
CLV_PCSK_FUR_1	20	24	PF00082	0.522
CLV_PCSK_KEX2_1	20	22	PF00082	0.529
CLV_PCSK_KEX2_1	234	236	PF00082	0.441
CLV_PCSK_KEX2_1	242	244	PF00082	0.536
CLV_PCSK_KEX2_1	321	323	PF00082	0.622
CLV_PCSK_SKI1_1	138	142	PF00082	0.495
CLV_PCSK_SKI1_1	26	30	PF00082	0.443
CLV_PCSK_SKI1_1	342	346	PF00082	0.549
CLV_PCSK_SKI1_1	395	399	PF00082	0.560
DEG_Nend_UBRbox_3	1	3	PF02207	0.580
DEG_SPOP_SBC_1	306	310	PF00917	0.585
DEG_SPOP_SBC_1	90	94	PF00917	0.492
DEG_SPOP_SBC_1	99	103	PF00917	0.439
DOC_CYCLIN_RxL_1	392	402	PF00134	0.579
DOC_PP1_RVXF_1	136	143	PF00149	0.489
DOC_PP2B_LxvP_1	245	248	PF13499	0.566
DOC_USP7_MATH_1	120	124	PF00917	0.590
DOC_USP7_MATH_1	320	324	PF00917	0.782
DOC_USP7_MATH_1	340	344	PF00917	0.528
DOC_USP7_MATH_1	358	362	PF00917	0.691
DOC_USP7_MATH_1	373	377	PF00917	0.659
DOC_USP7_MATH_1	378	382	PF00917	0.599
DOC_USP7_MATH_1	55	59	PF00917	0.580
DOC_USP7_MATH_1	60	64	PF00917	0.669
DOC_USP7_MATH_1	82	86	PF00917	0.626
DOC_USP7_MATH_1	90	94	PF00917	0.499
DOC_USP7_MATH_1	99	103	PF00917	0.397
DOC_WW_Pin1_4	140	145	PF00397	0.585
DOC_WW_Pin1_4	299	304	PF00397	0.618
DOC_WW_Pin1_4	342	347	PF00397	0.669
DOC_WW_Pin1_4	349	354	PF00397	0.572
DOC_WW_Pin1_4	371	376	PF00397	0.763
LIG_14-3-3_CanoR_1	138	143	PF00244	0.596
LIG_14-3-3_CanoR_1	293	297	PF00244	0.639
LIG_14-3-3_CanoR_1	393	398	PF00244	0.571
LIG_14-3-3_CanoR_1	46	50	PF00244	0.535
LIG_BIR_III_4	331	335	PF00653	0.710
LIG_CSL_BTD_1	245	248	PF09270	0.481
LIG_EVH1_1	253	257	PF00568	0.527
LIG_FHA_1	274	280	PF00498	0.570
LIG_FHA_1	343	349	PF00498	0.816
LIG_FHA_1	60	66	PF00498	0.527
LIG_FHA_1	92	98	PF00498	0.572
LIG_FHA_2	141	147	PF00498	0.540
LIG_FHA_2	177	183	PF00498	0.528
LIG_FHA_2	312	318	PF00498	0.632
LIG_FHA_2	326	332	PF00498	0.675
LIG_FHA_2	9	15	PF00498	0.449
LIG_LIR_Gen_1	151	161	PF02991	0.606
LIG_LIR_Gen_1	191	202	PF02991	0.457
LIG_LIR_Gen_1	216	224	PF02991	0.452
LIG_LIR_LC3C_4	103	108	PF02991	0.558
LIG_LIR_Nem_3	14	19	PF02991	0.463
LIG_LIR_Nem_3	151	157	PF02991	0.601
LIG_LIR_Nem_3	191	197	PF02991	0.439
LIG_LIR_Nem_3	216	221	PF02991	0.501
LIG_LIR_Nem_3	416	421	PF02991	0.422
LIG_NRBOX	105	111	PF00104	0.550
LIG_SH2_CRK	154	158	PF00017	0.592
LIG_SH2_CRK	194	198	PF00017	0.432
LIG_SH2_NCK_1	154	158	PF00017	0.424
LIG_SH2_STAT3	384	387	PF00017	0.660
LIG_SH2_STAT5	118	121	PF00017	0.463
LIG_SH3_1	253	259	PF00018	0.595
LIG_SH3_3	249	255	PF00018	0.762
LIG_SH3_3	405	411	PF00018	0.421
LIG_SUMO_SIM_par_1	105	112	PF11976	0.459
LIG_SUMO_SIM_par_1	345	350	PF11976	0.616
LIG_TRFH_1	34	38	PF08558	0.620
MOD_CDK_SPK_2	140	145	PF00069	0.585
MOD_CK1_1	100	106	PF00069	0.466
MOD_CK1_1	159	165	PF00069	0.521
