Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3K3_LEIBR

TriTrypDb:

LbrM.03.0320 , LBRM2903_030008200

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.566
CLV_C14_Caspase3-7	366	370	PF00656	0.398
CLV_NRD_NRD_1	184	186	PF00675	0.529
CLV_NRD_NRD_1	269	271	PF00675	0.715
CLV_NRD_NRD_1	296	298	PF00675	0.738
CLV_NRD_NRD_1	473	475	PF00675	0.469
CLV_NRD_NRD_1	5	7	PF00675	0.564
CLV_NRD_NRD_1	514	516	PF00675	0.501
CLV_NRD_NRD_1	58	60	PF00675	0.660
CLV_NRD_NRD_1	648	650	PF00675	0.687
CLV_PCSK_KEX2_1	184	186	PF00082	0.561
CLV_PCSK_KEX2_1	294	296	PF00082	0.736
CLV_PCSK_KEX2_1	473	475	PF00082	0.468
CLV_PCSK_KEX2_1	5	7	PF00082	0.564
CLV_PCSK_KEX2_1	514	516	PF00082	0.572
CLV_PCSK_KEX2_1	58	60	PF00082	0.685
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.627
CLV_PCSK_SKI1_1	167	171	PF00082	0.340
CLV_PCSK_SKI1_1	217	221	PF00082	0.439
CLV_PCSK_SKI1_1	240	244	PF00082	0.555
CLV_PCSK_SKI1_1	285	289	PF00082	0.658
CLV_PCSK_SKI1_1	297	301	PF00082	0.597
CLV_PCSK_SKI1_1	426	430	PF00082	0.652
CLV_PCSK_SKI1_1	498	502	PF00082	0.401
DEG_APCC_DBOX_1	376	384	PF00400	0.611
DEG_APCC_DBOX_1	497	505	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.528
DEG_SPOP_SBC_1	255	259	PF00917	0.555
DEG_SPOP_SBC_1	47	51	PF00917	0.608
DOC_CYCLIN_RxL_1	336	346	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.499
DOC_MAPK_DCC_7	594	603	PF00069	0.422
DOC_MAPK_gen_1	217	225	PF00069	0.425
DOC_MAPK_MEF2A_6	217	225	PF00069	0.435
DOC_MAPK_MEF2A_6	594	603	PF00069	0.421
DOC_PP2B_LxvP_1	575	578	PF13499	0.476
DOC_PP4_FxxP_1	428	431	PF00568	0.707
DOC_PP4_FxxP_1	570	573	PF00568	0.510
DOC_PP4_FxxP_1	644	647	PF00568	0.643
DOC_USP7_MATH_1	255	259	PF00917	0.802
DOC_USP7_MATH_1	269	273	PF00917	0.668
DOC_USP7_MATH_1	329	333	PF00917	0.438
DOC_USP7_MATH_1	431	435	PF00917	0.687
DOC_USP7_MATH_1	444	448	PF00917	0.709
DOC_USP7_MATH_1	475	479	PF00917	0.637
DOC_USP7_MATH_1	537	541	PF00917	0.442
DOC_USP7_MATH_1	576	580	PF00917	0.310
DOC_USP7_MATH_2	475	481	PF00917	0.385
DOC_USP7_UBL2_3	294	298	PF12436	0.675
DOC_WW_Pin1_4	152	157	PF00397	0.747
DOC_WW_Pin1_4	298	303	PF00397	0.772
DOC_WW_Pin1_4	41	46	PF00397	0.559
DOC_WW_Pin1_4	416	421	PF00397	0.724
DOC_WW_Pin1_4	427	432	PF00397	0.788
DOC_WW_Pin1_4	482	487	PF00397	0.473
DOC_WW_Pin1_4	589	594	PF00397	0.521
DOC_WW_Pin1_4	59	64	PF00397	0.556
DOC_WW_Pin1_4	8	13	PF00397	0.565
LIG_14-3-3_CanoR_1	184	189	PF00244	0.571
LIG_14-3-3_CanoR_1	270	277	PF00244	0.507
LIG_14-3-3_CanoR_1	285	292	PF00244	0.683
LIG_14-3-3_CanoR_1	296	302	PF00244	0.658
LIG_14-3-3_CanoR_1	413	422	PF00244	0.801
LIG_14-3-3_CanoR_1	465	475	PF00244	0.475
LIG_14-3-3_CanoR_1	538	545	PF00244	0.447
LIG_14-3-3_CanoR_1	594	598	PF00244	0.515
LIG_14-3-3_CanoR_1	618	626	PF00244	0.547
LIG_14-3-3_CanoR_1	640	645	PF00244	0.561
LIG_AP2alpha_2	629	631	PF02296	0.704
LIG_APCC_ABBA_1	139	144	PF00400	0.501
LIG_APCC_ABBA_1	341	346	PF00400	0.577
LIG_BIR_III_2	144	148	PF00653	0.459
LIG_BRCT_BRCA1_1	158	162	PF00533	0.595
LIG_Clathr_ClatBox_1	455	459	PF01394	0.317
LIG_CtBP_PxDLS_1	302	306	PF00389	0.549
LIG_deltaCOP1_diTrp_1	658	667	PF00928	0.673
LIG_deltaCOP1_diTrp_1	83	94	PF00928	0.469
LIG_FHA_1	276	282	PF00498	0.696
LIG_FHA_1	387	393	PF00498	0.670
LIG_FHA_1	41	47	PF00498	0.638
LIG_FHA_1	560	566	PF00498	0.481
LIG_FHA_1	581	587	PF00498	0.443
LIG_FHA_2	166	172	PF00498	0.434
LIG_FHA_2	241	247	PF00498	0.733
LIG_FHA_2	286	292	PF00498	0.758
LIG_FHA_2	370	376	PF00498	0.570
LIG_FHA_2	402	408	PF00498	0.725
LIG_LIR_Apic_2	425	431	PF02991	0.683
LIG_LIR_Apic_2	568	573	PF02991	0.477
LIG_LIR_Apic_2	643	647	PF02991	0.574
LIG_LIR_Gen_1	492	502	PF02991	0.442
LIG_LIR_Nem_3	187	191	PF02991	0.406
LIG_LIR_Nem_3	492	497	PF02991	0.419
LIG_MYND_1	156	160	PF01753	0.496
LIG_NRBOX	276	282	PF00104	0.675
LIG_NRBOX	496	502	PF00104	0.439
LIG_Pex14_2	230	234	PF04695	0.539
LIG_SH2_NCK_1	381	385	PF00017	0.355
LIG_SH2_SRC	381	384	PF00017	0.603
LIG_SH2_STAP1	381	385	PF00017	0.355
LIG_SH2_STAP1	479	483	PF00017	0.396
LIG_SH2_STAT3	135	138	PF00017	0.434
LIG_SH2_STAT5	466	469	PF00017	0.448
LIG_SH2_STAT5	597	600	PF00017	0.450
LIG_SH3_3	229	235	PF00018	0.462
LIG_SH3_3	310	316	PF00018	0.510
LIG_SH3_3	504	510	PF00018	0.574
LIG_SH3_3	6	12	PF00018	0.569
LIG_SH3_3	624	630	PF00018	0.417
LIG_SUMO_SIM_par_1	339	346	PF11976	0.419
LIG_SUMO_SIM_par_1	388	393	PF11976	0.468
LIG_SUMO_SIM_par_1	456	462	PF11976	0.506
LIG_SUMO_SIM_par_1	573	579	PF11976	0.459
LIG_TRAF2_1	373	376	PF00917	0.635
MOD_CDC14_SPxK_1	11	14	PF00782	0.565
MOD_CDC14_SPxK_1	16	19	PF00782	0.536
MOD_CDC14_SPxK_1	62	65	PF00782	0.536
MOD_CDK_SPK_2	589	594	PF00069	0.514
MOD_CDK_SPxK_1	59	65	PF00069	0.538
MOD_CDK_SPxK_1	8	14	PF00069	0.567
MOD_CK1_1	165	171	PF00069	0.394
MOD_CK1_1	272	278	PF00069	0.572
MOD_CK1_1	304	310	PF00069	0.766
MOD_CK1_1	418	424	PF00069	0.594
MOD_CK1_1	434	440	PF00069	0.577
MOD_CK1_1	540	546	PF00069	0.455
MOD_CK1_1	589	595	PF00069	0.569
MOD_CK2_1	245	251	PF00069	0.789
MOD_CK2_1	285	291	PF00069	0.525
MOD_CK2_1	356	362	PF00069	0.433
MOD_CK2_1	369	375	PF00069	0.539
MOD_CK2_1	401	407	PF00069	0.583
MOD_CK2_1	48	54	PF00069	0.516
MOD_CK2_1	668	674	PF00069	0.724
MOD_Cter_Amidation	292	295	PF01082	0.542
MOD_GlcNHglycan	152	155	PF01048	0.639
MOD_GlcNHglycan	244	250	PF01048	0.664
MOD_GlcNHglycan	26	29	PF01048	0.616
MOD_GlcNHglycan	271	274	PF01048	0.563
MOD_GlcNHglycan	306	309	PF01048	0.640
MOD_GlcNHglycan	358	361	PF01048	0.587
MOD_GlcNHglycan	433	436	PF01048	0.681
MOD_GlcNHglycan	461	464	PF01048	0.477
MOD_GlcNHglycan	578	581	PF01048	0.372
MOD_GlcNHglycan	633	636	PF01048	0.559
MOD_GlcNHglycan	73	76	PF01048	0.541
MOD_GSK3_1	146	153	PF00069	0.652
MOD_GSK3_1	158	165	PF00069	0.438
MOD_GSK3_1	240	247	PF00069	0.727
MOD_GSK3_1	272	279	PF00069	0.591
MOD_GSK3_1	297	304	PF00069	0.744
MOD_GSK3_1	401	408	PF00069	0.645
MOD_GSK3_1	414	421	PF00069	0.825
MOD_GSK3_1	427	434	PF00069	0.658
MOD_GSK3_1	477	484	PF00069	0.390
MOD_GSK3_1	576	583	PF00069	0.455
MOD_GSK3_1	589	596	PF00069	0.513
MOD_GSK3_1	668	675	PF00069	0.710
MOD_N-GLC_1	369	374	PF02516	0.437
MOD_N-GLC_1	672	677	PF02516	0.634
MOD_NEK2_1	134	139	PF00069	0.435
MOD_NEK2_1	150	155	PF00069	0.618
MOD_NEK2_1	356	361	PF00069	0.519
MOD_NEK2_1	399	404	PF00069	0.555
MOD_NEK2_1	422	427	PF00069	0.659
MOD_NEK2_1	46	51	PF00069	0.682
MOD_NEK2_1	481	486	PF00069	0.546
MOD_NEK2_1	523	528	PF00069	0.507
MOD_NEK2_1	566	571	PF00069	0.579
MOD_NEK2_1	631	636	PF00069	0.618
MOD_PIKK_1	134	140	PF00454	0.423
MOD_PIKK_1	329	335	PF00454	0.473
MOD_PIKK_1	466	472	PF00454	0.522
MOD_PIKK_1	537	543	PF00454	0.481
MOD_PIKK_1	617	623	PF00454	0.385
MOD_PIKK_1	93	99	PF00454	0.606
MOD_PKA_1	184	190	PF00069	0.396
MOD_PKA_1	297	303	PF00069	0.648
MOD_PKA_2	184	190	PF00069	0.580
MOD_PKA_2	269	275	PF00069	0.633
MOD_PKA_2	537	543	PF00069	0.445
MOD_PKA_2	593	599	PF00069	0.534
MOD_PKA_2	617	623	PF00069	0.541
MOD_PKA_2	71	77	PF00069	0.770
MOD_PKB_1	295	303	PF00069	0.553
MOD_Plk_1	123	129	PF00069	0.532
MOD_Plk_1	165	171	PF00069	0.499
MOD_Plk_1	657	663	PF00069	0.679
MOD_Plk_1	672	678	PF00069	0.688
MOD_Plk_2-3	401	407	PF00069	0.558
MOD_Plk_4	158	164	PF00069	0.422
MOD_Plk_4	276	282	PF00069	0.675
MOD_Plk_4	609	615	PF00069	0.431
MOD_Plk_4	657	663	PF00069	0.733
MOD_ProDKin_1	152	158	PF00069	0.746
MOD_ProDKin_1	298	304	PF00069	0.771
MOD_ProDKin_1	41	47	PF00069	0.561
MOD_ProDKin_1	416	422	PF00069	0.723
MOD_ProDKin_1	427	433	PF00069	0.785
MOD_ProDKin_1	482	488	PF00069	0.473
MOD_ProDKin_1	589	595	PF00069	0.515
MOD_ProDKin_1	59	65	PF00069	0.558
MOD_ProDKin_1	8	14	PF00069	0.567
MOD_SUMO_rev_2	213	221	PF00179	0.446
MOD_SUMO_rev_2	272	278	PF00179	0.494
TRG_DiLeu_BaEn_4	375	381	PF01217	0.619
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.507
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.472
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.487
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.538
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.587
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.483
TRG_ER_diArg_1	183	185	PF00400	0.483
TRG_ER_diArg_1	295	297	PF00400	0.665
TRG_ER_diArg_1	4	6	PF00400	0.728
TRG_ER_diArg_1	473	475	PF00400	0.564
TRG_ER_diArg_1	513	515	PF00400	0.505
TRG_ER_diArg_1	57	59	PF00400	0.694
TRG_ER_diArg_1	622	625	PF00400	0.575
TRG_NES_CRM1_1	210	222	PF08389	0.551
TRG_NLS_MonoCore_2	293	298	PF00514	0.551
TRG_NLS_MonoExtC_3	293	298	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.769
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I3	Leptomonas seymouri	55%	94%
A0A1X0P8P7	Trypanosomatidae	42%	100%
A0A3S5H535	Leishmania donovani	76%	100%
A4HRU3	Leishmania infantum	77%	100%
D0A241	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ACH8	Leishmania major	75%	100%
E9AJR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%