Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ubiquitin-like domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3N8_LEIBR

TriTrypDb:

LbrM.03.0670 , LBRM2903_030012600

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H3N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3N8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0043014	alpha-tubulin binding	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.351
CLV_C14_Caspase3-7	374	378	PF00656	0.333
CLV_C14_Caspase3-7	396	400	PF00656	0.602
CLV_C14_Caspase3-7	401	405	PF00656	0.647
CLV_NRD_NRD_1	42	44	PF00675	0.481
CLV_PCSK_KEX2_1	389	391	PF00082	0.491
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.491
CLV_PCSK_PC7_1	385	391	PF00082	0.277
CLV_PCSK_SKI1_1	158	162	PF00082	0.331
CLV_PCSK_SKI1_1	385	389	PF00082	0.431
CLV_PCSK_SKI1_1	495	499	PF00082	0.194
DEG_SPOP_SBC_1	465	469	PF00917	0.665
DOC_CDC14_PxL_1	134	142	PF14671	0.478
DOC_CDC14_PxL_1	175	183	PF14671	0.368
DOC_CKS1_1	197	202	PF01111	0.414
DOC_CYCLIN_RxL_1	179	188	PF00134	0.398
DOC_MAPK_gen_1	426	434	PF00069	0.389
DOC_MAPK_gen_1	56	65	PF00069	0.337
DOC_MAPK_MEF2A_6	190	198	PF00069	0.579
DOC_MAPK_MEF2A_6	414	422	PF00069	0.392
DOC_MAPK_MEF2A_6	426	434	PF00069	0.444
DOC_MAPK_MEF2A_6	59	67	PF00069	0.407
DOC_MAPK_MEF2A_6	69	77	PF00069	0.307
DOC_MAPK_MEF2A_6	8	15	PF00069	0.357
DOC_PP2B_LxvP_1	270	273	PF13499	0.459
DOC_USP7_MATH_1	11	15	PF00917	0.459
DOC_USP7_MATH_1	150	154	PF00917	0.500
DOC_USP7_MATH_1	213	217	PF00917	0.690
DOC_USP7_MATH_1	31	35	PF00917	0.356
DOC_USP7_MATH_1	465	469	PF00917	0.678
DOC_USP7_MATH_1	84	88	PF00917	0.637
DOC_USP7_UBL2_3	476	480	PF12436	0.439
DOC_USP7_UBL2_3	52	56	PF12436	0.333
DOC_WW_Pin1_4	1	6	PF00397	0.622
DOC_WW_Pin1_4	196	201	PF00397	0.610
DOC_WW_Pin1_4	407	412	PF00397	0.423
DOC_WW_Pin1_4	518	523	PF00397	0.500
LIG_14-3-3_CanoR_1	128	133	PF00244	0.448
LIG_14-3-3_CanoR_1	336	346	PF00244	0.326
LIG_14-3-3_CanoR_1	414	418	PF00244	0.274
LIG_14-3-3_CanoR_1	506	510	PF00244	0.452
LIG_BRCT_BRCA1_1	11	15	PF00533	0.310
LIG_Clathr_ClatBox_1	191	195	PF01394	0.503
LIG_deltaCOP1_diTrp_1	42	47	PF00928	0.613
LIG_eIF4E_1	382	388	PF01652	0.479
LIG_FHA_1	129	135	PF00498	0.380
LIG_FHA_1	146	152	PF00498	0.473
LIG_FHA_1	230	236	PF00498	0.316
LIG_FHA_1	285	291	PF00498	0.540
LIG_FHA_1	317	323	PF00498	0.409
LIG_FHA_1	332	338	PF00498	0.207
LIG_FHA_1	359	365	PF00498	0.434
LIG_FHA_1	414	420	PF00498	0.394
LIG_FHA_1	476	482	PF00498	0.485
LIG_FHA_1	90	96	PF00498	0.635
LIG_FHA_2	205	211	PF00498	0.562
LIG_FHA_2	343	349	PF00498	0.502
LIG_FHA_2	394	400	PF00498	0.463
LIG_FHA_2	519	525	PF00498	0.429
LIG_FHA_2	99	105	PF00498	0.310
LIG_Integrin_RGD_1	397	399	PF01839	0.389
LIG_LIR_Gen_1	338	344	PF02991	0.342
LIG_LIR_Gen_1	42	51	PF02991	0.516
LIG_LIR_Gen_1	446	456	PF02991	0.469
LIG_LIR_Nem_3	164	169	PF02991	0.442
LIG_LIR_Nem_3	224	230	PF02991	0.412
LIG_LIR_Nem_3	241	246	PF02991	0.388
LIG_LIR_Nem_3	338	342	PF02991	0.356
LIG_LIR_Nem_3	416	420	PF02991	0.361
LIG_LIR_Nem_3	42	48	PF02991	0.536
LIG_LIR_Nem_3	446	451	PF02991	0.513
LIG_LIR_Nem_3	529	535	PF02991	0.429
LIG_LYPXL_yS_3	417	420	PF13949	0.361
LIG_PTB_Apo_2	160	167	PF02174	0.408
LIG_RPA_C_Fungi	274	286	PF08784	0.259
LIG_SH2_CRK	299	303	PF00017	0.393
LIG_SH2_CRK	339	343	PF00017	0.378
LIG_SH2_NCK_1	461	465	PF00017	0.603
LIG_SH2_PTP2	448	451	PF00017	0.511
LIG_SH2_SRC	301	304	PF00017	0.313
LIG_SH2_STAP1	339	343	PF00017	0.334
LIG_SH2_STAP1	461	465	PF00017	0.545
LIG_SH2_STAT5	261	264	PF00017	0.445
LIG_SH2_STAT5	301	304	PF00017	0.348
LIG_SH2_STAT5	354	357	PF00017	0.298
LIG_SH2_STAT5	382	385	PF00017	0.325
LIG_SH2_STAT5	448	451	PF00017	0.511
LIG_SH2_STAT5	542	545	PF00017	0.389
LIG_SH3_1	121	127	PF00018	0.477
LIG_SH3_3	121	127	PF00018	0.477
LIG_SH3_3	140	146	PF00018	0.301
LIG_SH3_3	173	179	PF00018	0.418
LIG_SH3_3	194	200	PF00018	0.592
LIG_SH3_3	222	228	PF00018	0.466
LIG_SH3_3	292	298	PF00018	0.429
LIG_SH3_3	406	412	PF00018	0.563
LIG_SH3_4	501	508	PF00018	0.391
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.551
LIG_SUMO_SIM_anti_2	361	366	PF11976	0.438
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.487
LIG_SUMO_SIM_par_1	139	145	PF11976	0.301
LIG_SUMO_SIM_par_1	147	153	PF11976	0.401
LIG_SUMO_SIM_par_1	190	195	PF11976	0.274
LIG_SUMO_SIM_par_1	231	236	PF11976	0.211
LIG_SUMO_SIM_par_1	449	454	PF11976	0.469
LIG_TRAF2_1	207	210	PF00917	0.475
LIG_TYR_ITIM	337	342	PF00017	0.373
LIG_TYR_ITIM	415	420	PF00017	0.393
LIG_TYR_ITIM	530	535	PF00017	0.350
LIG_UBA3_1	307	311	PF00899	0.369
LIG_UBA3_1	493	501	PF00899	0.174
LIG_WRC_WIRS_1	332	337	PF05994	0.282
LIG_WW_3	411	415	PF00397	0.356
MOD_CDK_SPxxK_3	1	8	PF00069	0.486
MOD_CDK_SPxxK_3	407	414	PF00069	0.408
MOD_CK1_1	109	115	PF00069	0.477
MOD_CK1_1	204	210	PF00069	0.599
MOD_CK1_1	3	9	PF00069	0.721
MOD_CK1_1	468	474	PF00069	0.640
MOD_CK1_1	483	489	PF00069	0.203
MOD_CK1_1	508	514	PF00069	0.256
MOD_CK2_1	112	118	PF00069	0.400
MOD_CK2_1	204	210	PF00069	0.589
MOD_CK2_1	233	239	PF00069	0.219
MOD_CK2_1	342	348	PF00069	0.495
MOD_CK2_1	98	104	PF00069	0.478
MOD_GlcNHglycan	152	155	PF01048	0.320
