Putative 60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P2, putative

Species:

Leishmania braziliensis

UniProt:

A4H3L1_LEIBR

TriTrypDb:

LbrM.03.0400 , LBRM2903_030009100

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 13
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A4H3L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3L1

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0071704	organic substance metabolic process	2	14
GO:1901576	organic substance biosynthetic process	3	14
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14
GO:0005488	binding	1	1
GO:0008047	enzyme activator activity	3	1
GO:0019207	kinase regulator activity	3	1
GO:0019209	kinase activator activity	4	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0030295	protein kinase activator activity	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_MEF2A_6	39	46	PF00069	0.443
DOC_USP7_MATH_1	34	38	PF00917	0.503
DOC_USP7_UBL2_3	84	88	PF12436	0.522
LIG_FHA_1	1	7	PF00498	0.437
LIG_FHA_1	39	45	PF00498	0.446
LIG_FHA_2	20	26	PF00498	0.406
LIG_LIR_Gen_1	9	18	PF02991	0.405
LIG_LIR_Nem_3	100	106	PF02991	0.475
LIG_LIR_Nem_3	9	13	PF02991	0.394
LIG_SH2_CRK	10	14	PF00017	0.400
LIG_SH2_STAP1	10	14	PF00017	0.400
LIG_SH3_3	37	43	PF00018	0.470
LIG_TRAF2_1	93	96	PF00917	0.507
MOD_CK2_1	19	25	PF00069	0.501
MOD_GlcNHglycan	22	25	PF01048	0.392
MOD_GlcNHglycan	70	73	PF01048	0.339
MOD_GlcNHglycan	80	84	PF01048	0.230
MOD_GSK3_1	2	9	PF00069	0.353
MOD_GSK3_1	34	41	PF00069	0.413
MOD_GSK3_1	61	68	PF00069	0.485
MOD_NEK2_1	6	11	PF00069	0.410
MOD_NEK2_2	34	39	PF00069	0.424
MOD_PIKK_1	61	67	PF00454	0.371
MOD_PKA_2	38	44	PF00069	0.441
MOD_Plk_2-3	51	57	PF00069	0.465
TRG_ENDOCYTIC_2	10	13	PF00928	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K6	Leptomonas seymouri	46%	100%
A0A0S4IV06	Bodo saltans	56%	100%
A0A0S4JVF4	Bodo saltans	37%	100%
A0A1X0NTR3	Trypanosomatidae	44%	100%
A0A1X0P9L8	Trypanosomatidae	59%	92%
A0A3Q8IA63	Leishmania donovani	47%	99%
A0A3R7KRR7	Trypanosoma rangeli	48%	100%
A0A3R7NK96	Trypanosoma rangeli	60%	94%
A0A451EJP5	Leishmania donovani	77%	96%
A1XQU7	Sus scrofa	33%	94%
A4H3L0	Leishmania braziliensis	96%	99%
A4HRV3	Leishmania infantum	59%	96%
A4HRV4	Leishmania infantum	76%	96%
A4HWD9	Leishmania infantum	47%	99%
D0A247	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	76%
E9ACI8	Leishmania major	75%	100%
E9AI48	Leishmania braziliensis	49%	99%
E9AJS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9AJS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
E9AQ39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
H2E5X2	Penicillium crustosum	44%	100%
O01359	Oscheius tipulae	38%	96%
O23095	Arabidopsis thaliana	41%	95%
O44010	Leishmania braziliensis	44%	100%
O46313	Leishmania peruviana	100%	100%
P05318	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P05386	Homo sapiens	36%	94%
P08570	Drosophila melanogaster	44%	96%
P10622	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P17476	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	98%
P17477	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	97%
P18660	Gallus gallus	40%	94%
P19944	Rattus norvegicus	36%	94%
P22684	Dictyostelium discoideum	38%	95%
P29763	Chlamydomonas reinhardtii	45%	100%
P47955	Mus musculus	37%	94%
P49148	Alternaria alternata	34%	97%
P50344	Davidiella tassiana	42%	97%
P52855	Zea mays	49%	98%
P91913	Caenorhabditis elegans	41%	96%
Q49KL9	Penicillium brevicompactum	41%	100%
Q4QFE2	Leishmania major	47%	99%
Q56K14	Bos taurus	36%	94%
Q8LCW9	Arabidopsis thaliana	47%	96%
Q8LEQ0	Arabidopsis thaliana	43%	95%
Q9HFQ6	Candida albicans	42%	99%
Q9HFQ7	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	100%
Q9HGV0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	40%	96%
Q9UU78	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	98%