Uroporphyrinogen-III synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uroporphyrinogen-III synthase HemD, putative

Species:

Leishmania braziliensis

UniProt:

A4H3M9_LEIBR

TriTrypDb:

LbrM.03.0580 , LBRM2903_030011600

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M9

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006778	porphyrin-containing compound metabolic process	5	6
GO:0006779	porphyrin-containing compound biosynthetic process	6	6
GO:0006782	protoporphyrinogen IX biosynthetic process	7	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0033013	tetrapyrrole metabolic process	4	6
GO:0033014	tetrapyrrole biosynthetic process	5	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0046483	heterocycle metabolic process	3	6
GO:0046501	protoporphyrinogen IX metabolic process	6	6
GO:0071704	organic substance metabolic process	2	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004852	uroporphyrinogen-III synthase activity	5	6
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	15	17	PF00082	0.527
CLV_PCSK_KEX2_1	99	101	PF00082	0.527
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.527
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.287
CLV_PCSK_SKI1_1	3	7	PF00082	0.316
CLV_PCSK_SKI1_1	46	50	PF00082	0.527
CLV_PCSK_SKI1_1	99	103	PF00082	0.436
DOC_CKS1_1	37	42	PF01111	0.527
DOC_MAPK_gen_1	15	23	PF00069	0.287
DOC_MAPK_gen_1	233	243	PF00069	0.412
DOC_PP4_FxxP_1	168	171	PF00568	0.527
DOC_USP7_MATH_1	210	214	PF00917	0.389
DOC_USP7_MATH_1	220	224	PF00917	0.484
DOC_USP7_MATH_1	60	64	PF00917	0.527
DOC_USP7_MATH_1	66	70	PF00917	0.429
DOC_WW_Pin1_4	136	141	PF00397	0.527
DOC_WW_Pin1_4	231	236	PF00397	0.527
DOC_WW_Pin1_4	36	41	PF00397	0.527
LIG_14-3-3_CanoR_1	197	204	PF00244	0.484
LIG_14-3-3_CanoR_1	88	93	PF00244	0.395
LIG_BIR_II_1	1	5	PF00653	0.471
LIG_BRCT_BRCA1_1	13	17	PF00533	0.527
LIG_FHA_1	155	161	PF00498	0.527
LIG_FHA_1	194	200	PF00498	0.527
LIG_FHA_1	2	8	PF00498	0.313
LIG_FHA_2	45	51	PF00498	0.296
LIG_LIR_Gen_1	267	276	PF02991	0.287
LIG_LIR_Gen_1	55	66	PF02991	0.371
LIG_LIR_Nem_3	267	271	PF02991	0.527
LIG_LIR_Nem_3	55	61	PF02991	0.371
LIG_NRP_CendR_1	284	285	PF00754	0.421
LIG_SH2_STAP1	13	17	PF00017	0.369
LIG_SH2_STAT5	122	125	PF00017	0.406
LIG_SH2_STAT5	194	197	PF00017	0.462
LIG_SH2_STAT5	249	252	PF00017	0.527
LIG_SH2_STAT5	58	61	PF00017	0.527
LIG_SH3_3	132	138	PF00018	0.510
LIG_SH3_3	157	163	PF00018	0.527
LIG_SH3_3	192	198	PF00018	0.462
LIG_SH3_3	4	10	PF00018	0.309
LIG_SUMO_SIM_anti_2	157	162	PF11976	0.527
LIG_SUMO_SIM_anti_2	225	232	PF11976	0.516
LIG_UBA3_1	113	118	PF00899	0.287
LIG_WRC_WIRS_1	268	273	PF05994	0.527
MOD_CDK_SPK_2	231	236	PF00069	0.418
MOD_CK2_1	220	226	PF00069	0.527
MOD_CK2_1	44	50	PF00069	0.296
MOD_Cter_Amidation	97	100	PF01082	0.287
MOD_GlcNHglycan	149	152	PF01048	0.527
MOD_GlcNHglycan	204	207	PF01048	0.339
MOD_GlcNHglycan	212	215	PF01048	0.379
MOD_GlcNHglycan	222	225	PF01048	0.350
MOD_GlcNHglycan	70	73	PF01048	0.527
MOD_GlcNHglycan	85	88	PF01048	0.281
MOD_GlcNHglycan	90	93	PF01048	0.199
MOD_GSK3_1	193	200	PF00069	0.484
MOD_GSK3_1	202	209	PF00069	0.371
MOD_GSK3_1	83	90	PF00069	0.287
MOD_GSK3_1	99	106	PF00069	0.217
MOD_NEK2_1	1	6	PF00069	0.349
MOD_NEK2_1	147	152	PF00069	0.527
MOD_PKA_1	99	105	PF00069	0.527
MOD_PKA_2	87	93	PF00069	0.383
MOD_PKA_2	99	105	PF00069	0.475
MOD_Plk_1	266	272	PF00069	0.287
MOD_Plk_2-3	267	273	PF00069	0.527
MOD_Plk_2-3	44	50	PF00069	0.287
MOD_Plk_4	1	7	PF00069	0.456
MOD_Plk_4	109	115	PF00069	0.303
MOD_Plk_4	99	105	PF00069	0.474
MOD_ProDKin_1	136	142	PF00069	0.527
MOD_ProDKin_1	231	237	PF00069	0.527
MOD_ProDKin_1	36	42	PF00069	0.527
MOD_SUMO_rev_2	91	101	PF00179	0.287
TRG_DiLeu_BaEn_1	22	27	PF01217	0.527
TRG_DiLeu_BaEn_1	226	231	PF01217	0.527
TRG_ENDOCYTIC_2	58	61	PF00928	0.527
TRG_ENDOCYTIC_2	78	81	PF00928	0.199
TRG_ER_diArg_1	126	129	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H553	Leishmania donovani	82%	100%
A4HRV6	Leishmania infantum	82%	100%
E9ACL3	Leishmania major	82%	100%
E9AJV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%