Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3M8_LEIBR

TriTrypDb:

LbrM.03.0570 , LBRM2903_030011400

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.449
CLV_NRD_NRD_1	199	201	PF00675	0.665
CLV_NRD_NRD_1	351	353	PF00675	0.494
CLV_PCSK_KEX2_1	199	201	PF00082	0.665
CLV_PCSK_KEX2_1	351	353	PF00082	0.494
CLV_PCSK_KEX2_1	7	9	PF00082	0.586
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.552
CLV_PCSK_SKI1_1	297	301	PF00082	0.503
CLV_PCSK_SKI1_1	351	355	PF00082	0.583
CLV_PCSK_SKI1_1	409	413	PF00082	0.543
DEG_Nend_UBRbox_1	1	4	PF02207	0.635
DEG_SPOP_SBC_1	97	101	PF00917	0.469
DOC_CKS1_1	30	35	PF01111	0.411
DOC_CKS1_1	50	55	PF01111	0.535
DOC_MAPK_gen_1	199	205	PF00069	0.707
DOC_PP2B_LxvP_1	38	41	PF13499	0.500
DOC_PP4_FxxP_1	80	83	PF00568	0.319
DOC_USP7_MATH_1	10	14	PF00917	0.498
DOC_USP7_MATH_1	108	112	PF00917	0.568
DOC_USP7_MATH_1	239	243	PF00917	0.647
DOC_USP7_MATH_1	304	308	PF00917	0.454
DOC_USP7_MATH_1	324	328	PF00917	0.574
DOC_USP7_MATH_1	48	52	PF00917	0.482
DOC_USP7_MATH_1	63	67	PF00917	0.397
DOC_WW_Pin1_4	163	168	PF00397	0.639
DOC_WW_Pin1_4	212	217	PF00397	0.429
DOC_WW_Pin1_4	29	34	PF00397	0.376
DOC_WW_Pin1_4	345	350	PF00397	0.445
DOC_WW_Pin1_4	360	365	PF00397	0.563
DOC_WW_Pin1_4	432	437	PF00397	0.578
DOC_WW_Pin1_4	46	51	PF00397	0.546
DOC_WW_Pin1_4	467	472	PF00397	0.599
DOC_WW_Pin1_4	92	97	PF00397	0.750
LIG_14-3-3_CanoR_1	109	117	PF00244	0.449
LIG_14-3-3_CanoR_1	183	190	PF00244	0.633
LIG_14-3-3_CanoR_1	199	205	PF00244	0.689
LIG_14-3-3_CanoR_1	252	260	PF00244	0.436
LIG_14-3-3_CanoR_1	335	343	PF00244	0.545
LIG_14-3-3_CanoR_1	360	364	PF00244	0.571
LIG_14-3-3_CanoR_1	413	420	PF00244	0.567
LIG_BRCT_BRCA1_1	549	553	PF00533	0.407
LIG_deltaCOP1_diTrp_1	225	230	PF00928	0.481
LIG_eIF4E_1	218	224	PF01652	0.391
LIG_FHA_1	133	139	PF00498	0.518
LIG_FHA_1	190	196	PF00498	0.630
LIG_FHA_1	231	237	PF00498	0.365
LIG_FHA_1	309	315	PF00498	0.362
LIG_FHA_1	413	419	PF00498	0.609
LIG_FHA_1	423	429	PF00498	0.371
LIG_FHA_1	555	561	PF00498	0.454
LIG_FHA_1	99	105	PF00498	0.626
LIG_FHA_2	335	341	PF00498	0.483
LIG_FHA_2	441	447	PF00498	0.452
LIG_GBD_Chelix_1	555	563	PF00786	0.560
LIG_LIR_Apic_2	508	513	PF02991	0.549
LIG_LIR_Apic_2	78	83	PF02991	0.298
LIG_LIR_Gen_1	125	134	PF02991	0.669
LIG_LIR_Gen_1	225	235	PF02991	0.459
LIG_LIR_Gen_1	32	42	PF02991	0.276
LIG_LIR_LC3C_4	298	302	PF02991	0.426
LIG_LIR_Nem_3	225	230	PF02991	0.342
LIG_LIR_Nem_3	278	283	PF02991	0.469
LIG_LIR_Nem_3	32	38	PF02991	0.272
LIG_LIR_Nem_3	442	448	PF02991	0.486
LIG_LIR_Nem_3	76	80	PF02991	0.371
LIG_MYND_1	79	83	PF01753	0.295
LIG_PCNA_yPIPBox_3	169	180	PF02747	0.524
LIG_Pex14_1	17	21	PF04695	0.326
LIG_Pex14_1	73	77	PF04695	0.480
LIG_Rb_LxCxE_1	540	562	PF01857	0.473
LIG_SH2_CRK	22	26	PF00017	0.446
LIG_SH2_CRK	35	39	PF00017	0.277
LIG_SH2_CRK	510	514	PF00017	0.542
LIG_SH2_GRB2like	21	24	PF00017	0.318
LIG_SH2_NCK_1	510	514	PF00017	0.542
LIG_SH2_PTP2	164	167	PF00017	0.456
LIG_SH2_STAT5	126	129	PF00017	0.485
LIG_SH2_STAT5	134	137	PF00017	0.521
LIG_SH2_STAT5	164	167	PF00017	0.606
LIG_SH3_3	111	117	PF00018	0.429
LIG_SH3_3	153	159	PF00018	0.691
LIG_SH3_3	233	239	PF00018	0.462
LIG_SH3_3	254	260	PF00018	0.433
LIG_SH3_3	298	304	PF00018	0.466
LIG_SH3_3	393	399	PF00018	0.511
LIG_SH3_3	47	53	PF00018	0.568
LIG_SH3_3	529	535	PF00018	0.571
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.456
LIG_SUMO_SIM_par_1	446	452	PF11976	0.433
LIG_SUMO_SIM_par_1	455	460	PF11976	0.465
LIG_TRFH_1	212	216	PF08558	0.404
LIG_TYR_ITIM	20	25	PF00017	0.460
MOD_CDC14_SPxK_1	166	169	PF00782	0.624
MOD_CDK_SPxK_1	163	169	PF00069	0.631
MOD_CDK_SPxK_1	345	351	PF00069	0.267
MOD_CDK_SPxK_1	469	475	PF00069	0.599
MOD_CDK_SPxxK_3	345	352	PF00069	0.397
MOD_CK1_1	307	313	PF00069	0.365
MOD_CK1_1	329	335	PF00069	0.583
MOD_CK1_1	49	55	PF00069	0.594
MOD_CK2_1	334	340	PF00069	0.522
MOD_GlcNHglycan	106	109	PF01048	0.554
MOD_GlcNHglycan	110	113	PF01048	0.501
MOD_GlcNHglycan	243	246	PF01048	0.635
MOD_GlcNHglycan	306	309	PF01048	0.399
MOD_GlcNHglycan	317	320	PF01048	0.506
MOD_GlcNHglycan	324	327	PF01048	0.599
MOD_GlcNHglycan	328	331	PF01048	0.462
MOD_GlcNHglycan	357	360	PF01048	0.470
MOD_GlcNHglycan	85	89	PF01048	0.616
MOD_GSK3_1	104	111	PF00069	0.577
MOD_GSK3_1	185	192	PF00069	0.663
MOD_GSK3_1	288	295	PF00069	0.488
MOD_GSK3_1	304	311	PF00069	0.301
MOD_GSK3_1	322	329	PF00069	0.629
MOD_GSK3_1	330	337	PF00069	0.315
MOD_GSK3_1	355	362	PF00069	0.539
MOD_GSK3_1	430	437	PF00069	0.613
MOD_GSK3_1	465	472	PF00069	0.547
MOD_GSK3_1	554	561	PF00069	0.328
MOD_GSK3_1	61	68	PF00069	0.474
MOD_GSK3_1	92	99	PF00069	0.664
MOD_N-GLC_1	64	69	PF02516	0.449
MOD_NEK2_1	230	235	PF00069	0.354
MOD_NEK2_1	248	253	PF00069	0.548
MOD_NEK2_1	276	281	PF00069	0.393
MOD_NEK2_1	322	327	PF00069	0.492
MOD_NEK2_1	367	372	PF00069	0.425
MOD_NEK2_1	422	427	PF00069	0.546
MOD_NEK2_1	430	435	PF00069	0.581
MOD_NEK2_1	466	471	PF00069	0.564
MOD_NEK2_1	505	510	PF00069	0.475
MOD_NEK2_1	559	564	PF00069	0.451
MOD_NEK2_1	91	96	PF00069	0.712
MOD_NEK2_2	330	335	PF00069	0.344
MOD_PIKK_1	251	257	PF00454	0.633
MOD_PIKK_1	440	446	PF00454	0.611
MOD_PIKK_1	554	560	PF00454	0.494
MOD_PKA_2	108	114	PF00069	0.442
MOD_PKA_2	146	152	PF00069	0.511
MOD_PKA_2	182	188	PF00069	0.618
MOD_PKA_2	198	204	PF00069	0.679
MOD_PKA_2	251	257	PF00069	0.503
MOD_PKA_2	304	310	PF00069	0.415
MOD_PKA_2	334	340	PF00069	0.549
MOD_PKA_2	359	365	PF00069	0.560
MOD_PKA_2	412	418	PF00069	0.575
MOD_Plk_1	330	336	PF00069	0.569
MOD_Plk_1	64	70	PF00069	0.465
MOD_Plk_4	191	197	PF00069	0.704
MOD_Plk_4	362	368	PF00069	0.504
MOD_Plk_4	559	565	PF00069	0.524
MOD_Plk_4	65	71	PF00069	0.456
MOD_ProDKin_1	163	169	PF00069	0.631
MOD_ProDKin_1	212	218	PF00069	0.421
MOD_ProDKin_1	29	35	PF00069	0.379
MOD_ProDKin_1	345	351	PF00069	0.445
MOD_ProDKin_1	360	366	PF00069	0.552
MOD_ProDKin_1	432	438	PF00069	0.587
MOD_ProDKin_1	46	52	PF00069	0.547
MOD_ProDKin_1	467	473	PF00069	0.598
MOD_ProDKin_1	92	98	PF00069	0.750
TRG_DiLeu_BaEn_2	396	402	PF01217	0.507
TRG_DiLeu_BaEn_2	75	81	PF01217	0.446
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.582
TRG_ENDOCYTIC_2	126	129	PF00928	0.544
TRG_ENDOCYTIC_2	21	24	PF00928	0.464
TRG_ENDOCYTIC_2	280	283	PF00928	0.412
TRG_ENDOCYTIC_2	35	38	PF00928	0.269
TRG_ENDOCYTIC_2	77	80	PF00928	0.362
TRG_ER_diArg_1	350	352	PF00400	0.565
TRG_ER_diArg_1	426	429	PF00400	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSY5	Leptomonas seymouri	55%	98%
A0A0S4J7P5	Bodo saltans	24%	100%
A0A1X0P955	Trypanosomatidae	30%	100%
A0A3S5H552	Leishmania donovani	85%	100%
A0A422NMI0	Trypanosoma rangeli	31%	100%
D0A270	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ACL2	Leishmania major	85%	100%
E9AG56	Leishmania infantum	85%	100%
E9AJV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BXE2	Trypanosoma cruzi	32%	100%