MOD_CK1_1	170	176	PF00069	0.521
MOD_CK1_1	260	266	PF00069	0.672
MOD_CK1_1	295	301	PF00069	0.569
MOD_CK1_1	380	386	PF00069	0.726
MOD_CK1_1	396	402	PF00069	0.387
MOD_CK1_1	63	69	PF00069	0.755
MOD_CK2_1	275	281	PF00069	0.546
MOD_CK2_1	396	402	PF00069	0.542
MOD_CK2_1	8	14	PF00069	0.452
MOD_DYRK1A_RPxSP_1	342	346	PF00069	0.549
MOD_GlcNHglycan	135	138	PF01048	0.517
MOD_GlcNHglycan	158	161	PF01048	0.455
MOD_GlcNHglycan	169	172	PF01048	0.711
MOD_GlcNHglycan	259	262	PF01048	0.563
MOD_GlcNHglycan	281	287	PF01048	0.574
MOD_GlcNHglycan	303	306	PF01048	0.555
MOD_GlcNHglycan	322	325	PF01048	0.785
MOD_GlcNHglycan	360	363	PF01048	0.626
MOD_GlcNHglycan	57	60	PF01048	0.590
MOD_GlcNHglycan	84	87	PF01048	0.621
MOD_GSK3_1	126	133	PF00069	0.583
MOD_GSK3_1	159	166	PF00069	0.623
MOD_GSK3_1	259	266	PF00069	0.725
MOD_GSK3_1	291	298	PF00069	0.558
MOD_GSK3_1	301	308	PF00069	0.531
MOD_GSK3_1	338	345	PF00069	0.777
MOD_GSK3_1	373	380	PF00069	0.752
MOD_GSK3_1	55	62	PF00069	0.633
MOD_N-GLC_1	120	125	PF02516	0.598
MOD_N-GLC_1	26	31	PF02516	0.446
MOD_N-GLC_1	338	343	PF02516	0.720
MOD_NEK2_1	189	194	PF00069	0.584
MOD_NEK2_1	40	45	PF00069	0.606
MOD_NEK2_1	98	103	PF00069	0.461
MOD_PIKK_1	165	171	PF00454	0.500
MOD_PIKK_1	295	301	PF00454	0.687
MOD_PIKK_1	312	318	PF00454	0.589
MOD_PK_1	275	281	PF00069	0.546
MOD_PKA_2	292	298	PF00069	0.702
MOD_PKA_2	320	326	PF00069	0.714
MOD_PKA_2	335	341	PF00069	0.586
MOD_PKA_2	45	51	PF00069	0.534
MOD_Plk_1	111	117	PF00069	0.445
MOD_Plk_1	120	126	PF00069	0.521
MOD_Plk_4	111	117	PF00069	0.445
MOD_Plk_4	121	127	PF00069	0.531
MOD_Plk_4	149	155	PF00069	0.499
MOD_Plk_4	60	66	PF00069	0.661
MOD_ProDKin_1	140	146	PF00069	0.583
MOD_ProDKin_1	299	305	PF00069	0.620
MOD_ProDKin_1	342	348	PF00069	0.668
MOD_ProDKin_1	349	355	PF00069	0.569
MOD_ProDKin_1	371	377	PF00069	0.757
MOD_SUMO_for_1	274	277	PF00179	0.689
MOD_SUMO_rev_2	323	330	PF00179	0.569
TRG_AP2beta_CARGO_1	14	23	PF09066	0.391
TRG_DiLeu_BaEn_1	14	19	PF01217	0.463
TRG_DiLeu_BaEn_1	402	407	PF01217	0.508
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.629
TRG_DiLeu_BaLyEn_6	416	421	PF01217	0.422
TRG_ENDOCYTIC_2	154	157	PF00928	0.597
TRG_ENDOCYTIC_2	194	197	PF00928	0.437
TRG_ENDOCYTIC_2	418	421	PF00928	0.430
TRG_ER_diArg_1	19	22	PF00400	0.512
TRG_ER_diArg_1	233	235	PF00400	0.430
TRG_ER_diArg_1	241	244	PF00400	0.487
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J3	Leptomonas seymouri	45%	98%
A0A3S5H559	Leishmania donovani	72%	100%
A4HRW7	Leishmania infantum	71%	100%
E9ACM4	Leishmania major	73%	94%
E9AJW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%