LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
A4H3M6_LEIBR
TriTrypDb:
LbrM.03.0550 , LBRM2903_030011200 *
Length:
772

Annotations

LeishMANIAdb annotations

This highly expanded family of Kinetoplastid transporters is likely responsible for the uptake of critical nutrients. Might be a thiamine transporter if relate to human SLC35F proteins.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4H3M6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 41 45 PF00656 0.594
CLV_C14_Caspase3-7 427 431 PF00656 0.392
CLV_NRD_NRD_1 206 208 PF00675 0.341
CLV_NRD_NRD_1 304 306 PF00675 0.367
CLV_NRD_NRD_1 742 744 PF00675 0.546
CLV_NRD_NRD_1 747 749 PF00675 0.536
CLV_PCSK_FUR_1 740 744 PF00082 0.549
CLV_PCSK_KEX2_1 206 208 PF00082 0.386
CLV_PCSK_KEX2_1 304 306 PF00082 0.367
CLV_PCSK_KEX2_1 742 744 PF00082 0.546
CLV_PCSK_KEX2_1 746 748 PF00082 0.538
CLV_PCSK_PC7_1 742 748 PF00082 0.536
CLV_PCSK_SKI1_1 362 366 PF00082 0.297
DEG_Nend_UBRbox_2 1 3 PF02207 0.560
DEG_SPOP_SBC_1 118 122 PF00917 0.603
DOC_CYCLIN_RxL_1 359 367 PF00134 0.396
DOC_CYCLIN_yCln2_LP_2 639 645 PF00134 0.317
DOC_MAPK_gen_1 304 310 PF00069 0.592
DOC_MAPK_gen_1 312 321 PF00069 0.465
DOC_MAPK_gen_1 746 755 PF00069 0.654
DOC_MAPK_HePTP_8 21 33 PF00069 0.601
DOC_MAPK_MEF2A_6 24 33 PF00069 0.603
DOC_MAPK_MEF2A_6 314 323 PF00069 0.443
DOC_MAPK_MEF2A_6 369 378 PF00069 0.520
DOC_PP1_RVXF_1 695 701 PF00149 0.458
DOC_PP2B_LxvP_1 452 455 PF13499 0.379
DOC_USP7_MATH_1 118 122 PF00917 0.603
DOC_USP7_MATH_1 17 21 PF00917 0.600
DOC_USP7_MATH_1 251 255 PF00917 0.546
DOC_USP7_MATH_1 263 267 PF00917 0.529
DOC_USP7_MATH_1 274 278 PF00917 0.394
DOC_USP7_MATH_1 32 36 PF00917 0.584
DOC_USP7_MATH_1 328 332 PF00917 0.317
DOC_USP7_MATH_1 388 392 PF00917 0.377
DOC_USP7_MATH_1 429 433 PF00917 0.347
DOC_USP7_MATH_1 523 527 PF00917 0.672
DOC_USP7_MATH_1 705 709 PF00917 0.682
DOC_USP7_MATH_1 711 715 PF00917 0.663
DOC_USP7_UBL2_3 362 366 PF12436 0.521
DOC_WW_Pin1_4 119 124 PF00397 0.608
DOC_WW_Pin1_4 137 142 PF00397 0.603
DOC_WW_Pin1_4 168 173 PF00397 0.688
DOC_WW_Pin1_4 189 194 PF00397 0.622
DOC_WW_Pin1_4 25 30 PF00397 0.671
DOC_WW_Pin1_4 338 343 PF00397 0.324
DOC_WW_Pin1_4 658 663 PF00397 0.398
LIG_14-3-3_CanoR_1 207 217 PF00244 0.510
