Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3K3_LEIBR

TriTrypDb:

LbrM.03.0320 , LBRM2903_030008200

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H3K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K3

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.566
CLV_C14_Caspase3-7	366	370	PF00656	0.398
CLV_NRD_NRD_1	184	186	PF00675	0.529
CLV_NRD_NRD_1	269	271	PF00675	0.715
CLV_NRD_NRD_1	296	298	PF00675	0.738
CLV_NRD_NRD_1	473	475	PF00675	0.469
CLV_NRD_NRD_1	5	7	PF00675	0.564
CLV_NRD_NRD_1	514	516	PF00675	0.501
CLV_NRD_NRD_1	58	60	PF00675	0.660
CLV_NRD_NRD_1	648	650	PF00675	0.687

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I3	Leptomonas seymouri	55%	94%
A0A1X0P8P7	Trypanosomatidae	42%	100%
A0A3S5H535	Leishmania donovani	76%	100%
A4HRU3	Leishmania infantum	77%	100%
D0A241	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACH8	Leishmania major	75%	100%
E9AJR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%

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