LeishMANIAdb
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DDRGK_domain_containing_protein_-_putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DDRGK_domain_containing_protein_-_putative
Gene product:
DDRGK domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4H3K4_LEIBR
TriTrypDb:
LbrM.03.0330 , LBRM2903_030008300 *
Length:
347

Annotations

LeishMANIAdb annotations

Similar to distant Eukaryotic DDRGK proteins. Likely bound to the ER.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

A4H3K4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K4

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 174 178 PF00656 0.693
CLV_MEL_PAP_1 327 333 PF00089 0.288
CLV_NRD_NRD_1 102 104 PF00675 0.437
CLV_NRD_NRD_1 142 144 PF00675 0.415
CLV_NRD_NRD_1 155 157 PF00675 0.342
CLV_NRD_NRD_1 182 184 PF00675 0.461
CLV_NRD_NRD_1 186 188 PF00675 0.404
CLV_NRD_NRD_1 229 231 PF00675 0.348
CLV_NRD_NRD_1 41 43 PF00675 0.434
CLV_NRD_NRD_1 87 89 PF00675 0.528
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I1I6 Leptomonas seymouri 52% 100%
A0A3R7MKY1 Trypanosoma rangeli 42% 100%
A0A3S5H536 Leishmania donovani 77% 100%
A4HRU4 Leishmania infantum 79% 100%
B0WIW5 Culex quinquefasciatus 26% 100%
B4KB40 Drosophila mojavensis 27% 100%
D0A242 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 99%
E9ACH9 Leishmania major 78% 100%
E9AJR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 94%
V5C2C3 Trypanosoma cruzi 46% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS