Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3L8_LEIBR

TriTrypDb:

LbrM.03.0470 , LBRM2903_030010400

Length:

714

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3L8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.509
CLV_NRD_NRD_1	309	311	PF00675	0.631
CLV_NRD_NRD_1	369	371	PF00675	0.477
CLV_NRD_NRD_1	393	395	PF00675	0.482
CLV_NRD_NRD_1	442	444	PF00675	0.628
CLV_NRD_NRD_1	564	566	PF00675	0.612
CLV_PCSK_FUR_1	562	566	PF00082	0.605
CLV_PCSK_KEX2_1	219	221	PF00082	0.509
CLV_PCSK_KEX2_1	309	311	PF00082	0.627
CLV_PCSK_KEX2_1	369	371	PF00082	0.477
CLV_PCSK_KEX2_1	393	395	PF00082	0.482
CLV_PCSK_KEX2_1	441	443	PF00082	0.633
CLV_PCSK_KEX2_1	564	566	PF00082	0.612
CLV_PCSK_PC7_1	305	311	PF00082	0.505
CLV_PCSK_SKI1_1	192	196	PF00082	0.566
CLV_PCSK_SKI1_1	310	314	PF00082	0.494
DEG_ODPH_VHL_1	635	646	PF01847	0.638
DEG_SCF_FBW7_1	155	161	PF00400	0.655
DEG_SCF_FBW7_1	274	279	PF00400	0.646
DEG_SPOP_SBC_1	170	174	PF00917	0.708
DEG_SPOP_SBC_1	483	487	PF00917	0.421
DEG_SPOP_SBC_1	505	509	PF00917	0.429
DEG_SPOP_SBC_1	530	534	PF00917	0.520
DOC_CKS1_1	155	160	PF01111	0.741
DOC_CKS1_1	598	603	PF01111	0.694
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.395
DOC_MAPK_gen_1	235	245	PF00069	0.643
DOC_MAPK_gen_1	309	315	PF00069	0.640
DOC_MAPK_MEF2A_6	633	641	PF00069	0.613
DOC_PP1_RVXF_1	465	472	PF00149	0.405
DOC_PP2B_LxvP_1	423	426	PF13499	0.395
DOC_PP2B_LxvP_1	548	551	PF13499	0.395
DOC_PP2B_LxvP_1	674	677	PF13499	0.610
DOC_USP7_MATH_1	107	111	PF00917	0.627
DOC_USP7_MATH_1	176	180	PF00917	0.770
DOC_USP7_MATH_1	262	266	PF00917	0.774
DOC_USP7_MATH_1	276	280	PF00917	0.628
DOC_USP7_MATH_1	328	332	PF00917	0.699
DOC_USP7_MATH_1	453	457	PF00917	0.513
DOC_USP7_MATH_1	474	478	PF00917	0.522
DOC_USP7_MATH_1	482	486	PF00917	0.477
DOC_USP7_MATH_1	491	495	PF00917	0.382
DOC_USP7_MATH_1	519	523	PF00917	0.479
DOC_USP7_MATH_1	530	534	PF00917	0.490
DOC_USP7_MATH_1	540	544	PF00917	0.264
DOC_USP7_MATH_1	596	600	PF00917	0.771
DOC_USP7_MATH_1	66	70	PF00917	0.716
DOC_USP7_UBL2_3	576	580	PF12436	0.630
DOC_WW_Pin1_4	154	159	PF00397	0.844
DOC_WW_Pin1_4	199	204	PF00397	0.790
DOC_WW_Pin1_4	243	248	PF00397	0.642
DOC_WW_Pin1_4	272	277	PF00397	0.701
DOC_WW_Pin1_4	370	375	PF00397	0.702
DOC_WW_Pin1_4	462	467	PF00397	0.426
DOC_WW_Pin1_4	52	57	PF00397	0.641
DOC_WW_Pin1_4	583	588	PF00397	0.736
DOC_WW_Pin1_4	594	599	PF00397	0.721
DOC_WW_Pin1_4	62	67	PF00397	0.640
DOC_WW_Pin1_4	700	705	PF00397	0.759
LIG_14-3-3_CanoR_1	128	138	PF00244	0.787
LIG_14-3-3_CanoR_1	162	167	PF00244	0.645
LIG_14-3-3_CanoR_1	192	197	PF00244	0.759
LIG_14-3-3_CanoR_1	205	212	PF00244	0.623
LIG_14-3-3_CanoR_1	335	342	PF00244	0.631
LIG_14-3-3_CanoR_1	352	362	PF00244	0.682
LIG_14-3-3_CanoR_1	459	463	PF00244	0.476
LIG_14-3-3_CanoR_1	529	539	PF00244	0.402
LIG_14-3-3_CanoR_1	696	702	PF00244	0.729
LIG_14-3-3_CanoR_1	72	79	PF00244	0.638
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BRCT_BRCA1_1	1	5	PF00533	0.662
LIG_BRCT_BRCA1_1	27	31	PF00533	0.626
LIG_Clathr_ClatBox_1	429	433	PF01394	0.395
LIG_deltaCOP1_diTrp_1	667	672	PF00928	0.701
LIG_eIF4E_1	287	293	PF01652	0.745
LIG_FHA_1	139	145	PF00498	0.717
LIG_FHA_1	287	293	PF00498	0.687
LIG_FHA_1	302	308	PF00498	0.693
LIG_FHA_1	379	385	PF00498	0.640
LIG_FHA_1	420	426	PF00498	0.395
LIG_FHA_1	459	465	PF00498	0.438
LIG_FHA_1	573	579	PF00498	0.633
LIG_FHA_1	697	703	PF00498	0.730
LIG_FHA_1	83	89	PF00498	0.705
LIG_FHA_2	132	138	PF00498	0.642
LIG_FHA_2	155	161	PF00498	0.643
LIG_FHA_2	31	37	PF00498	0.725
LIG_Integrin_RGD_1	135	137	PF01839	0.441
LIG_LIR_Gen_1	2	12	PF02991	0.678
LIG_LIR_Gen_1	28	38	PF02991	0.651
LIG_LIR_Gen_1	349	358	PF02991	0.632
LIG_LIR_Gen_1	413	424	PF02991	0.315
LIG_LIR_Gen_1	612	620	PF02991	0.583
LIG_LIR_Nem_3	2	8	PF02991	0.668
LIG_LIR_Nem_3	28	34	PF02991	0.659
LIG_LIR_Nem_3	349	353	PF02991	0.636
LIG_LIR_Nem_3	413	419	PF02991	0.315
LIG_LIR_Nem_3	612	618	PF02991	0.684
LIG_LIR_Nem_3	643	648	PF02991	0.661
LIG_PCNA_PIPBox_1	638	647	PF02747	0.611
LIG_PCNA_yPIPBox_3	631	645	PF02747	0.616
LIG_PDZ_Class_2	709	714	PF00595	0.690
LIG_Pex14_1	652	656	PF04695	0.530
LIG_SH2_CRK	656	660	PF00017	0.540
LIG_SH2_STAP1	648	652	PF00017	0.646
LIG_SH3_3	152	158	PF00018	0.799
LIG_SH3_3	264	270	PF00018	0.660
LIG_SH3_3	316	322	PF00018	0.645
LIG_SH3_3	368	374	PF00018	0.743
LIG_SH3_3	403	409	PF00018	0.705
LIG_SH3_3	460	466	PF00018	0.401
LIG_SH3_3	595	601	PF00018	0.697
LIG_SH3_3	652	658	PF00018	0.556
LIG_SH3_3	673	679	PF00018	0.650
LIG_TRAF2_1	678	681	PF00917	0.801
LIG_TYR_ITIM	646	651	PF00017	0.591
MOD_CDC14_SPxK_1	202	205	PF00782	0.638
MOD_CDK_SPK_2	154	159	PF00069	0.742
MOD_CDK_SPK_2	462	467	PF00069	0.402
MOD_CDK_SPK_2	700	705	PF00069	0.672
MOD_CDK_SPxK_1	199	205	PF00069	0.642
MOD_CDK_SPxK_1	272	278	PF00069	0.649
MOD_CK1_1	208	214	PF00069	0.740
MOD_CK1_1	215	221	PF00069	0.681
MOD_CK1_1	26	32	PF00069	0.690
MOD_CK1_1	272	278	PF00069	0.709
MOD_CK1_1	373	379	PF00069	0.717
MOD_CK1_1	380	386	PF00069	0.717
MOD_CK1_1	389	395	PF00069	0.584
MOD_CK1_1	486	492	PF00069	0.490
MOD_CK1_1	513	519	PF00069	0.533
MOD_CK1_1	531	537	PF00069	0.480
MOD_CK1_1	55	61	PF00069	0.706
MOD_CK1_1	585	591	PF00069	0.670
MOD_CK1_1	597	603	PF00069	0.771
MOD_CK1_1	608	614	PF00069	0.691
MOD_CK2_1	222	228	PF00069	0.645
MOD_CK2_1	489	495	PF00069	0.418
MOD_CK2_1	608	614	PF00069	0.704
MOD_DYRK1A_RPxSP_1	370	374	PF00069	0.730
MOD_GlcNHglycan	104	107	PF01048	0.499
MOD_GlcNHglycan	178	181	PF01048	0.541
MOD_GlcNHglycan	207	210	PF01048	0.551
MOD_GlcNHglycan	214	217	PF01048	0.596
MOD_GlcNHglycan	25	28	PF01048	0.433
MOD_GlcNHglycan	258	261	PF01048	0.555
MOD_GlcNHglycan	278	281	PF01048	0.533
MOD_GlcNHglycan	316	319	PF01048	0.608
MOD_GlcNHglycan	324	327	PF01048	0.500
MOD_GlcNHglycan	337	340	PF01048	0.465
MOD_GlcNHglycan	451	454	PF01048	0.721
MOD_GlcNHglycan	491	494	PF01048	0.811
MOD_GlcNHglycan	517	520	PF01048	0.685
