LeishMANIAdb
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Putative MFS transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative MFS transporter
Gene product:
MFS transporter, putative
Species:
Leishmania braziliensis
UniProt:
A4H3K8_LEIBR
TriTrypDb:
LbrM.03.0370 , LBRM2903_030008800 *
Length:
687

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 17
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

A4H3K8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 19
GO:0022857 transmembrane transporter activity 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 382 386 PF00656 0.737
CLV_NRD_NRD_1 10 12 PF00675 0.588
CLV_NRD_NRD_1 296 298 PF00675 0.463
CLV_NRD_NRD_1 481 483 PF00675 0.265
CLV_NRD_NRD_1 629 631 PF00675 0.434
CLV_NRD_NRD_1 632 634 PF00675 0.452
CLV_NRD_NRD_1 683 685 PF00675 0.529
CLV_PCSK_FUR_1 630 634 PF00082 0.308
CLV_PCSK_KEX2_1 10 12 PF00082 0.493
CLV_PCSK_KEX2_1 296 298 PF00082 0.411
CLV_PCSK_KEX2_1 327 329 PF00082 0.559
CLV_PCSK_KEX2_1 481 483 PF00082 0.275
CLV_PCSK_KEX2_1 615 617 PF00082 0.277
CLV_PCSK_KEX2_1 631 633 PF00082 0.428
CLV_PCSK_KEX2_1 683 685 PF00082 0.562
CLV_PCSK_PC1ET2_1 327 329 PF00082 0.592
CLV_PCSK_PC1ET2_1 615 617 PF00082 0.332
CLV_PCSK_PC1ET2_1 631 633 PF00082 0.479
CLV_PCSK_PC1ET2_1 683 685 PF00082 0.442
CLV_PCSK_PC7_1 679 685 PF00082 0.398
CLV_PCSK_SKI1_1 484 488 PF00082 0.259
CLV_PCSK_SKI1_1 611 615 PF00082 0.322
CLV_PCSK_SKI1_1 679 683 PF00082 0.420
DEG_COP1_1 387 397 PF00400 0.574
DEG_SCF_FBW7_1 26 33 PF00400 0.668
DEG_SPOP_SBC_1 553 557 PF00917 0.473
DOC_CKS1_1 201 206 PF01111 0.301
DOC_CYCLIN_RxL_1 478 491 PF00134 0.549
DOC_MAPK_FxFP_2 273 276 PF00069 0.428
DOC_MAPK_gen_1 478 487 PF00069 0.458
DOC_MAPK_MEF2A_6 516 524 PF00069 0.211
DOC_MAPK_RevD_3 264 278 PF00069 0.428
DOC_PP4_FxxP_1 242 245 PF00568 0.262
DOC_PP4_FxxP_1 273 276 PF00568 0.309
DOC_PP4_FxxP_1 471 474 PF00568 0.354
DOC_PP4_FxxP_1 536 539 PF00568 0.303
DOC_SPAK_OSR1_1 89 93 PF12202 0.473
DOC_USP7_MATH_1 189 193 PF00917 0.389
DOC_USP7_MATH_1 20 24 PF00917 0.659
DOC_USP7_MATH_1 423 427 PF00917 0.284
DOC_USP7_MATH_1 662 666 PF00917 0.694
DOC_USP7_UBL2_3 611 615 PF12436 0.549
DOC_WW_Pin1_4 200 205 PF00397 0.301
DOC_WW_Pin1_4 26 31 PF00397 0.777
DOC_WW_Pin1_4 580 585 PF00397 0.319
DOC_WW_Pin1_4 90 95 PF00397 0.450
LIG_14-3-3_CanoR_1 328 336 PF00244 0.644
LIG_14-3-3_CanoR_1 414 420 PF00244 0.567
LIG_14-3-3_CanoR_1 632 641 PF00244 0.682
LIG_AP2alpha_2 86 88 PF02296 0.566
LIG_BIR_II_1 1 5 PF00653 0.703
LIG_BRCT_BRCA1_1 191 195 PF00533 0.487
LIG_deltaCOP1_diTrp_1 86 90 PF00928 0.573
LIG_eIF4E_1 263 269 PF01652 0.317
LIG_FHA_1 131 137 PF00498 0.309
LIG_FHA_1 194 200 PF00498 0.301
LIG_FHA_1 201 207 PF00498 0.287
LIG_FHA_1 238 244 PF00498 0.266
LIG_FHA_1 500 506 PF00498 0.379
LIG_FHA_1 566 572 PF00498 0.353
LIG_FHA_1 604 610 PF00498 0.426
LIG_FHA_1 67 73 PF00498 0.709
LIG_FHA_2 327 333 PF00498 0.610
LIG_FHA_2 581 587 PF00498 0.280
LIG_FHA_2 615 621 PF00498 0.555
LIG_GBD_Chelix_1 266 274 PF00786 0.302
LIG_GBD_Chelix_1 496 504 PF00786 0.382
LIG_Integrin_RGD_1 84 86 PF01839 0.339
LIG_IRF3_LxIS_1 419 425 PF10401 0.428
LIG_IRF3_LxIS_1 95 102 PF10401 0.349
LIG_LIR_Apic_2 240 245 PF02991 0.259
LIG_LIR_Gen_1 192 202 PF02991 0.412
LIG_LIR_Gen_1 262 271 PF02991 0.334
LIG_LIR_Gen_1 415 424 PF02991 0.465
LIG_LIR_Gen_1 93 104 PF02991 0.293
LIG_LIR_Nem_3 192 198 PF02991 0.464
LIG_LIR_Nem_3 262 266 PF02991 0.334
LIG_LIR_Nem_3 415 420 PF02991 0.497
LIG_LIR_Nem_3 454 459 PF02991 0.207
LIG_LIR_Nem_3 514 520 PF02991 0.270
LIG_LIR_Nem_3 573 579 PF02991 0.324
LIG_LIR_Nem_3 93 99 PF02991 0.303
LIG_MYND_1 62 66 PF01753 0.721
LIG_NRBOX 167 173 PF00104 0.387
LIG_NRBOX 499 505 PF00104 0.405
LIG_Pex14_2 253 257 PF04695 0.267
LIG_PTB_Apo_2 206 213 PF02174 0.459
LIG_SH2_CRK 263 267 PF00017 0.381
LIG_SH2_CRK 483 487 PF00017 0.472
LIG_SH2_GRB2like 120 123 PF00017 0.204
LIG_SH2_PTP2 139 142 PF00017 0.323
LIG_SH2_PTP2 178 181 PF00017 0.228
LIG_SH2_PTP2 518 521 PF00017 0.232
LIG_SH2_SRC 12 15 PF00017 0.611
LIG_SH2_STAP1 263 267 PF00017 0.428
LIG_SH2_STAT3 187 190 PF00017 0.303
LIG_SH2_STAT5 120 123 PF00017 0.259
LIG_SH2_STAT5 135 138 PF00017 0.282
LIG_SH2_STAT5 139 142 PF00017 0.304
LIG_SH2_STAT5 178 181 PF00017 0.274
LIG_SH2_STAT5 187 190 PF00017 0.349
LIG_SH2_STAT5 518 521 PF00017 0.335
LIG_SH2_STAT5 544 547 PF00017 0.549
LIG_SH3_3 14 20 PF00018 0.765
LIG_SH3_3 233 239 PF00018 0.309
LIG_SH3_3 273 279 PF00018 0.277
LIG_SH3_3 464 470 PF00018 0.348
LIG_SH3_4 611 618 PF00018 0.549
LIG_SUMO_SIM_anti_2 491 497 PF11976 0.372
LIG_SUMO_SIM_anti_2 597 603 PF11976 0.294
LIG_SUMO_SIM_par_1 196 203 PF11976 0.303
LIG_SUMO_SIM_par_1 420 426 PF11976 0.302
LIG_SUMO_SIM_par_1 497 502 PF11976 0.357
LIG_SUMO_SIM_par_1 543 549 PF11976 0.466
LIG_SUMO_SIM_par_1 605 610 PF11976 0.375
LIG_SUMO_SIM_par_1 97 102 PF11976 0.303
LIG_Vh1_VBS_1 485 503 PF01044 0.302
LIG_WRC_WIRS_1 238 243 PF05994 0.291
LIG_WRC_WIRS_1 590 595 PF05994 0.425
MOD_CK1_1 415 421 PF00069 0.514
MOD_CK1_1 597 603 PF00069 0.260
MOD_CK1_1 672 678 PF00069 0.697
MOD_CK2_1 191 197 PF00069 0.288
MOD_CK2_1 326 332 PF00069 0.809
MOD_CK2_1 385 391 PF00069 0.757
MOD_CK2_1 423 429 PF00069 0.297
MOD_CK2_1 580 586 PF00069 0.321
MOD_CK2_1 614 620 PF00069 0.532
MOD_CK2_1 70 76 PF00069 0.655
MOD_Cter_Amidation 479 482 PF01082 0.349
MOD_GlcNHglycan 14 17 PF01048 0.540
MOD_GlcNHglycan 22 25 PF01048 0.571
MOD_GlcNHglycan 225 228 PF01048 0.323
MOD_GlcNHglycan 357 360 PF01048 0.575
MOD_GlcNHglycan 425 428 PF01048 0.303
MOD_GlcNHglycan 453 456 PF01048 0.387
MOD_GlcNHglycan 556 559 PF01048 0.271
MOD_GlcNHglycan 563 566 PF01048 0.291
MOD_GlcNHglycan 635 638 PF01048 0.485
MOD_GlcNHglycan 659 663 PF01048 0.566
MOD_GlcNHglycan 671 674 PF01048 0.559
MOD_GSK3_1 189 196 PF00069 0.323
MOD_GSK3_1 20 27 PF00069 0.814
MOD_GSK3_1 219 226 PF00069 0.270
MOD_GSK3_1 447 454 PF00069 0.188
MOD_GSK3_1 561 568 PF00069 0.379
MOD_GSK3_1 578 585 PF00069 0.290
MOD_GSK3_1 603 610 PF00069 0.432
MOD_GSK3_1 658 665 PF00069 0.716
MOD_GSK3_1 66 73 PF00069 0.695
MOD_LATS_1 68 74 PF00433 0.533
MOD_N-GLC_1 123 128 PF02516 0.444
MOD_N-GLC_1 415 420 PF02516 0.336
MOD_N-GLC_2 366 368 PF02516 0.537
MOD_NEK2_1 123 128 PF00069 0.280
MOD_NEK2_1 130 135 PF00069 0.332
MOD_NEK2_1 259 264 PF00069 0.256
MOD_NEK2_1 422 427 PF00069 0.329
MOD_NEK2_1 552 557 PF00069 0.472
MOD_NEK2_1 561 566 PF00069 0.280
MOD_NEK2_1 570 575 PF00069 0.230
MOD_NEK2_1 607 612 PF00069 0.370
MOD_NEK2_1 660 665 PF00069 0.704
MOD_NEK2_1 99 104 PF00069 0.291
MOD_OFUCOSY 344 349 PF10250 0.443
MOD_PIKK_1 123 129 PF00454 0.316
MOD_PIKK_1 660 666 PF00454 0.696
MOD_PKA_1 327 333 PF00069 0.752
MOD_PKA_1 355 361 PF00069 0.625
MOD_PKA_2 327 333 PF00069 0.749
MOD_PKA_2 669 675 PF00069 0.729
MOD_Plk_1 123 129 PF00069 0.257
MOD_Plk_1 415 421 PF00069 0.492
MOD_Plk_1 546 552 PF00069 0.467
MOD_Plk_2-3 307 313 PF00069 0.590
MOD_Plk_2-3 385 391 PF00069 0.658
MOD_Plk_4 131 137 PF00069 0.302
MOD_Plk_4 219 225 PF00069 0.320
MOD_Plk_4 237 243 PF00069 0.212
MOD_Plk_4 30 36 PF00069 0.707
MOD_Plk_4 435 441 PF00069 0.316
MOD_Plk_4 463 469 PF00069 0.331
MOD_Plk_4 488 494 PF00069 0.341
MOD_Plk_4 499 505 PF00069 0.331
MOD_Plk_4 570 576 PF00069 0.319
MOD_Plk_4 594 600 PF00069 0.287
MOD_Plk_4 603 609 PF00069 0.280
MOD_ProDKin_1 200 206 PF00069 0.301
MOD_ProDKin_1 26 32 PF00069 0.775
MOD_ProDKin_1 580 586 PF00069 0.319
MOD_ProDKin_1 90 96 PF00069 0.450
MOD_SUMO_rev_2 582 590 PF00179 0.246
TRG_DiLeu_BaEn_1 214 219 PF01217 0.375
TRG_DiLeu_BaLyEn_6 202 207 PF01217 0.323
TRG_DiLeu_BaLyEn_6 59 64 PF01217 0.722
TRG_ENDOCYTIC_2 120 123 PF00928 0.273
TRG_ENDOCYTIC_2 139 142 PF00928 0.295
TRG_ENDOCYTIC_2 263 266 PF00928 0.381
TRG_ENDOCYTIC_2 483 486 PF00928 0.476
TRG_ENDOCYTIC_2 517 520 PF00928 0.214
TRG_ER_diArg_1 10 12 PF00400 0.623
TRG_ER_diArg_1 296 299 PF00400 0.641
TRG_ER_diArg_1 481 483 PF00400 0.481
TRG_ER_diArg_1 630 633 PF00400 0.679
TRG_ER_diLys_1 683 687 PF00400 0.644
TRG_NLS_Bipartite_1 615 635 PF00514 0.678
TRG_NLS_MonoCore_2 276 281 PF00514 0.533
TRG_NLS_MonoCore_2 629 634 PF00514 0.508
TRG_NLS_MonoExtN_4 276 281 PF00514 0.533
TRG_NLS_MonoExtN_4 630 635 PF00514 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 27% 97%
A0A0N1IHM9 Leptomonas seymouri 71% 97%
A0A0S4J2T0 Bodo saltans 34% 100%
A0A1X0NWR8 Trypanosomatidae 26% 100%
A0A1X0PA49 Trypanosomatidae 51% 100%
A0A3Q8IBI9 Leishmania donovani 27% 94%
A0A3S5H541 Leishmania donovani 82% 100%
A0A422NQJ7 Trypanosoma rangeli 51% 100%
A4HRV1 Leishmania infantum 82% 100%
A4HYN7 Leishmania infantum 26% 94%
D0A244 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9ACI6 Leishmania major 82% 99%
E9AJS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
E9AUH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 95%
Q4QD06 Leishmania major 26% 100%
V5BCB7 Trypanosoma cruzi 55% 100%
V5BQV3 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS