DUF1989 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3M0_LEIBR

TriTrypDb:

LbrM.03.0490 , LBRM2903_150017900

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.703
CLV_NRD_NRD_1	173	175	PF00675	0.705
CLV_PCSK_FUR_1	147	151	PF00082	0.567
CLV_PCSK_KEX2_1	149	151	PF00082	0.493
CLV_PCSK_KEX2_1	175	177	PF00082	0.537
CLV_PCSK_KEX2_1	30	32	PF00082	0.569
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.490
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.537
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.434
CLV_PCSK_SKI1_1	2	6	PF00082	0.406
CLV_PCSK_SKI1_1	93	97	PF00082	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.443
DEG_SPOP_SBC_1	83	87	PF00917	0.469
DOC_PP1_RVXF_1	22	28	PF00149	0.564
DOC_PP2B_LxvP_1	73	76	PF13499	0.461
DOC_USP7_MATH_1	127	131	PF00917	0.617
DOC_USP7_MATH_1	37	41	PF00917	0.503
DOC_USP7_MATH_1	83	87	PF00917	0.616
DOC_USP7_UBL2_3	125	129	PF12436	0.531
DOC_USP7_UBL2_3	171	175	PF12436	0.644
DOC_WW_Pin1_4	44	49	PF00397	0.603
LIG_14-3-3_CanoR_1	117	121	PF00244	0.605
LIG_14-3-3_CanoR_1	93	100	PF00244	0.606
LIG_BRCT_BRCA1_1	86	90	PF00533	0.596
LIG_CSL_BTD_1	25	28	PF09270	0.485
LIG_FHA_1	40	46	PF00498	0.441
LIG_FHA_1	67	73	PF00498	0.585
LIG_FHA_2	12	18	PF00498	0.599
LIG_FHA_2	152	158	PF00498	0.603
LIG_FHA_2	94	100	PF00498	0.531
LIG_LIR_Nem_3	52	58	PF02991	0.460
LIG_SH3_3	163	169	PF00018	0.617
LIG_SH3_3	42	48	PF00018	0.369
LIG_SUMO_SIM_par_1	40	47	PF11976	0.368
LIG_SUMO_SIM_par_1	69	78	PF11976	0.460
MOD_CK1_1	130	136	PF00069	0.629
MOD_CK1_1	47	53	PF00069	0.607
MOD_CK1_1	86	92	PF00069	0.581
MOD_CK2_1	151	157	PF00069	0.566
MOD_CK2_1	162	168	PF00069	0.764
MOD_Cter_Amidation	28	31	PF01082	0.419
MOD_GlcNHglycan	129	132	PF01048	0.616
MOD_GlcNHglycan	51	54	PF01048	0.599
MOD_GlcNHglycan	86	89	PF01048	0.604
MOD_GSK3_1	116	123	PF00069	0.553
MOD_GSK3_1	82	89	PF00069	0.566
MOD_N-GLC_1	161	166	PF02516	0.477
MOD_NEK2_1	58	63	PF00069	0.481
MOD_PKA_1	174	180	PF00069	0.720
MOD_PKA_2	116	122	PF00069	0.548
MOD_PKA_2	151	157	PF00069	0.655
MOD_Plk_1	161	167	PF00069	0.596
MOD_Plk_2-3	151	157	PF00069	0.404
MOD_Plk_4	162	168	PF00069	0.606
MOD_ProDKin_1	44	50	PF00069	0.606
MOD_SUMO_for_1	148	151	PF00179	0.536
MOD_SUMO_rev_2	168	177	PF00179	0.668
TRG_ENDOCYTIC_2	55	58	PF00928	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ04	Leptomonas seymouri	68%	99%
A0A0S4INX7	Bodo saltans	44%	91%
A0A1X0P8U1	Trypanosomatidae	42%	92%
A0A3S5H549	Leishmania donovani	87%	100%
A0A422NMF6	Trypanosoma rangeli	41%	96%
D0A262	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	80%
E9ACK3	Leishmania major	86%	99%
E9AG47	Leishmania infantum	87%	100%
E9AJU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%