Putative cytochrome c oxidase copper chaperone

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase copper chaperone, putative

Species:

Leishmania braziliensis

UniProt:

A4H3N5_LEIBR

TriTrypDb:

LbrM.03.0640 , LBRM2903_030012300

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	9
GO:0031970	organelle envelope lumen	5	9
GO:0031974	membrane-enclosed lumen	2	9
GO:0043233	organelle lumen	3	9
GO:0070013	intracellular organelle lumen	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H3N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3N5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005507	copper ion binding	6	9
GO:0016530	metallochaperone activity	2	9
GO:0016531	copper chaperone activity	3	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0140104	molecular carrier activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.441
CLV_PCSK_KEX2_1	35	37	PF00082	0.441
CLV_PCSK_KEX2_1	75	77	PF00082	0.515
CLV_PCSK_KEX2_1	79	81	PF00082	0.538
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.515
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.538
DOC_MAPK_gen_1	35	44	PF00069	0.201
DOC_USP7_MATH_1	52	56	PF00917	0.209
DOC_USP7_UBL2_3	22	26	PF12436	0.262
DOC_USP7_UBL2_3	75	79	PF12436	0.515
DOC_WW_Pin1_4	16	21	PF00397	0.615
LIG_14-3-3_CanoR_1	4	12	PF00244	0.559
LIG_LIR_Gen_1	55	66	PF02991	0.276
LIG_LIR_Nem_3	55	61	PF02991	0.276
LIG_SH2_CRK	58	62	PF00017	0.216
LIG_SH2_STAP1	58	62	PF00017	0.172
LIG_SH3_3	17	23	PF00018	0.498
LIG_SH3_3	9	15	PF00018	0.628
LIG_SH3_4	22	29	PF00018	0.230
LIG_TRAF2_1	67	70	PF00917	0.428
MOD_CDC14_SPxK_1	19	22	PF00782	0.390
MOD_CDK_SPK_2	16	21	PF00069	0.404
MOD_CDK_SPxK_1	16	22	PF00069	0.401
MOD_CK1_1	6	12	PF00069	0.616
MOD_CK2_1	64	70	PF00069	0.216
MOD_GlcNHglycan	53	57	PF01048	0.399
MOD_GlcNHglycan	6	9	PF01048	0.695
MOD_GlcNHglycan	66	69	PF01048	0.525
MOD_NMyristoyl	1	7	PF02799	0.595
MOD_PKA_1	75	81	PF00069	0.538
MOD_PKA_2	3	9	PF00069	0.531
MOD_PKA_2	75	81	PF00069	0.447
MOD_Plk_1	52	58	PF00069	0.276
MOD_ProDKin_1	16	22	PF00069	0.613
TRG_DiLeu_BaEn_4	69	75	PF01217	0.418
TRG_ENDOCYTIC_2	58	61	PF00928	0.216
TRG_ER_diArg_1	35	38	PF00400	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM2	Leptomonas seymouri	69%	100%
A0A3S5H556	Leishmania donovani	71%	96%
A0A422MU41	Trypanosoma rangeli	57%	79%
A4HRW2	Leishmania infantum	71%	96%
C9ZKG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9ACL9	Leishmania major	70%	100%
E9AJV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%
P81045	Sus scrofa	38%	100%
Q14061	Homo sapiens	39%	100%
Q54ID0	Dictyostelium discoideum	36%	100%
Q6J3Q7	Canis lupus familiaris	37%	100%
Q9LJQ9	Arabidopsis thaliana	38%	100%