Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TatD related DNase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3N6_LEIBR

TriTrypDb:

LbrM.03.0650 , LBRM2903_030012400

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3N6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008297	single-stranded DNA exodeoxyribonuclease activity	7	1
GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	8	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	510	514	PF00656	0.571
CLV_C14_Caspase3-7	535	539	PF00656	0.467
CLV_C14_Caspase3-7	625	629	PF00656	0.595
CLV_C14_Caspase3-7	649	653	PF00656	0.671
CLV_C14_Caspase3-7	731	735	PF00656	0.611
CLV_NRD_NRD_1	109	111	PF00675	0.265
CLV_NRD_NRD_1	121	123	PF00675	0.265
CLV_NRD_NRD_1	18	20	PF00675	0.675
CLV_NRD_NRD_1	346	348	PF00675	0.206
CLV_NRD_NRD_1	759	761	PF00675	0.522
CLV_PCSK_FUR_1	580	584	PF00082	0.579
CLV_PCSK_KEX2_1	121	123	PF00082	0.308
CLV_PCSK_KEX2_1	18	20	PF00082	0.675
CLV_PCSK_KEX2_1	540	542	PF00082	0.558
CLV_PCSK_KEX2_1	579	581	PF00082	0.502
CLV_PCSK_KEX2_1	582	584	PF00082	0.540
CLV_PCSK_KEX2_1	759	761	PF00082	0.522
CLV_PCSK_KEX2_1	763	765	PF00082	0.500
CLV_PCSK_KEX2_1	767	769	PF00082	0.501
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.540
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.509
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.540
CLV_PCSK_PC1ET2_1	763	765	PF00082	0.500
CLV_PCSK_PC1ET2_1	767	769	PF00082	0.501
CLV_PCSK_PC7_1	759	765	PF00082	0.509
CLV_PCSK_SKI1_1	10	14	PF00082	0.662
CLV_PCSK_SKI1_1	110	114	PF00082	0.243
CLV_PCSK_SKI1_1	157	161	PF00082	0.246
CLV_PCSK_SKI1_1	239	243	PF00082	0.206
CLV_PCSK_SKI1_1	267	271	PF00082	0.323
CLV_PCSK_SKI1_1	347	351	PF00082	0.226
CLV_PCSK_SKI1_1	487	491	PF00082	0.202
CLV_PCSK_SKI1_1	587	591	PF00082	0.560
CLV_PCSK_SKI1_1	699	703	PF00082	0.542
DEG_Kelch_Keap1_1	736	741	PF01344	0.560
DEG_SPOP_SBC_1	641	645	PF00917	0.668
DOC_ANK_TNKS_1	687	694	PF00023	0.547
DOC_CKS1_1	38	43	PF01111	0.563
DOC_CKS1_1	431	436	PF01111	0.465
DOC_CYCLIN_yCln2_LP_2	405	408	PF00134	0.508
DOC_MAPK_DCC_7	44	54	PF00069	0.339
DOC_MAPK_gen_1	239	249	PF00069	0.406
DOC_MAPK_gen_1	540	548	PF00069	0.394
DOC_MAPK_MEF2A_6	274	283	PF00069	0.508
DOC_PP1_RVXF_1	173	180	PF00149	0.508
DOC_PP2B_LxvP_1	405	408	PF13499	0.508
DOC_PP2B_LxvP_1	60	63	PF13499	0.365
DOC_PP4_MxPP_1	48	51	PF00568	0.339
DOC_USP7_MATH_1	12	16	PF00917	0.658
DOC_USP7_MATH_1	200	204	PF00917	0.475
DOC_USP7_MATH_1	326	330	PF00917	0.578
DOC_USP7_MATH_1	34	38	PF00917	0.586
DOC_USP7_MATH_1	392	396	PF00917	0.429
DOC_USP7_MATH_1	607	611	PF00917	0.679
DOC_USP7_MATH_1	63	67	PF00917	0.588
DOC_USP7_MATH_1	641	645	PF00917	0.676
DOC_USP7_MATH_1	95	99	PF00917	0.336
DOC_USP7_UBL2_3	32	36	PF12436	0.644
DOC_USP7_UBL2_3	582	586	PF12436	0.545
DOC_USP7_UBL2_3	695	699	PF12436	0.598
DOC_USP7_UBL2_3	763	767	PF12436	0.495
DOC_WW_Pin1_4	198	203	PF00397	0.553
DOC_WW_Pin1_4	37	42	PF00397	0.601
DOC_WW_Pin1_4	43	48	PF00397	0.480
DOC_WW_Pin1_4	430	435	PF00397	0.465
LIG_14-3-3_CanoR_1	141	145	PF00244	0.611
LIG_14-3-3_CanoR_1	614	621	PF00244	0.590
LIG_BIR_III_4	322	326	PF00653	0.406
LIG_eIF4E_1	263	269	PF01652	0.508
LIG_FHA_1	294	300	PF00498	0.523
LIG_FHA_1	358	364	PF00498	0.437
LIG_FHA_1	451	457	PF00498	0.409
LIG_FHA_2	315	321	PF00498	0.423
LIG_FHA_2	378	384	PF00498	0.431
LIG_FHA_2	456	462	PF00498	0.508
LIG_FHA_2	471	477	PF00498	0.534
LIG_FHA_2	508	514	PF00498	0.585
LIG_FHA_2	62	68	PF00498	0.682
LIG_GBD_Chelix_1	482	490	PF00786	0.206
LIG_Integrin_RGD_1	774	776	PF01839	0.527
LIG_LIR_Apic_2	182	186	PF02991	0.406
LIG_LIR_Apic_2	35	41	PF02991	0.590
LIG_LIR_Gen_1	210	219	PF02991	0.406
LIG_LIR_Gen_1	458	468	PF02991	0.467
LIG_LIR_Gen_1	595	605	PF02991	0.585
LIG_LIR_Nem_3	210	215	PF02991	0.418
LIG_LIR_Nem_3	595	600	PF02991	0.576
LIG_NRBOX	305	311	PF00104	0.523
LIG_NRBOX	419	425	PF00104	0.465
LIG_NRBOX	542	548	PF00104	0.535
LIG_PDZ_Class_3	778	783	PF00595	0.578
LIG_Pex14_2	269	273	PF04695	0.529
LIG_PTB_Apo_2	599	606	PF02174	0.591
LIG_Rb_pABgroove_1	454	462	PF01858	0.505
LIG_SH2_CRK	183	187	PF00017	0.406
LIG_SH2_CRK	212	216	PF00017	0.465
LIG_SH2_CRK	334	338	PF00017	0.402
LIG_SH2_CRK	369	373	PF00017	0.406
LIG_SH2_CRK	38	42	PF00017	0.589
LIG_SH2_CRK	452	456	PF00017	0.508
LIG_SH2_NCK_1	183	187	PF00017	0.406
LIG_SH2_NCK_1	369	373	PF00017	0.406
LIG_SH2_NCK_1	38	42	PF00017	0.589
LIG_SH2_STAP1	288	292	PF00017	0.426
LIG_SH2_STAP1	452	456	PF00017	0.523
LIG_SH2_STAP1	82	86	PF00017	0.313
LIG_SH2_STAT3	454	457	PF00017	0.523
LIG_SH2_STAT5	183	186	PF00017	0.406
LIG_SH2_STAT5	38	41	PF00017	0.583
LIG_SH2_STAT5	452	455	PF00017	0.441
LIG_SH3_1	21	27	PF00018	0.637
LIG_SH3_1	44	50	PF00018	0.425
LIG_SH3_1	443	449	PF00018	0.426
LIG_SH3_3	21	27	PF00018	0.637
LIG_SH3_3	276	282	PF00018	0.508
LIG_SH3_3	44	50	PF00018	0.425
LIG_SH3_3	443	449	PF00018	0.465
LIG_SH3_3	492	498	PF00018	0.383
LIG_SH3_3	742	748	PF00018	0.543
LIG_SUMO_SIM_anti_2	478	484	PF11976	0.406
LIG_TRAF2_1	123	126	PF00917	0.465
LIG_TRAF2_1	380	383	PF00917	0.440
LIG_TRAF2_1	610	613	PF00917	0.679
LIG_TRAF2_1	623	626	PF00917	0.547
LIG_TYR_ITIM	332	337	PF00017	0.402
LIG_WW_3	406	410	PF00397	0.500
MOD_CDK_SPxxK_3	37	44	PF00069	0.558
MOD_CK1_1	193	199	PF00069	0.433
MOD_CK1_1	201	207	PF00069	0.437
MOD_CK1_1	37	43	PF00069	0.500
MOD_CK1_1	395	401	PF00069	0.518
MOD_CK1_1	506	512	PF00069	0.537
MOD_CK1_1	595	601	PF00069	0.578
MOD_CK1_1	643	649	PF00069	0.722
MOD_CK1_1	66	72	PF00069	0.548
MOD_CK1_1	736	742	PF00069	0.777
MOD_CK2_1	291	297	PF00069	0.523
MOD_CK2_1	377	383	PF00069	0.494
MOD_CK2_1	470	476	PF00069	0.406
MOD_CK2_1	578	584	PF00069	0.573
MOD_CK2_1	607	613	PF00069	0.663
MOD_CK2_1	61	67	PF00069	0.491
MOD_CK2_1	620	626	PF00069	0.665
MOD_Cter_Amidation	697	700	PF01082	0.556
MOD_GlcNHglycan	203	206	PF01048	0.226
MOD_GlcNHglycan	32	35	PF01048	0.618
