Putative 26S protease regulatory subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan SJ, family S16, putative

Species:

Leishmania braziliensis

UniProt:

A4H3L6_LEIBR

TriTrypDb:

LbrM.03.0450 , LBRM2903_030010200

Length:

396

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0005737	cytoplasm	2	11
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12
GO:0008540	proteasome regulatory particle, base subcomplex	2	1
GO:0031597	cytosolic proteasome complex	4	1

Expansion

Sequence features

A4H3L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3L6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006950	response to stress	2	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0031334	positive regulation of protein-containing complex assembly	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043254	regulation of protein-containing complex assembly	5	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044087	regulation of cellular component biogenesis	4	1
GO:0044089	positive regulation of cellular component biogenesis	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045898	regulation of RNA polymerase II transcription preinitiation complex assembly	6	1
GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0060260	regulation of transcription initiation by RNA polymerase II	8	1
GO:0060261	positive regulation of transcription initiation by RNA polymerase II	9	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901698	response to nitrogen compound	3	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2000142	regulation of DNA-templated transcription initiation	7	1
GO:2000144	positive regulation of DNA-templated transcription initiation	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008233	peptidase activity	3	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0036402	proteasome-activating activity	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.303
CLV_C14_Caspase3-7	289	293	PF00656	0.397
CLV_MEL_PAP_1	165	171	PF00089	0.410
CLV_NRD_NRD_1	302	304	PF00675	0.303
CLV_NRD_NRD_1	377	379	PF00675	0.407
CLV_NRD_NRD_1	89	91	PF00675	0.373
CLV_PCSK_KEX2_1	248	250	PF00082	0.303
CLV_PCSK_KEX2_1	384	386	PF00082	0.603
CLV_PCSK_KEX2_1	68	70	PF00082	0.363
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.303
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.603
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.363
CLV_PCSK_SKI1_1	103	107	PF00082	0.254
CLV_PCSK_SKI1_1	11	15	PF00082	0.602
CLV_PCSK_SKI1_1	175	179	PF00082	0.303
CLV_PCSK_SKI1_1	187	191	PF00082	0.303
CLV_PCSK_SKI1_1	223	227	PF00082	0.321
CLV_PCSK_SKI1_1	25	29	PF00082	0.400
CLV_PCSK_SKI1_1	325	329	PF00082	0.325
CLV_PCSK_SKI1_1	91	95	PF00082	0.266
DEG_Nend_UBRbox_3	1	3	PF02207	0.618
DOC_CYCLIN_yClb1_LxF_4	95	100	PF00134	0.506
DOC_MAPK_gen_1	150	160	PF00069	0.397
DOC_MAPK_gen_1	297	307	PF00069	0.303
DOC_MAPK_gen_1	325	334	PF00069	0.552
DOC_MAPK_gen_1	90	100	PF00069	0.466
DOC_MAPK_JIP1_4	94	100	PF00069	0.488
DOC_MAPK_MEF2A_6	153	160	PF00069	0.394
DOC_MAPK_MEF2A_6	230	238	PF00069	0.330
DOC_MAPK_MEF2A_6	300	309	PF00069	0.313
DOC_MAPK_MEF2A_6	99	108	PF00069	0.468
DOC_MAPK_NFAT4_5	153	161	PF00069	0.537
DOC_MAPK_RevD_3	234	249	PF00069	0.303
DOC_MAPK_RevD_3	75	91	PF00069	0.530
DOC_PP1_RVXF_1	133	140	PF00149	0.465
DOC_PP1_RVXF_1	95	101	PF00149	0.489
DOC_SPAK_OSR1_1	74	78	PF12202	0.506
DOC_USP7_MATH_1	13	17	PF00917	0.541
DOC_USP7_MATH_1	244	248	PF00917	0.443
DOC_USP7_UBL2_3	375	379	PF12436	0.401
LIG_14-3-3_CanoR_1	25	32	PF00244	0.548
LIG_14-3-3_CanoR_1	350	359	PF00244	0.303
LIG_Actin_WH2_2	191	206	PF00022	0.303
LIG_Actin_WH2_2	20	35	PF00022	0.583
LIG_Actin_WH2_2	52	70	PF00022	0.458
LIG_BIR_III_4	243	247	PF00653	0.303
LIG_BRCT_BRCA1_1	340	344	PF00533	0.303
LIG_FHA_1	108	114	PF00498	0.476
LIG_FHA_2	159	165	PF00498	0.403
LIG_FHA_2	260	266	PF00498	0.331
LIG_FHA_2	3	9	PF00498	0.449
LIG_LIR_Gen_1	109	118	PF02991	0.563
LIG_LIR_Gen_1	136	147	PF02991	0.433
LIG_LIR_Gen_1	164	174	PF02991	0.407
LIG_LIR_Gen_1	199	210	PF02991	0.330
LIG_LIR_Gen_1	271	281	PF02991	0.303
LIG_LIR_Gen_1	331	340	PF02991	0.319
LIG_LIR_Nem_3	109	114	PF02991	0.563
LIG_LIR_Nem_3	136	142	PF02991	0.443
LIG_LIR_Nem_3	164	169	PF02991	0.437
LIG_LIR_Nem_3	199	205	PF02991	0.330
LIG_LIR_Nem_3	271	276	PF02991	0.303
LIG_LIR_Nem_3	331	337	PF02991	0.303
LIG_MAD2	115	123	PF02301	0.542
LIG_NRBOX	262	268	PF00104	0.303
LIG_PCNA_yPIPBox_3	257	267	PF02747	0.303
LIG_PTB_Apo_2	367	374	PF02174	0.319
LIG_SH2_CRK	180	184	PF00017	0.303
LIG_SH2_STAP1	126	130	PF00017	0.495
LIG_SH2_STAT3	126	129	PF00017	0.433
LIG_SH2_STAT3	393	396	PF00017	0.573
LIG_SH2_STAT5	214	217	PF00017	0.305
LIG_SH2_STAT5	367	370	PF00017	0.303
LIG_SH2_STAT5	62	65	PF00017	0.364
LIG_SH3_3	3	9	PF00018	0.684
LIG_UBA3_1	318	325	PF00899	0.513
LIG_WRC_WIRS_1	108	113	PF05994	0.563
MOD_CK2_1	158	164	PF00069	0.407
MOD_CK2_1	252	258	PF00069	0.303
MOD_CK2_1	259	265	PF00069	0.303
MOD_GlcNHglycan	217	220	PF01048	0.324
MOD_GlcNHglycan	322	325	PF01048	0.516
MOD_GlcNHglycan	80	83	PF01048	0.282
MOD_N-GLC_1	25	30	PF02516	0.472
MOD_N-GLC_2	351	353	PF02516	0.303
MOD_NEK2_1	106	111	PF00069	0.488
MOD_NEK2_1	386	391	PF00069	0.650
MOD_NEK2_2	89	94	PF00069	0.474
MOD_PIKK_1	25	31	PF00454	0.536
MOD_PKA_2	89	95	PF00069	0.563
MOD_Plk_1	106	112	PF00069	0.474
MOD_Plk_1	135	141	PF00069	0.465
MOD_Plk_4	185	191	PF00069	0.303
MOD_Plk_4	2	8	PF00069	0.462
MOD_Plk_4	206	212	PF00069	0.323
MOD_Plk_4	333	339	PF00069	0.319
MOD_SUMO_for_1	93	96	PF00179	0.488
TRG_NES_CRM1_1	107	120	PF08389	0.488
TRG_NES_CRM1_1	151	164	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E9	Leptomonas seymouri	93%	100%
A0A0N0P5B8	Leptomonas seymouri	46%	89%
A0A0N0P7K1	Leptomonas seymouri	44%	97%
A0A0N1HRH8	Leptomonas seymouri	37%	73%
A0A0N1IGY9	Leptomonas seymouri	43%	95%
A0A0N1IM81	Leptomonas seymouri	43%	90%
A0A0N1PAS8	Leptomonas seymouri	50%	91%
A0A0S4IJE6	Bodo saltans	50%	91%
A0A0S4ITX1	Bodo saltans	45%	89%
A0A0S4IUM1	Bodo saltans	32%	67%
A0A0S4IY28	Bodo saltans	83%	100%
A0A0S4JAH0	Bodo saltans	34%	68%
A0A0S4JCD0	Bodo saltans	44%	99%
A0A0S4JDU3	Bodo saltans	47%	100%
A0A0S4JSD8	Bodo saltans	43%	100%
A0A1X0NMZ3	Trypanosomatidae	45%	91%
A0A1X0NNS1	Trypanosomatidae	46%	96%
A0A1X0NT86	Trypanosomatidae	48%	90%
A0A1X0NUX3	Trypanosomatidae	50%	91%
A0A1X0P1T5	Trypanosomatidae	47%	97%
A0A1X0P8T7	Trypanosomatidae	79%	99%
A0A3Q8IIF1	Leishmania donovani	33%	73%
A0A3Q8IJP7	Leishmania donovani	34%	66%
A0A3Q8IJS0	Leishmania donovani	48%	97%
A0A3R7KKD0	Trypanosoma rangeli	33%	69%
A0A3R7LUG9	Trypanosoma rangeli	49%	90%
A0A3R7N4Y5	Trypanosoma rangeli	45%	98%
A0A3S5H547	Leishmania donovani	97%	100%
A0A3S7WRY0	Leishmania donovani	43%	96%
A0A3S7WSK7	Leishmania donovani	43%	90%
A0A3S7WX14	Leishmania donovani	46%	89%
A0A3S7WX46	Leishmania donovani	50%	91%
A0A422NDS9	Trypanosoma rangeli	51%	91%
A0A422NLD8	Trypanosoma rangeli	45%	91%
A0A422NMN6	Trypanosoma rangeli	80%	99%
A0A422NUD9	Trypanosoma rangeli	44%	99%
A0JWY3	Arthrobacter sp. (strain FB24)	39%	67%
A3CV35	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	52%	96%
A4G0S4	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	51%	97%
A4H6T6	Leishmania braziliensis	43%	100%
A4H795	Leishmania braziliensis	43%	91%
A4H9H1	Leishmania braziliensis	34%	66%
A4HAA8	Leishmania braziliensis	33%	66%
A4HCA3	Leishmania braziliensis	50%	91%
A4HCA7	Leishmania braziliensis	46%	89%
A4HPV3	Leishmania braziliensis	47%	97%
A4HVN7	Leishmania infantum	43%	90%
A4HXT7	Leishmania infantum	34%	66%
A4HZT4	Leishmania infantum	50%	91%
A4HZT9	Leishmania infantum	46%	89%
A4IAA1	Leishmania infantum	32%	73%
A4IE38	Leishmania infantum	48%	97%
A6UQT3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	50%	97%
A6VHR1	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	51%	97%
A7I8B8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	51%	91%
A9A916	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	51%	97%
A9WSI4	Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)	38%	67%
B0K657	Thermoanaerobacter sp. (strain X514)	36%	78%
B3DRN4	Bifidobacterium longum (strain DJO10A)	36%	76%
B6YXR2	Thermococcus onnurineus (strain NA1)	49%	99%
B7GUP3	Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)	35%	76%
B8GGN4	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	48%	96%
B8H8L3	Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)	38%	68%
C3MRF1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	44%	100%
C3MY47	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	44%	100%
C3MZI6	Sulfolobus islandicus (strain M.16.27)	44%	100%
C3N7K8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	44%	100%
C3NFW6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	44%	100%
C4KIR6	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	44%	100%
C5A6P8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	49%	100%
C5BVA6	Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432)	36%	71%
C7LYP4	Acidimicrobium ferrooxidans (strain DSM 10331 / JCM 15462 / NBRC 103882 / ICP)	38%	68%
C7PVU9	Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)	36%	67%
C9ZQC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
C9ZRM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	91%
C9ZRM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	89%
D0A0W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	69%
D0A259	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	99%
D0A4A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
D0A6K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	91%
D1BHU2	Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)	34%	68%
D1BS23	Xylanimonas cellulosilytica (strain DSM 15894 / CECT 5975 / LMG 20990 / XIL07)	36%	73%
D2S6D9	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / KCC A-0152 / KCTC 9177 / NBRC 13315 / NRRL B-3577 / G-20)	34%	67%
D4GUJ7	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	43%	98%
E9ACJ9	Leishmania major	97%	100%
E9AG43	Leishmania infantum	97%	100%
E9AGB0	Leishmania infantum	43%	96%
E9AJT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9ANU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	96%
E9APD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	90%
E9ATM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
E9AVN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	91%
E9AVP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	89%
O04019	Arabidopsis thaliana	48%	94%
O14126	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	90%
O16368	Caenorhabditis elegans	43%	89%
O17071	Caenorhabditis elegans	63%	98%
O18413	Drosophila melanogaster	48%	98%
O23894	Brassica campestris	48%	93%
O26824	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	50%	97%
O28303	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	51%	99%
O42586	Xenopus laevis	39%	98%
O42587	Xenopus laevis	39%	94%
O42931	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	90%
O57940	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	48%	99%
O64982	Prunus persica	48%	93%
O74445	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	66%	100%
O74894	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O76371	Caenorhabditis elegans	43%	92%
O88685	Mus musculus	39%	90%
P0DKJ9	Oryza sativa subsp. japonica	44%	93%
P0DKK0	Oryza sativa subsp. japonica	44%	93%
P17980	Homo sapiens	39%	90%
P33297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	91%
P33298	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	93%
P33299	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	85%
P34123	Dictyostelium discoideum	46%	98%
P34124	Dictyostelium discoideum	45%	98%
P35998	Homo sapiens	42%	91%
P36612	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	88%
P40327	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	91%
P41836	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	98%
P43686	Homo sapiens	44%	95%
P46465	Oryza sativa subsp. japonica	49%	92%
P46466	Oryza sativa subsp. japonica	44%	88%
P46470	Xenopus laevis	47%	86%
P46471	Mus musculus	42%	91%
P46472	Xenopus laevis	42%	91%
P46502	Caenorhabditis elegans	45%	96%
P46507	Manduca sexta	46%	95%
P48601	Drosophila melanogaster	44%	90%
P53549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	91%
P54775	Mus musculus	44%	95%
P54776	Solanum lycopersicum	48%	94%
P54778	Solanum tuberosum	45%	96%
P54814	Manduca sexta	48%	99%
P62191	Homo sapiens	44%	90%
P62192	Mus musculus	44%	90%
P62193	Rattus norvegicus	44%	90%
P62194	Bos taurus	48%	98%
P62195	Homo sapiens	48%	98%
P62196	Mus musculus	48%	98%
P62197	Sus scrofa	48%	98%
P62198	Rattus norvegicus	48%	98%
P62333	Homo sapiens	65%	100%
P62334	Mus musculus	65%	100%
P62335	Ictidomys tridecemlineatus	65%	100%
P78578	Aspergillus niger	41%	94%
P85200	Helianthus annuus	44%	96%
Q01939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	98%
Q0W257	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	45%	95%
Q18787	Caenorhabditis elegans	48%	91%
Q25544	Naegleria fowleri	46%	96%
Q2FQ56	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	49%	96%
Q2KIW6	Bos taurus	64%	100%
Q3T030	Bos taurus	44%	95%
Q41365	Spinacia oleracea	48%	93%
Q47NX7	Thermobifida fusca (strain YX)	37%	68%
Q4Q0X8	Leishmania major	48%	100%
Q4Q2K9	Leishmania major	33%	74%
Q4QBT5	Leishmania major	46%	89%
Q4QBU0	Leishmania major	50%	100%
Q4QDY0	Leishmania major	34%	66%
Q4QG45	Leishmania major	43%	100%
Q4QGS2	Leishmania major	43%	100%
Q4R4R0	Macaca fascicularis	42%	91%
Q4R7L3	Macaca fascicularis	44%	95%
Q54PJ1	Dictyostelium discoideum	64%	100%
Q54PN7	Dictyostelium discoideum	42%	94%
Q55BV5	Dictyostelium discoideum	48%	90%
Q58576	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	51%	92%
Q58889	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q5E9F9	Bos taurus	42%	91%
Q5JHS5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	50%	100%
Q5R8D7	Pongo abelii	42%	91%
Q5UT56	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	41%	96%
Q63347	Rattus norvegicus	42%	91%
Q63569	Rattus norvegicus	39%	90%
Q63570	Rattus norvegicus	44%	95%
Q6LWR0	Methanococcus maripaludis (strain S2 / LL)	50%	97%
Q86JA1	Dictyostelium discoideum	48%	93%
Q8G3G6	Bifidobacterium longum (strain NCC 2705)	35%	76%
Q8PY58	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	46%	94%
Q8SQI9	Encephalitozoon cuniculi (strain GB-M1)	44%	100%
Q8SQK0	Encephalitozoon cuniculi (strain GB-M1)	46%	100%
Q8SR13	Encephalitozoon cuniculi (strain GB-M1)	42%	99%
Q8SRH0	Encephalitozoon cuniculi (strain GB-M1)	44%	93%
Q8TI88	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	46%	94%
Q8TX03	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	48%	91%
Q8U4H3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	49%	100%
Q90732	Gallus gallus	44%	90%
Q94BQ2	Arabidopsis thaliana	48%	95%
Q975U2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	48%	100%
Q980M1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	46%	100%
Q9C5U3	Arabidopsis thaliana	47%	95%
Q9HNP9	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	40%	96%
Q9HRW6	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	41%	98%
Q9MAK9	Arabidopsis thaliana	62%	99%
Q9SEI2	Arabidopsis thaliana	48%	93%
Q9SEI3	Arabidopsis thaliana	63%	99%
Q9SEI4	Arabidopsis thaliana	45%	97%
Q9SEX2	Arabidopsis thaliana	38%	76%
Q9SL67	Arabidopsis thaliana	44%	89%
Q9SSB4	Arabidopsis thaliana	47%	85%
Q9SSB5	Arabidopsis thaliana	48%	93%
Q9SZD4	Arabidopsis thaliana	44%	89%
Q9V287	Pyrococcus abyssi (strain GE5 / Orsay)	48%	100%
Q9XTT9	Caenorhabditis elegans	49%	95%
Q9YAC7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	48%	97%
V5AV12	Trypanosoma cruzi	44%	91%
V5B5X1	Trypanosoma cruzi	51%	91%
V5B5X6	Trypanosoma cruzi	49%	90%
V5BKL6	Trypanosoma cruzi	48%	98%
V5BSS5	Trypanosoma cruzi	80%	99%