LIG_14-3-3_CanoR_1 24 29 PF00244 0.637
LIG_14-3-3_CanoR_1 470 480 PF00244 0.602
LIG_14-3-3_CanoR_1 627 633 PF00244 0.545
LIG_14-3-3_CanoR_1 68 73 PF00244 0.784
LIG_14-3-3_CanoR_1 746 756 PF00244 0.682
LIG_APCC_ABBA_1 541 546 PF00400 0.527
LIG_APCC_ABBA_1 679 684 PF00400 0.353
LIG_BIR_III_2 573 577 PF00653 0.371
LIG_BIR_III_2 659 663 PF00653 0.396
LIG_BIR_III_4 16 20 PF00653 0.596
LIG_BRCT_BRCA1_1 356 360 PF00533 0.384
LIG_BRCT_BRCA1_1 611 615 PF00533 0.376
LIG_BRCT_BRCA1_2 356 362 PF00533 0.377
LIG_FHA_1 209 215 PF00498 0.516
LIG_FHA_1 222 228 PF00498 0.374
LIG_FHA_1 25 31 PF00498 0.598
LIG_FHA_1 278 284 PF00498 0.318
LIG_FHA_1 339 345 PF00498 0.331
LIG_FHA_1 359 365 PF00498 0.368
LIG_FHA_1 476 482 PF00498 0.514
LIG_FHA_1 611 617 PF00498 0.320
LIG_FHA_1 642 648 PF00498 0.326
LIG_FHA_1 67 73 PF00498 0.659
LIG_FHA_2 120 126 PF00498 0.792
LIG_FHA_2 197 203 PF00498 0.599
LIG_FHA_2 36 42 PF00498 0.727
LIG_FHA_2 425 431 PF00498 0.420
LIG_FHA_2 470 476 PF00498 0.576
LIG_FHA_2 57 63 PF00498 0.641
LIG_FHA_2 685 691 PF00498 0.501
LIG_FHA_2 78 84 PF00498 0.670
LIG_GBD_Chelix_1 294 302 PF00786 0.298
LIG_IBAR_NPY_1 373 375 PF08397 0.461
LIG_LIR_Apic_2 189 193 PF02991 0.624
LIG_LIR_Apic_2 370 374 PF02991 0.567
LIG_LIR_Gen_1 199 208 PF02991 0.673
LIG_LIR_Gen_1 277 287 PF02991 0.346
LIG_LIR_Gen_1 291 301 PF02991 0.311
LIG_LIR_Gen_1 372 383 PF02991 0.501
LIG_LIR_Gen_1 391 397 PF02991 0.432
LIG_LIR_Gen_1 612 623 PF02991 0.370
LIG_LIR_Gen_1 661 672 PF02991 0.265
LIG_LIR_Gen_1 719 728 PF02991 0.566
LIG_LIR_Gen_1 750 760 PF02991 0.716
LIG_LIR_LC3C_4 202 205 PF02991 0.515
LIG_LIR_Nem_3 199 203 PF02991 0.607
LIG_LIR_Nem_3 277 282 PF02991 0.422
LIG_LIR_Nem_3 291 296 PF02991 0.383
LIG_LIR_Nem_3 372 378 PF02991 0.460
LIG_LIR_Nem_3 379 383 PF02991 0.287
LIG_LIR_Nem_3 391 396 PF02991 0.433
LIG_LIR_Nem_3 612 618 PF02991 0.371
LIG_LIR_Nem_3 661 667 PF02991 0.256
LIG_LIR_Nem_3 719 723 PF02991 0.559
LIG_LIR_Nem_3 750 755 PF02991 0.710
LIG_LYPXL_SIV_4 374 382 PF13949 0.377
LIG_NRBOX 212 218 PF00104 0.390
LIG_Pex14_1 240 244 PF04695 0.329
LIG_Pex14_1 446 450 PF04695 0.307
LIG_Pex14_1 463 467 PF04695 0.493
LIG_Pex14_2 232 236 PF04695 0.437
LIG_Pex14_2 289 293 PF04695 0.315
LIG_RPA_C_Fungi 202 214 PF08784 0.400
LIG_SH2_CRK 148 152 PF00017 0.534
