Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3M7_LEIBR

TriTrypDb:

LbrM.03.0560 , LBRM2903_030011300

Length:

803

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H3M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	509	513	PF00656	0.617
CLV_C14_Caspase3-7	560	564	PF00656	0.748
CLV_C14_Caspase3-7	91	95	PF00656	0.634
CLV_NRD_NRD_1	210	212	PF00675	0.353
CLV_NRD_NRD_1	228	230	PF00675	0.280
CLV_NRD_NRD_1	297	299	PF00675	0.338
CLV_NRD_NRD_1	362	364	PF00675	0.472
CLV_NRD_NRD_1	97	99	PF00675	0.533
CLV_PCSK_FUR_1	226	230	PF00082	0.303
CLV_PCSK_KEX2_1	210	212	PF00082	0.353
CLV_PCSK_KEX2_1	228	230	PF00082	0.280
CLV_PCSK_KEX2_1	297	299	PF00082	0.338
CLV_PCSK_KEX2_1	362	364	PF00082	0.482
CLV_PCSK_KEX2_1	7	9	PF00082	0.396
CLV_PCSK_KEX2_1	96	98	PF00082	0.532
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.396
CLV_PCSK_PC7_1	206	212	PF00082	0.350
CLV_PCSK_SKI1_1	123	127	PF00082	0.448
CLV_PCSK_SKI1_1	233	237	PF00082	0.290
CLV_PCSK_SKI1_1	355	359	PF00082	0.380
CLV_PCSK_SKI1_1	677	681	PF00082	0.571
CLV_PCSK_SKI1_1	97	101	PF00082	0.466
CLV_Separin_Metazoa	10	14	PF03568	0.611
DEG_APCC_DBOX_1	228	236	PF00400	0.548
DEG_ODPH_VHL_1	191	204	PF01847	0.572
DEG_SCF_FBW7_1	99	106	PF00400	0.635
DOC_ANK_TNKS_1	391	398	PF00023	0.333
DOC_CKS1_1	100	105	PF01111	0.633
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.380
DOC_MAPK_gen_1	210	217	PF00069	0.549
DOC_MAPK_gen_1	297	303	PF00069	0.534
DOC_MAPK_gen_1	359	369	PF00069	0.670
DOC_MAPK_gen_1	6	14	PF00069	0.702
DOC_MAPK_HePTP_8	4	16	PF00069	0.701
DOC_MAPK_MEF2A_6	233	240	PF00069	0.565
DOC_MAPK_MEF2A_6	36	44	PF00069	0.633
DOC_MAPK_MEF2A_6	398	405	PF00069	0.328
DOC_MAPK_MEF2A_6	7	16	PF00069	0.707
DOC_PP1_RVXF_1	231	238	PF00149	0.490
DOC_PP2B_LxvP_1	191	194	PF13499	0.591
DOC_PP2B_LxvP_1	406	409	PF13499	0.380
DOC_PP4_FxxP_1	100	103	PF00568	0.677
DOC_PP4_FxxP_1	275	278	PF00568	0.380
DOC_USP7_MATH_1	103	107	PF00917	0.717
DOC_USP7_MATH_1	168	172	PF00917	0.662
DOC_USP7_MATH_1	184	188	PF00917	0.601
DOC_USP7_MATH_1	216	220	PF00917	0.520
DOC_USP7_MATH_1	321	325	PF00917	0.380
DOC_USP7_MATH_1	340	344	PF00917	0.208
DOC_USP7_MATH_1	46	50	PF00917	0.713
DOC_USP7_MATH_1	530	534	PF00917	0.651
DOC_USP7_MATH_1	556	560	PF00917	0.733
DOC_USP7_MATH_1	570	574	PF00917	0.645
DOC_USP7_MATH_1	712	716	PF00917	0.447
DOC_USP7_MATH_1	79	83	PF00917	0.647
DOC_WW_Pin1_4	132	137	PF00397	0.647
DOC_WW_Pin1_4	265	270	PF00397	0.413
DOC_WW_Pin1_4	42	47	PF00397	0.642
DOC_WW_Pin1_4	479	484	PF00397	0.638
DOC_WW_Pin1_4	573	578	PF00397	0.711
DOC_WW_Pin1_4	64	69	PF00397	0.646
DOC_WW_Pin1_4	719	724	PF00397	0.439
DOC_WW_Pin1_4	740	745	PF00397	0.421
DOC_WW_Pin1_4	75	80	PF00397	0.661
DOC_WW_Pin1_4	99	104	PF00397	0.650
LIG_14-3-3_CanoR_1	123	132	PF00244	0.685
LIG_14-3-3_CanoR_1	154	162	PF00244	0.693
LIG_14-3-3_CanoR_1	228	233	PF00244	0.564
LIG_14-3-3_CanoR_1	64	68	PF00244	0.650
LIG_14-3-3_CanoR_1	788	796	PF00244	0.694
LIG_Actin_WH2_2	220	235	PF00022	0.503
LIG_Actin_WH2_2	344	361	PF00022	0.242
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BIR_III_2	654	658	PF00653	0.487
LIG_BRCT_BRCA1_1	299	303	PF00533	0.572
LIG_BRCT_BRCA1_1	406	410	PF00533	0.521
LIG_BRCT_BRCA1_1	465	469	PF00533	0.744
LIG_Clathr_ClatBox_1	798	802	PF01394	0.599
LIG_deltaCOP1_diTrp_1	396	405	PF00928	0.328
LIG_eIF4E_1	498	504	PF01652	0.673
LIG_FHA_1	162	168	PF00498	0.632
LIG_FHA_1	282	288	PF00498	0.364
LIG_FHA_1	332	338	PF00498	0.381
LIG_FHA_1	472	478	PF00498	0.630
LIG_FHA_1	479	485	PF00498	0.617
LIG_FHA_1	529	535	PF00498	0.660
LIG_FHA_1	58	64	PF00498	0.663
LIG_FHA_1	645	651	PF00498	0.380
LIG_FHA_2	148	154	PF00498	0.640
LIG_FHA_2	17	23	PF00498	0.717
LIG_FHA_2	438	444	PF00498	0.609
LIG_FHA_2	679	685	PF00498	0.374
LIG_FHA_2	89	95	PF00498	0.637
LIG_LIR_Apic_2	273	278	PF02991	0.380
LIG_LIR_Gen_1	199	209	PF02991	0.607
LIG_LIR_Gen_1	284	293	PF02991	0.310
LIG_LIR_Gen_1	419	429	PF02991	0.551
LIG_LIR_Gen_1	666	676	PF02991	0.288
LIG_LIR_Nem_3	199	204	PF02991	0.611
LIG_LIR_Nem_3	284	289	PF02991	0.322
LIG_LIR_Nem_3	384	389	PF02991	0.539
LIG_LIR_Nem_3	396	402	PF02991	0.350
LIG_LIR_Nem_3	407	413	PF02991	0.337
LIG_LIR_Nem_3	419	424	PF02991	0.464
LIG_LIR_Nem_3	666	672	PF02991	0.290
LIG_LIR_Nem_3	743	749	PF02991	0.296
LIG_NRBOX	284	290	PF00104	0.380
LIG_PCNA_PIPBox_1	252	261	PF02747	0.415
LIG_Pex14_1	259	263	PF04695	0.462
LIG_Pex14_1	325	329	PF04695	0.423
LIG_Pex14_1	400	404	PF04695	0.528
LIG_Pex14_1	417	421	PF04695	0.450
LIG_Pex14_2	113	117	PF04695	0.633
LIG_Pex14_2	282	286	PF04695	0.380
LIG_Pex14_2	352	356	PF04695	0.387
LIG_Pex14_2	686	690	PF04695	0.458
LIG_PTAP_UEV_1	80	85	PF05743	0.640
LIG_SH2_CRK	293	297	PF00017	0.503
LIG_SH2_CRK	386	390	PF00017	0.400
LIG_SH2_CRK	421	425	PF00017	0.540
LIG_SH2_CRK	688	692	PF00017	0.401
LIG_SH2_CRK	747	751	PF00017	0.306
LIG_SH2_GRB2like	705	708	PF00017	0.564
LIG_SH2_GRB2like	746	749	PF00017	0.313
LIG_SH2_NCK_1	747	751	PF00017	0.306
LIG_SH2_SRC	705	708	PF00017	0.415
LIG_SH2_STAP1	272	276	PF00017	0.328
LIG_SH2_STAP1	329	333	PF00017	0.384
LIG_SH2_STAP1	349	353	PF00017	0.199
LIG_SH2_STAP1	709	713	PF00017	0.528
LIG_SH2_STAP1	778	782	PF00017	0.569
LIG_SH2_STAT5	201	204	PF00017	0.614
LIG_SH2_STAT5	272	275	PF00017	0.328
LIG_SH2_STAT5	293	296	PF00017	0.443
LIG_SH2_STAT5	333	336	PF00017	0.406
LIG_SH2_STAT5	368	371	PF00017	0.498
LIG_SH2_STAT5	425	428	PF00017	0.641
LIG_SH2_STAT5	688	691	PF00017	0.402
LIG_SH2_STAT5	692	695	PF00017	0.396
LIG_SH2_STAT5	700	703	PF00017	0.383
LIG_SH2_STAT5	705	708	PF00017	0.410
LIG_SH2_STAT5	762	765	PF00017	0.363
LIG_SH3_3	191	197	PF00018	0.605
LIG_SH3_3	727	733	PF00018	0.380
LIG_SH3_3	78	84	PF00018	0.659
LIG_SH3_5	197	201	PF00018	0.569
LIG_SUMO_SIM_anti_2	725	731	PF11976	0.528
LIG_SUMO_SIM_par_1	481	487	PF11976	0.688
LIG_SUMO_SIM_par_1	728	734	PF11976	0.380
LIG_SUMO_SIM_par_1	797	802	PF11976	0.598
LIG_TRAF2_1	69	72	PF00917	0.652
LIG_WW_1	193	196	PF00397	0.571
MOD_CK1_1	118	124	PF00069	0.716
MOD_CK1_1	175	181	PF00069	0.636
MOD_CK1_1	262	268	PF00069	0.402
MOD_CK1_1	332	338	PF00069	0.402
MOD_CK1_1	448	454	PF00069	0.626
MOD_CK1_1	45	51	PF00069	0.735
MOD_CK1_1	463	469	PF00069	0.622
MOD_CK1_1	493	499	PF00069	0.669
MOD_CK1_1	53	59	PF00069	0.688
MOD_CK1_1	573	579	PF00069	0.638
MOD_CK1_1	715	721	PF00069	0.380
MOD_CK1_1	722	728	PF00069	0.316
MOD_CK2_1	147	153	PF00069	0.640
MOD_CK2_1	437	443	PF00069	0.599
MOD_CK2_1	479	485	PF00069	0.628
MOD_CK2_1	678	684	PF00069	0.276
MOD_CK2_1	787	793	PF00069	0.653
MOD_GlcNHglycan	126	129	PF01048	0.427
MOD_GlcNHglycan	175	178	PF01048	0.420
MOD_GlcNHglycan	450	453	PF01048	0.510
MOD_GlcNHglycan	464	468	PF01048	0.444
MOD_GlcNHglycan	48	51	PF01048	0.505
MOD_GlcNHglycan	52	55	PF01048	0.502
MOD_GlcNHglycan	572	575	PF01048	0.445
MOD_GlcNHglycan	665	668	PF01048	0.587
MOD_GlcNHglycan	709	712	PF01048	0.360
MOD_GlcNHglycan	81	84	PF01048	0.446
MOD_GSK3_1	115	122	PF00069	0.692
MOD_GSK3_1	168	175	PF00069	0.635
MOD_GSK3_1	321	328	PF00069	0.491
MOD_GSK3_1	42	49	PF00069	0.734
MOD_GSK3_1	459	466	PF00069	0.718
MOD_GSK3_1	528	535	PF00069	0.735
MOD_GSK3_1	53	60	PF00069	0.674
MOD_GSK3_1	659	666	PF00069	0.383
MOD_GSK3_1	715	722	PF00069	0.380
MOD_GSK3_1	75	82	PF00069	0.679
MOD_GSK3_1	88	95	PF00069	0.649
MOD_GSK3_1	99	106	PF00069	0.640
MOD_LATS_1	786	792	PF00433	0.547
MOD_N-GLC_1	270	275	PF02516	0.656
MOD_N-GLC_1	75	80	PF02516	0.559
MOD_N-GLC_2	344	346	PF02516	0.380
MOD_NEK2_1	119	124	PF00069	0.682
MOD_NEK2_1	204	209	PF00069	0.673
MOD_NEK2_1	281	286	PF00069	0.372
MOD_NEK2_1	311	316	PF00069	0.376
MOD_NEK2_1	358	363	PF00069	0.629
MOD_NEK2_1	373	378	PF00069	0.363
MOD_NEK2_1	381	386	PF00069	0.367
MOD_NEK2_1	404	409	PF00069	0.521
MOD_NEK2_1	614	619	PF00069	0.572
MOD_NEK2_1	63	68	PF00069	0.650
MOD_NEK2_1	644	649	PF00069	0.528
MOD_NEK2_1	690	695	PF00069	0.528
MOD_NEK2_1	696	701	PF00069	0.429
MOD_NEK2_1	74	79	PF00069	0.646
MOD_NEK2_2	368	373	PF00069	0.380
MOD_NEK2_2	678	683	PF00069	0.373
MOD_PIKK_1	161	167	PF00454	0.672
MOD_PIKK_1	612	618	PF00454	0.716
MOD_PIKK_1	715	721	PF00454	0.380
MOD_PK_1	211	217	PF00069	0.613
MOD_PKA_1	228	234	PF00069	0.501
MOD_PKA_1	297	303	PF00069	0.534
MOD_PKA_2	153	159	PF00069	0.696
MOD_PKA_2	228	234	PF00069	0.602
MOD_PKA_2	297	303	PF00069	0.579
MOD_PKA_2	358	364	PF00069	0.481
MOD_PKA_2	437	443	PF00069	0.528
MOD_PKA_2	63	69	PF00069	0.646
MOD_PKA_2	787	793	PF00069	0.680
MOD_PKB_1	226	234	PF00069	0.500
MOD_PKB_1	436	444	PF00069	0.624
MOD_Plk_1	270	276	PF00069	0.434
MOD_Plk_1	626	632	PF00069	0.557
MOD_Plk_1	638	644	PF00069	0.272
MOD_Plk_2-3	766	772	PF00069	0.579
MOD_Plk_4	281	287	PF00069	0.346
MOD_Plk_4	291	297	PF00069	0.316
MOD_Plk_4	321	327	PF00069	0.528
MOD_Plk_4	368	374	PF00069	0.499
MOD_Plk_4	381	387	PF00069	0.290
MOD_Plk_4	416	422	PF00069	0.465
MOD_Plk_4	465	471	PF00069	0.742
MOD_Plk_4	490	496	PF00069	0.609
MOD_Plk_4	614	620	PF00069	0.647
MOD_Plk_4	626	632	PF00069	0.513
MOD_Plk_4	712	718	PF00069	0.410
MOD_Plk_4	88	94	PF00069	0.665
MOD_ProDKin_1	132	138	PF00069	0.648
MOD_ProDKin_1	265	271	PF00069	0.406
MOD_ProDKin_1	42	48	PF00069	0.641
MOD_ProDKin_1	479	485	PF00069	0.639
MOD_ProDKin_1	573	579	PF00069	0.711
MOD_ProDKin_1	64	70	PF00069	0.647
MOD_ProDKin_1	719	725	PF00069	0.439
MOD_ProDKin_1	740	746	PF00069	0.418
MOD_ProDKin_1	75	81	PF00069	0.657
MOD_ProDKin_1	99	105	PF00069	0.651
MOD_SUMO_rev_2	766	774	PF00179	0.554
MOD_SUMO_rev_2	777	782	PF00179	0.520
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.584
TRG_ENDOCYTIC_2	201	204	PF00928	0.614
TRG_ENDOCYTIC_2	272	275	PF00928	0.328
TRG_ENDOCYTIC_2	293	296	PF00928	0.562
TRG_ENDOCYTIC_2	349	352	PF00928	0.402
TRG_ENDOCYTIC_2	386	389	PF00928	0.400
TRG_ENDOCYTIC_2	421	424	PF00928	0.541
TRG_ENDOCYTIC_2	688	691	PF00928	0.382
TRG_ENDOCYTIC_2	746	749	PF00928	0.328
TRG_ER_diArg_1	209	211	PF00400	0.555
TRG_ER_diArg_1	226	229	PF00400	0.482
TRG_ER_diArg_1	296	298	PF00400	0.588
TRG_ER_diArg_1	435	438	PF00400	0.598
TRG_ER_diArg_1	96	98	PF00400	0.732
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJR6	Leishmania donovani	72%	100%
A4HDG5	Leishmania braziliensis	24%	100%
E9ACL1	Leishmania major	67%	94%
E9AG55	Leishmania infantum	72%	100%
E9AJU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%