LeishMANIAdb
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GPR1/FUN34/YaaH-class plasma membrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GPR1/FUN34/YaaH-class plasma membrane protein
Gene product:
GPR1/FUN34/yaaH family, putative
Species:
Leishmania braziliensis
UniProt:
A4H3K7_LEIBR
TriTrypDb:
LbrM.03.0360 , LBRM2903_030008600 *
Length:
358

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005886 plasma membrane 3 2

Expansion

Sequence features

A4H3K7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006811 monoatomic ion transport 4 2
GO:0006820 monoatomic anion transport 5 2
GO:0006835 dicarboxylic acid transport 7 2
GO:0006846 acetate transport 6 2
GO:0009987 cellular process 1 2
GO:0015711 organic anion transport 5 2
GO:0015718 monocarboxylic acid transport 7 2
GO:0015740 C4-dicarboxylate transport 8 2
GO:0015744 succinate transport 6 2
GO:0015849 organic acid transport 5 2
GO:0034220 monoatomic ion transmembrane transport 3 2
GO:0035433 acetate transmembrane transport 5 2
GO:0046942 carboxylic acid transport 6 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071422 succinate transmembrane transport 5 2
GO:0071702 organic substance transport 4 2
GO:0098656 monoatomic anion transmembrane transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0008028 monocarboxylic acid transmembrane transporter activity 5 2
GO:0008324 monoatomic cation transmembrane transporter activity 4 2
GO:0008509 monoatomic anion transmembrane transporter activity 4 2
GO:0008514 organic anion transmembrane transporter activity 5 2
GO:0015075 monoatomic ion transmembrane transporter activity 3 2
GO:0015078 proton transmembrane transporter activity 5 2
GO:0015123 acetate transmembrane transporter activity 6 2
GO:0015291 secondary active transmembrane transporter activity 4 2
GO:0015293 symporter activity 5 2
GO:0015294 solute:monoatomic cation symporter activity 5 2
GO:0015295 solute:proton symporter activity 6 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2
GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5 2
GO:0015360 acetate:proton symporter activity 7 2
GO:0022804 active transmembrane transporter activity 3 2
GO:0022853 active monoatomic ion transmembrane transporter activity 4 2
GO:0022857 transmembrane transporter activity 2 2
GO:0022890 inorganic cation transmembrane transporter activity 4 2
GO:0043893 acetate:monoatomic cation symporter activity 6 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 59 63 PF00656 0.583
CLV_NRD_NRD_1 102 104 PF00675 0.428
CLV_PCSK_KEX2_1 102 104 PF00082 0.378
CLV_PCSK_SKI1_1 328 332 PF00082 0.307
CLV_PCSK_SKI1_1 349 353 PF00082 0.362
DEG_APCC_DBOX_1 174 182 PF00400 0.201
DEG_APCC_DBOX_1 327 335 PF00400 0.575
DEG_SPOP_SBC_1 351 355 PF00917 0.531
DOC_MAPK_DCC_7 149 158 PF00069 0.535
DOC_MAPK_DCC_7 328 336 PF00069 0.554
DOC_MAPK_MEF2A_6 268 277 PF00069 0.538
DOC_MAPK_MEF2A_6 328 336 PF00069 0.567
DOC_USP7_MATH_1 212 216 PF00917 0.405
DOC_USP7_MATH_1 234 238 PF00917 0.284
DOC_USP7_MATH_1 4 8 PF00917 0.613
DOC_USP7_MATH_1 69 73 PF00917 0.725
DOC_WW_Pin1_4 45 50 PF00397 0.562
LIG_14-3-3_CanoR_1 102 110 PF00244 0.738
LIG_14-3-3_CanoR_1 175 185 PF00244 0.212
LIG_14-3-3_CanoR_1 204 209 PF00244 0.481
LIG_14-3-3_CanoR_1 235 242 PF00244 0.214
LIG_Actin_RPEL_3 321 340 PF02755 0.498
LIG_Actin_WH2_2 285 302 PF00022 0.223
LIG_BIR_II_1 1 5 PF00653 0.714
LIG_BRCT_BRCA1_1 243 247 PF00533 0.338
LIG_deltaCOP1_diTrp_1 201 208 PF00928 0.538
LIG_FHA_1 163 169 PF00498 0.313
LIG_FHA_1 178 184 PF00498 0.323
LIG_FHA_1 277 283 PF00498 0.355
LIG_FHA_1 335 341 PF00498 0.604
LIG_FHA_1 62 68 PF00498 0.585
LIG_FHA_2 57 63 PF00498 0.586
LIG_LIR_Gen_1 17 28 PF02991 0.555
LIG_LIR_Gen_1 207 216 PF02991 0.364
LIG_LIR_Gen_1 259 269 PF02991 0.416
LIG_LIR_Gen_1 281 292 PF02991 0.375
LIG_LIR_Gen_1 312 322 PF02991 0.310
LIG_LIR_Gen_1 324 334 PF02991 0.455
LIG_LIR_Nem_3 207 211 PF02991 0.324
LIG_LIR_Nem_3 214 219 PF02991 0.293
LIG_LIR_Nem_3 244 250 PF02991 0.287
LIG_LIR_Nem_3 259 263 PF02991 0.367
LIG_LIR_Nem_3 281 287 PF02991 0.314
LIG_LIR_Nem_3 312 318 PF02991 0.270
LIG_LIR_Nem_3 324 329 PF02991 0.417
LIG_MLH1_MIPbox_1 243 247 PF16413 0.338
LIG_SH2_CRK 55 59 PF00017 0.704
LIG_SH2_STAT5 246 249 PF00017 0.384
LIG_SH2_STAT5 251 254 PF00017 0.390
LIG_SH2_STAT5 315 318 PF00017 0.326
LIG_SH2_STAT5 57 60 PF00017 0.715
LIG_SH2_STAT5 90 93 PF00017 0.707
LIG_SH3_3 329 335 PF00018 0.464
LIG_SUMO_SIM_anti_2 222 227 PF11976 0.223
LIG_SUMO_SIM_anti_2 279 284 PF11976 0.414
LIG_SUMO_SIM_par_1 274 279 PF11976 0.335
LIG_TRAF2_1 124 127 PF00917 0.535
LIG_TYR_ITIM 53 58 PF00017 0.581
LIG_UBA3_1 339 346 PF00899 0.464
LIG_WRC_WIRS_1 257 262 PF05994 0.414
LIG_WRC_WIRS_1 6 11 PF05994 0.593
MOD_CDK_SPK_2 45 50 PF00069 0.562
MOD_CK1_1 27 33 PF00069 0.581
MOD_CK1_1 34 40 PF00069 0.560
MOD_CK1_1 350 356 PF00069 0.621
MOD_CK1_1 48 54 PF00069 0.750
MOD_CK1_1 61 67 PF00069 0.616
MOD_CK2_1 121 127 PF00069 0.567
MOD_CK2_1 19 25 PF00069 0.633
MOD_CK2_1 235 241 PF00069 0.269
MOD_CK2_1 351 357 PF00069 0.618
MOD_GlcNHglycan 149 152 PF01048 0.215
MOD_GlcNHglycan 25 29 PF01048 0.502
MOD_GlcNHglycan 50 53 PF01048 0.496
MOD_GSK3_1 115 122 PF00069 0.713
MOD_GSK3_1 27 34 PF00069 0.547
MOD_GSK3_1 288 295 PF00069 0.432
MOD_GSK3_1 347 354 PF00069 0.577
MOD_GSK3_1 57 64 PF00069 0.728
MOD_GSK3_1 80 87 PF00069 0.780
MOD_GSK3_1 97 104 PF00069 0.751
MOD_N-GLC_1 235 240 PF02516 0.457
MOD_N-GLC_1 4 9 PF02516 0.394
MOD_N-GLC_2 107 109 PF02516 0.362
MOD_N-GLC_2 146 148 PF02516 0.173
MOD_NEK2_1 147 152 PF00069 0.496
MOD_NEK2_1 161 166 PF00069 0.310
MOD_NEK2_1 170 175 PF00069 0.297
MOD_NEK2_1 219 224 PF00069 0.361
MOD_NEK2_1 263 268 PF00069 0.313
MOD_NEK2_1 278 283 PF00069 0.309
MOD_NEK2_1 292 297 PF00069 0.328
MOD_NEK2_2 115 120 PF00069 0.552
MOD_NEK2_2 19 24 PF00069 0.562
MOD_NEK2_2 256 261 PF00069 0.310
MOD_PIKK_1 292 298 PF00454 0.308
MOD_PIKK_1 334 340 PF00454 0.538
MOD_PIKK_1 61 67 PF00454 0.678
MOD_PK_1 235 241 PF00069 0.201
MOD_PKA_1 102 108 PF00069 0.570
MOD_PKA_1 80 86 PF00069 0.694
MOD_PKA_2 101 107 PF00069 0.681
MOD_PKA_2 234 240 PF00069 0.201
MOD_Plk_1 115 121 PF00069 0.549
MOD_Plk_1 235 241 PF00069 0.229
MOD_Plk_1 24 30 PF00069 0.540
MOD_Plk_1 347 353 PF00069 0.536
MOD_Plk_1 4 10 PF00069 0.615
MOD_Plk_1 70 76 PF00069 0.576
MOD_Plk_2-3 121 127 PF00069 0.544
MOD_Plk_4 162 168 PF00069 0.311
MOD_Plk_4 177 183 PF00069 0.276
MOD_Plk_4 219 225 PF00069 0.333
MOD_Plk_4 235 241 PF00069 0.283
MOD_Plk_4 27 33 PF00069 0.611
MOD_Plk_4 278 284 PF00069 0.374
MOD_ProDKin_1 45 51 PF00069 0.563
TRG_DiLeu_BaEn_1 126 131 PF01217 0.531
TRG_DiLeu_LyEn_5 126 131 PF01217 0.479
TRG_ENDOCYTIC_2 216 219 PF00928 0.331
TRG_ENDOCYTIC_2 251 254 PF00928 0.352
TRG_ENDOCYTIC_2 304 307 PF00928 0.356
TRG_ENDOCYTIC_2 315 318 PF00928 0.312
TRG_ENDOCYTIC_2 55 58 PF00928 0.705
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.368

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAF6 Leptomonas seymouri 53% 98%
A0A3R7M294 Trypanosoma rangeli 33% 100%
A0A3S5H538 Leishmania donovani 63% 97%
A0A3S5H540 Leishmania donovani 72% 100%
A4H3K6 Leishmania braziliensis 83% 100%
A4HRU8 Leishmania infantum 64% 97%
A4HRV0 Leishmania infantum 72% 100%
E9ACI2 Leishmania major 26% 100%
E9ACI3 Leishmania major 60% 100%
E9ACI5 Leishmania major 74% 100%
E9AJS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AJS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 96%
E9AJS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
O14201 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 100%
P32907 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
V5BCC6 Trypanosoma cruzi 36% 100%
V5DU51 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS