LeishMANIAdb
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Putative DNA repair helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative DNA repair helicase
Gene product:
DNA repair helicase, putative (fragment)
Species:
Leishmania braziliensis
UniProt:
A4H3M1_LEIBR
TriTrypDb:
LbrM.03.0500 , LBRM2903_150018000 *
Length:
899

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005654 nucleoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H3M1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 5
GO:0006725 cellular aromatic compound metabolic process 3 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0006996 organelle organization 4 1
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0032392 DNA geometric change 7 1
GO:0032508 DNA duplex unwinding 8 1
GO:0034085 establishment of sister chromatid cohesion 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0046483 heterocycle metabolic process 3 5
GO:0051276 chromosome organization 5 1
GO:0071103 DNA conformation change 6 1
GO:0071704 organic substance metabolic process 2 5
GO:0071840 cellular component organization or biogenesis 2 1
GO:1901360 organic cyclic compound metabolic process 3 5
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003676 nucleic acid binding 3 7
GO:0003677 DNA binding 4 7
GO:0003678 DNA helicase activity 3 7
GO:0003824 catalytic activity 1 7
GO:0004386 helicase activity 2 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0008094 ATP-dependent activity, acting on DNA 2 7
GO:0016787 hydrolase activity 2 7
GO:0016817 hydrolase activity, acting on acid anhydrides 3 7
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140097 catalytic activity, acting on DNA 3 7
GO:0140640 catalytic activity, acting on a nucleic acid 2 7
GO:0140657 ATP-dependent activity 1 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 659 663 PF00656 0.439
CLV_C14_Caspase3-7 747 751 PF00656 0.579
CLV_C14_Caspase3-7 862 866 PF00656 0.790
CLV_NRD_NRD_1 172 174 PF00675 0.677
CLV_NRD_NRD_1 175 177 PF00675 0.704
CLV_NRD_NRD_1 183 185 PF00675 0.581
CLV_NRD_NRD_1 189 191 PF00675 0.576
CLV_NRD_NRD_1 283 285 PF00675 0.637
CLV_NRD_NRD_1 397 399 PF00675 0.356
CLV_NRD_NRD_1 427 429 PF00675 0.585
CLV_NRD_NRD_1 516 518 PF00675 0.398
CLV_NRD_NRD_1 616 618 PF00675 0.714
CLV_NRD_NRD_1 629 631 PF00675 0.571
CLV_NRD_NRD_1 649 651 PF00675 0.506
CLV_NRD_NRD_1 710 712 PF00675 0.480
CLV_NRD_NRD_1 897 899 PF00675 0.807
CLV_PCSK_FUR_1 173 177 PF00082 0.587
CLV_PCSK_FUR_1 514 518 PF00082 0.398
CLV_PCSK_FUR_1 627 631 PF00082 0.785
