Putative MP99

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative MP99

Gene product:

mitochondrial protein 99, putative

Species:

Leishmania braziliensis

UniProt:

A4H3M3_LEIBR

TriTrypDb:

LbrM.03.0520 , LBRM2903_030010800

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016605	PML body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	1
GO:0008081	phosphoric diester hydrolase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.500
CLV_C14_Caspase3-7	485	489	PF00656	0.736
CLV_C14_Caspase3-7	530	534	PF00656	0.352
CLV_C14_Caspase3-7	573	577	PF00656	0.495
CLV_C14_Caspase3-7	653	657	PF00656	0.535
CLV_NRD_NRD_1	119	121	PF00675	0.225
CLV_NRD_NRD_1	125	127	PF00675	0.483
CLV_NRD_NRD_1	277	279	PF00675	0.524
CLV_NRD_NRD_1	549	551	PF00675	0.559
CLV_NRD_NRD_1	95	97	PF00675	0.427
CLV_NRD_NRD_1	99	101	PF00675	0.417
CLV_PCSK_KEX2_1	119	121	PF00082	0.508
CLV_PCSK_KEX2_1	125	127	PF00082	0.519
CLV_PCSK_KEX2_1	277	279	PF00082	0.434
CLV_PCSK_KEX2_1	553	555	PF00082	0.488
CLV_PCSK_KEX2_1	95	97	PF00082	0.411
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.353
CLV_PCSK_SKI1_1	119	123	PF00082	0.561
CLV_PCSK_SKI1_1	277	281	PF00082	0.419
CLV_PCSK_SKI1_1	339	343	PF00082	0.536
CLV_PCSK_SKI1_1	355	359	PF00082	0.438
CLV_PCSK_SKI1_1	374	378	PF00082	0.265
CLV_PCSK_SKI1_1	553	557	PF00082	0.385
DEG_APCC_DBOX_1	282	290	PF00400	0.487
DEG_APCC_DBOX_1	358	366	PF00400	0.476
DEG_APCC_DBOX_1	99	107	PF00400	0.484
DEG_Kelch_Keap1_1	657	662	PF01344	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	651	655	PF00917	0.521
DOC_ANK_TNKS_1	612	619	PF00023	0.542
DOC_CKS1_1	154	159	PF01111	0.530
DOC_CKS1_1	166	171	PF01111	0.384
DOC_CKS1_1	197	202	PF01111	0.595
DOC_CKS1_1	329	334	PF01111	0.458
DOC_CYCLIN_RxL_1	95	108	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.346
DOC_MAPK_gen_1	100	107	PF00069	0.263
DOC_MAPK_gen_1	444	454	PF00069	0.563
DOC_MAPK_MEF2A_6	100	107	PF00069	0.260
DOC_MAPK_MEF2A_6	283	291	PF00069	0.353
DOC_MAPK_MEF2A_6	355	362	PF00069	0.458
DOC_MAPK_MEF2A_6	374	383	PF00069	0.487
DOC_MAPK_NFAT4_5	100	108	PF00069	0.400
DOC_PP1_RVXF_1	337	344	PF00149	0.551
DOC_PP2B_LxvP_1	305	308	PF13499	0.301
DOC_USP7_MATH_1	39	43	PF00917	0.333
DOC_USP7_MATH_1	424	428	PF00917	0.718
DOC_USP7_MATH_1	568	572	PF00917	0.685
DOC_USP7_MATH_1	651	655	PF00917	0.658
DOC_USP7_MATH_1	666	670	PF00917	0.532
DOC_USP7_MATH_1	99	103	PF00917	0.393
DOC_WW_Pin1_4	134	139	PF00397	0.371
DOC_WW_Pin1_4	153	158	PF00397	0.426
DOC_WW_Pin1_4	165	170	PF00397	0.353
DOC_WW_Pin1_4	196	201	PF00397	0.481
DOC_WW_Pin1_4	220	225	PF00397	0.411
DOC_WW_Pin1_4	328	333	PF00397	0.682
DOC_WW_Pin1_4	415	420	PF00397	0.480
DOC_WW_Pin1_4	490	495	PF00397	0.612
LIG_14-3-3_CanoR_1	100	104	PF00244	0.422
LIG_14-3-3_CanoR_1	130	140	PF00244	0.472
LIG_14-3-3_CanoR_1	277	286	PF00244	0.340
LIG_14-3-3_CanoR_1	31	40	PF00244	0.574
LIG_14-3-3_CanoR_1	337	342	PF00244	0.563
LIG_14-3-3_CanoR_1	388	397	PF00244	0.416
LIG_14-3-3_CanoR_1	447	454	PF00244	0.522
LIG_14-3-3_CanoR_1	527	532	PF00244	0.592
LIG_14-3-3_CanoR_1	677	682	PF00244	0.788
LIG_14-3-3_CanoR_1	87	93	PF00244	0.518
LIG_Actin_WH2_2	243	259	PF00022	0.558
LIG_APCC_ABBAyCdc20_2	339	345	PF00400	0.531
LIG_BIR_III_4	587	591	PF00653	0.502
LIG_BRCT_BRCA1_1	339	343	PF00533	0.536
LIG_BRCT_BRCA1_1	602	606	PF00533	0.473
LIG_CSL_BTD_1	416	419	PF09270	0.589
LIG_eIF4E_1	67	73	PF01652	0.573
LIG_FHA_1	166	172	PF00498	0.518
LIG_FHA_1	204	210	PF00498	0.437
LIG_FHA_1	282	288	PF00498	0.348
LIG_FHA_1	296	302	PF00498	0.411
LIG_FHA_1	3	9	PF00498	0.696
LIG_FHA_1	401	407	PF00498	0.503
LIG_FHA_1	437	443	PF00498	0.601
LIG_FHA_1	456	462	PF00498	0.528
LIG_FHA_1	505	511	PF00498	0.496
LIG_FHA_1	540	546	PF00498	0.483
LIG_FHA_1	550	556	PF00498	0.472
LIG_FHA_1	67	73	PF00498	0.489
LIG_FHA_1	89	95	PF00498	0.485
LIG_FHA_2	148	154	PF00498	0.565
LIG_FHA_2	200	206	PF00498	0.482
LIG_FHA_2	393	399	PF00498	0.538
LIG_FHA_2	501	507	PF00498	0.401
LIG_FHA_2	511	517	PF00498	0.424
LIG_FHA_2	528	534	PF00498	0.513
LIG_FHA_2	571	577	PF00498	0.663
LIG_LIR_Apic_2	488	494	PF02991	0.599
LIG_LIR_Gen_1	223	233	PF02991	0.462
LIG_LIR_Gen_1	246	256	PF02991	0.417
LIG_LIR_Gen_1	314	322	PF02991	0.453
LIG_LIR_Gen_1	603	612	PF02991	0.456
LIG_LIR_Nem_3	214	220	PF02991	0.437
LIG_LIR_Nem_3	223	228	PF02991	0.443
LIG_LIR_Nem_3	246	252	PF02991	0.460
LIG_LIR_Nem_3	38	43	PF02991	0.449
LIG_LIR_Nem_3	443	448	PF02991	0.565
LIG_LIR_Nem_3	603	607	PF02991	0.386
LIG_MAD2	371	379	PF02301	0.306
LIG_NRBOX	102	108	PF00104	0.468
LIG_NRBOX	251	257	PF00104	0.575
LIG_NRBOX	287	293	PF00104	0.481
LIG_NRBOX	364	370	PF00104	0.483
LIG_PCNA_PIPBox_1	1	10	PF02747	0.671
LIG_SH2_STAP1	127	131	PF00017	0.544
LIG_SH2_STAT5	10	13	PF00017	0.667
LIG_SH2_STAT5	141	144	PF00017	0.444
LIG_SH2_STAT5	179	182	PF00017	0.464
LIG_SH2_STAT5	290	293	PF00017	0.371
LIG_SH2_STAT5	316	319	PF00017	0.455
LIG_SH2_STAT5	459	462	PF00017	0.490
LIG_SH2_STAT5	491	494	PF00017	0.570
LIG_SH2_STAT5	67	70	PF00017	0.519
LIG_SH3_3	163	169	PF00018	0.461
LIG_SH3_3	188	194	PF00018	0.579
LIG_SH3_3	207	213	PF00018	0.486
LIG_SH3_3	378	384	PF00018	0.620
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.329
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.411
LIG_SUMO_SIM_par_1	179	185	PF11976	0.407
LIG_SUMO_SIM_par_1	438	443	PF11976	0.613
LIG_SUMO_SIM_par_1	506	511	PF11976	0.448
LIG_SUMO_SIM_par_1	54	59	PF11976	0.491
LIG_TRAF2_1	563	566	PF00917	0.596
LIG_Vh1_VBS_1	545	563	PF01044	0.552
LIG_WRC_WIRS_1	601	606	PF05994	0.315
MOD_CK1_1	134	140	PF00069	0.380
MOD_CK1_1	20	26	PF00069	0.720
MOD_CK1_1	427	433	PF00069	0.726
MOD_CK1_1	579	585	PF00069	0.531
MOD_CK1_1	634	640	PF00069	0.465
MOD_CK1_1	642	648	PF00069	0.566
MOD_CK1_1	652	658	PF00069	0.703
MOD_CK2_1	147	153	PF00069	0.590
MOD_CK2_1	239	245	PF00069	0.427
MOD_CK2_1	392	398	PF00069	0.568
MOD_CK2_1	479	485	PF00069	0.665
MOD_CK2_1	500	506	PF00069	0.420
MOD_CK2_1	656	662	PF00069	0.723
MOD_Cter_Amidation	123	126	PF01082	0.494
MOD_GlcNHglycan	163	166	PF01048	0.435
MOD_GlcNHglycan	176	179	PF01048	0.328
MOD_GlcNHglycan	19	22	PF01048	0.725
MOD_GlcNHglycan	408	411	PF01048	0.385
MOD_GlcNHglycan	429	432	PF01048	0.728
MOD_GlcNHglycan	448	451	PF01048	0.501
MOD_GlcNHglycan	471	474	PF01048	0.715
MOD_GlcNHglycan	481	484	PF01048	0.699
MOD_GlcNHglycan	488	491	PF01048	0.564
MOD_GlcNHglycan	570	573	PF01048	0.691
MOD_GlcNHglycan	674	677	PF01048	0.752
MOD_GSK3_1	16	23	PF00069	0.694
MOD_GSK3_1	161	168	PF00069	0.507
MOD_GSK3_1	199	206	PF00069	0.511
MOD_GSK3_1	239	246	PF00069	0.428
MOD_GSK3_1	260	267	PF00069	0.509
MOD_GSK3_1	277	284	PF00069	0.507
MOD_GSK3_1	388	395	PF00069	0.530
MOD_GSK3_1	411	418	PF00069	0.538
MOD_GSK3_1	427	434	PF00069	0.609
MOD_GSK3_1	455	462	PF00069	0.509
MOD_GSK3_1	475	482	PF00069	0.460
MOD_GSK3_1	486	493	PF00069	0.558
MOD_GSK3_1	500	507	PF00069	0.513
MOD_GSK3_1	596	603	PF00069	0.435
MOD_GSK3_1	652	659	PF00069	0.678
MOD_LATS_1	29	35	PF00433	0.346
MOD_N-GLC_1	203	208	PF02516	0.306
MOD_N-GLC_1	226	231	PF02516	0.390
MOD_N-GLC_1	31	36	PF02516	0.477
MOD_N-GLC_1	436	441	PF02516	0.677
MOD_N-GLC_1	579	584	PF02516	0.529
MOD_N-GLC_1	639	644	PF02516	0.661
MOD_N-GLC_1	656	661	PF02516	0.651
MOD_N-GLC_1	677	682	PF02516	0.543
MOD_NEK2_1	147	152	PF00069	0.549
MOD_NEK2_1	406	411	PF00069	0.390
MOD_NEK2_1	436	441	PF00069	0.641
MOD_NEK2_1	500	505	PF00069	0.437
MOD_NEK2_1	508	513	PF00069	0.382
MOD_NEK2_1	606	611	PF00069	0.555
MOD_NEK2_1	61	66	PF00069	0.493
MOD_NEK2_1	650	655	PF00069	0.739
MOD_PIKK_1	31	37	PF00454	0.343
MOD_PIKK_1	411	417	PF00454	0.576
MOD_PIKK_1	510	516	PF00454	0.451
MOD_PIKK_1	561	567	PF00454	0.609
MOD_PK_1	337	343	PF00069	0.582
MOD_PKA_1	277	283	PF00069	0.268
MOD_PKA_2	147	153	PF00069	0.557
MOD_PKA_2	277	283	PF00069	0.268
MOD_PKA_2	30	36	PF00069	0.469
MOD_PKA_2	387	393	PF00069	0.554
MOD_PKA_2	446	452	PF00069	0.558
MOD_PKA_2	549	555	PF00069	0.580
MOD_PKA_2	568	574	PF00069	0.500
MOD_PKA_2	78	84	PF00069	0.397
MOD_PKA_2	99	105	PF00069	0.486
MOD_Plk_1	203	209	PF00069	0.403
MOD_Plk_1	226	232	PF00069	0.390
MOD_Plk_1	31	37	PF00069	0.343
MOD_Plk_1	56	62	PF00069	0.475
MOD_Plk_4	239	245	PF00069	0.523
MOD_Plk_4	392	398	PF00069	0.523
MOD_Plk_4	431	437	PF00069	0.683
MOD_Plk_4	455	461	PF00069	0.465
MOD_Plk_4	504	510	PF00069	0.427
MOD_Plk_4	56	62	PF00069	0.463
MOD_Plk_4	600	606	PF00069	0.318
MOD_Plk_4	88	94	PF00069	0.477
MOD_ProDKin_1	134	140	PF00069	0.371
MOD_ProDKin_1	153	159	PF00069	0.425
MOD_ProDKin_1	165	171	PF00069	0.348
MOD_ProDKin_1	196	202	PF00069	0.475
MOD_ProDKin_1	220	226	PF00069	0.412
MOD_ProDKin_1	328	334	PF00069	0.681
MOD_ProDKin_1	415	421	PF00069	0.490
MOD_ProDKin_1	490	496	PF00069	0.610
MOD_SUMO_for_1	628	631	PF00179	0.556
MOD_SUMO_rev_2	462	467	PF00179	0.611
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.257
TRG_ENDOCYTIC_2	316	319	PF00928	0.455
TRG_ENDOCYTIC_2	621	624	PF00928	0.471
TRG_ER_diArg_1	119	121	PF00400	0.503
TRG_ER_diArg_1	125	127	PF00400	0.546
TRG_ER_diArg_1	277	279	PF00400	0.524
TRG_ER_diArg_1	358	361	PF00400	0.491
TRG_ER_diArg_1	94	96	PF00400	0.449
TRG_NLS_MonoExtC_3	549	554	PF00514	0.334
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUJ3	Leptomonas seymouri	56%	100%
A0A0S4J9X6	Bodo saltans	31%	84%
A0A1X0P940	Trypanosomatidae	42%	76%
A0A3S5H550	Leishmania donovani	78%	100%
A0A422NMS5	Trypanosoma rangeli	40%	75%
C9ZRZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	76%
D0A265	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	73%
E9AG51	Leishmania infantum	78%	100%
E9AJU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q6T444	Leishmania major	77%	98%