MOD_GlcNHglycan	328	331	PF01048	0.378
MOD_GlcNHglycan	394	397	PF01048	0.311
MOD_GlcNHglycan	414	417	PF01048	0.171
MOD_GlcNHglycan	476	480	PF01048	0.393
MOD_GlcNHglycan	505	508	PF01048	0.642
MOD_GlcNHglycan	645	648	PF01048	0.643
MOD_GlcNHglycan	654	657	PF01048	0.636
MOD_GlcNHglycan	704	707	PF01048	0.675
MOD_GSK3_1	13	20	PF00069	0.621
MOD_GSK3_1	165	172	PF00069	0.421
MOD_GSK3_1	26	33	PF00069	0.641
MOD_GSK3_1	291	298	PF00069	0.508
MOD_GSK3_1	36	43	PF00069	0.559
MOD_GSK3_1	388	395	PF00069	0.437
MOD_GSK3_1	455	462	PF00069	0.423
MOD_GSK3_1	502	509	PF00069	0.622
MOD_GSK3_1	620	627	PF00069	0.663
MOD_GSK3_1	641	648	PF00069	0.626
MOD_GSK3_1	707	714	PF00069	0.554
MOD_GSK3_1	71	78	PF00069	0.647
MOD_GSK3_1	729	736	PF00069	0.641
MOD_N-GLC_1	253	258	PF02516	0.308
MOD_N-GLC_1	30	35	PF02516	0.688
MOD_N-GLC_1	450	455	PF02516	0.293
MOD_N-GLC_1	592	597	PF02516	0.568
MOD_N-GLC_1	729	734	PF02516	0.639
MOD_NEK2_1	145	150	PF00069	0.506
MOD_NEK2_1	17	22	PF00069	0.611
MOD_NEK2_1	295	300	PF00069	0.508
MOD_NEK2_1	340	345	PF00069	0.508
MOD_NEK2_1	424	429	PF00069	0.475
MOD_NEK2_1	459	464	PF00069	0.406
MOD_NEK2_1	642	647	PF00069	0.546
MOD_NEK2_1	755	760	PF00069	0.504
MOD_NEK2_2	207	212	PF00069	0.406
MOD_NEK2_2	95	100	PF00069	0.326
MOD_PIKK_1	418	424	PF00454	0.465
MOD_PIKK_1	522	528	PF00454	0.579
MOD_PKA_2	140	146	PF00069	0.611
MOD_PKA_2	17	23	PF00069	0.628
MOD_PKA_2	607	613	PF00069	0.679
MOD_Plk_1	450	456	PF00069	0.406
MOD_Plk_1	475	481	PF00069	0.494
MOD_Plk_1	595	601	PF00069	0.578
MOD_Plk_1	729	735	PF00069	0.551
MOD_Plk_2-3	291	297	PF00069	0.508
MOD_Plk_2-3	729	735	PF00069	0.551
MOD_Plk_2-3	776	782	PF00069	0.572
MOD_Plk_4	140	146	PF00069	0.523
MOD_Plk_4	207	213	PF00069	0.447
MOD_Plk_4	450	456	PF00069	0.513
MOD_Plk_4	746	752	PF00069	0.552
MOD_ProDKin_1	198	204	PF00069	0.553
MOD_ProDKin_1	37	43	PF00069	0.599
MOD_ProDKin_1	430	436	PF00069	0.465
MOD_SUMO_rev_2	125	130	PF00179	0.523
MOD_SUMO_rev_2	5	15	PF00179	0.660
TRG_DiLeu_BaEn_1	140	145	PF01217	0.523
TRG_DiLeu_BaEn_1	553	558	PF01217	0.389
TRG_DiLeu_BaEn_1	668	673	PF01217	0.440
TRG_DiLeu_LyEn_5	668	673	PF01217	0.412
TRG_ENDOCYTIC_2	212	215	PF00928	0.465
TRG_ENDOCYTIC_2	334	337	PF00928	0.402
TRG_ENDOCYTIC_2	369	372	PF00928	0.424
TRG_ENDOCYTIC_2	452	455	PF00928	0.465
TRG_ENDOCYTIC_2	460	463	PF00928	0.465
TRG_ER_diArg_1	120	122	PF00400	0.508
TRG_ER_diArg_1	17	19	PF00400	0.677
TRG_ER_diArg_1	759	762	PF00400	0.516
TRG_ER_FFAT_2	33	43	PF00635	0.592
TRG_NLS_MonoExtN_4	759	766	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.323
TRG_Pf-PMV_PEXEL_1	443	448	PF00026	0.217

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E3	Leptomonas seymouri	55%	97%
A0A1X0P9U8	Trypanosomatidae	32%	98%
A0A451EJS4	Leishmania donovani	67%	100%
A4HRW3	Leishmania infantum	67%	100%
E9ACM0	Leishmania major	68%	100%
E9AJV8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%