CLV_PCSK_FUR_1 895 899 PF00082 0.806
CLV_PCSK_KEX2_1 172 174 PF00082 0.632
CLV_PCSK_KEX2_1 175 177 PF00082 0.630
CLV_PCSK_KEX2_1 183 185 PF00082 0.585
CLV_PCSK_KEX2_1 191 193 PF00082 0.564
CLV_PCSK_KEX2_1 397 399 PF00082 0.356
CLV_PCSK_KEX2_1 427 429 PF00082 0.650
CLV_PCSK_KEX2_1 516 518 PF00082 0.398
CLV_PCSK_KEX2_1 616 618 PF00082 0.714
CLV_PCSK_KEX2_1 627 629 PF00082 0.608
CLV_PCSK_KEX2_1 649 651 PF00082 0.555
CLV_PCSK_KEX2_1 710 712 PF00082 0.480
CLV_PCSK_KEX2_1 875 877 PF00082 0.772
CLV_PCSK_KEX2_1 897 899 PF00082 0.807
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.659
CLV_PCSK_PC1ET2_1 875 877 PF00082 0.772
CLV_PCSK_PC7_1 187 193 PF00082 0.613
CLV_PCSK_SKI1_1 223 227 PF00082 0.490
CLV_PCSK_SKI1_1 307 311 PF00082 0.506
CLV_PCSK_SKI1_1 439 443 PF00082 0.524
CLV_PCSK_SKI1_1 474 478 PF00082 0.347
CLV_PCSK_SKI1_1 531 535 PF00082 0.350
CLV_PCSK_SKI1_1 553 557 PF00082 0.350
CLV_PCSK_SKI1_1 710 714 PF00082 0.540
CLV_PCSK_SKI1_1 723 727 PF00082 0.531
CLV_Separin_Metazoa 157 161 PF03568 0.672
DEG_APCC_DBOX_1 473 481 PF00400 0.293
DEG_SPOP_SBC_1 246 250 PF00917 0.625
DOC_CYCLIN_RxL_1 528 538 PF00134 0.598
DOC_CYCLIN_RxL_1 707 714 PF00134 0.469
DOC_CYCLIN_RxL_1 791 800 PF00134 0.439
DOC_MAPK_gen_1 187 195 PF00069 0.738
DOC_MAPK_gen_1 284 290 PF00069 0.547
DOC_MAPK_gen_1 729 738 PF00069 0.489
DOC_PP1_RVXF_1 285 291 PF00149 0.468
DOC_PP2B_LxvP_1 358 361 PF13499 0.552
DOC_PP4_FxxP_1 352 355 PF00568 0.573
DOC_PP4_FxxP_1 575 578 PF00568 0.755
DOC_USP7_MATH_1 118 122 PF00917 0.749
DOC_USP7_MATH_1 141 145 PF00917 0.730
DOC_USP7_MATH_1 246 250 PF00917 0.625
DOC_USP7_MATH_1 329 333 PF00917 0.741
DOC_USP7_MATH_1 346 350 PF00917 0.592
DOC_USP7_MATH_1 363 367 PF00917 0.674
DOC_USP7_MATH_1 576 580 PF00917 0.791
DOC_USP7_MATH_1 602 606 PF00917 0.509
DOC_USP7_MATH_1 648 652 PF00917 0.550
DOC_USP7_MATH_1 749 753 PF00917 0.353
DOC_WW_Pin1_4 126 131 PF00397 0.502
DOC_WW_Pin1_4 255 260 PF00397 0.555
DOC_WW_Pin1_4 351 356 PF00397 0.840
DOC_WW_Pin1_4 441 446 PF00397 0.669
DOC_WW_Pin1_4 579 584 PF00397 0.773
DOC_WW_Pin1_4 58 63 PF00397 0.597
DOC_WW_Pin1_4 635 640 PF00397 0.542
DOC_WW_Pin1_4 770 775 PF00397 0.790
DOC_WW_Pin1_4 780 785 PF00397 0.644
DOC_WW_Pin1_4 83 88 PF00397 0.485
LIG_14-3-3_CanoR_1 143 147 PF00244 0.600
LIG_14-3-3_CanoR_1 223 229 PF00244 0.529
LIG_14-3-3_CanoR_1 236 244 PF00244 0.768
LIG_14-3-3_CanoR_1 293 302 PF00244 0.493
LIG_14-3-3_CanoR_1 320 324 PF00244 0.627
LIG_14-3-3_CanoR_1 378 384 PF00244 0.577
LIG_14-3-3_CanoR_1 45 54 PF00244 0.796
LIG_14-3-3_CanoR_1 617 626 PF00244 0.732
LIG_14-3-3_CanoR_1 649 654 PF00244 0.538
LIG_14-3-3_CanoR_1 694 704 PF00244 0.534
LIG_14-3-3_CanoR_1 778 784 PF00244 0.525
LIG_14-3-3_CanoR_1 867 871 PF00244 0.595
LIG_APCC_ABBA_1 680 685 PF00400 0.508
LIG_APCC_ABBA_1 713 718 PF00400 0.270
LIG_BRCT_BRCA1_1 101 105 PF00533 0.512
LIG_BRCT_BRCA1_1 348 352 PF00533 0.656
LIG_BRCT_BRCA1_1 750 754 PF00533 0.381
LIG_eIF4E_1 527 533 PF01652 0.598
LIG_FHA_1 225 231 PF00498 0.507
LIG_FHA_1 239 245 PF00498 0.484
LIG_FHA_1 37 43 PF00498 0.533
LIG_FHA_1 49 55 PF00498 0.494
LIG_FHA_1 528 534 PF00498 0.550
LIG_FHA_1 641 647 PF00498 0.550
LIG_FHA_1 696 702 PF00498 0.486
LIG_FHA_1 791 797 PF00498 0.556
LIG_FHA_1 815 821 PF00498 0.474
LIG_FHA_1 869 875 PF00498 0.569
LIG_FHA_2 152 158 PF00498 0.721
LIG_FHA_2 489 495 PF00498 0.570
LIG_FHA_2 564 570 PF00498 0.712
LIG_FHA_2 783 789 PF00498 0.623
LIG_GSK3_LRP6_1 62 67 PF00069 0.609
LIG_Integrin_isoDGR_2 340 342 PF01839 0.539
LIG_Integrin_RGD_1 231 233 PF01839 0.778
LIG_LIR_Apic_2 349 355 PF02991 0.573
LIG_LIR_Gen_1 662 673 PF02991 0.653
LIG_LIR_Gen_1 811 820 PF02991 0.564
LIG_LIR_Nem_3 102 108 PF02991 0.528
LIG_LIR_Nem_3 538 544 PF02991 0.550
LIG_LIR_Nem_3 811 816 PF02991 0.568
LIG_MYND_1 356 360 PF01753 0.545
LIG_NRBOX 472 478 PF00104 0.285
LIG_NRBOX 702 708 PF00104 0.288
LIG_PCNA_PIPBox_1 23 32 PF02747 0.450
LIG_PCNA_yPIPBox_3 92 105 PF02747 0.400
LIG_SH2_CRK 544 548 PF00017 0.512
LIG_SH2_CRK 7 11 PF00017 0.396
LIG_SH2_CRK 813 817 PF00017 0.563
LIG_SH2_SRC 7 10 PF00017 0.397
LIG_SH2_STAP1 720 724 PF00017 0.532
LIG_SH2_STAP1 834 838 PF00017 0.631
LIG_SH2_STAT3 16 19 PF00017 0.428
LIG_SH2_STAT3 219 222 PF00017 0.730
LIG_SH2_STAT3 29 32 PF00017 0.493
LIG_SH2_STAT3 426 429 PF00017 0.662
LIG_SH2_STAT5 289 292 PF00017 0.445
LIG_SH2_STAT5 29 32 PF00017 0.470
LIG_SH2_STAT5 410 413 PF00017 0.630
LIG_SH2_STAT5 467 470 PF00017 0.493
LIG_SH2_STAT5 479 482 PF00017 0.524
LIG_SH2_STAT5 510 513 PF00017 0.598
LIG_SH2_STAT5 527 530 PF00017 0.568
LIG_SH2_STAT5 546 549 PF00017 0.382
LIG_SH2_STAT5 692 695 PF00017 0.383
LIG_SH3_3 144 150 PF00018 0.770
LIG_SH3_3 311 317 PF00018 0.653
LIG_SH3_3 354 360 PF00018 0.830
LIG_SH3_3 60 66 PF00018 0.603
LIG_SH3_3 781 787 PF00018 0.624
LIG_SH3_3 9 15 PF00018 0.426
LIG_SUMO_SIM_anti_2 79 86 PF11976 0.557
LIG_SUMO_SIM_par_1 51 58 PF11976 0.525
LIG_TRAF2_1 154 157 PF00917 0.608
LIG_TRAF2_1 17 20 PF00917 0.422
LIG_TRAF2_1 842 845 PF00917 0.416
LIG_TYR_ITIM 542 547 PF00017 0.370
LIG_UBA3_1 280 287 PF00899 0.703
LIG_UBA3_1 735 741 PF00899 0.270
LIG_WRC_WIRS_1 798 803 PF05994 0.479
LIG_WRC_WIRS_1 815 820 PF05994 0.443
MOD_CDK_SPxxK_3 441 448 PF00069 0.666
MOD_CK1_1 224 230 PF00069 0.556
MOD_CK1_1 240 246 PF00069 0.688
MOD_CK1_1 247 253 PF00069 0.665
MOD_CK1_1 254 260 PF00069 0.648
MOD_CK1_1 351 357 PF00069 0.756
MOD_CK1_1 36 42 PF00069 0.539
MOD_CK1_1 367 373 PF00069 0.518
MOD_CK1_1 43 49 PF00069 0.540
MOD_CK1_1 508 514 PF00069 0.491
MOD_CK1_1 579 585 PF00069 0.802
MOD_CK1_1 58 64 PF00069 0.497
MOD_CK1_1 605 611 PF00069 0.693
MOD_CK1_1 640 646 PF00069 0.549
MOD_CK1_1 695 701 PF00069 0.597
MOD_CK1_1 782 788 PF00069 0.662
MOD_CK1_1 99 105 PF00069 0.579
MOD_CK2_1 151 157 PF00069 0.619
MOD_CK2_1 200 206 PF00069 0.781
MOD_CK2_1 356 362 PF00069 0.550
MOD_CK2_1 488 494 PF00069 0.552
MOD_CK2_1 563 569 PF00069 0.703
MOD_CK2_1 649 655 PF00069 0.534
MOD_CK2_1 782 788 PF00069 0.554
MOD_CK2_1 839 845 PF00069 0.401
MOD_GlcNHglycan 118 121 PF01048 0.763
MOD_GlcNHglycan 202 205 PF01048 0.793
MOD_GlcNHglycan 244 247 PF01048 0.753
MOD_GlcNHglycan 330 334 PF01048 0.753
MOD_GlcNHglycan 499 502 PF01048 0.720
MOD_GlcNHglycan 57 60 PF01048 0.570
MOD_GlcNHglycan 69 72 PF01048 0.565
MOD_GlcNHglycan 694 697 PF01048 0.632
MOD_GlcNHglycan 861 864 PF01048 0.762
MOD_GlcNHglycan 879 882 PF01048 0.493
MOD_GSK3_1 238 245 PF00069 0.681
MOD_GSK3_1 246 253 PF00069 0.687
MOD_GSK3_1 254 261 PF00069 0.689
MOD_GSK3_1 272 279 PF00069 0.629
MOD_GSK3_1 289 296 PF00069 0.465
MOD_GSK3_1 325 332 PF00069 0.695
MOD_GSK3_1 36 43 PF00069 0.602
MOD_GSK3_1 363 370 PF00069 0.574
MOD_GSK3_1 468 475 PF00069 0.565
MOD_GSK3_1 504 511 PF00069 0.312
MOD_GSK3_1 559 566 PF00069 0.700
MOD_GSK3_1 578 585 PF00069 0.528
MOD_GSK3_1 58 65 PF00069 0.563
MOD_GSK3_1 635 642 PF00069 0.555
MOD_GSK3_1 67 74 PF00069 0.708
MOD_GSK3_1 719 726 PF00069 0.600
MOD_GSK3_1 779 786 PF00069 0.686
MOD_GSK3_1 83 90 PF00069 0.419
MOD_GSK3_1 851 858 PF00069 0.680
MOD_GSK3_1 884 891 PF00069 0.642
MOD_LATS_1 647 653 PF00433 0.546
MOD_NEK2_1 200 205 PF00069 0.679
MOD_NEK2_1 238 243 PF00069 0.705
MOD_NEK2_1 244 249 PF00069 0.672
MOD_NEK2_1 305 310 PF00069 0.503
MOD_NEK2_1 417 422 PF00069 0.639
MOD_NEK2_1 57 62 PF00069 0.523
MOD_NEK2_1 620 625 PF00069 0.459
MOD_NEK2_1 664 669 PF00069 0.571
MOD_NEK2_1 67 72 PF00069 0.540
MOD_NEK2_1 819 824 PF00069 0.457
MOD_NEK2_1 96 101 PF00069 0.564
MOD_NEK2_2 749 754 PF00069 0.367
MOD_PIKK_1 149 155 PF00454 0.480
MOD_PIKK_1 209 215 PF00454 0.717
MOD_PIKK_1 293 299 PF00454 0.496
MOD_PIKK_1 43 49 PF00454 0.704
MOD_PIKK_1 819 825 PF00454 0.534
MOD_PIKK_1 90 96 PF00454 0.416
MOD_PK_1 649 655 PF00069 0.690
MOD_PKA_1 649 655 PF00069 0.534
MOD_PKA_2 142 148 PF00069 0.692
MOD_PKA_2 319 325 PF00069 0.621