MOD_GlcNHglycan	215	218	PF01048	0.710
MOD_GlcNHglycan	24	27	PF01048	0.570
MOD_GlcNHglycan	404	408	PF01048	0.666
MOD_GlcNHglycan	510	513	PF01048	0.269
MOD_GlcNHglycan	79	83	PF01048	0.591
MOD_GlcNHglycan	86	89	PF01048	0.556
MOD_GSK3_1	145	152	PF00069	0.500
MOD_GSK3_1	161	168	PF00069	0.343
MOD_GSK3_1	229	236	PF00069	0.256
MOD_GSK3_1	312	319	PF00069	0.426
MOD_GSK3_1	331	338	PF00069	0.190
MOD_GSK3_1	342	349	PF00069	0.487
MOD_GSK3_1	403	410	PF00069	0.643
MOD_GSK3_1	437	444	PF00069	0.598
MOD_GSK3_1	464	471	PF00069	0.625
MOD_N-GLC_1	161	166	PF02516	0.418
MOD_N-GLC_1	213	218	PF02516	0.621
MOD_N-GLC_1	312	317	PF02516	0.370
MOD_N-GLC_1	346	351	PF02516	0.322
MOD_N-GLC_1	98	103	PF02516	0.293
MOD_NEK2_1	161	166	PF00069	0.347
MOD_NEK2_1	233	238	PF00069	0.212
MOD_NEK2_1	316	321	PF00069	0.504
MOD_NEK2_1	335	340	PF00069	0.181
MOD_NEK2_1	451	456	PF00069	0.239
MOD_PIKK_1	255	261	PF00454	0.442
MOD_PIKK_1	475	481	PF00454	0.386
MOD_PIKK_1	516	522	PF00454	0.295
MOD_PKA_2	335	341	PF00069	0.304
MOD_PKA_2	366	372	PF00069	0.504
MOD_PKA_2	413	419	PF00069	0.337
MOD_PKA_2	505	511	PF00069	0.316
MOD_Plk_1	109	115	PF00069	0.353
MOD_Plk_1	213	219	PF00069	0.441
MOD_Plk_1	31	37	PF00069	0.633
MOD_Plk_1	311	317	PF00069	0.407
MOD_Plk_1	98	104	PF00069	0.388
MOD_Plk_4	11	17	PF00069	0.402
MOD_Plk_4	303	309	PF00069	0.399
MOD_Plk_4	338	344	PF00069	0.420
MOD_Plk_4	451	457	PF00069	0.440
MOD_ProDKin_1	1	7	PF00069	0.627
MOD_ProDKin_1	196	202	PF00069	0.618
MOD_ProDKin_1	407	413	PF00069	0.418
MOD_ProDKin_1	518	524	PF00069	0.370
MOD_SUMO_rev_2	25	31	PF00179	0.378
TRG_DiLeu_BaEn_1	118	123	PF01217	0.472
TRG_DiLeu_BaEn_4	32	38	PF01217	0.424
TRG_ENDOCYTIC_2	299	302	PF00928	0.349
TRG_ENDOCYTIC_2	339	342	PF00928	0.323
TRG_ENDOCYTIC_2	417	420	PF00928	0.361
TRG_ENDOCYTIC_2	448	451	PF00928	0.511
TRG_ENDOCYTIC_2	532	535	PF00928	0.350
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.174

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTC4	Leptomonas seymouri	61%	100%
A0A0S4JLX2	Bodo saltans	38%	100%
A0A1X0P967	Trypanosomatidae	43%	100%
A0A3S5H558	Leishmania donovani	81%	100%
A0A422NHN6	Trypanosoma rangeli	44%	100%
A4HRW5	Leishmania infantum	81%	100%
C9ZKH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ACM2	Leishmania major	80%	100%
E9AJW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q15813	Homo sapiens	22%	100%
Q32KS0	Bos taurus	22%	100%
Q5RBD9	Pongo abelii	22%	100%
Q5U508	Xenopus laevis	21%	100%
Q8GRL7	Arabidopsis thaliana	25%	100%
V5C274	Trypanosoma cruzi	43%	100%