RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3L4_LEIBR

TriTrypDb:

LbrM.03.0430 , LBRM2903_030010000

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000243	commitment complex	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0016604	nuclear body	2	1
GO:0016607	nuclear speck	3	1
GO:0032991	protein-containing complex	1	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0089701	U2AF complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H3L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3L4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003727	single-stranded RNA binding	5	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0030628	pre-mRNA 3'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.485
CLV_C14_Caspase3-7	464	468	PF00656	0.502
CLV_C14_Caspase3-7	757	761	PF00656	0.786
CLV_C14_Caspase3-7	76	80	PF00656	0.528
CLV_C14_Caspase3-7	764	768	PF00656	0.504
CLV_C14_Caspase3-7	776	780	PF00656	0.705
CLV_C14_Caspase3-7	8	12	PF00656	0.741
CLV_NRD_NRD_1	279	281	PF00675	0.441
CLV_NRD_NRD_1	285	287	PF00675	0.389
CLV_NRD_NRD_1	313	315	PF00675	0.378
CLV_NRD_NRD_1	35	37	PF00675	0.598
CLV_NRD_NRD_1	408	410	PF00675	0.413
CLV_NRD_NRD_1	48	50	PF00675	0.683
CLV_NRD_NRD_1	651	653	PF00675	0.476
CLV_NRD_NRD_1	68	70	PF00675	0.756
CLV_PCSK_FUR_1	33	37	PF00082	0.774
CLV_PCSK_FUR_1	643	647	PF00082	0.425
CLV_PCSK_KEX2_1	279	281	PF00082	0.441
CLV_PCSK_KEX2_1	285	287	PF00082	0.389
CLV_PCSK_KEX2_1	313	315	PF00082	0.378
CLV_PCSK_KEX2_1	35	37	PF00082	0.586
CLV_PCSK_KEX2_1	408	410	PF00082	0.413
CLV_PCSK_KEX2_1	48	50	PF00082	0.686
CLV_PCSK_KEX2_1	645	647	PF00082	0.447
CLV_PCSK_KEX2_1	651	653	PF00082	0.456
CLV_PCSK_KEX2_1	68	70	PF00082	0.667
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.423
CLV_PCSK_PC7_1	31	37	PF00082	0.616
CLV_PCSK_SKI1_1	391	395	PF00082	0.498
CLV_PCSK_SKI1_1	423	427	PF00082	0.386
CLV_PCSK_SKI1_1	439	443	PF00082	0.196
CLV_PCSK_SKI1_1	447	451	PF00082	0.265
CLV_PCSK_SKI1_1	466	470	PF00082	0.178
CLV_PCSK_SKI1_1	495	499	PF00082	0.408
CLV_PCSK_SKI1_1	570	574	PF00082	0.521
CLV_PCSK_SKI1_1	696	700	PF00082	0.375
CLV_PCSK_SKI1_1	775	779	PF00082	0.529
DEG_SPOP_SBC_1	181	185	PF00917	0.591
DEG_SPOP_SBC_1	207	211	PF00917	0.525
DEG_SPOP_SBC_1	799	803	PF00917	0.687
DOC_CKS1_1	605	610	PF01111	0.480
DOC_CYCLIN_RxL_1	388	397	PF00134	0.512
DOC_CYCLIN_RxL_1	444	452	PF00134	0.502
DOC_CYCLIN_RxL_1	567	576	PF00134	0.578
DOC_MAPK_FxFP_2	743	746	PF00069	0.532
DOC_MAPK_gen_1	363	372	PF00069	0.371
DOC_MAPK_gen_1	640	649	PF00069	0.391
DOC_MAPK_MEF2A_6	226	233	PF00069	0.648
DOC_MAPK_MEF2A_6	365	374	PF00069	0.368
DOC_MAPK_MEF2A_6	500	507	PF00069	0.481
DOC_MAPK_NFAT4_5	226	234	PF00069	0.654
DOC_PP1_RVXF_1	445	452	PF00149	0.554
DOC_PP2B_LxvP_1	268	271	PF13499	0.548
DOC_PP2B_LxvP_1	647	650	PF13499	0.373
DOC_PP4_FxxP_1	128	131	PF00568	0.746
DOC_PP4_FxxP_1	47	50	PF00568	0.692
DOC_PP4_FxxP_1	577	580	PF00568	0.559
DOC_PP4_FxxP_1	605	608	PF00568	0.469
DOC_PP4_FxxP_1	743	746	PF00568	0.532
DOC_SPAK_OSR1_1	585	589	PF12202	0.337
DOC_USP7_MATH_1	131	135	PF00917	0.640
DOC_USP7_MATH_1	246	250	PF00917	0.710
DOC_USP7_MATH_1	287	291	PF00917	0.473
DOC_USP7_MATH_1	434	438	PF00917	0.547
DOC_USP7_MATH_1	527	531	PF00917	0.725
DOC_USP7_MATH_1	548	552	PF00917	0.682
DOC_USP7_MATH_1	756	760	PF00917	0.532
DOC_USP7_MATH_1	799	803	PF00917	0.665
DOC_USP7_UBL2_3	516	520	PF12436	0.513
DOC_WW_Pin1_4	604	609	PF00397	0.503
DOC_WW_Pin1_4	820	825	PF00397	0.598
LIG_14-3-3_CanoR_1	313	321	PF00244	0.503
LIG_14-3-3_CanoR_1	363	368	PF00244	0.474
LIG_14-3-3_CanoR_1	737	746	PF00244	0.406
LIG_AP2alpha_2	45	47	PF02296	0.674
LIG_APCC_ABBA_1	613	618	PF00400	0.405
LIG_BIR_III_2	412	416	PF00653	0.507
LIG_BRCT_BRCA1_1	365	369	PF00533	0.372
LIG_BRCT_BRCA1_1	741	745	PF00533	0.428
LIG_Clathr_ClatBox_1	265	269	PF01394	0.640
LIG_Clathr_ClatBox_1	448	452	PF01394	0.465
LIG_FHA_1	208	214	PF00498	0.693
LIG_FHA_1	326	332	PF00498	0.394
LIG_FHA_1	343	349	PF00498	0.635
LIG_FHA_1	400	406	PF00498	0.575
LIG_FHA_1	527	533	PF00498	0.642
LIG_FHA_1	536	542	PF00498	0.571
LIG_FHA_1	605	611	PF00498	0.376
LIG_FHA_1	700	706	PF00498	0.485
LIG_FHA_1	739	745	PF00498	0.460
LIG_FHA_1	821	827	PF00498	0.601
LIG_FHA_2	294	300	PF00498	0.440
LIG_FHA_2	415	421	PF00498	0.518
LIG_FHA_2	504	510	PF00498	0.452
LIG_FHA_2	576	582	PF00498	0.568
LIG_FHA_2	716	722	PF00498	0.478
LIG_FHA_2	750	756	PF00498	0.609
LIG_LIR_Apic_2	45	50	PF02991	0.683
LIG_LIR_Apic_2	574	580	PF02991	0.567
LIG_LIR_Apic_2	603	608	PF02991	0.510
LIG_LIR_Apic_2	741	746	PF02991	0.525
LIG_LIR_Apic_2	79	85	PF02991	0.724
LIG_LIR_Gen_1	302	312	PF02991	0.405
LIG_LIR_Gen_1	366	377	PF02991	0.349
LIG_LIR_Gen_1	461	468	PF02991	0.490
LIG_LIR_Gen_1	624	634	PF02991	0.403
LIG_LIR_Gen_1	715	723	PF02991	0.400
LIG_LIR_LC3C_4	551	556	PF02991	0.466
LIG_LIR_Nem_3	218	223	PF02991	0.621
LIG_LIR_Nem_3	302	308	PF02991	0.386
LIG_LIR_Nem_3	366	372	PF02991	0.355
LIG_LIR_Nem_3	443	448	PF02991	0.463
LIG_LIR_Nem_3	461	465	PF02991	0.393
LIG_LIR_Nem_3	624	630	PF02991	0.411
LIG_LIR_Nem_3	639	644	PF02991	0.395
LIG_LIR_Nem_3	715	719	PF02991	0.396
LIG_LIR_Nem_3	742	748	PF02991	0.434
LIG_LYPXL_S_1	589	593	PF13949	0.513
LIG_LYPXL_yS_3	106	109	PF13949	0.520
LIG_LYPXL_yS_3	403	406	PF13949	0.465
LIG_LYPXL_yS_3	590	593	PF13949	0.558
LIG_MAD2	423	431	PF02301	0.439
LIG_MYND_1	591	595	PF01753	0.484
LIG_NRBOX	167	173	PF00104	0.577
LIG_NRBOX	493	499	PF00104	0.432
LIG_PCNA_TLS_4	298	305	PF02747	0.495
LIG_Pex14_1	86	90	PF04695	0.491
LIG_Pex14_2	128	132	PF04695	0.644
LIG_Rb_pABgroove_1	610	618	PF01858	0.387
LIG_SH2_CRK	445	449	PF00017	0.530
LIG_SH2_CRK	627	631	PF00017	0.436
LIG_SH2_CRK	641	645	PF00017	0.343
LIG_SH2_CRK	709	713	PF00017	0.516
LIG_SH2_GRB2like	597	600	PF00017	0.597
LIG_SH2_NCK_1	716	720	PF00017	0.412
LIG_SH2_SRC	457	460	PF00017	0.530
LIG_SH2_SRC	597	600	PF00017	0.557
LIG_SH2_STAP1	623	627	PF00017	0.436
LIG_SH2_STAT5	304	307	PF00017	0.387
LIG_SH2_STAT5	517	520	PF00017	0.567
LIG_SH3_3	219	225	PF00018	0.571
LIG_SH3_3	304	310	PF00018	0.292
LIG_SH3_3	424	430	PF00018	0.428
LIG_SH3_3	483	489	PF00018	0.392
LIG_SH3_3	585	591	PF00018	0.445
LIG_SH3_3	653	659	PF00018	0.513
LIG_SH3_3	86	92	PF00018	0.492
LIG_SH3_5	664	668	PF00018	0.609
LIG_SUMO_SIM_anti_2	420	428	PF11976	0.440
LIG_SUMO_SIM_anti_2	551	560	PF11976	0.445
LIG_SUMO_SIM_anti_2	607	613	PF11976	0.339
LIG_SUMO_SIM_par_1	264	269	PF11976	0.682
LIG_SUMO_SIM_par_1	551	560	PF11976	0.653
LIG_TRAF2_1	297	300	PF00917	0.462
LIG_TRAF2_1	752	755	PF00917	0.601
LIG_TRAF2_1	762	765	PF00917	0.781
LIG_TYR_ITIM	588	593	PF00017	0.358
LIG_TYR_ITIM	714	719	PF00017	0.389
LIG_UBA3_1	744	750	PF00899	0.496
LIG_WRC_WIRS_1	364	369	PF05994	0.297
LIG_WRC_WIRS_1	740	745	PF05994	0.407
LIG_WW_3	187	191	PF00397	0.684
LIG_WW_3	49	53	PF00397	0.682
MOD_CK1_1	180	186	PF00069	0.550
MOD_CK1_1	206	212	PF00069	0.705
MOD_CK1_1	600	606	PF00069	0.545
MOD_CK1_1	625	631	PF00069	0.480
MOD_CK1_1	802	808	PF00069	0.532
MOD_CK2_1	213	219	PF00069	0.666
MOD_CK2_1	293	299	PF00069	0.444
MOD_CK2_1	347	353	PF00069	0.602
MOD_CK2_1	365	371	PF00069	0.362
MOD_CK2_1	429	435	PF00069	0.551
MOD_CK2_1	715	721	PF00069	0.422
MOD_CK2_1	749	755	PF00069	0.583
MOD_GlcNHglycan	133	136	PF01048	0.727
MOD_GlcNHglycan	145	148	PF01048	0.803
MOD_GlcNHglycan	200	203	PF01048	0.660
MOD_GlcNHglycan	205	208	PF01048	0.674
MOD_GlcNHglycan	238	241	PF01048	0.654
MOD_GlcNHglycan	248	251	PF01048	0.718
MOD_GlcNHglycan	289	292	PF01048	0.525
MOD_GlcNHglycan	384	387	PF01048	0.462
MOD_GlcNHglycan	513	516	PF01048	0.419
MOD_GlcNHglycan	528	532	PF01048	0.701
MOD_GlcNHglycan	551	554	PF01048	0.726
MOD_GlcNHglycan	57	62	PF01048	0.721
MOD_GSK3_1	177	184	PF00069	0.663
MOD_GSK3_1	203	210	PF00069	0.626
MOD_GSK3_1	5	12	PF00069	0.791
MOD_GSK3_1	600	607	PF00069	0.522
MOD_GSK3_1	735	742	PF00069	0.472
MOD_GSK3_1	798	805	PF00069	0.533
MOD_N-GLC_1	394	399	PF02516	0.477
MOD_N-GLC_1	625	630	PF02516	0.483
MOD_N-GLC_2	156	158	PF02516	0.521
MOD_NEK2_1	393	398	PF00069	0.471
MOD_NEK2_1	573	578	PF00069	0.532
MOD_NEK2_2	434	439	PF00069	0.538
MOD_PIKK_1	112	118	PF00454	0.521
MOD_PIKK_1	597	603	PF00454	0.606
MOD_PIKK_1	625	631	PF00454	0.480
MOD_PIKK_1	800	806	PF00454	0.694
MOD_PK_1	355	361	PF00069	0.448
MOD_PKA_2	9	15	PF00069	0.670
MOD_Plk_1	394	400	PF00069	0.478
MOD_Plk_1	434	440	PF00069	0.502
MOD_Plk_1	503	509	PF00069	0.505
MOD_Plk_1	527	533	PF00069	0.664
MOD_Plk_1	573	579	PF00069	0.543
MOD_Plk_1	625	631	PF00069	0.437
MOD_Plk_1	735	741	PF00069	0.504
MOD_Plk_2-3	715	721	PF00069	0.394
MOD_Plk_2-3	754	760	PF00069	0.525
MOD_Plk_4	224	230	PF00069	0.536
MOD_Plk_4	600	606	PF00069	0.520
MOD_Plk_4	739	745	PF00069	0.400
MOD_ProDKin_1	604	610	PF00069	0.494
MOD_ProDKin_1	820	826	PF00069	0.598
MOD_SUMO_for_1	331	334	PF00179	0.615
MOD_SUMO_for_1	449	452	PF00179	0.502
MOD_SUMO_for_1	790	793	PF00179	0.544
MOD_SUMO_rev_2	350	357	PF00179	0.506
MOD_SUMO_rev_2	420	425	PF00179	0.479
MOD_SUMO_rev_2	767	777	PF00179	0.553
TRG_DiLeu_BaEn_1	326	331	PF01217	0.547
TRG_ENDOCYTIC_2	106	109	PF00928	0.721
TRG_ENDOCYTIC_2	304	307	PF00928	0.446
TRG_ENDOCYTIC_2	403	406	PF00928	0.505
TRG_ENDOCYTIC_2	445	448	PF00928	0.493
TRG_ENDOCYTIC_2	459	462	PF00928	0.399
TRG_ENDOCYTIC_2	491	494	PF00928	0.315
TRG_ENDOCYTIC_2	590	593	PF00928	0.558
TRG_ENDOCYTIC_2	627	630	PF00928	0.403
TRG_ENDOCYTIC_2	641	644	PF00928	0.390
TRG_ENDOCYTIC_2	709	712	PF00928	0.436
TRG_ENDOCYTIC_2	716	719	PF00928	0.375
TRG_ER_diArg_1	279	282	PF00400	0.460
TRG_ER_diArg_1	31	34	PF00400	0.778
TRG_ER_diArg_1	312	314	PF00400	0.364
TRG_ER_diArg_1	407	409	PF00400	0.398
TRG_ER_diArg_1	47	49	PF00400	0.642
TRG_ER_diArg_1	650	652	PF00400	0.424
TRG_ER_diArg_1	68	71	PF00400	0.666
TRG_NES_CRM1_1	567	581	PF08389	0.577
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWG2	Leptomonas seymouri	55%	99%
A0A0S4IUY1	Bodo saltans	31%	100%
A0A3R7MIS4	Trypanosoma rangeli	40%	94%
A0A3S5H546	Leishmania donovani	81%	98%
E9ACJ7	Leishmania major	80%	100%
E9AG41	Leishmania infantum	80%	97%
E9AJT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
V5DU29	Trypanosoma cruzi	42%	99%