Kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase-like protein

Gene product:

kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H3M2_LEIBR

TriTrypDb:

LbrM.03.0510 , LBRM2903_030010700

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0003924	GTPase activity	7	8
GO:0005488	binding	1	8
GO:0005525	GTP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	8
GO:0019001	guanyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032561	guanyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.272
CLV_NRD_NRD_1	212	214	PF00675	0.306
CLV_NRD_NRD_1	23	25	PF00675	0.462
CLV_NRD_NRD_1	276	278	PF00675	0.302
CLV_NRD_NRD_1	297	299	PF00675	0.489
CLV_PCSK_KEX2_1	23	25	PF00082	0.462
CLV_PCSK_KEX2_1	276	278	PF00082	0.302
CLV_PCSK_KEX2_1	297	299	PF00082	0.489
CLV_PCSK_SKI1_1	172	176	PF00082	0.272
CLV_PCSK_SKI1_1	213	217	PF00082	0.218
CLV_PCSK_SKI1_1	23	27	PF00082	0.401
CLV_PCSK_SKI1_1	239	243	PF00082	0.218
CLV_PCSK_SKI1_1	28	32	PF00082	0.300
CLV_PCSK_SKI1_1	62	66	PF00082	0.332
DEG_COP1_1	245	255	PF00400	0.352
DEG_Nend_UBRbox_3	1	3	PF02207	0.477
DEG_SCF_SKP2-CKS1_1	346	353	PF00560	0.486
DOC_CKS1_1	315	320	PF01111	0.309
DOC_CYCLIN_yCln2_LP_2	181	184	PF00134	0.272
DOC_MAPK_gen_1	112	120	PF00069	0.190
DOC_MAPK_gen_1	194	200	PF00069	0.272
DOC_MAPK_gen_1	87	97	PF00069	0.332
DOC_MAPK_MEF2A_6	172	181	PF00069	0.272
DOC_MAPK_MEF2A_6	58	65	PF00069	0.221
DOC_MAPK_MEF2A_6	87	94	PF00069	0.332
DOC_PP2B_LxvP_1	180	183	PF13499	0.272
DOC_PP4_FxxP_1	237	240	PF00568	0.332
DOC_USP7_MATH_1	128	132	PF00917	0.280
DOC_USP7_MATH_1	33	37	PF00917	0.356
DOC_USP7_MATH_1	38	42	PF00917	0.307
DOC_USP7_MATH_1	71	75	PF00917	0.184
DOC_WW_Pin1_4	126	131	PF00397	0.272
DOC_WW_Pin1_4	314	319	PF00397	0.457
DOC_WW_Pin1_4	347	352	PF00397	0.559
DOC_WW_Pin1_4	65	70	PF00397	0.280
LIG_14-3-3_CanoR_1	276	282	PF00244	0.332
LIG_APCC_ABBAyCdc20_2	226	232	PF00400	0.332
LIG_BIR_III_2	348	352	PF00653	0.485
LIG_deltaCOP1_diTrp_1	254	263	PF00928	0.283
LIG_eIF4E_1	287	293	PF01652	0.272
LIG_FHA_1	159	165	PF00498	0.272
LIG_FHA_1	223	229	PF00498	0.190
LIG_FHA_1	52	58	PF00498	0.242
LIG_FHA_2	111	117	PF00498	0.272
LIG_FHA_2	205	211	PF00498	0.272
LIG_FHA_2	263	269	PF00498	0.470
LIG_FHA_2	29	35	PF00498	0.272
LIG_FHA_2	315	321	PF00498	0.414
LIG_FHA_2	327	333	PF00498	0.478
LIG_LIR_Apic_2	124	128	PF02991	0.341
LIG_LIR_Gen_1	140	151	PF02991	0.395
LIG_LIR_Gen_1	254	262	PF02991	0.332
LIG_LIR_Nem_3	140	146	PF02991	0.395
LIG_NRBOX	43	49	PF00104	0.352
LIG_Pex14_2	154	158	PF04695	0.332
LIG_Pex14_2	284	288	PF04695	0.272
LIG_SH2_PTP2	125	128	PF00017	0.332
LIG_SH2_STAP1	224	228	PF00017	0.332
LIG_SH2_STAT5	125	128	PF00017	0.332
LIG_SH2_STAT5	224	227	PF00017	0.340
LIG_SH2_STAT5	230	233	PF00017	0.325
LIG_SH2_STAT5	287	290	PF00017	0.272
LIG_SH2_STAT5	3	6	PF00017	0.552
LIG_SH2_STAT5	83	86	PF00017	0.308
LIG_SH3_3	1	7	PF00018	0.578
LIG_SUMO_SIM_anti_2	323	329	PF11976	0.480
LIG_SUMO_SIM_par_1	144	150	PF11976	0.373
LIG_SUMO_SIM_par_1	196	202	PF11976	0.272
LIG_SUMO_SIM_par_1	240	245	PF11976	0.272
LIG_SUMO_SIM_par_1	93	98	PF11976	0.295
LIG_TRAF2_1	245	248	PF00917	0.352
MOD_CDK_SPK_2	314	319	PF00069	0.457
MOD_CDK_SPxK_1	347	353	PF00069	0.488
MOD_CK1_1	101	107	PF00069	0.272
MOD_CK1_1	222	228	PF00069	0.252
MOD_CK2_1	110	116	PF00069	0.272
MOD_CK2_1	183	189	PF00069	0.272
MOD_CK2_1	242	248	PF00069	0.420
MOD_CK2_1	262	268	PF00069	0.290
MOD_CK2_1	28	34	PF00069	0.277
MOD_CK2_1	314	320	PF00069	0.427
MOD_CK2_1	326	332	PF00069	0.477
MOD_GlcNHglycan	130	133	PF01048	0.332
MOD_GlcNHglycan	185	188	PF01048	0.304
MOD_GlcNHglycan	221	224	PF01048	0.397
MOD_GlcNHglycan	244	247	PF01048	0.332
MOD_GlcNHglycan	268	271	PF01048	0.275
MOD_GlcNHglycan	65	68	PF01048	0.276
MOD_GSK3_1	262	269	PF00069	0.301
MOD_GSK3_1	28	35	PF00069	0.273
MOD_GSK3_1	38	45	PF00069	0.245
MOD_GSK3_1	52	59	PF00069	0.290
MOD_GSK3_1	97	104	PF00069	0.272
MOD_NEK2_1	158	163	PF00069	0.296
MOD_NEK2_1	262	267	PF00069	0.339
MOD_NEK2_1	32	37	PF00069	0.332
MOD_NEK2_1	63	68	PF00069	0.332
MOD_NEK2_1	76	81	PF00069	0.332
MOD_NEK2_2	38	43	PF00069	0.265
MOD_PIKK_1	166	172	PF00454	0.332
MOD_PKA_2	42	48	PF00069	0.218
MOD_Plk_1	110	116	PF00069	0.272
MOD_Plk_4	104	110	PF00069	0.272
MOD_Plk_4	121	127	PF00069	0.272
MOD_ProDKin_1	126	132	PF00069	0.272
MOD_ProDKin_1	314	320	PF00069	0.457
MOD_ProDKin_1	347	353	PF00069	0.563
MOD_ProDKin_1	65	71	PF00069	0.280
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.190
TRG_ENDOCYTIC_2	285	288	PF00928	0.364
TRG_ER_diArg_1	275	277	PF00400	0.302
TRG_ER_diArg_1	297	299	PF00400	0.494
TRG_NLS_MonoExtN_4	87	92	PF00514	0.190
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.218
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P9	Leptomonas seymouri	80%	100%
A0A0S4JDW1	Bodo saltans	55%	87%
A0A451EJR1	Leishmania donovani	88%	100%
A8XGZ9	Caenorhabditis briggsae	39%	86%
E9ACK6	Leishmania major	87%	100%
E9AG50	Leishmania infantum	87%	100%
E9AJU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O28980	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	32%	100%
O58012	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	32%	100%
P27254	Escherichia coli (strain K12)	38%	100%
P37895	Caulobacter vibrioides (strain ATCC 19089 / CB15)	44%	100%
P63578	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	43%	100%
P9WPZ0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	100%
P9WPZ1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
Q22111	Caenorhabditis elegans	38%	88%
Q8C7H1	Mus musculus	38%	85%
Q8IVH4	Homo sapiens	39%	84%
Q9V225	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%