GPR1/FUN34/yaaH family-domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPR1/FUN34/yaaH family, putative

Species:

Leishmania braziliensis

UniProt:

A4H3K6_LEIBR

TriTrypDb:

LbrM.03.0350 , LBRM2903_030008700

Length:

297

Annotations

LeishMANIAdb annotations

Most closely related to Prokaryotic SatP transporters. Especially expanded in the Leptomonas lineage

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005886	plasma membrane	3	2

Expansion

Sequence features

A4H3K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0006835	dicarboxylic acid transport	7	2
GO:0006846	acetate transport	6	2
GO:0009987	cellular process	1	2
GO:0015711	organic anion transport	5	2
GO:0015718	monocarboxylic acid transport	7	2
GO:0015740	C4-dicarboxylate transport	8	2
GO:0015744	succinate transport	6	2
GO:0015849	organic acid transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0035433	acetate transmembrane transport	5	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071422	succinate transmembrane transport	5	2
GO:0071702	organic substance transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015078	proton transmembrane transporter activity	5	2
GO:0015123	acetate transmembrane transporter activity	6	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015293	symporter activity	5	2
GO:0015294	solute:monoatomic cation symporter activity	5	2
GO:0015295	solute:proton symporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0015355	secondary active monocarboxylate transmembrane transporter activity	5	2
GO:0015360	acetate:proton symporter activity	7	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022853	active monoatomic ion transmembrane transporter activity	4	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0043893	acetate:monoatomic cation symporter activity	6	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.517
CLV_NRD_NRD_1	49	51	PF00675	0.487
CLV_NRD_NRD_1	59	61	PF00675	0.344
CLV_NRD_NRD_1	76	78	PF00675	0.307
CLV_PCSK_KEX2_1	59	61	PF00082	0.402
CLV_PCSK_KEX2_1	76	78	PF00082	0.238
CLV_PCSK_SKI1_1	256	260	PF00082	0.324
DEG_APCC_DBOX_1	102	110	PF00400	0.196
DEG_APCC_DBOX_1	255	263	PF00400	0.524
DEG_ODPH_VHL_1	73	86	PF01847	0.385
DOC_MAPK_DCC_7	256	264	PF00069	0.524
DOC_MAPK_gen_1	50	56	PF00069	0.494
DOC_MAPK_MEF2A_6	196	205	PF00069	0.452
DOC_MAPK_MEF2A_6	256	264	PF00069	0.524
DOC_USP7_MATH_1	140	144	PF00917	0.286
DOC_USP7_MATH_1	162	166	PF00917	0.291
DOC_USP7_MATH_2	15	21	PF00917	0.545
DOC_USP7_UBL2_3	26	30	PF12436	0.564
LIG_14-3-3_CanoR_1	103	113	PF00244	0.199
LIG_14-3-3_CanoR_1	132	137	PF00244	0.478
LIG_14-3-3_CanoR_1	163	170	PF00244	0.196
LIG_14-3-3_CanoR_1	50	55	PF00244	0.597
LIG_14-3-3_CanoR_1	76	84	PF00244	0.381
LIG_Actin_RPEL_3	249	268	PF02755	0.478
LIG_Actin_WH2_2	213	230	PF00022	0.215
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	171	175	PF00533	0.319
LIG_deltaCOP1_diTrp_1	129	136	PF00928	0.519
LIG_FHA_1	106	112	PF00498	0.313
LIG_FHA_1	205	211	PF00498	0.317
LIG_FHA_1	263	269	PF00498	0.537
LIG_FHA_1	91	97	PF00498	0.298
LIG_LIR_Gen_1	135	144	PF02991	0.295
LIG_LIR_Gen_1	187	197	PF02991	0.309
LIG_LIR_Gen_1	209	220	PF02991	0.394
LIG_LIR_Gen_1	240	250	PF02991	0.232
LIG_LIR_Gen_1	252	262	PF02991	0.371
LIG_LIR_Nem_3	135	139	PF02991	0.295
LIG_LIR_Nem_3	142	147	PF02991	0.296
LIG_LIR_Nem_3	172	178	PF02991	0.276
LIG_LIR_Nem_3	187	191	PF02991	0.285
LIG_LIR_Nem_3	209	215	PF02991	0.386
LIG_LIR_Nem_3	240	246	PF02991	0.232
LIG_LIR_Nem_3	252	257	PF02991	0.371
LIG_LIR_Nem_3	269	273	PF02991	0.550
LIG_MLH1_MIPbox_1	171	175	PF16413	0.319
LIG_SH2_GRB2like	31	34	PF00017	0.524
LIG_SH2_STAT5	174	177	PF00017	0.295
LIG_SH2_STAT5	179	182	PF00017	0.292
LIG_SH2_STAT5	243	246	PF00017	0.311
LIG_SH3_3	1	7	PF00018	0.568
LIG_SH3_3	257	263	PF00018	0.488
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.215
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.275
LIG_SUMO_SIM_par_1	14	20	PF11976	0.554
LIG_SUMO_SIM_par_1	202	207	PF11976	0.215
LIG_WRC_WIRS_1	185	190	PF05994	0.331
MOD_CK1_1	2	8	PF00069	0.638
MOD_CK2_1	163	169	PF00069	0.196
MOD_GlcNHglycan	1	4	PF01048	0.415
MOD_GlcNHglycan	46	49	PF01048	0.315
MOD_GlcNHglycan	80	83	PF01048	0.314
MOD_GSK3_1	216	223	PF00069	0.443
MOD_GSK3_1	279	286	PF00069	0.644
MOD_N-GLC_1	163	168	PF02516	0.416
MOD_N-GLC_1	284	289	PF02516	0.404
MOD_N-GLC_1	34	39	PF02516	0.443
MOD_N-GLC_1	44	49	PF02516	0.324
MOD_NEK2_1	147	152	PF00069	0.329
MOD_NEK2_1	191	196	PF00069	0.307
MOD_NEK2_1	206	211	PF00069	0.372
MOD_NEK2_1	220	225	PF00069	0.268
MOD_NEK2_1	284	289	PF00069	0.549
MOD_NEK2_1	89	94	PF00069	0.297
MOD_NEK2_1	98	103	PF00069	0.274
MOD_NEK2_2	184	189	PF00069	0.275
MOD_PIKK_1	220	226	PF00454	0.295
MOD_PIKK_1	262	268	PF00454	0.519
MOD_PIKK_1	35	41	PF00454	0.623
MOD_PK_1	163	169	PF00069	0.196
MOD_PKA_1	50	56	PF00069	0.515
MOD_PKA_2	162	168	PF00069	0.261
MOD_PKA_2	49	55	PF00069	0.611
MOD_PKA_2	75	81	PF00069	0.373
MOD_Plk_1	163	169	PF00069	0.245
MOD_Plk_1	284	290	PF00069	0.561
MOD_Plk_4	105	111	PF00069	0.257
MOD_Plk_4	147	153	PF00069	0.314
MOD_Plk_4	163	169	PF00069	0.211
MOD_Plk_4	206	212	PF00069	0.386
MOD_Plk_4	50	56	PF00069	0.506
MOD_Plk_4	90	96	PF00069	0.316
TRG_DiLeu_BaEn_4	279	285	PF01217	0.532
TRG_ENDOCYTIC_2	144	147	PF00928	0.321
TRG_ENDOCYTIC_2	179	182	PF00928	0.329
TRG_ENDOCYTIC_2	232	235	PF00928	0.329
TRG_ENDOCYTIC_2	243	246	PF00928	0.329
TRG_ER_diArg_1	59	62	PF00400	0.571
TRG_ER_diArg_1	75	77	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I5	Leptomonas seymouri	47%	75%
A0A0N1PAF6	Leptomonas seymouri	57%	81%
A0A1X0P8X4	Trypanosomatidae	42%	100%
A0A1X0P9Q6	Trypanosomatidae	48%	100%
A0A3R7M294	Trypanosoma rangeli	35%	100%
A0A3S5H538	Leishmania donovani	70%	80%
A0A3S5H540	Leishmania donovani	69%	98%
A4H3K7	Leishmania braziliensis	83%	100%
A4HRU8	Leishmania infantum	70%	80%
A4HRV0	Leishmania infantum	70%	98%
B0YBR5	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	27%	100%
E9ACI3	Leishmania major	74%	80%
E9ACI5	Leishmania major	70%	100%
E9AJS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AJS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	80%
E9AJS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
O14201	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	98%
O26317	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
P25613	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P32907	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P41943	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	100%
Q24JP1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q5B2K4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	100%