LIG_SH2_CRK 356 360 PF00017 0.285
LIG_SH2_CRK 371 375 PF00017 0.268
LIG_SH2_CRK 607 611 PF00017 0.327
LIG_SH2_GRB2like 371 374 PF00017 0.444
LIG_SH2_GRB2like 624 627 PF00017 0.346
LIG_SH2_NCK_1 336 340 PF00017 0.458
LIG_SH2_NCK_1 356 360 PF00017 0.483
LIG_SH2_NCK_1 371 375 PF00017 0.330
LIG_SH2_NCK_1 4 8 PF00017 0.436
LIG_SH2_PTP2 375 378 PF00017 0.377
LIG_SH2_PTP2 664 667 PF00017 0.377
LIG_SH2_PTP2 752 755 PF00017 0.537
LIG_SH2_SRC 116 119 PF00017 0.668
LIG_SH2_SRC 490 493 PF00017 0.482
LIG_SH2_STAP1 279 283 PF00017 0.377
LIG_SH2_STAP1 356 360 PF00017 0.410
LIG_SH2_STAP1 4 8 PF00017 0.536
LIG_SH2_STAP1 628 632 PF00017 0.320
LIG_SH2_STAT5 109 112 PF00017 0.579
LIG_SH2_STAT5 279 282 PF00017 0.443
LIG_SH2_STAT5 371 374 PF00017 0.415
LIG_SH2_STAT5 375 378 PF00017 0.354
LIG_SH2_STAT5 395 398 PF00017 0.267
LIG_SH2_STAT5 471 474 PF00017 0.424
LIG_SH2_STAT5 480 483 PF00017 0.457
LIG_SH2_STAT5 490 493 PF00017 0.540
LIG_SH2_STAT5 607 610 PF00017 0.300
LIG_SH2_STAT5 619 622 PF00017 0.301
LIG_SH2_STAT5 624 627 PF00017 0.356
LIG_SH2_STAT5 664 667 PF00017 0.289
LIG_SH2_STAT5 680 683 PF00017 0.352
LIG_SH2_STAT5 752 755 PF00017 0.579
LIG_SH3_2 29 34 PF14604 0.496
LIG_SH3_3 108 114 PF00018 0.507
LIG_SH3_3 166 172 PF00018 0.664
LIG_SH3_3 26 32 PF00018 0.566
LIG_SH3_3 284 290 PF00018 0.298
LIG_SH3_3 510 516 PF00018 0.588
LIG_SH3_3 531 537 PF00018 0.522
LIG_SH3_3 565 571 PF00018 0.366
LIG_SH3_3 757 763 PF00018 0.539
LIG_Sin3_3 292 299 PF02671 0.199
LIG_SUMO_SIM_anti_2 644 650 PF11976 0.331
LIG_SUMO_SIM_par_1 52 60 PF11976 0.590
LIG_SUMO_SIM_par_1 551 559 PF11976 0.377
LIG_SUMO_SIM_par_1 669 674 PF11976 0.297
LIG_TRAF2_1 687 690 PF00917 0.396
LIG_WRC_WIRS_1 279 284 PF05994 0.394
LIG_WRC_WIRS_1 289 294 PF05994 0.407
LIG_WRC_WIRS_1 377 382 PF05994 0.367
LIG_WRC_WIRS_1 425 430 PF05994 0.432
MOD_CK1_1 171 177 PF00069 0.507
MOD_CK1_1 196 202 PF00069 0.446
MOD_CK1_1 254 260 PF00069 0.625
MOD_CK1_1 261 267 PF00069 0.667
MOD_CK1_1 277 283 PF00069 0.425
MOD_CK1_1 35 41 PF00069 0.691
MOD_CK1_1 407 413 PF00069 0.695
MOD_CK1_1 43 49 PF00069 0.611
MOD_CK1_1 432 438 PF00069 0.574
MOD_CK1_1 634 640 PF00069 0.334
MOD_CK1_1 674 680 PF00069 0.418
MOD_CK2_1 196 202 PF00069 0.467
MOD_CK2_1 470 476 PF00069 0.281
MOD_CK2_1 580 586 PF00069 0.414
MOD_CK2_1 684 690 PF00069 0.330
MOD_CK2_1 716 722 PF00069 0.594
MOD_CK2_1 77 83 PF00069 0.674
MOD_GlcNHglycan 253 256 PF01048 0.670
MOD_GlcNHglycan 261 264 PF01048 0.719
MOD_GlcNHglycan 265 268 PF01048 0.695
MOD_GlcNHglycan 284 287 PF01048 0.317
MOD_GlcNHglycan 330 333 PF01048 0.317
MOD_GlcNHglycan 356 359 PF01048 0.420
MOD_GlcNHglycan 405 409 PF01048 0.717
MOD_GlcNHglycan 436 439 PF01048 0.460
MOD_GlcNHglycan 51 54 PF01048 0.595
MOD_GlcNHglycan 517 520 PF01048 0.772
MOD_GlcNHglycan 621 624 PF01048 0.315
MOD_GlcNHglycan 639 642 PF01048 0.207
MOD_GlcNHglycan 713 716 PF01048 0.641
MOD_GSK3_1 182 189 PF00069 0.588
MOD_GSK3_1 246 253 PF00069 0.557
MOD_GSK3_1 254 261 PF00069 0.638
MOD_GSK3_1 274 281 PF00069 0.431
MOD_GSK3_1 354 361 PF00069 0.384
MOD_GSK3_1 40 47 PF00069 0.662
MOD_GSK3_1 400 407 PF00069 0.643
MOD_GSK3_1 430 437 PF00069 0.534
MOD_GSK3_1 450 457 PF00069 0.370
MOD_GSK3_1 471 478 PF00069 0.339
MOD_GSK3_1 56 63 PF00069 0.598
MOD_GSK3_1 637 644 PF00069 0.317
MOD_GSK3_1 650 657 PF00069 0.412
MOD_GSK3_1 723 730 PF00069 0.632
MOD_GSK3_1 91 98 PF00069 0.520
MOD_LATS_1 402 408 PF00433 0.410
MOD_LATS_1 745 751 PF00433 0.580
MOD_N-GLC_1 246 251 PF02516 0.595
MOD_N-GLC_1 589 594 PF02516 0.340
MOD_N-GLC_1 60 65 PF02516 0.672
MOD_N-GLC_1 654 659 PF02516 0.478
MOD_N-GLC_1 74 79 PF02516 0.517
MOD_N-GLC_1 95 100 PF02516 0.527
MOD_NEK2_1 186 191 PF00069 0.699
MOD_NEK2_1 221 226 PF00069 0.354
MOD_NEK2_1 256 261 PF00069 0.686
MOD_NEK2_1 275 280 PF00069 0.450
MOD_NEK2_1 282 287 PF00069 0.342
MOD_NEK2_1 294 299 PF00069 0.305
MOD_NEK2_1 348 353 PF00069 0.307
MOD_NEK2_1 382 387 PF00069 0.346
MOD_NEK2_1 450 455 PF00069 0.365
MOD_NEK2_1 578 583 PF00069 0.461
MOD_NEK2_1 610 615 PF00069 0.308
MOD_NEK2_1 671 676 PF00069 0.298
MOD_NEK2_1 728 733 PF00069 0.519
MOD_NEK2_1 95 100 PF00069 0.527
MOD_NEK2_2 388 393 PF00069 0.377
MOD_NEK2_2 580 585 PF00069 0.385
MOD_NEK2_2 663 668 PF00069 0.377
MOD_NEK2_2 9 14 PF00069 0.454
MOD_PIKK_1 407 413 PF00454 0.537
MOD_PIKK_1 634 640 PF00454 0.377
MOD_PIKK_1 66 72 PF00454 0.609
MOD_PIKK_1 728 734 PF00454 0.690
MOD_PIKK_1 95 101 PF00454 0.527
MOD_PKA_1 747 753 PF00069 0.642
MOD_PKA_2 23 29 PF00069 0.520
MOD_PKA_2 469 475 PF00069 0.486
MOD_PKA_2 626 632 PF00069 0.415
MOD_PKA_2 747 753 PF00069 0.707
MOD_PKA_2 77 83 PF00069 0.554
MOD_Plk_1 475 481 PF00069 0.365
MOD_Plk_1 546 552 PF00069 0.379
MOD_Plk_1 60 66 PF00069 0.511
MOD_Plk_1 684 690 PF00069 0.449
MOD_Plk_1 723 729 PF00069 0.665
MOD_Plk_2-3 684 690 PF00069 0.353
MOD_Plk_4 17 23 PF00069 0.671
MOD_Plk_4 182 188 PF00069 0.768
MOD_Plk_4 196 202 PF00069 0.500
MOD_Plk_4 209 215 PF00069 0.314
MOD_Plk_4 221 227 PF00069 0.169
MOD_Plk_4 278 284 PF00069 0.377
MOD_Plk_4 288 294 PF00069 0.345
MOD_Plk_4 348 354 PF00069 0.270
MOD_Plk_4 376 382 PF00069 0.332
MOD_Plk_4 388 394 PF00069 0.243
MOD_Plk_4 454 460 PF00069 0.377
MOD_Plk_4 462 468 PF00069 0.388
MOD_Plk_4 631 637 PF00069 0.314
MOD_Plk_4 663 669 PF00069 0.327
MOD_Plk_4 674 680 PF00069 0.304
MOD_ProDKin_1 119 125 PF00069 0.507
MOD_ProDKin_1 137 143 PF00069 0.496
MOD_ProDKin_1 168 174 PF00069 0.616
MOD_ProDKin_1 189 195 PF00069 0.511
MOD_ProDKin_1 25 31 PF00069 0.595
MOD_ProDKin_1 338 344 PF00069 0.385
MOD_ProDKin_1 658 664 PF00069 0.487
MOD_SUMO_for_1 698 701 PF00179 0.358
MOD_SUMO_rev_2 684 693 PF00179 0.449
TRG_DiLeu_BaLyEn_6 26 31 PF01217 0.596
TRG_ENDOCYTIC_2 148 151 PF00928 0.535
TRG_ENDOCYTIC_2 279 282 PF00928 0.448
TRG_ENDOCYTIC_2 356 359 PF00928 0.380
TRG_ENDOCYTIC_2 375 378 PF00928 0.398
TRG_ENDOCYTIC_2 607 610 PF00928 0.327
TRG_ENDOCYTIC_2 664 667 PF00928 0.284
TRG_ENDOCYTIC_2 720 723 PF00928 0.540
TRG_ENDOCYTIC_2 752 755 PF00928 0.655
TRG_ER_diArg_1 205 207 PF00400 0.442
TRG_ER_diArg_1 303 305 PF00400 0.470
TRG_ER_diArg_1 739 742 PF00400 0.694
TRG_ER_diArg_1 746 748 PF00400 0.690
TRG_NES_CRM1_1 562 573 PF08389 0.331

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I037 Leptomonas seymouri 56% 79%
A0A1X0NW47 Trypanosomatidae 24% 100%
A0A1X0P8U7 Trypanosomatidae 39% 100%
A0A3S5H7D1 Leishmania donovani 25% 100%
A0A451EJR5 Leishmania donovani 68% 87%
A4I0U6 Leishmania infantum 25% 100%
D0A268 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9ACL0 Leishmania major 68% 100%
E9AG54 Leishmania infantum 68% 87%
E9AJU8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 87%
E9AWV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4QAM4 Leishmania major 27% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS