DDRGK_domain_containing_protein_-_putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DDRGK domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3K4_LEIBR

TriTrypDb:

LbrM.03.0330 , LBRM2903_030008300

Length:

347

Annotations

LeishMANIAdb annotations

Similar to distant Eukaryotic DDRGK proteins. Likely bound to the ER.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H3K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.693
CLV_MEL_PAP_1	327	333	PF00089	0.288
CLV_NRD_NRD_1	102	104	PF00675	0.437
CLV_NRD_NRD_1	142	144	PF00675	0.415
CLV_NRD_NRD_1	155	157	PF00675	0.342
CLV_NRD_NRD_1	182	184	PF00675	0.461
CLV_NRD_NRD_1	186	188	PF00675	0.404
CLV_NRD_NRD_1	229	231	PF00675	0.348
CLV_NRD_NRD_1	41	43	PF00675	0.434
CLV_NRD_NRD_1	87	89	PF00675	0.528
CLV_NRD_NRD_1	98	100	PF00675	0.464
CLV_PCSK_KEX2_1	102	104	PF00082	0.423
CLV_PCSK_KEX2_1	155	157	PF00082	0.394
CLV_PCSK_KEX2_1	182	184	PF00082	0.461
CLV_PCSK_KEX2_1	231	233	PF00082	0.373
CLV_PCSK_KEX2_1	86	88	PF00082	0.536
CLV_PCSK_KEX2_1	97	99	PF00082	0.458
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.272
CLV_PCSK_PC7_1	98	104	PF00082	0.412
CLV_PCSK_SKI1_1	145	149	PF00082	0.467
CLV_PCSK_SKI1_1	309	313	PF00082	0.275
DEG_SPOP_SBC_1	258	262	PF00917	0.558
DOC_MAPK_gen_1	326	333	PF00069	0.535
DOC_PP4_FxxP_1	312	315	PF00568	0.535
DOC_USP7_MATH_1	251	255	PF00917	0.665
DOC_USP7_MATH_1	258	262	PF00917	0.709
DOC_USP7_UBL2_3	144	148	PF12436	0.599
LIG_14-3-3_CanoR_1	235	240	PF00244	0.628
LIG_14-3-3_CanoR_1	28	35	PF00244	0.582
LIG_14-3-3_CanoR_1	293	300	PF00244	0.501
LIG_14-3-3_CanoR_1	328	334	PF00244	0.453
LIG_14-3-3_CanoR_1	46	53	PF00244	0.662
LIG_BIR_II_1	1	5	PF00653	0.396
LIG_FHA_2	260	266	PF00498	0.600
LIG_GBD_Chelix_1	6	14	PF00786	0.207
LIG_LIR_Nem_3	316	321	PF02991	0.452
LIG_NRBOX	7	13	PF00104	0.362
LIG_PCNA_PIPBox_1	233	242	PF02747	0.574
LIG_PCNA_yPIPBox_3	230	240	PF02747	0.581
LIG_SH2_PTP2	310	313	PF00017	0.535
LIG_SH2_STAP1	210	214	PF00017	0.574
LIG_SH2_STAT5	310	313	PF00017	0.515
LIG_SH3_3	32	38	PF00018	0.587
LIG_Sin3_3	9	16	PF02671	0.207
LIG_SUMO_SIM_par_1	269	275	PF11976	0.482
LIG_SUMO_SIM_par_1	279	286	PF11976	0.482
LIG_TRAF2_1	189	192	PF00917	0.634
LIG_TRAF2_1	262	265	PF00917	0.716
LIG_TRAF2_1	283	286	PF00917	0.535
LIG_TRAF2_1	332	335	PF00917	0.535
LIG_WRC_WIRS_1	236	241	PF05994	0.544
MOD_CK1_1	2	8	PF00069	0.459
MOD_CK1_1	260	266	PF00069	0.615
MOD_CK1_1	49	55	PF00069	0.704
MOD_CK2_1	258	264	PF00069	0.698
MOD_CK2_1	280	286	PF00069	0.418
MOD_CK2_1	329	335	PF00069	0.318
MOD_CK2_1	62	68	PF00069	0.650
MOD_Cter_Amidation	84	87	PF01082	0.776
MOD_GlcNHglycan	253	256	PF01048	0.619
MOD_GlcNHglycan	48	51	PF01048	0.618
MOD_GlcNHglycan	53	56	PF01048	0.724
MOD_GSK3_1	23	30	PF00069	0.511
MOD_GSK3_1	49	56	PF00069	0.698
MOD_GSK3_1	62	69	PF00069	0.468
MOD_N-GLC_1	62	67	PF02516	0.621
MOD_PIKK_1	23	29	PF00454	0.542
MOD_PIKK_1	292	298	PF00454	0.459
MOD_PKA_2	27	33	PF00069	0.497
MOD_PKA_2	292	298	PF00069	0.222
MOD_PKA_2	329	335	PF00069	0.304
MOD_Plk_1	2	8	PF00069	0.207
MOD_Plk_1	30	36	PF00069	0.719
MOD_Plk_4	235	241	PF00069	0.517
MOD_SUMO_rev_2	184	190	PF00179	0.509
MOD_SUMO_rev_2	200	205	PF00179	0.479
TRG_DiLeu_BaEn_4	220	226	PF01217	0.642
TRG_DiLeu_LyEn_5	316	321	PF01217	0.459
TRG_ENDOCYTIC_2	310	313	PF00928	0.348
TRG_ER_diArg_1	167	170	PF00400	0.491
TRG_ER_diArg_1	229	232	PF00400	0.544
TRG_ER_diArg_1	325	328	PF00400	0.418
TRG_ER_diArg_1	86	88	PF00400	0.686
TRG_ER_diArg_1	97	99	PF00400	0.594
TRG_NLS_MonoExtC_3	41	46	PF00514	0.514
TRG_NLS_MonoExtN_4	140	147	PF00514	0.620
TRG_NLS_MonoExtN_4	42	47	PF00514	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I6	Leptomonas seymouri	52%	100%
A0A3R7MKY1	Trypanosoma rangeli	42%	100%
A0A3S5H536	Leishmania donovani	77%	100%
A4HRU4	Leishmania infantum	79%	100%
B0WIW5	Culex quinquefasciatus	26%	100%
B4KB40	Drosophila mojavensis	27%	100%
D0A242	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	99%
E9ACH9	Leishmania major	78%	100%
E9AJR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	94%
V5C2C3	Trypanosoma cruzi	46%	100%