MOD_PKA_2 33 39 PF00069 0.602
MOD_PKA_2 377 383 PF00069 0.603
MOD_PKA_2 618 624 PF00069 0.723
MOD_PKA_2 648 654 PF00069 0.539
MOD_PKA_2 856 862 PF00069 0.604
MOD_PKA_2 866 872 PF00069 0.632
MOD_PKA_2 877 883 PF00069 0.747
MOD_PKB_1 617 625 PF00069 0.452
MOD_Plk_1 141 147 PF00069 0.550
MOD_Plk_1 749 755 PF00069 0.566
MOD_Plk_2-3 839 845 PF00069 0.401
MOD_Plk_4 142 148 PF00069 0.549
MOD_Plk_4 276 282 PF00069 0.727
MOD_Plk_4 505 511 PF00069 0.491
MOD_Plk_4 749 755 PF00069 0.378
MOD_Plk_4 797 803 PF00069 0.480
MOD_Plk_4 814 820 PF00069 0.443
MOD_Plk_4 96 102 PF00069 0.564
MOD_ProDKin_1 126 132 PF00069 0.504
MOD_ProDKin_1 255 261 PF00069 0.554
MOD_ProDKin_1 351 357 PF00069 0.838
MOD_ProDKin_1 441 447 PF00069 0.665
MOD_ProDKin_1 579 585 PF00069 0.773
MOD_ProDKin_1 58 64 PF00069 0.599
MOD_ProDKin_1 635 641 PF00069 0.542
MOD_ProDKin_1 770 776 PF00069 0.793
MOD_ProDKin_1 780 786 PF00069 0.640
MOD_ProDKin_1 83 89 PF00069 0.490
MOD_SUMO_rev_2 264 273 PF00179 0.500
MOD_SUMO_rev_2 839 849 PF00179 0.427
TRG_DiLeu_BaEn_1 142 147 PF01217 0.550
TRG_DiLeu_BaEn_1 206 211 PF01217 0.775
TRG_DiLeu_BaEn_2 733 739 PF01217 0.482
TRG_DiLeu_BaLyEn_6 528 533 PF01217 0.491
TRG_DiLeu_BaLyEn_6 708 713 PF01217 0.397
TRG_DiLeu_BaLyEn_6 720 725 PF01217 0.499
TRG_DiLeu_BaLyEn_6 771 776 PF01217 0.507
TRG_ENDOCYTIC_2 544 547 PF00928 0.370
TRG_ENDOCYTIC_2 813 816 PF00928 0.564
TRG_ER_diArg_1 159 162 PF00400 0.684
TRG_ER_diArg_1 175 178 PF00400 0.478
TRG_ER_diArg_1 190 193 PF00400 0.500
TRG_ER_diArg_1 396 398 PF00400 0.337
TRG_ER_diArg_1 426 428 PF00400 0.628
TRG_ER_diArg_1 514 517 PF00400 0.491
TRG_ER_diArg_1 616 619 PF00400 0.718
TRG_ER_diArg_1 626 629 PF00400 0.620
TRG_ER_diArg_1 648 650 PF00400 0.559
TRG_ER_diArg_1 710 712 PF00400 0.484
TRG_ER_diArg_1 895 898 PF00400 0.805
TRG_NLS_Bipartite_1 172 194 PF00514 0.444
TRG_NLS_MonoCore_2 283 288 PF00514 0.587
TRG_NLS_MonoExtC_3 189 194 PF00514 0.675
TRG_NLS_MonoExtN_4 187 194 PF00514 0.670
TRG_NLS_MonoExtN_4 282 288 PF00514 0.601
TRG_Pf-PMV_PEXEL_1 162 166 PF00026 0.684
TRG_Pf-PMV_PEXEL_1 184 188 PF00026 0.692
TRG_Pf-PMV_PEXEL_1 313 318 PF00026 0.381
TRG_Pf-PMV_PEXEL_1 516 521 PF00026 0.423
TRG_Pf-PMV_PEXEL_1 710 714 PF00026 0.467
TRG_Pf-PMV_PEXEL_1 733 737 PF00026 0.280

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IWB2 Bodo saltans 23% 83%
A0A3S7WNM9 Leishmania donovani 69% 67%
D0A263 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 85%
E9ACK4 Leishmania major 69% 66%
E9AG48 Leishmania infantum 70% 67%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS