tRNA_edit domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3N2_LEIBR

TriTrypDb:

LbrM.03.0610 , LBRM2903_030012000

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3N2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	9
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0052689	carboxylic ester hydrolase activity	4	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140101	catalytic activity, acting on a tRNA	4	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.641
CLV_NRD_NRD_1	167	169	PF00675	0.192
CLV_NRD_NRD_1	52	54	PF00675	0.654
CLV_PCSK_KEX2_1	134	136	PF00082	0.279
CLV_PCSK_KEX2_1	167	169	PF00082	0.254
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.289
CLV_PCSK_SKI1_1	131	135	PF00082	0.318
CLV_PCSK_SKI1_1	43	47	PF00082	0.607
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DOC_CYCLIN_RxL_1	43	51	PF00134	0.490
DOC_MAPK_MEF2A_6	159	166	PF00069	0.463
DOC_MAPK_RevD_3	106	121	PF00069	0.509
DOC_PP1_RVXF_1	44	51	PF00149	0.559
DOC_USP7_MATH_1	115	119	PF00917	0.509
DOC_USP7_MATH_1	179	183	PF00917	0.438
DOC_USP7_MATH_1	83	87	PF00917	0.607
DOC_USP7_UBL2_3	116	120	PF12436	0.472
DOC_USP7_UBL2_3	121	125	PF12436	0.438
DOC_USP7_UBL2_3	54	58	PF12436	0.666
DOC_USP7_UBL2_3	62	66	PF12436	0.656
LIG_14-3-3_CanoR_1	167	172	PF00244	0.509
LIG_14-3-3_CanoR_1	43	49	PF00244	0.474
LIG_APCC_ABBA_1	158	163	PF00400	0.447
LIG_APCC_ABBA_1	20	25	PF00400	0.431
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.430
LIG_BRCT_BRCA1_1	46	50	PF00533	0.562
LIG_deltaCOP1_diTrp_1	199	207	PF00928	0.492
LIG_FHA_1	27	33	PF00498	0.562
LIG_FHA_2	184	190	PF00498	0.509
LIG_LIR_Apic_2	170	174	PF02991	0.396
LIG_LIR_Gen_1	199	205	PF02991	0.482
LIG_LIR_Nem_3	139	144	PF02991	0.509
LIG_LIR_Nem_3	199	203	PF02991	0.507
LIG_SH2_PTP2	171	174	PF00017	0.509
LIG_SH2_SRC	161	164	PF00017	0.521
LIG_SH2_SRC	171	174	PF00017	0.521
LIG_SH2_STAP1	193	197	PF00017	0.641
LIG_SH2_STAT5	141	144	PF00017	0.509
LIG_SH2_STAT5	161	164	PF00017	0.521
LIG_SH2_STAT5	171	174	PF00017	0.521
MOD_CK1_1	222	228	PF00069	0.706
MOD_CK1_1	26	32	PF00069	0.577
MOD_CK1_1	88	94	PF00069	0.710
MOD_CK2_1	183	189	PF00069	0.499
MOD_CK2_1	213	219	PF00069	0.621
MOD_GlcNHglycan	117	120	PF01048	0.330
MOD_GlcNHglycan	223	227	PF01048	0.620
MOD_GlcNHglycan	25	29	PF01048	0.550
MOD_GlcNHglycan	79	83	PF01048	0.759
MOD_GSK3_1	175	182	PF00069	0.409
MOD_GSK3_1	218	225	PF00069	0.646
MOD_GSK3_1	44	51	PF00069	0.501
MOD_N-GLC_1	179	184	PF02516	0.205
MOD_N-GLC_1	23	28	PF02516	0.460
MOD_NEK2_1	162	167	PF00069	0.461
MOD_NEK2_1	23	28	PF00069	0.616
MOD_NEK2_1	48	53	PF00069	0.499
MOD_NEK2_1	69	74	PF00069	0.588
MOD_NEK2_2	179	184	PF00069	0.396
MOD_PIKK_1	48	54	PF00454	0.489
MOD_PKA_1	167	173	PF00069	0.396
MOD_PKA_2	167	173	PF00069	0.486
MOD_Plk_1	162	168	PF00069	0.454
MOD_Plk_1	179	185	PF00069	0.521
MOD_SUMO_for_1	133	136	PF00179	0.471
TRG_ENDOCYTIC_2	141	144	PF00928	0.509
TRG_ENDOCYTIC_2	161	164	PF00928	0.521
TRG_ER_diArg_1	166	168	PF00400	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U1	Leptomonas seymouri	58%	100%
A0A1X0P8W1	Trypanosomatidae	44%	100%
A0A3R7N573	Trypanosoma rangeli	40%	100%
A0A3S5H554	Leishmania donovani	68%	100%
A4HRV9	Leishmania infantum	69%	100%
E9ACL6	Leishmania major	71%	99%
E9AJV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%