MOD_GlcNHglycan	52	55	PF01048	0.534
MOD_GlcNHglycan	521	524	PF01048	0.640
MOD_GlcNHglycan	533	536	PF01048	0.666
MOD_GlcNHglycan	566	569	PF01048	0.428
MOD_GlcNHglycan	57	60	PF01048	0.617
MOD_GlcNHglycan	74	77	PF01048	0.484
MOD_GSK3_1	154	161	PF00069	0.705
MOD_GSK3_1	197	204	PF00069	0.715
MOD_GSK3_1	208	215	PF00069	0.726
MOD_GSK3_1	21	28	PF00069	0.698
MOD_GSK3_1	218	225	PF00069	0.717
MOD_GSK3_1	252	259	PF00069	0.706
MOD_GSK3_1	272	279	PF00069	0.753
MOD_GSK3_1	301	308	PF00069	0.683
MOD_GSK3_1	373	380	PF00069	0.707
MOD_GSK3_1	415	422	PF00069	0.395
MOD_GSK3_1	449	456	PF00069	0.508
MOD_GSK3_1	458	465	PF00069	0.441
MOD_GSK3_1	482	489	PF00069	0.420
MOD_GSK3_1	500	507	PF00069	0.490
MOD_GSK3_1	511	518	PF00069	0.529
MOD_GSK3_1	524	531	PF00069	0.589
MOD_GSK3_1	574	581	PF00069	0.688
MOD_GSK3_1	605	612	PF00069	0.650
MOD_GSK3_1	62	69	PF00069	0.690
MOD_GSK3_1	683	690	PF00069	0.698
MOD_GSK3_1	696	703	PF00069	0.694
MOD_N-GLC_1	176	181	PF02516	0.439
MOD_N-GLC_1	687	692	PF02516	0.564
MOD_NEK2_1	212	217	PF00069	0.791
MOD_NEK2_1	286	291	PF00069	0.692
MOD_NEK2_1	419	424	PF00069	0.350
MOD_NEK2_2	328	333	PF00069	0.640
MOD_NEK2_2	524	529	PF00069	0.442
MOD_PIKK_1	187	193	PF00454	0.644
MOD_PIKK_1	683	689	PF00454	0.644
MOD_PK_1	386	392	PF00069	0.666
MOD_PKA_1	564	570	PF00069	0.820
MOD_PKA_2	102	108	PF00069	0.804
MOD_PKA_2	158	164	PF00069	0.658
MOD_PKA_2	218	224	PF00069	0.680
MOD_PKA_2	458	464	PF00069	0.502
MOD_PKA_2	528	534	PF00069	0.428
MOD_PKA_2	564	570	PF00069	0.820
MOD_PKA_2	71	77	PF00069	0.775
MOD_PKB_1	562	570	PF00069	0.814
MOD_Plk_1	444	450	PF00069	0.494
MOD_Plk_1	500	506	PF00069	0.444
MOD_Plk_1	578	584	PF00069	0.670
MOD_Plk_2-3	30	36	PF00069	0.727
MOD_Plk_2-3	574	580	PF00069	0.668
MOD_Plk_4	151	157	PF00069	0.761
MOD_Plk_4	328	334	PF00069	0.753
MOD_Plk_4	415	421	PF00069	0.333
MOD_Plk_4	540	546	PF00069	0.348
MOD_Plk_4	578	584	PF00069	0.736
MOD_Plk_4	697	703	PF00069	0.733
MOD_ProDKin_1	154	160	PF00069	0.844
MOD_ProDKin_1	199	205	PF00069	0.792
MOD_ProDKin_1	243	249	PF00069	0.642
MOD_ProDKin_1	272	278	PF00069	0.701
MOD_ProDKin_1	370	376	PF00069	0.701
MOD_ProDKin_1	462	468	PF00069	0.426
MOD_ProDKin_1	52	58	PF00069	0.644
MOD_ProDKin_1	583	589	PF00069	0.737
MOD_ProDKin_1	594	600	PF00069	0.721
MOD_ProDKin_1	62	68	PF00069	0.639
MOD_ProDKin_1	700	706	PF00069	0.758
MOD_SUMO_for_1	618	621	PF00179	0.545
MOD_SUMO_rev_2	227	236	PF00179	0.642
MOD_SUMO_rev_2	569	578	PF00179	0.634
TRG_ENDOCYTIC_2	615	618	PF00928	0.742
TRG_ENDOCYTIC_2	648	651	PF00928	0.702
TRG_ENDOCYTIC_2	656	659	PF00928	0.623
TRG_ER_diArg_1	369	371	PF00400	0.681
TRG_ER_diArg_1	440	443	PF00400	0.431
TRG_ER_diArg_1	562	565	PF00400	0.803
TRG_Pf-PMV_PEXEL_1	633	638	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4E7	Leptomonas seymouri	29%	100%
A0A3S5H548	Leishmania donovani	60%	100%
E9ACK1	Leishmania major	58%	97%
E9AG45	Leishmania infantum	59%	100%
E9AJT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%