Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3M5_LEIBR

TriTrypDb:

LbrM.03.0540 , LBRM2903_030011100

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.570
CLV_C14_Caspase3-7	47	51	PF00656	0.397
CLV_C14_Caspase3-7	59	63	PF00656	0.502
CLV_NRD_NRD_1	3	5	PF00675	0.616
CLV_NRD_NRD_1	348	350	PF00675	0.422
CLV_NRD_NRD_1	421	423	PF00675	0.591
CLV_NRD_NRD_1	500	502	PF00675	0.413
CLV_NRD_NRD_1	57	59	PF00675	0.367
CLV_PCSK_KEX2_1	3	5	PF00082	0.616
CLV_PCSK_KEX2_1	348	350	PF00082	0.470
CLV_PCSK_KEX2_1	499	501	PF00082	0.405
CLV_PCSK_KEX2_1	57	59	PF00082	0.367
CLV_PCSK_KEX2_1	600	602	PF00082	0.487
CLV_PCSK_PC1ET2_1	600	602	PF00082	0.509
CLV_PCSK_SKI1_1	110	114	PF00082	0.443
CLV_PCSK_SKI1_1	167	171	PF00082	0.406
CLV_PCSK_SKI1_1	256	260	PF00082	0.620
CLV_PCSK_SKI1_1	291	295	PF00082	0.592
CLV_PCSK_SKI1_1	318	322	PF00082	0.326
CLV_PCSK_SKI1_1	350	354	PF00082	0.641
CLV_PCSK_SKI1_1	465	469	PF00082	0.373
CLV_PCSK_SKI1_1	488	492	PF00082	0.581
CLV_PCSK_SKI1_1	508	512	PF00082	0.364
CLV_PCSK_SKI1_1	555	559	PF00082	0.417
CLV_Separin_Metazoa	288	292	PF03568	0.498
DEG_APCC_DBOX_1	310	318	PF00400	0.449
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DEG_ODPH_VHL_1	385	397	PF01847	0.277
DEG_SPOP_SBC_1	245	249	PF00917	0.684
DOC_CKS1_1	476	481	PF01111	0.316
DOC_CYCLIN_RxL_1	347	355	PF00134	0.564
DOC_CYCLIN_RxL_1	462	469	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.303
DOC_MAPK_FxFP_2	29	32	PF00069	0.410
DOC_MAPK_gen_1	308	317	PF00069	0.393
DOC_MAPK_gen_1	348	354	PF00069	0.547
DOC_MAPK_JIP1_4	311	317	PF00069	0.405
DOC_MAPK_MEF2A_6	274	281	PF00069	0.312
DOC_MAPK_MEF2A_6	308	316	PF00069	0.326
DOC_MAPK_MEF2A_6	318	325	PF00069	0.318
DOC_MAPK_MEF2A_6	360	368	PF00069	0.371
DOC_MAPK_MEF2A_6	488	497	PF00069	0.427
DOC_MAPK_NFAT4_5	274	282	PF00069	0.284
DOC_MAPK_NFAT4_5	488	496	PF00069	0.310
DOC_MAPK_RevD_3	43	58	PF00069	0.317
DOC_PP2B_LxvP_1	321	324	PF13499	0.351
DOC_PP2B_LxvP_1	446	449	PF13499	0.314
DOC_PP2B_LxvP_1	491	494	PF13499	0.545
DOC_PP4_FxxP_1	29	32	PF00568	0.410
DOC_SPAK_OSR1_1	144	148	PF12202	0.257
DOC_USP7_MATH_1	219	223	PF00917	0.680
DOC_USP7_MATH_1	225	229	PF00917	0.720
DOC_USP7_MATH_1	246	250	PF00917	0.624
DOC_USP7_MATH_1	417	421	PF00917	0.514
DOC_USP7_MATH_1	477	481	PF00917	0.472
DOC_USP7_MATH_1	67	71	PF00917	0.706
DOC_USP7_UBL2_3	106	110	PF12436	0.448
DOC_WW_Pin1_4	127	132	PF00397	0.454
DOC_WW_Pin1_4	2	7	PF00397	0.663
DOC_WW_Pin1_4	247	252	PF00397	0.638
DOC_WW_Pin1_4	475	480	PF00397	0.340
LIG_14-3-3_CanoR_1	13	18	PF00244	0.510
LIG_14-3-3_CanoR_1	84	90	PF00244	0.548
LIG_Actin_RPEL_3	353	372	PF02755	0.539
LIG_Actin_WH2_2	275	293	PF00022	0.449
LIG_APCC_ABBA_1	395	400	PF00400	0.432
LIG_BIR_III_2	603	607	PF00653	0.455
LIG_BIR_III_4	400	404	PF00653	0.494
LIG_BIR_III_4	50	54	PF00653	0.457
LIG_BRCT_BRCA1_1	480	484	PF00533	0.504
LIG_Clathr_ClatBox_1	112	116	PF01394	0.484
LIG_CtBP_PxDLS_1	24	28	PF00389	0.483
LIG_EH1_1	592	600	PF00400	0.438
LIG_FHA_1	191	197	PF00498	0.334
LIG_FHA_1	324	330	PF00498	0.363
LIG_FHA_1	433	439	PF00498	0.367
LIG_FHA_1	454	460	PF00498	0.555
LIG_FHA_1	84	90	PF00498	0.620
LIG_FHA_2	301	307	PF00498	0.537
LIG_FHA_2	409	415	PF00498	0.521
LIG_FHA_2	562	568	PF00498	0.466
LIG_LIR_Apic_2	26	32	PF02991	0.397
LIG_LIR_Apic_2	306	312	PF02991	0.432
LIG_LIR_Gen_1	273	282	PF02991	0.484
LIG_LIR_Gen_1	440	449	PF02991	0.416
LIG_LIR_Gen_1	481	491	PF02991	0.475
LIG_LIR_Nem_3	263	267	PF02991	0.518
LIG_LIR_Nem_3	273	279	PF02991	0.489
LIG_LIR_Nem_3	440	444	PF02991	0.325
LIG_LIR_Nem_3	481	487	PF02991	0.487
LIG_LYPXL_S_1	516	520	PF13949	0.521
LIG_MYND_1	215	219	PF01753	0.463
LIG_NRBOX	316	322	PF00104	0.450
LIG_NRBOX	367	373	PF00104	0.445
LIG_PCNA_yPIPBox_3	283	291	PF02747	0.423
LIG_PDZ_Class_2	602	607	PF00595	0.447
LIG_Pex14_2	201	205	PF04695	0.325
LIG_SH2_CRK	369	373	PF00017	0.392
LIG_SH2_GRB2like	178	181	PF00017	0.343
LIG_SH2_NCK_1	405	409	PF00017	0.519
LIG_SH2_SRC	342	345	PF00017	0.438
LIG_SH2_SRC	405	408	PF00017	0.578
LIG_SH2_SRC	543	546	PF00017	0.348
LIG_SH2_STAP1	141	145	PF00017	0.383
LIG_SH2_STAP1	159	163	PF00017	0.444
LIG_SH2_STAP1	434	438	PF00017	0.309
LIG_SH2_STAP1	441	445	PF00017	0.302
LIG_SH2_STAP1	576	580	PF00017	0.357
LIG_SH2_STAT5	276	279	PF00017	0.455
LIG_SH2_STAT5	30	33	PF00017	0.439
LIG_SH2_STAT5	335	338	PF00017	0.432
LIG_SH2_STAT5	342	345	PF00017	0.465
LIG_SH2_STAT5	434	437	PF00017	0.328
LIG_SH2_STAT5	543	546	PF00017	0.348
LIG_SH3_2	251	256	PF14604	0.483
LIG_SH3_3	125	131	PF00018	0.567
LIG_SH3_3	209	215	PF00018	0.641
LIG_SH3_3	248	254	PF00018	0.503
LIG_SH3_3	473	479	PF00018	0.383
LIG_SUMO_SIM_anti_2	111	116	PF11976	0.482
LIG_SUMO_SIM_par_1	111	116	PF11976	0.482
LIG_SUMO_SIM_par_1	472	478	PF11976	0.424
LIG_TRAF2_1	584	587	PF00917	0.410
LIG_TRFH_1	468	472	PF08558	0.404
LIG_TYR_ITIM	574	579	PF00017	0.339
LIG_UBA3_1	314	318	PF00899	0.317
LIG_UBA3_1	353	358	PF00899	0.532
LIG_WRC_WIRS_1	17	22	PF05994	0.519
LIG_WW_3	250	254	PF00397	0.496
MOD_CDC14_SPxK_1	250	253	PF00782	0.581
MOD_CDK_SPK_2	2	7	PF00069	0.579
MOD_CDK_SPxK_1	247	253	PF00069	0.589
MOD_CK1_1	108	114	PF00069	0.276
MOD_CK1_1	16	22	PF00069	0.511
MOD_CK1_1	228	234	PF00069	0.747
MOD_CK1_1	237	243	PF00069	0.775
MOD_CK1_1	244	250	PF00069	0.683
MOD_CK1_1	63	69	PF00069	0.563
MOD_CK1_1	74	80	PF00069	0.694
MOD_CK2_1	300	306	PF00069	0.542
MOD_CK2_1	561	567	PF00069	0.436
MOD_CK2_1	581	587	PF00069	0.264
MOD_CK2_1	97	103	PF00069	0.552
MOD_GlcNHglycan	123	126	PF01048	0.436
MOD_GlcNHglycan	236	239	PF01048	0.783
MOD_GlcNHglycan	551	554	PF01048	0.348
MOD_GlcNHglycan	65	68	PF01048	0.719
MOD_GlcNHglycan	69	72	PF01048	0.728
MOD_GlcNHglycan	73	76	PF01048	0.690
MOD_GlcNHglycan	89	92	PF01048	0.418
MOD_GSK3_1	12	19	PF00069	0.470
MOD_GSK3_1	179	186	PF00069	0.375
MOD_GSK3_1	224	231	PF00069	0.765
MOD_GSK3_1	233	240	PF00069	0.786
MOD_GSK3_1	241	248	PF00069	0.654
MOD_GSK3_1	478	485	PF00069	0.444
MOD_GSK3_1	551	558	PF00069	0.336
MOD_GSK3_1	56	63	PF00069	0.608
MOD_GSK3_1	67	74	PF00069	0.702
MOD_GSK3_1	80	87	PF00069	0.568
MOD_GSK3_1	89	96	PF00069	0.643
MOD_LATS_1	297	303	PF00433	0.346
MOD_N-GLC_1	148	153	PF02516	0.532
MOD_N-GLC_1	179	184	PF02516	0.348
MOD_N-GLC_1	409	414	PF02516	0.600
MOD_NEK2_1	544	549	PF00069	0.339
MOD_NEK2_1	561	566	PF00069	0.376
MOD_PK_1	13	19	PF00069	0.583
MOD_PKA_1	499	505	PF00069	0.371
MOD_PKA_2	12	18	PF00069	0.486
MOD_PKA_2	233	239	PF00069	0.510
MOD_PKA_2	499	505	PF00069	0.485
MOD_PKA_2	56	62	PF00069	0.601
MOD_PKA_2	83	89	PF00069	0.495
MOD_PKB_1	58	66	PF00069	0.415
MOD_Plk_1	179	185	PF00069	0.364
MOD_Plk_1	409	415	PF00069	0.646
MOD_Plk_1	97	103	PF00069	0.615
MOD_Plk_4	108	114	PF00069	0.502
MOD_Plk_4	16	22	PF00069	0.456
MOD_Plk_4	478	484	PF00069	0.557
MOD_Plk_4	526	532	PF00069	0.349
MOD_ProDKin_1	127	133	PF00069	0.448
MOD_ProDKin_1	2	8	PF00069	0.662
MOD_ProDKin_1	247	253	PF00069	0.637
MOD_ProDKin_1	475	481	PF00069	0.355
MOD_SUMO_rev_2	416	425	PF00179	0.599
MOD_SUMO_rev_2	584	591	PF00179	0.385
TRG_DiLeu_BaEn_1	263	268	PF01217	0.314
TRG_DiLeu_BaEn_1	594	599	PF01217	0.405
TRG_DiLeu_BaEn_4	287	293	PF01217	0.497
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.442
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.470
TRG_ENDOCYTIC_2	276	279	PF00928	0.407
TRG_ENDOCYTIC_2	369	372	PF00928	0.390
TRG_ENDOCYTIC_2	441	444	PF00928	0.326
TRG_ENDOCYTIC_2	517	520	PF00928	0.537
TRG_ENDOCYTIC_2	576	579	PF00928	0.349
TRG_ER_diArg_1	2	4	PF00400	0.631
TRG_ER_diArg_1	499	501	PF00400	0.441
TRG_ER_diArg_1	57	60	PF00400	0.379
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	514	519	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q3	Leptomonas seymouri	63%	99%
A0A0S4JDH1	Bodo saltans	29%	100%
A0A1X0P9P0	Trypanosomatidae	48%	100%
A0A422NMG4	Trypanosoma rangeli	48%	100%
A0A451EJR4	Leishmania donovani	87%	100%
D0A267	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9ACK9	Leishmania major	87%	100%
E9AG53	Leishmania infantum	87%	100%
E9AJU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BSR7	Trypanosoma cruzi	47%	100%